IQEC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IQEC2_MOUSE
• UniProt AC: Q5DU25
• Protein Name: IQ motif and SEC7 domain-containing protein 2
• Gene Name: Iqsec2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1478
• Subcellular Localization: Cytoplasm .
• Protein Description: Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins..
• Protein Sequence: MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRDLREESQLHRGELHRDPLGARDSPGRESQYQNLRETQFHHRELRESQFHQASRDVGYPNRDGAYQNREAIYRDKEREASYQLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGQRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRNVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPTSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLPPVPPPMPPGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTLARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPPLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEAGSGPPGGPG ---CCCCCCCCCCCC	55.99	-
13	Phosphorylation	GPPGGPGSESPNRAV CCCCCCCCCCHHHHH	37.73	20415495
15	Phosphorylation	PGGPGSESPNRAVEY CCCCCCCCHHHHHHH	29.22	18056256
82	Phosphorylation	DPLGARDSPGRESQY CCCCCCCCCCCHHHH	24.57	25521595
87	Phosphorylation	RDSPGRESQYQNLRE CCCCCCHHHHHHHHH	32.59	25367039
89	Phosphorylation	SPGRESQYQNLRETQ CCCCHHHHHHHHHHH	14.51	25521595
95	Phosphorylation	QYQNLRETQFHHREL HHHHHHHHHHHHHHH	30.05	29899451
111	Phosphorylation	ESQFHQASRDVGYPN HHHHHHHHHCCCCCC	23.57	26824392
123	Phosphorylation	YPNRDGAYQNREAIY CCCCCCCCCCHHHHH	16.32	29899451
138	Phosphorylation	RDKEREASYQLQDTT CCCHHHHHHCCCCCC	14.52	29899451
188	Phosphorylation	GREKEAGYSAAVGVG CCCCCCCCCCCCCCC	11.37	29899451
210	Phosphorylation	GQLSRGASRSSSPGA CCCCCCCCCCCCCCC	35.20	29899451
212	Phosphorylation	LSRGASRSSSPGAGG CCCCCCCCCCCCCCC	32.45	24925903
213	Phosphorylation	SRGASRSSSPGAGGG CCCCCCCCCCCCCCC	39.17	24925903
214	Phosphorylation	RGASRSSSPGAGGGH CCCCCCCCCCCCCCC	28.71	25521595
222	Phosphorylation	PGAGGGHSTSTSTSP CCCCCCCCCCCCCCC	27.59	24925903
223	Phosphorylation	GAGGGHSTSTSTSPA CCCCCCCCCCCCCCC	30.28	24925903
224	Phosphorylation	AGGGHSTSTSTSPAT CCCCCCCCCCCCCCC	24.31	24925903
225	Phosphorylation	GGGHSTSTSTSPATT CCCCCCCCCCCCCCC	35.79	24925903
226	Phosphorylation	GGHSTSTSTSPATTL CCCCCCCCCCCCCCC	27.01	24925903
227	Phosphorylation	GHSTSTSTSPATTLQ CCCCCCCCCCCCCCC	38.53	24925903
228	Phosphorylation	HSTSTSTSPATTLQR CCCCCCCCCCCCCCC	16.59	24925903
231	Phosphorylation	STSTSPATTLQRNVE CCCCCCCCCCCCCCC	31.27	24925903
232	Phosphorylation	TSTSPATTLQRNVEG CCCCCCCCCCCCCCC	24.01	30635358
237	Phosphorylation	ATTLQRNVEGDAPGS CCCCCCCCCCCCCCC	10.68	-
244	Phosphorylation	VEGDAPGSDLSTAVD CCCCCCCCCCCCCCC	34.03	-
252	Phosphorylation	DLSTAVDSPGSQPPY CCCCCCCCCCCCCCC	25.27	22817900
254	Phosphorylation	STAVDSPGSQPPYRL CCCCCCCCCCCCCCH	42.75	-
