ANR44_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANR44_HUMAN
• UniProt AC: Q8N8A2
• Protein Name: Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
• Gene Name: ANKRD44
• Organism: Homo sapiens (Human).
• Sequence Length: 993
• Protein Description: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates..
• Protein Sequence: MAVLKLTDQPPLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNALQTPLHVAARNGLKVVVEELLAKGACVLAVDENASRSNGPRSTPGTAVQKEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Ubiquitination	EIRMLIHKTEDVNTL HHHHHEECCCCCCCC	46.76	-
95	Acetylation	EAVQVLIKHSADVNA HHHHHHHHHCCCCCC	27.61	7663061
105	Ubiquitination	ADVNARDKNWQTPLH CCCCCCCCCCCCCHH	55.31	-
171	Acetylation	ANINAFDKKDRRALH CCCCCCCHHHHHHHH	50.55	26051181
171	Malonylation	ANINAFDKKDRRALH CCCCCCCHHHHHHHH	50.55	26320211
308	Phosphorylation	IQSKDGKSPLHMTAV EECCCCCCCCCEEEE	37.92	28555341
320	Phosphorylation	TAVHGRFTRSQTLIQ EEECCCCCCCCEEEC	28.22	18785766
322	Phosphorylation	VHGRFTRSQTLIQNG ECCCCCCCCEEECCC	25.18	27080861
324	Phosphorylation	GRFTRSQTLIQNGGE CCCCCCCEEECCCCE	27.37	27080861
349	Phosphorylation	PLHVAARYGHELLIN CEEEHHHHCHHHHHH	20.36	10460205
357	Phosphorylation	GHELLINTLITSGAD CHHHHHHHHHHCCCC	16.73	29888752
360	Phosphorylation	LLINTLITSGADTAK HHHHHHHHCCCCCCC	24.99	29888752
390	Ubiquitination	AHSDCCRKLLSSGFE HCCHHHHHHHHCCCE	39.61	-
400	Phosphorylation	SSGFEIDTPDKFGRT HCCCEECCCCCCCCH	38.76	69213305
403	Ubiquitination	FEIDTPDKFGRTCLH CEECCCCCCCCHHHH	51.42	-
433	Ubiquitination	SSGADFHKKDKCGRT HCCCCCCCCCCCCCC	63.76	-
487	Ubiquitination	ASDMDRNKTILGNAH HHCCCCCCCCCCCCC	37.52	-
916	Ubiquitination	PLHLACSKGHEKCAL CCHHHHCCCCHHHHE	65.26	-
920	Ubiquitination	ACSKGHEKCALLILD HHCCCCHHHHEEEHH	21.09	-
938	Ubiquitination	DESLINEKNNALQTP CHHHHCCCCCCCCCH	51.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANR44_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANR44_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANR44_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP6_HUMAN	USP6	physical	16555005
ANR28_HUMAN	ANKRD28	physical	26186194
NOTC1_HUMAN	NOTCH1	physical	26186194
NOTC2_HUMAN	NOTCH2	physical	26186194
NOTC3_HUMAN	NOTCH3	physical	26186194
PP6R2_HUMAN	PPP6R2	physical	26186194
ANFY1_HUMAN	ANKFY1	physical	26186194
PP6R1_HUMAN	PPP6R1	physical	26186194
PP6R3_HUMAN	PPP6R3	physical	26186194
HIF1N_HUMAN	HIF1AN	physical	26186194
MTCL1_HUMAN	MTCL1	physical	26186194
PPP6_HUMAN	PPP6C	physical	26186194
CDN2C_HUMAN	CDKN2C	physical	26186194
PP6R2_HUMAN	PPP6R2	physical	28514442
NOTC1_HUMAN	NOTCH1	physical	28514442
ANR28_HUMAN	ANKRD28	physical	28514442
CDN2C_HUMAN	CDKN2C	physical	28514442
PP6R1_HUMAN	PPP6R1	physical	28514442
NOTC2_HUMAN	NOTCH2	physical	28514442
NOTC3_HUMAN	NOTCH3	physical	28514442
HIF1N_HUMAN	HIF1AN	physical	28514442
MTCL1_HUMAN	MTCL1	physical	28514442
PP6R3_HUMAN	PPP6R3	physical	28514442
PPP6_HUMAN	PPP6C	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.