dbPTM

3BP5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	3BP5_MOUSE
UniProt AC	Q9Z131
Protein Name	SH3 domain-binding protein 5
Gene Name	Sh3bp5
Organism	Mus musculus (Mouse).
Sequence Length	463
Subcellular Localization	Mitochondrion.
Protein Description	Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death..
Protein Sequence	MDTALKRSRSDEPAELPPPAREVEEKEEEEERMEQGLEEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELAKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGVGAEGSIASVENLPVSKPEPDAISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLGSTNGGSGRSRSQSSTSLESQALETRMKQLSLQCSKGRDGIIADIKMIFIFYTFLQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MDTALKRSRSDEPAE CCCHHHHCCCCCCCC	34.25	30635358
10	Phosphorylation	TALKRSRSDEPAELP CHHHHCCCCCCCCCC	47.80	26824392
91	Ubiquitination	TVKLDELAKKIGKAV HHCHHHHHHHHHHHH	14.73	27667366
122	Phosphorylation	QLEAQKATQDFQRAT HHHHHHHHHHHHHHH	35.39	25619855
136	Ubiquitination	TEVLRAAKETISLAE HHHHHHHHHHHHHHH	55.17	22790023
184	Acetylation	TRSELVHKETAARYN CHHHHHHHHHHHHHH	49.64	7718343
202	Acetylation	GRMRQLEKKLKRAIN HHHHHHHHHHHHHHH	72.50	7718355
247	Acetylation	ALAKGEYKAALKSLE HHHHHHHHHHHHHHH	23.92	6566709
249	Ubiquitination	AKGEYKAALKSLERI HHHHHHHHHHHHHHH	16.03	27667366
251	Ubiquitination	GEYKAALKSLERISD HHHHHHHHHHHHHHH	48.55	22790023
354	Phosphorylation	PGSLDLPSPVSLSEF CCCCCCCCCCCHHHH	45.27	21743459
357	Phosphorylation	LDLPSPVSLSEFGMM CCCCCCCCHHHHCCC	29.57	21743459
359	Phosphorylation	LPSPVSLSEFGMMFP CCCCCCHHHHCCCCC	24.31	21743459
375	Phosphorylation	LGPRSECSGASSPEC CCCCHHCCCCCCCCC	33.08	30635358
378	Phosphorylation	RSECSGASSPECEVE CHHCCCCCCCCCEEC	50.37	29899451
379	Phosphorylation	SECSGASSPECEVER HHCCCCCCCCCEECC	24.96	30635358
398	Phosphorylation	EGAENKMSDKANNNR CCHHHHCCCCCCCCC	37.25	25521595
409	Phosphorylation	NNNRVLGSTNGGSGR CCCCCCCCCCCCCCC	17.97	30635358
410	Phosphorylation	NNRVLGSTNGGSGRS CCCCCCCCCCCCCCC	35.76	30635358
414	Phosphorylation	LGSTNGGSGRSRSQS CCCCCCCCCCCCCCC	32.22	30635358
417	Phosphorylation	TNGGSGRSRSQSSTS CCCCCCCCCCCCCCC	39.55	23984901
419 (in isoform 2)	Phosphorylation	-	35.34	24719451
419	Phosphorylation	GGSGRSRSQSSTSLE CCCCCCCCCCCCCHH	35.34	25521595
421	Phosphorylation	SGRSRSQSSTSLESQ CCCCCCCCCCCHHHH	36.51	25521595
422	Phosphorylation	GRSRSQSSTSLESQA CCCCCCCCCCHHHHH	17.87	27742792
423	Phosphorylation	RSRSQSSTSLESQAL CCCCCCCCCHHHHHH	42.45	27742792
424	Phosphorylation	SRSQSSTSLESQALE CCCCCCCCHHHHHHH	31.89	25521595
427	Phosphorylation	QSSTSLESQALETRM CCCCCHHHHHHHHHH	26.50	27742792
432	Phosphorylation	LESQALETRMKQLSL HHHHHHHHHHHHHHH	36.59	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
354	S	Phosphorylation	Kinase	MAPK9	Q9WTU6	Uniprot
354	S	Phosphorylation	Kinase	MAPK12	O08911	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of 3BP5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of 3BP5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of 3BP5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of 3BP5_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421, AND MASSSPECTROMETRY.	17242355 [Abstract]