SLK_MOUSE - dbPTM
SLK_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLK_MOUSE
UniProt AC O54988
Protein Name STE20-like serine/threonine-protein kinase
Gene Name Slk
Organism Mus musculus (Mouse).
Sequence Length 1233
Subcellular Localization Cytoplasm .
Protein Description Mediates apoptosis and actin stress fiber dissolution..
Protein Sequence MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFVTVDSNKPVRELIAEAKAEVTEEVEDGKEEDEEEEAENALPIPANKRASSDLSIASSEEDKLSQNACILESVSERTEQSTSEDKFSNKILNEKPTTDGPEKAVDEHASDVNLETGAELNDQTVGIHENGREKKRPKLENLPDTQDQQTVDVNSVSEENENNRVTLETNTDCLKPEEDRNKENQETLESKLIQSEEINDTHIQTMDLVSQETGEKEADFQAVDNEVGLTKEETQEKLGKDGTAQKVITSDRSSEVGTDEALDDTQKAAELSKAAQSGEGDEALAPTQTLAEKPTEGPEAGGAEEEPPGGERVEDKQPEQQPAVCEAEGQLTSTSETTRATLEQPETDEVEQVSESNSIEELERLVVTGAEARALGSEGEAAATEVDLERKENAQKVPVKAESQAPAASQPSEPHPVLIPSININSETTENKEEMGALPKPETILPPEPEHEKGNDTDSGTGSTVENSSGDLNLSISSFLSKAKDSGSVSLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRLLQKEEQRAQQQLNGKLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNVLKNRKKEVMNEVEKAPRELRRELTKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEEKRQKNERMAQHQKHESQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSAQSRISKFYPIPTLHSTGS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSFFNFRKI
------CCCCCHHHH		50.2625338131
14PhosphorylationRKIFKLGSEKKKKQY
HHHHCCCCHHHHHHH		57.5918779572
177PhosphorylationKLADFGVSAKNTRTI
EEHHHCCCCCCCCEE		33.6329176673
181PhosphorylationFGVSAKNTRTIQRRD
HCCCCCCCCEECCCC		28.6023608596
183PhosphorylationVSAKNTRTIQRRDSF
CCCCCCCEECCCCCC		21.3023684622
189PhosphorylationRTIQRRDSFIGTPYW
CEECCCCCCCCCCCC		19.5625521595
193PhosphorylationRRDSFIGTPYWMAPE
CCCCCCCCCCCCCCE		14.3725521595
195PhosphorylationDSFIGTPYWMAPEVV
CCCCCCCCCCCCEEE		13.9825521595
197OxidationFIGTPYWMAPEVVMC
CCCCCCCCCCEEEEE		3.5317242355
203OxidationWMAPEVVMCETSKDR
CCCCEEEEEECCCCC		1.7517242355
206PhosphorylationPEVVMCETSKDRPYD
CEEEEEECCCCCCCC		35.8325777480
207PhosphorylationEVVMCETSKDRPYDY
EEEEEECCCCCCCCC		15.4025777480
298UbiquitinationFVTVDSNKPVRELIA
EEECCCCCCHHHHHH		49.1722790023
340PhosphorylationIPANKRASSDLSIAS
CCCCHHCCCCCCCCC		28.5525521595
341PhosphorylationPANKRASSDLSIASS
CCCHHCCCCCCCCCC		41.4025521595
344PhosphorylationKRASSDLSIASSEED
HHCCCCCCCCCCCCH		22.5427087446
347PhosphorylationSSDLSIASSEEDKLS
CCCCCCCCCCCHHHH		36.2925521595
348PhosphorylationSDLSIASSEEDKLSQ
CCCCCCCCCCHHHHC		35.6625521595
354PhosphorylationSSEEDKLSQNACILE
CCCCHHHHCCCHHHH		27.4225619855