255	Phosphorylation	TAVDSPGSQPPYRLS CCCCCCCCCCCCCHH	42.78	29899451
262	Phosphorylation	SQPPYRLSQLPPTSS CCCCCCHHHCCCCCC	22.22	-
310	Phosphorylation	IKRSKALSDSYELST HHHHHHHHHHHHCCH	29.39	30635358
312	Phosphorylation	RSKALSDSYELSTDL HHHHHHHHHHCCHHH	19.68	21082442
313	Phosphorylation	SKALSDSYELSTDLQ HHHHHHHHHCCHHHH	26.36	29899451
316	Phosphorylation	LSDSYELSTDLQDKK HHHHHHCCHHHHHHH	14.13	22817900
317	Phosphorylation	SDSYELSTDLQDKKV HHHHHCCHHHHHHHH	54.04	29899451
334	Phosphorylation	LERKYGGSFLSRRAA HHHHHCCCHHHHHHH	20.74	22817900
337	Phosphorylation	KYGGSFLSRRAARTI HHCCCHHHHHHHHHH	20.08	-
351	Phosphorylation	IQTAFRQYRMNKNFE HHHHHHHHHHCCCHH	13.94	23140645
362	Phosphorylation	KNFERLRSSASESRM CCHHHHHHHHCHHHH	34.54	22324799
363	Phosphorylation	NFERLRSSASESRMS CHHHHHHHHCHHHHH	29.40	22324799
365	Phosphorylation	ERLRSSASESRMSRR HHHHHHHCHHHHHHH	37.74	22324799
367	Phosphorylation	LRSSASESRMSRRII HHHHHCHHHHHHHHH	30.68	29899451
370	Phosphorylation	SASESRMSRRIILSN HHCHHHHHHHHHHHH	19.80	29514104
383	Phosphorylation	SNMRMQFSFEEYEKA HHCCEEECHHHHHHH	18.17	25521595
387	Phosphorylation	MQFSFEEYEKAQNPA EEECHHHHHHHCCCH	18.61	28066266
399	Ubiquitination	NPAYFEGKPASLDEG CCHHHCCCCCCCCCC	30.16	-
402	Phosphorylation	YFEGKPASLDEGAMA HHCCCCCCCCCCCCC	44.90	25521595
422	Phosphorylation	RLERGLPYGGSCGGG CCCCCCCCCCCCCCC	38.88	29899451
425	Phosphorylation	RGLPYGGSCGGGIDG CCCCCCCCCCCCCCC	12.77	29899451
435	Phosphorylation	GGIDGGGSSVTTSGE CCCCCCCCCCCCCCC	25.55	29899451
439	Phosphorylation	GGGSSVTTSGEFSND CCCCCCCCCCCCCCC	32.36	29899451
440	Phosphorylation	GGSSVTTSGEFSNDI CCCCCCCCCCCCCCC	27.28	29899451
444	Phosphorylation	VTTSGEFSNDITELE CCCCCCCCCCCHHHH	29.32	29899451
448	Phosphorylation	GEFSNDITELEDSFS CCCCCCCHHHHHHHH	37.06	29899451
460	Phosphorylation	SFSKQVKSLAESIDE HHHHHHHHHHHHHHH	33.67	22817900
464	Phosphorylation	QVKSLAESIDEALNC HHHHHHHHHHHHHCC	29.72	22817900
491	Phosphorylation	AQLEKRESKEQQEDS HHHHHHHCHHHHCCC	45.59	22817900
518	Phosphorylation	DDPVPPPSPERLPST CCCCCCCCCCCCCCC	45.20	22817900
590	Phosphorylation	LLTIEPPSDSSVDLS EEEECCCCCCCCCCC	61.92	19060867
592	Phosphorylation	TIEPPSDSSVDLSDR EECCCCCCCCCCCCC	36.28	19060867
593	Phosphorylation	IEPPSDSSVDLSDRS ECCCCCCCCCCCCCC	25.33	19060867
597	Phosphorylation	SDSSVDLSDRSDRGS CCCCCCCCCCCCCCC	26.89	22817900
600	Phosphorylation	SVDLSDRSDRGSVHR CCCCCCCCCCCCHHH	36.33	29899451
604	Phosphorylation	SDRSDRGSVHRQLVY CCCCCCCCHHHHHHH	18.68	29899451
611	Phosphorylation	SVHRQLVYEADGCSP CHHHHHHHCCCCCCC	17.62	22324799
617	Phosphorylation	VYEADGCSPHGTLKH HHCCCCCCCCCCCCC	26.01	21082442
621	Phosphorylation	DGCSPHGTLKHKGPP CCCCCCCCCCCCCCC	29.60	26745281
728	Phosphorylation	KQTYQRETRHSWDSP HHHHCCCCCCCCCCC	35.55	22324799
731	Phosphorylation	YQRETRHSWDSPAFN HCCCCCCCCCCCCCC	29.32	25521595
