| UniProt ID | GRM2_MOUSE | |
|---|---|---|
| UniProt AC | Q14BI2 | |
| Protein Name | Metabotropic glutamate receptor 2 | |
| Gene Name | Grm2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 872 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite. |
|
| Protein Description | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.. | |
| Protein Sequence | MESLLRFLALLLLRGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATLSDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQNLDPWNNSRNPWFREFWEERFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGNGRYRYQKVGYWAEGLTLDTSIIPWASPSAGTLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGIGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQLVPTVCNGREVVDSTTSSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 203 | N-linked_Glycosylation | AEILRFFNWTYVSTV HHHHHHCCCEEEEEE | 27.71 | - | |
| 286 | N-linked_Glycosylation | LAATQRLNASFTWVA HHHHHHHHCEEEEEE | 35.41 | - | |
| 338 | N-linked_Glycosylation | FQNLDPWNNSRNPWF HHCCCCCCCCCCHHH | 41.82 | - | |
| 402 | N-linked_Glycosylation | MHRALCPNTTRLCDA HHHHHCCCHHHHHHH | 53.75 | - | |
| 547 | N-linked_Glycosylation | CGLGYWPNASLTGCF CCCCCCCCCCEECCE | 28.19 | - | |
| 832 | Phosphorylation | VVSHRAPTSRFGSAA CCCCCCCCCCCCCCC | 31.39 | 29899451 | |
| 833 | Phosphorylation | VSHRAPTSRFGSAAP CCCCCCCCCCCCCCC | 25.26 | 29899451 | |
| 837 | Phosphorylation | APTSRFGSAAPRASA CCCCCCCCCCCCHHC | 20.67 | 29899451 | |
| 850 | Phosphorylation | SANLGQGSGSQLVPT HCCCCCCCCCCCCCE | 27.64 | 29899451 | |
| 870 | Phosphorylation | EVVDSTTSSL----- EEECCCCCCC----- | 29.72 | 29899451 | |
| 871 | Phosphorylation | VVDSTTSSL------ EECCCCCCC------ | 35.69 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GRM2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GRM2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GRM2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GRM2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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