PP6R1_MOUSE - dbPTM
PP6R1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PP6R1_MOUSE
UniProt AC Q7TSI3
Protein Name Serine/threonine-protein phosphatase 6 regulatory subunit 1
Gene Name Ppp6r1
Organism Mus musculus (Mouse).
Sequence Length 856
Subcellular Localization Cytoplasm.
Protein Description Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha (By similarity)..
Protein Sequence MFWKFDLHTSSHLDTLLEKEDLSLPELLDEEDVLQECKVVNRKLLDFLLQPSHLQAMVAWVTQEPPASGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSGDSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLRHIGTSAIMDLLLRLLTCVERPQLRQDVFNWLNEEKIVQRLIEQIHPSKDDNQHSNASQSLCDIIRLSREQMIQGQDSPEPDQLLATLEKQETIEQLLSNMFEGEQCQSVIVSGIQVLLTLLEPRRPRSDSVTMNNFFSSVDGQLELLAQGALDDALSSMGALHALRPRLDRFHQLLLEPPKLEPLQMTWGSLAPPLGNTRLHVVKLLASALSANAAALTQELLVLDVPNTLLDLFFHYVFNNFLHAQVEVCVSAMLSSGPPPDSSSETPVPNPIVKHLLQHCRLVERILASWEENDRVQSGGGPRKGYMGHLTRVANAVVQNAEQGPNAEQLGQLLKELPEEQQQRWEAFVSGPLAETNKKNTVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDEEEEEEEGQGSAESDGEYGAWQGSQPVRASQASQPPGVRSGGSTDSEEEDEEEDEEEDEGAEQAACGRTSPSSFPSPSTQPPGPSWTATFDTVPMDAPTGPPVSKEADMSSIQIPSSPPAHGSPQLRSQDPTHPSAPQEVTDSSKVAEPLAPCQALVSVADVQATLHGMRSAPSSLDSATRDPSTSVPDFKAHQSPQTMEGKRSPEHLGLPQSQSALEMPNGSTPGGPISSGSQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
190UbiquitinationFNWLNEEKIVQRLIE
HHHHCHHHHHHHHHH		41.83-
232PhosphorylationQMIQGQDSPEPDQLL
HHHCCCCCCCHHHHH		24.2321082442
455PhosphorylationEENDRVQSGGGPRKG
HHCCCCCCCCCCCCC		36.2323684622
518PhosphorylationAETNKKNTVDLVNTH
CCCCCCCCEEEEECC		25.0325266776
524PhosphorylationNTVDLVNTHHLHSSS
CCEEEEECCCCCCCC		11.8226824392
529PhosphorylationVNTHHLHSSSDDEDD
EECCCCCCCCCCCCH		37.5927087446
530PhosphorylationNTHHLHSSSDDEDDR
ECCCCCCCCCCCCHH		27.3427087446
531PhosphorylationTHHLHSSSDDEDDRL
CCCCCCCCCCCCHHH		52.6927087446
633PhosphorylationEEEEGQGSAESDGEY
HHHCCCCCCCCCCCC		22.4523684622
636PhosphorylationEGQGSAESDGEYGAW
CCCCCCCCCCCCCCC		51.1125521595
640PhosphorylationSAESDGEYGAWQGSQ
CCCCCCCCCCCCCCC		20.0629899451
646PhosphorylationEYGAWQGSQPVRASQ
CCCCCCCCCCCCHHH		19.0622324799
655PhosphorylationPVRASQASQPPGVRS
CCCHHHCCCCCCCCC		35.2730482847
662PhosphorylationSQPPGVRSGGSTDSE
CCCCCCCCCCCCCCH		45.1323684622
665PhosphorylationPGVRSGGSTDSEEED
CCCCCCCCCCCHHCC		32.3525521595
666PhosphorylationGVRSGGSTDSEEEDE
CCCCCCCCCCHHCCH		46.9825521595
668PhosphorylationRSGGSTDSEEEDEEE
CCCCCCCCHHCCHHH		47.1723684622
691PhosphorylationEQAACGRTSPSSFPS
HHHHCCCCCCCCCCC		30.2123684622
692PhosphorylationQAACGRTSPSSFPSP
HHHCCCCCCCCCCCC		22.7924704852
694PhosphorylationACGRTSPSSFPSPST
HCCCCCCCCCCCCCC		44.3622942356
695PhosphorylationCGRTSPSSFPSPSTQ
CCCCCCCCCCCCCCC		44.5623737553
698PhosphorylationTSPSSFPSPSTQPPG
CCCCCCCCCCCCCCC		29.4923737553
700PhosphorylationPSSFPSPSTQPPGPS
CCCCCCCCCCCCCCC		43.9724704852
701PhosphorylationSSFPSPSTQPPGPSW
CCCCCCCCCCCCCCC		48.7825777480
707PhosphorylationSTQPPGPSWTATFDT
CCCCCCCCCEEEEEE		42.8721183079
709PhosphorylationQPPGPSWTATFDTVP
CCCCCCCEEEEEEEC		21.8425777480
711PhosphorylationPGPSWTATFDTVPMD
