dbPTM

DRG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DRG2_MOUSE
UniProt AC	Q9QXB9
Protein Name	Developmentally-regulated GTP-binding protein 2
Gene Name	Drg2
Organism	Mus musculus (Mouse).
Sequence Length	364
Subcellular Localization	Cytoplasm.
Protein Description	May play a role in cell proliferation, differentiation and death..
Protein Sequence	MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEPSKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGRGRGRQVIAVARTADVVVMMLDATKGDVQRSLLEKELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVLFREDCSPDDFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVISCGMKLNLDYLLEMLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKYALVWGTSTKYSPQRVGLTHTMEHEDVIQIVKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MGILEKISEIEKE --CCHHHHHHHHHHH	48.35	22826441
8	Phosphorylation	MGILEKISEIEKEIA CCHHHHHHHHHHHHH	43.52	23737553
12	Acetylation	EKISEIEKEIARTQK HHHHHHHHHHHHHHH	61.14	22826441
21	Hydroxylation	IARTQKNKATEYHLG HHHHHHCHHHHHHHH	64.82	-
23	Phosphorylation	RTQKNKATEYHLGLL HHHHCHHHHHHHHHH	38.39	20531401
25	Phosphorylation	QKNKATEYHLGLLKA HHCHHHHHHHHHHHH	9.67	20531401
37	Phosphorylation	LKAKLAKYRAQLLEP HHHHHHHHHHHHCCC	12.94	25367039
46	Malonylation	AQLLEPSKSASSKGE HHHCCCCCCCCCCCC	61.84	26320211
47	Phosphorylation	QLLEPSKSASSKGEG HHCCCCCCCCCCCCC	37.41	29176673
49	Phosphorylation	LEPSKSASSKGEGFD CCCCCCCCCCCCCCE	39.41	29176673
50	Phosphorylation	EPSKSASSKGEGFDV CCCCCCCCCCCCCEE	44.38	29176673
51	Ubiquitination	PSKSASSKGEGFDVM CCCCCCCCCCCCEEE	59.49	27667366
59	Ubiquitination	GEGFDVMKSGDARVA CCCCEEECCCCEEEE	51.65	27667366
161	Ubiquitination	VQRSLLEKELESVGI HHHHHHHHHHHHHCC	68.51	22790023
174	Acetylation	GIRLNKHKPNIYFKP CCCCCCCCCCEEECC	41.17	23806337
174	Succinylation	GIRLNKHKPNIYFKP CCCCCCCCCCEEECC	41.17	23806337
192	Phosphorylation	GGISFNSTVTLTQCS CCEECCCEEEEHHCC	20.72	22817900
199	Phosphorylation	TVTLTQCSEKLVQLI EEEEHHCCHHHHHHH	28.13	22817900
270	S-nitrosocysteine	PNSVVISCGMKLNLD CCEEEEECCCCCCHH	4.19	-
270	S-nitrosylation	PNSVVISCGMKLNLD CCEEEEECCCCCCHH	4.19	21278135
319	Glutathionylation	GASVEHVCHRIHRSL CCCHHHHHHHHHHHH	1.60	24333276
325	Phosphorylation	VCHRIHRSLASQFKY HHHHHHHHHHHHCCE	17.71	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DRG2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
21	K	Hydroxylation		-
Hydroxylated (with S stereochemistry) at C-3 of Lys-21 by JMJD7.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DRG2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DRG2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DRG2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199, AND MASSSPECTROMETRY.	17242355 [Abstract]