MIPT3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIPT3_MOUSE
• UniProt AC: Q149C2
• Protein Name: TRAF3-interacting protein 1
• Gene Name: Traf3ip1
• Organism: Mus musculus (Mouse).
• Sequence Length: 625
• Subcellular Localization: Cytoplasm, cytoskeleton . Cell projection, cilium . Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, cilium basal body . Microtubules. In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip.
• Protein Description: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in epithelial morphogenesis and in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. [PubMed: 26487268 Involved in ciliogenesis]
• Protein Sequence: MNAAVVRRTQEALGKVIRRPPLTEKLLNKPPFRYLHDIITEVIRITGFMKGLYTDAEMKSENVKDKDAKISFLQKAIDVVMMVSGEPLAAKPARIVAGHEPERTNELLQLIGKCCLSKLSSDEAVKRVLAGDKGDSRGRAQRTSKAQEPNNKSGKEEESRIHKEDKRSSEAKERSASAEHKQKEELKEDSKPREKERDKEKAKEADRDRHRDPDRDRNRDGEREKARARAKDRDRNNRDRDREAERDRERDRRSEGGKEKERVKDRDRDRDKGRDRERRKSKNGEHTRDPDREKSRDADKPEKKSSSSGEISRKLSDGSFKDVKAEMEADISVGASRSSTLKPSKRRSKHSLEGDSPSDAEVEAGPAGQDKPEVMENAEVPSELPSSLRRIPRPGSARPAPPRVKRQESTETLVVDRSGSGKTVSSVIIDSQNSDNEDDEQFVVEAAPQLSEIADIDMVPSGELEDEEKHGGLVKKILETKKDYEKLQQSLKPGEKERSLIFESAWKKEKDIVSKEIEKLRVSIQTLCKSALPLGKIMDYIQEDVDAMQNELQLWHSENRQHAEALSQEQSITDSAVEPLKAELSELEQQIRDQQDKICAVKANILKNEEKIQKMVHSINLSSRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Phosphorylation	IDVVMMVSGEPLAAK HCEEEECCCCCCCCC	21.39	27357545
118	Acetylation	IGKCCLSKLSSDEAV HHHHHHHCCCCHHHH	39.17	2390093
126	Acetylation	LSSDEAVKRVLAGDK CCCHHHHHHHHCCCC	43.78	23576753
133	Acetylation	KRVLAGDKGDSRGRA HHHHCCCCCCHHHHH	64.79	2390109
136	Phosphorylation	LAGDKGDSRGRAQRT HCCCCCCHHHHHHHC	45.35	19854140
190	Phosphorylation	KEELKEDSKPREKER HHHHHHCCCHHHHHH	45.72	28464351
306	Phosphorylation	DKPEKKSSSSGEISR CCCCCCCCCCCCHHH	37.09	25338131
316	Phosphorylation	GEISRKLSDGSFKDV CCHHHHHCCCCHHHH	42.85	26824392
319	Phosphorylation	SRKLSDGSFKDVKAE HHHHCCCCHHHHHHH	33.83	22817900
351	Phosphorylation	SKRRSKHSLEGDSPS CCCCCCCCCCCCCCC	31.67	25293948
356	Phosphorylation	KHSLEGDSPSDAEVE CCCCCCCCCCCCCCC	36.84	21183079
358	Phosphorylation	SLEGDSPSDAEVEAG CCCCCCCCCCCCCCC	54.10	28507225
387	Phosphorylation	VPSELPSSLRRIPRP CCCCCCHHHCCCCCC	24.77	23140645
409	Phosphorylation	PRVKRQESTETLVVD CCCCCCCCCCEEEEC	24.17	25521595
410	Phosphorylation	RVKRQESTETLVVDR CCCCCCCCCEEEECC	32.03	27742792
412	Phosphorylation	KRQESTETLVVDRSG CCCCCCCEEEECCCC	25.58	27742792
614	Acetylation	KNEEKIQKMVHSINL CCHHHHHHHHHHCCC	46.49	7624015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIPT3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIPT3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIPT3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MIPT3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND MASSSPECTROMETRY.
PubMed: 19367708