HECW1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HECW1_MOUSE
• UniProt AC: Q8K4P8
• Protein Name: E3 ubiquitin-protein ligase HECW1
• Gene Name: Hecw1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1604
• Subcellular Localization: Cytoplasm .
• Protein Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1..
• Protein Sequence: MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNIDIRNGAHDAITIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIGEVSSENFLDYKNRGVNGSHRGQIIWKIDASSYFVESETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKGIGSEETAQSQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSTIIGNTVNPIWQAEHFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHADDEEISLSAEPESSAETQDSIMNSMVGNSNGEPSGDATEFCKDAKPESPSEGNGVNSSENQNQEHAGPVEEAAGAMEARDGSNVSEAPEEPGELQDPEQHDTQPTLSAEEVAEGLPLDEDSPSSLLPEENTALGSKVEEETVPENGAREEEMQKGKDEEEEEEDVSTLEQGEPGLELRVSVRKKSRPCSLPVSELETVIASACGDAETPRTHYIRIHTLLHSMPSAQRGSTTEEEDGLEEESTLKESSEKDGLSEVDTIAADPQSMEDGESDGATLCMAPSDCSGGHFSSLSKGIGAGQDGEAHPSTGSESDSSPQQGADHSCEGCDASCCSPSCYSTSCYSSSCYSSSCYSSSCYNGNNRFASHTRFSSVDSAKISESTVFSSQEDEEEENSAFESVPDSVQSPELDPESTNGAGPWQDELAAPGGNAARSTEGLESPMAGPSNRREGECPILHNSQPISQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHINRTTTWQRPSMAPTPDGMIRSGSVHQMEQLNRRYQNIQRTMATERAEEDSGNQNSEQIPDGGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKVTLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDHQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLIAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLDKLSCDADLVILLSLFEEEIMSYVPLQSAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENYLEWFRFSGRILGLALIHQYLLDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALLRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Methylation	VKNLYQNRFLGLAAM CCHHHCCCHHHHHHH	16.79	58856127
15	Dimethylation	VKNLYQNRFLGLAAM CCHHHCCCHHHHHHH	16.79	-
24	Phosphorylation	LGLAAMASPSRNSQS HHHHHHCCCCCCHHH	15.43	-
41	Phosphorylation	RCKEPLRYSYNPDQF HCCCCCCCCCCHHHC	24.16	29899451
42	Phosphorylation	CKEPLRYSYNPDQFH CCCCCCCCCCHHHCC	16.40	26370283
66	Phosphorylation	DAITIPRSTSDTDLV CCEECCCCCCCCCCC	27.23	23527152
67	Phosphorylation	AITIPRSTSDTDLVT CEECCCCCCCCCCCC	31.72	25521595
68	Phosphorylation	ITIPRSTSDTDLVTS EECCCCCCCCCCCCC	39.50	25521595
80	Phosphorylation	VTSDSRSTLMVSSSY CCCCCCCEEEEECEE	20.12	28576409
208	Phosphorylation	SRRLISFSLSDFQAM CCEEEEEEHHHHHHC	21.85	-
210	Phosphorylation	RLISFSLSDFQAMGL EEEEEEHHHHHHCCC	34.87	-
300	Ubiquitination	IIKRFLGKLSMPVQR HHHHHHHHCCCHHHH	39.26	-
396	Phosphorylation	CKDAKPESPSEGNGV HHCCCCCCCCCCCCC	42.10	29899451
398	Phosphorylation	DAKPESPSEGNGVNS CCCCCCCCCCCCCCC	68.37	29899451
514	Phosphorylation	EEEEEDVSTLEQGEP HHHHHHHCHHHCCCC	39.33	29899451
515	Phosphorylation	EEEEDVSTLEQGEPG HHHHHHCHHHCCCCC	33.88	29899451
533	Phosphorylation	RVSVRKKSRPCSLPV EEEEECCCCCCCCCH	44.48	29899451
537	Phosphorylation	RKKSRPCSLPVSELE ECCCCCCCCCHHHHH	38.09	29899451
