NCDN_MOUSE - dbPTM
NCDN_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NCDN_MOUSE
UniProt AC Q9Z0E0
Protein Name Neurochondrin
Gene Name Ncdn
Organism Mus musculus (Mouse).
Sequence Length 729
Subcellular Localization Cytoplasm, cytosol. Cell projection, dendrite. Localizes to somatic regions of neurons..
Protein Description Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth..
Protein Sequence MSCCDLAAAGQLGKAGIMASDCEPALNQAESRNPTLERYLGALREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALGVALLACFCSDPELASHPQVLNKIPILSTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHLIAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQRAEDASKFELCQLLPLFLPPTTVPPECHRDLQAGLARILGSKLSSWQRNPALKLAARLAHACGSDWIPVGSSGSKFLALLVNLACVEVRLALEETGTEVKEDVVTACYALMELGIQECTRCEQSLLKEPQKVQLVSIMKEAIGAVIHYLLQVGPEKQKEPFVFASVRILGAWLAEETSSLRKEVCQLLPFLVRYAKTLYEEAEEASDISQQVANLAISPTTPGPSWPGDALRLLLPGWCHLTVEDGPREILIKEGAPSLLCKYFLQQWELTSPGHDTSVLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPSLVQQQGRLLLAANVATLGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPDYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMAALEQCLSEP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSCCDLAAA
------CCHHHHHHC		24.37-
2Phosphorylation------MSCCDLAAA
------CCHHHHHHC		24.3725619855
3 (in isoform 2)Phosphorylation-1.7026824392
3S-palmitoylation-----MSCCDLAAAG
-----CCHHHHHHCC		1.70-
4S-palmitoylation----MSCCDLAAAGQ
----CCHHHHHHCCC		3.63-
20PhosphorylationGKAGIMASDCEPALN
CCCCCCHHCCHHHHH		25.9726745281
54UbiquitinationKNDSEQFAALLLVTK
CCCHHHHHHHHHHHH		9.2627667366
61UbiquitinationAALLLVTKAVKAGDI
HHHHHHHHHHHHCCC		43.6422790023
71UbiquitinationKAGDIDAKTRRRIFD
HHCCCCHHHHHHHHH		38.5227667366
75Asymmetric dimethylarginineIDAKTRRRIFDAVGF
CCHHHHHHHHHHHCC		30.54-
75MethylationIDAKTRRRIFDAVGF
CCHHHHHHHHHHHCC		30.5424129315
83PhosphorylationIFDAVGFTFPNRLLT
HHHHHCCCCCCCCCC		32.0522817900
92UbiquitinationPNRLLTTKEAPDGCP
CCCCCCCCCCCCCCC		46.7922790023
113S-palmitoylationLGVALLACFCSDPEL
HHHHHHHHHHCCHHH		3.4028680068
150PhosphorylationPDDAARRSMIDDTYQ
CCHHHHHHHHCCHHH		17.9729899451
255UbiquitinationLPPTTVPPECHRDLQ
CCCCCCCHHHCHHHH		53.1327667366
266UbiquitinationRDLQAGLARILGSKL
HHHHHHHHHHHCCCC		8.7827667366
272UbiquitinationLARILGSKLSSWQRN
HHHHHCCCCHHCCCC		51.0622790023
283UbiquitinationWQRNPALKLAARLAH
CCCCHHHHHHHHHHH		37.8822790023
366PhosphorylationPQKVQLVSIMKEAIG
CCHHHHHHHHHHHHH		26.0929514104
378PhosphorylationAIGAVIHYLLQVGPE
HHHHHHHHHHHHCCH		9.6629514104
407PhosphorylationGAWLAEETSSLRKEV
HHHHHHHCHHHHHHH		18.3420415495
408PhosphorylationAWLAEETSSLRKEVC
HHHHHHCHHHHHHHH		30.5622324799
409PhosphorylationWLAEETSSLRKEVCQ
HHHHHCHHHHHHHHH		39.3422324799
412UbiquitinationEETSSLRKEVCQLLP
HHCHHHHHHHHHHHH		60.8522790023
415S-nitrosylationSSLRKEVCQLLPFLV
HHHHHHHHHHHHHHH		2.1822588120
448PhosphorylationQVANLAISPTTPGPS
HHHHHCCCCCCCCCC		15.5822817900
450PhosphorylationANLAISPTTPGPSWP
HHHCCCCCCCCCCCC		38.5420415495
451PhosphorylationNLAISPTTPGPSWPG
HHCCCCCCCCCCCCH		29.6320415495
455PhosphorylationSPTTPGPSWPGDALR
CCCCCCCCCCHHHHH		52.3920415495
469S-palmitoylationRLLLPGWCHLTVEDG
HHHCCCEEEEEECCC		2.0328680068
483UbiquitinationGPREILIKEGAPSLL
CCCEEEEECCCHHHH		46.8022790023
581PhosphorylationLLMARLLSTSPALQG
HHHHHHHCCCHHHCC		31.2820415495
582PhosphorylationLMARLLSTSPALQGT
HHHHHHCCCHHHCCC		38.4020415495
583PhosphorylationMARLLSTSPALQGTP
HHHHHCCCHHHCCCC		12.5625521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NCDN_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NCDN_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NCDN_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NCDN_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NCDN_MOUSE

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Related Literatures of Post-Translational Modification

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