370PhosphorylationVSERTEQSTSEDKFS
HHHHHCCCCCCCHHC		27.8925338131
372PhosphorylationERTEQSTSEDKFSNK
HHHCCCCCCCHHCCH		49.39-
377PhosphorylationSTSEDKFSNKILNEK
CCCCCHHCCHHHCCC		42.8423684622
434PhosphorylationKLENLPDTQDQQTVD
CHHCCCCCCCCCEEC		31.9125619855
439PhosphorylationPDTQDQQTVDVNSVS
CCCCCCCEECCCCCC		17.0325619855
444PhosphorylationQQTVDVNSVSEENEN
CCEECCCCCCCCCCC		27.2025619855
446PhosphorylationTVDVNSVSEENENNR
EECCCCCCCCCCCCC		38.7325619855
464AcetylationETNTDCLKPEEDRNK
EECCCCCCCHHHCCH		57.6322826441
484PhosphorylationLESKLIQSEEINDTH
HHHHHHCHHHCCCCC		30.1529514104
494PhosphorylationINDTHIQTMDLVSQE
CCCCCCCHHHHHCCC		16.4329514104
499PhosphorylationIQTMDLVSQETGEKE
CCHHHHHCCCCCCCC		29.6025338131
502PhosphorylationMDLVSQETGEKEADF
HHHHCCCCCCCCHHH		42.9029514104
519PhosphorylationVDNEVGLTKEETQEK
HHCCCCCCHHHHHHH		30.4029899451
523PhosphorylationVGLTKEETQEKLGKD
CCCCHHHHHHHHCCC		43.0229899451
538PhosphorylationGTAQKVITSDRSSEV
CCCCEEECCCCCCCC		27.8027742792
539PhosphorylationTAQKVITSDRSSEVG
CCCEEECCCCCCCCC		21.6527742792
542PhosphorylationKVITSDRSSEVGTDE
EEECCCCCCCCCCHH		35.5225521595
543PhosphorylationVITSDRSSEVGTDEA
EECCCCCCCCCCHHH		36.8825521595
547PhosphorylationDRSSEVGTDEALDDT
CCCCCCCCHHHHHHH		35.5225619855
554PhosphorylationTDEALDDTQKAAELS
CHHHHHHHHHHHHHH		31.4722322096
561PhosphorylationTQKAAELSKAAQSGE
HHHHHHHHHHHHCCC		16.26-
566PhosphorylationELSKAAQSGEGDEAL
HHHHHHHCCCCCCCC		33.80-
630PhosphorylationTSETTRATLEQPETD
CCHHHCHHCCCCCCC		27.7725619855
636PhosphorylationATLEQPETDEVEQVS
HHCCCCCCCHHHHHC		44.1125619855
643PhosphorylationTDEVEQVSESNSIEE
CCHHHHHCCCCCHHH		34.6925521595
645PhosphorylationEVEQVSESNSIEELE
HHHHHCCCCCHHHHH		28.5025521595
647PhosphorylationEQVSESNSIEELERL
HHHCCCCCHHHHHHH		40.4325521595
657PhosphorylationELERLVVTGAEARAL
HHHHHHHHHHHHHHH		24.1623984901
666PhosphorylationAEARALGSEGEAAAT
HHHHHHCCCCCCCCC		43.1926824392
746PhosphorylationEHEKGNDTDSGTGST
CCCCCCCCCCCCCCC		35.7426643407
748PhosphorylationEKGNDTDSGTGSTVE
CCCCCCCCCCCCCCC		40.1126643407
750PhosphorylationGNDTDSGTGSTVENS
CCCCCCCCCCCCCCC		31.7326643407
752PhosphorylationDTDSGTGSTVENSSG
CCCCCCCCCCCCCCC		29.1726643407
753PhosphorylationTDSGTGSTVENSSGD
CCCCCCCCCCCCCCC		32.9326745281
757PhosphorylationTGSTVENSSGDLNLS
CCCCCCCCCCCEEEE		23.3826643407
758PhosphorylationGSTVENSSGDLNLSI
CCCCCCCCCCEEEEH		48.1626643407
764PhosphorylationSSGDLNLSISSFLSK
CCCCEEEEHHHHHHH		21.2527087446
775PhosphorylationFLSKAKDSGSVSLQE
HHHHHCCCCCCCHHH		32.0627087446