734	Phosphorylation	ETRHSWDSPAFNNDV CCCCCCCCCCCCCHH	16.33	25521595
772	Phosphorylation	LIERGFLSDTPVGVA HHHCCCCCCCCCHHH	36.86	29899451
774	Phosphorylation	ERGFLSDTPVGVAHF HCCCCCCCCCHHHHH	19.25	29899451
903	Ubiquitination	MKLDDFIKNLRGVDN CCHHHHHHHHCCCCC	50.34	-
923	Phosphorylation	RDLLVGIYQRIQGRE HHHHHHHHHHHCCCC	5.94	20415495
1038	Phosphorylation	QFGIKLLSAVPGGER HHHHHHHHCCCCCCE	37.34	30482847
1097	Phosphorylation	GMMRPNASQPGGAKD CCCCCCCCCCCCCHH	43.48	-
1109	Phosphorylation	AKDSVNGTLARSSLE CHHCCCCEEECHHHH	16.43	29899451
1113	Phosphorylation	VNGTLARSSLEDTYG CCCEEECHHHHCCCC	33.40	25521595
1114	Phosphorylation	NGTLARSSLEDTYGA CCEEECHHHHCCCCC	30.17	30635358
1118	Phosphorylation	ARSSLEDTYGAGDGL ECHHHHCCCCCCCHH	17.93	25521595
1119	Phosphorylation	RSSLEDTYGAGDGLK CHHHHCCCCCCCHHH	19.80	25521595
1126	Ubiquitination	YGAGDGLKRGALSSS CCCCCHHHHCHHHHH	55.08	-
1131	Phosphorylation	GLKRGALSSSLRDLS HHHHCHHHHHHHHHH	19.83	29899451
1132	Phosphorylation	LKRGALSSSLRDLSD HHHCHHHHHHHHHHH	33.95	29899451
1133	Phosphorylation	KRGALSSSLRDLSDA HHCHHHHHHHHHHHH	24.85	22942356
1138	Phosphorylation	SSSLRDLSDAGKRGR HHHHHHHHHHHHHCC	29.69	22324799
1148	Phosphorylation	GKRGRRNSVGSLDST HHHCCCCCCCCCCCC	26.50	21082442
1151	Phosphorylation	GRRNSVGSLDSTIEG CCCCCCCCCCCCCCC	27.18	21082442
1154	Phosphorylation	NSVGSLDSTIEGSVI CCCCCCCCCCCCCCC	36.26	22324799
1155	Phosphorylation	SVGSLDSTIEGSVIS CCCCCCCCCCCCCCC	23.78	22817900
1159	Phosphorylation	LDSTIEGSVISSPRP CCCCCCCCCCCCCCC	11.95	20415495
1162	Phosphorylation	TIEGSVISSPRPHQR CCCCCCCCCCCCCCC	31.94	22817900
1163	Phosphorylation	IEGSVISSPRPHQRM CCCCCCCCCCCCCCC	17.50	22817900
1184	Phosphorylation	PPPEEYKSQRPVSNS CCCHHHHCCCCCCCC	30.44	29899451
1189	Phosphorylation	YKSQRPVSNSSSFLG HHCCCCCCCCHHHHH	33.41	29899451
1191	Phosphorylation	SQRPVSNSSSFLGSL CCCCCCCCHHHHHHH	21.61	29899451
1192	Phosphorylation	QRPVSNSSSFLGSLF CCCCCCCHHHHHHHH	29.38	29899451
1193	Phosphorylation	RPVSNSSSFLGSLFG CCCCCCHHHHHHHHC	25.06	29899451
1201	Phosphorylation	FLGSLFGSKRGKGPF HHHHHHCCCCCCCCC	16.31	22817900
1335	Methylation	RPGRAPRRGAGGHPQ CCCCCCCCCCCCCCC	37.95	24129315
1355	Phosphorylation	RHPLHQPTSPLPLYS CCCCCCCCCCCCCCC	36.08	29899451
1356	Phosphorylation	HPLHQPTSPLPLYSP CCCCCCCCCCCCCCC	30.99	29899451
1362	Phosphorylation	TSPLPLYSPAPQHPP CCCCCCCCCCCCCCC	23.44	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IQEC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IQEC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IQEC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IQEC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383 AND SER-402, ANDMASS SPECTROMETRY.
PubMed: 19144319

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82; TYR-89; TYR-611;TYR-923 AND TYR-1119, AND MASS SPECTROMETRY.
PubMed: 18034455