CCCCCEEEEEEECCC		18.0526026062
714PhosphorylationSWTATFDTVPMDAPT
CCEEEEEEECCCCCC		23.4823649490
721PhosphorylationTVPMDAPTGPPVSKE
EECCCCCCCCCCCCC		65.1325777480
726PhosphorylationAPTGPPVSKEADMSS
CCCCCCCCCCCCCCC		30.4725777480
732PhosphorylationVSKEADMSSIQIPSS
CCCCCCCCCCCCCCC		25.4927742792
733PhosphorylationSKEADMSSIQIPSSP
CCCCCCCCCCCCCCC		16.3325619855
738PhosphorylationMSSIQIPSSPPAHGS
CCCCCCCCCCCCCCC		58.0427742792
739PhosphorylationSSIQIPSSPPAHGSP
CCCCCCCCCCCCCCC		29.5527087446
745PhosphorylationSSPPAHGSPQLRSQD
CCCCCCCCCCCCCCC		10.2927742792
750PhosphorylationHGSPQLRSQDPTHPS
CCCCCCCCCCCCCCC		47.7526643407
754PhosphorylationQLRSQDPTHPSAPQE
CCCCCCCCCCCCCCC		55.5026643407
757PhosphorylationSQDPTHPSAPQEVTD
CCCCCCCCCCCCCCC		45.0026643407
763PhosphorylationPSAPQEVTDSSKVAE
CCCCCCCCCCCCCCC		29.4326643407
765PhosphorylationAPQEVTDSSKVAEPL
CCCCCCCCCCCCCCC		23.7726643407
766PhosphorylationPQEVTDSSKVAEPLA
CCCCCCCCCCCCCCH		33.6826643407
796PhosphorylationHGMRSAPSSLDSATR
HHHHCCCCCCCCCCC		43.1630635358
797PhosphorylationGMRSAPSSLDSATRD
HHHCCCCCCCCCCCC		34.8330635358
800PhosphorylationSAPSSLDSATRDPST
CCCCCCCCCCCCCCC		36.5130635358
802PhosphorylationPSSLDSATRDPSTSV
CCCCCCCCCCCCCCC		39.2930635358
808PhosphorylationATRDPSTSVPDFKAH
CCCCCCCCCCCCCCC		35.6729899451
817PhosphorylationPDFKAHQSPQTMEGK
CCCCCCCCCCCCCCC		14.7630635358
820PhosphorylationKAHQSPQTMEGKRSP
CCCCCCCCCCCCCCH		22.1530635358
826PhosphorylationQTMEGKRSPEHLGLP
CCCCCCCCHHHHCCC		37.8221082442
835PhosphorylationEHLGLPQSQSALEMP
HHHCCCHHHCHHCCC		24.9428285833
837PhosphorylationLGLPQSQSALEMPNG
HCCCHHHCHHCCCCC		39.8229550500
841OxidationQSQSALEMPNGSTPG
HHHCHHCCCCCCCCC		3.0417242355
845PhosphorylationALEMPNGSTPGGPIS
HHCCCCCCCCCCCCC		37.7622802335
846PhosphorylationLEMPNGSTPGGPISS
HCCCCCCCCCCCCCC		27.6122802335
852PhosphorylationSTPGGPISSGSQ---
CCCCCCCCCCCC---		31.6022802335
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PP6R1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PP6R1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PP6R1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BLMH_HUMANBLMHphysical
26496610
QOR_HUMANCRYZphysical
26496610
TF3C1_HUMANGTF3C1physical
26496610
PPP6_HUMANPPP6Cphysical
26496610
PRKDC_HUMANPRKDCphysical
26496610
TFR1_HUMANTFRCphysical
26496610
TIAR_HUMANTIAL1physical
26496610
ARHG2_HUMANARHGEF2physical
26496610
TRAP1_HUMANTRAP1physical
26496610
TBA1B_HUMANTUBA1Bphysical
26496610
GCN1_HUMANGCN1L1physical
26496610
SPART_HUMANSPG20physical
26496610
ANR28_HUMANANKRD28physical
26496610
SPA5L_HUMANSPATA5L1physical
26496610
ESRP2_HUMANESRP2physical
26496610
TBB6_HUMANTUBB6physical
26496610
MYPN_HUMANMYPNphysical
26496610
ANR44_HUMANANKRD44physical
26496610
C1QT6_HUMANC1QTNF6physical
26496610
TBB5_HUMANTUBBphysical
26496610
ANR52_HUMANANKRD52physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PP6R1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-529; SER-530; SER-531AND SER-826, AND MASS SPECTROMETRY.

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