777PhosphorylationSKAKDSGSVSLQETR
HHHCCCCCCCHHHHH		16.6927087446
779PhosphorylationAKDSGSVSLQETRRQ
HCCCCCCCHHHHHHH		26.4925619855
783PhosphorylationGSVSLQETRRQKKTL
CCCCHHHHHHHHHHH		20.4230635358
804PhosphorylationIVDGVEVSVTTSKIV
EECCEEEEEEECEEE		10.5520469934
806PhosphorylationDGVEVSVTTSKIVTD
CCEEEEEEECEEEEC		20.1820469934
807PhosphorylationGVEVSVTTSKIVTDS
CEEEEEEECEEEECC		26.3520469934
808PhosphorylationVEVSVTTSKIVTDSD
EEEEEEECEEEECCC		15.8320469934
812PhosphorylationVTTSKIVTDSDSKTE
EEECEEEECCCCCHH		33.0026824392
814PhosphorylationTSKIVTDSDSKTEEL
ECEEEECCCCCHHHH		34.1226824392
816PhosphorylationKIVTDSDSKTEELRF
EEEECCCCCHHHHHH		45.4926824392
818PhosphorylationVTDSDSKTEELRFLR
EECCCCCHHHHHHHH		38.3519060867
867PhosphorylationRFEQEMLSKKRQYDQ
HHHHHHHHHHHHHHH		34.5229109428
1085AcetylationKTRMAMFKKSLRINS
HHHHHHHHHHHHCCC		28.507627591
1086AcetylationTRMAMFKKSLRINST
HHHHHHHHHHHCCCC		43.387629085
1087PhosphorylationRMAMFKKSLRINSTA
HHHHHHHHHHCCCCC		24.3829514104
1092PhosphorylationKKSLRINSTATPDQD
HHHHHCCCCCCCCHH		19.6325338131
1095PhosphorylationLRINSTATPDQDREK
HHCCCCCCCCHHHHH		27.73-
1104UbiquitinationDQDREKIKQFAAQEE
CHHHHHHHHHHHHHH		50.8922790023
1151GlutathionylationHQLQNEKCHLLVEHE
HHHHHHCCCCHHHHH		1.9224333276
1185UbiquitinationEKLRPRKKTLEEEFA
HHHHHCHHHHHHHHH		60.6722790023
1186PhosphorylationKLRPRKKTLEEEFAR
HHHHCHHHHHHHHHH		42.3027600695
1210GlutathionylationKMTGESECLNPSAQS
HHCCCHHHCCHHHHH		6.5724333276
1217PhosphorylationCLNPSAQSRISKFYP
HCCHHHHHHHHHCCC		31.1629514104
1220PhosphorylationPSAQSRISKFYPIPT
HHHHHHHHHCCCCCC		18.6629514104
1223PhosphorylationQSRISKFYPIPTLHS
HHHHHHCCCCCCCCC		12.1829514104
1227PhosphorylationSKFYPIPTLHSTGS-
HHCCCCCCCCCCCC-		37.5120415495
1230PhosphorylationYPIPTLHSTGS----
CCCCCCCCCCC----		37.2620415495
1230O-linked_GlycosylationYPIPTLHSTGS----
CCCCCCCCCCC----		37.2655413881
1231PhosphorylationPIPTLHSTGS-----
CCCCCCCCCC-----		30.6020415495
1233PhosphorylationPTLHSTGS-------
CCCCCCCC-------		36.8226745281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLK_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLK_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLK_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SLK_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLK_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189 AND SER-348, ANDMASS SPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-543 ANDSER-777, AND MASS SPECTROMETRY.

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