541	Phosphorylation	RPCSLPVSELETVIA CCCCCCHHHHHHHHH	34.23	29899451
549	Phosphorylation	ELETVIASACGDAET HHHHHHHHHHCCCCC	16.99	29899451
556	Phosphorylation	SACGDAETPRTHYIR HHHCCCCCCCCEEEE	21.57	21183079
573	Phosphorylation	TLLHSMPSAQRGSTT HHHHHCCCCCCCCCC	28.52	29899451
578	Phosphorylation	MPSAQRGSTTEEEDG CCCCCCCCCCCCCCC	34.05	25521595
579	Phosphorylation	PSAQRGSTTEEEDGL CCCCCCCCCCCCCCC	40.84	30372032
580	Phosphorylation	SAQRGSTTEEEDGLE CCCCCCCCCCCCCCC	43.00	29899451
717	Phosphorylation	FASHTRFSSVDSAKI CCCCCEEECCCCCCC	26.59	29899451
718	Phosphorylation	ASHTRFSSVDSAKIS CCCCEEECCCCCCCC	27.51	29899451
786	Phosphorylation	RSTEGLESPMAGPSN CCCCCCCCCCCCCCC	25.64	29899451
862	Phosphorylation	QRPSMAPTPDGMIRS CCCCCCCCCCCCCCC	25.19	-
869	Phosphorylation	TPDGMIRSGSVHQME CCCCCCCCCCHHHHH	25.21	29899451
871	Phosphorylation	DGMIRSGSVHQMEQL CCCCCCCCHHHHHHH	20.06	19060867
917	Phosphorylation	GGGGGGGSDSEAESS CCCCCCCCHHHHHHH	41.04	25293948
919	Phosphorylation	GGGGGSDSEAESSQS CCCCCCHHHHHHHCC	40.16	25293948
923	Phosphorylation	GSDSEAESSQSSLDL CCHHHHHHHCCCCHH	40.50	25293948
924	Phosphorylation	SDSEAESSQSSLDLR CHHHHHHHCCCCHHH	26.11	25293948
926	Phosphorylation	SEAESSQSSLDLRRE HHHHHHCCCCHHHHC	34.51	25293948
927	Phosphorylation	EAESSQSSLDLRREG HHHHHCCCCHHHHCC	20.47	25293948
935	Phosphorylation	LDLRREGSLSPVNSQ CHHHHCCCCCCCCHH	22.41	25521595
937	Phosphorylation	LRREGSLSPVNSQKV HHHCCCCCCCCHHHE	28.62	25521595
941	Phosphorylation	GSLSPVNSQKVTLLL CCCCCCCHHHEEEEE	31.45	20415495
957	Phosphorylation	SPAVKFITNPEFFTV CCCEEEECCHHHHHH	48.10	21930439
963	Phosphorylation	ITNPEFFTVLHANYS ECCHHHHHHHCCCCC	27.72	21930439
969	Phosphorylation	FTVLHANYSAYRVFT HHHHCCCCCEEEEEC	8.75	-
970	Phosphorylation	TVLHANYSAYRVFTS HHHCCCCCEEEEECC	20.73	21930439
972	Phosphorylation	LHANYSAYRVFTSST HCCCCCEEEEECCHH	11.02	-
979	Phosphorylation	YRVFTSSTCLKHMIL EEEECCHHHHHHHHH	22.94	-
1071	Phosphorylation	QHLQRLRSYSAGEAS HHHHHHHHCCCCCCH	28.21	25521595
1072	Phosphorylation	HLQRLRSYSAGEASE HHHHHHHCCCCCCHH	8.98	25521595
1073	Phosphorylation	LQRLRSYSAGEASEV HHHHHHCCCCCCHHH	30.92	23527152
1081	Phosphorylation	AGEASEVSRNRGASL CCCCHHHHHHCCCCC	21.56	29899451
1087	Phosphorylation	VSRNRGASLLARPGH HHHHCCCCCCCCCCH	27.09	29899451
1202	Phosphorylation	SPRCSPCSSPQNSPG CCCCCCCCCCCCCCC	48.73	29899451
1203	Phosphorylation	PRCSPCSSPQNSPGL CCCCCCCCCCCCCCH	36.90	29899451
1207	Phosphorylation	PCSSPQNSPGLQRAS CCCCCCCCCCHHHHH	18.33	29899451
1219	Phosphorylation	RASARAPSPYRRDFE HHHCCCCCCCHHHHH	33.31	-
1342	Phosphorylation	YLEWFRFSGRILGLA HHHHHHHHHHHHHHH	23.94	23140645
1503	Phosphorylation	NTEYRGGYHDGHLVI CCCCCCCCCCCHHHH	10.28	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HECW1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HECW1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HECW1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HECW1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.