| UniProt ID | AGAP2_MOUSE | |
|---|---|---|
| UniProt AC | Q3UHD9 | |
| Protein Name | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 | |
| Gene Name | Agap2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1186 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase (By similarity).. | |
| Protein Sequence | MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAPGARGSEPRDPGSPRGSEEPGKKRHERLFHRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKVAPPPPAPKPFKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSTAGTGASAAAAGGGGSAAVTTSGGVGAGAGTRGKLSPRKGKSKTLDNSDLHPGPSAGSPPLTVPAIPVPATSVTATSTQPLGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGPGPLPGPQGLSSSSGSRELLGAELRTSPKAVVNSQEWTLSRSIPELRLGVLGDVRSGKSSLIHRFLTGSYQVLEKIESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDESSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCTDMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDAEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGPEASTPMPSPSPSPSSLQLPTDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLSTPSKTEGSAVQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSTCVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPTRDSSREERESWIRAKYEQLLFLAPLGTTEEPLGRQLWAAVEAQDVAAVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSTATTPSAATTPSITATPSPRRRSSAASLGRVDTTIALV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSRGAGALQ ------CCCCCHHCH | 51.21 | 22324799 | |
| 26 | Phosphorylation | LTLVKLESVPPPPPS EEEEEHHCCCCCCCC | 50.81 | 22817900 | |
| 33 | Phosphorylation | SVPPPPPSPSAAAAG CCCCCCCCCCHHHCC | 36.94 | 25338131 | |
| 35 | Phosphorylation | PPPPPSPSAAAAGAP CCCCCCCCHHHCCCC | 34.57 | 29899451 | |
| 54 | Phosphorylation | SEPRDPGSPRGSEEP CCCCCCCCCCCCCCC | 19.47 | 25521595 | |
| 58 | Phosphorylation | DPGSPRGSEEPGKKR CCCCCCCCCCCCCHH | 39.81 | 29899451 | |
| 79 | Phosphorylation | RQDALWISTSSAGTG CCCEEEEECCCCCCC | 15.62 | 19060867 | |
| 81 | Phosphorylation | DALWISTSSAGTGGA CEEEEECCCCCCCCC | 16.05 | 21082442 | |
| 99 | Phosphorylation | ALSPAPASPARPVSP CCCCCCCCCCCCCCC | 20.31 | 22324799 | |
| 113 | Phosphorylation | PAPGRRLSLWAAPPG CCCCCEEEEEECCCC | 21.76 | 29899451 | |
| 124 | Phosphorylation | APPGPPLSGGLSPDS CCCCCCCCCCCCCCC | 36.27 | 30372032 | |
| 128 | Phosphorylation | PPLSGGLSPDSKPGG CCCCCCCCCCCCCCC | 29.90 | 29899451 | |
| 131 | Phosphorylation | SGGLSPDSKPGGAPS CCCCCCCCCCCCCCC | 44.10 | 22817900 | |
| 138 | Phosphorylation | SKPGGAPSSSRRPLL CCCCCCCCCCCCCCC | 40.17 | 29899451 | |
| 139 | Phosphorylation | KPGGAPSSSRRPLLS CCCCCCCCCCCCCCC | 27.14 | 22807455 | |
| 140 | Phosphorylation | PGGAPSSSRRPLLSS CCCCCCCCCCCCCCC | 36.32 | 22807455 | |
| 146 | Phosphorylation | SSRRPLLSSPSWGGP CCCCCCCCCCCCCCC | 48.13 | 26804993 | |
| 147 | Phosphorylation | SRRPLLSSPSWGGPE CCCCCCCCCCCCCCC | 23.95 | 29899451 | |
| 149 | Phosphorylation | RPLLSSPSWGGPEPE CCCCCCCCCCCCCCC | 40.06 | 25521595 | |
| 167 | Phosphorylation | GGGVPGSSSPHPGTG CCCCCCCCCCCCCCC | 54.53 | 29899451 | |
| 168 | Phosphorylation | GGVPGSSSPHPGTGS CCCCCCCCCCCCCCC | 29.00 | 29899451 | |
| 173 | Phosphorylation | SSSPHPGTGSRRLKV CCCCCCCCCCCCEEE | 36.11 | 29899451 | |
| 175 | Phosphorylation | SPHPGTGSRRLKVAP CCCCCCCCCCEEECC | 17.67 | 29899451 | |
| 208 | Phosphorylation | GGGKGAGSRLSWPES CCCCCCCCCCCCCHH | 29.52 | 20415495 | |
| 211 | Phosphorylation | KGAGSRLSWPESEGK CCCCCCCCCCHHCCC | 39.20 | 22817900 | |
| 215 | Phosphorylation | SRLSWPESEGKPRVK CCCCCCHHCCCCCCC | 47.79 | 20415495 | |
| 224 | Phosphorylation | GKPRVKGSKSTAGTG CCCCCCCCCCCCCCC | 20.09 | 29899451 | |
| 233 | Phosphorylation | STAGTGASAAAAGGG CCCCCCHHHHHCCCC | 21.56 | 29899451 | |
| 248 | Phosphorylation | GSAAVTTSGGVGAGA CCEEEECCCCCCCCC | 24.96 | 29899451 | |
| 262 | Phosphorylation | AGTRGKLSPRKGKSK CCCCCCCCCCCCCCC | 26.58 | 22817900 | |
| 326 | Methylation | APGLKRGREGGRAST CCCCCCCCCCCCCCH | 43.34 | - | |
| 343 | Phosphorylation | RKMLKFISGIFTKST HHHHHHHHHCCCCCC | 29.03 | 22817900 | |
| 347 | Phosphorylation | KFISGIFTKSTGGPP HHHHHCCCCCCCCCC | 23.36 | 20415495 | |
| 349 | Phosphorylation | ISGIFTKSTGGPPGP HHHCCCCCCCCCCCC | 29.27 | 25521595 | |
| 350 | Phosphorylation | SGIFTKSTGGPPGPG HHCCCCCCCCCCCCC | 47.95 | 25521595 | |
| 366 | Phosphorylation | LPGPQGLSSSSGSRE CCCCCCCCCCCCCHH | 34.69 | 29899451 | |
| 367 | Phosphorylation | PGPQGLSSSSGSREL CCCCCCCCCCCCHHH | 33.30 | 29899451 | |
| 368 | Phosphorylation | GPQGLSSSSGSRELL CCCCCCCCCCCHHHC | 35.03 | 19060867 | |
| 369 | Phosphorylation | PQGLSSSSGSRELLG CCCCCCCCCCHHHCC | 42.61 | 22807455 | |
| 371 | Phosphorylation | GLSSSSGSRELLGAE CCCCCCCCHHHCCCE | 25.24 | 29899451 | |
| 381 | Phosphorylation | LLGAELRTSPKAVVN HCCCEEECCCCEEEC | 63.10 | 22324799 | |
| 382 | Phosphorylation | LGAELRTSPKAVVNS CCCEEECCCCEEECC | 20.26 | 25521595 | |
| 422 | Phosphorylation | SLIHRFLTGSYQVLE HHHHHHHHCCHHHHH | 22.75 | 29899451 | |
| 424 | Phosphorylation | IHRFLTGSYQVLEKI HHHHHHCCHHHHHHH | 13.73 | 25521595 | |
| 425 | Phosphorylation | HRFLTGSYQVLEKIE HHHHHCCHHHHHHHH | 12.18 | 26804993 | |
| 436 | Phosphorylation | EKIESEQYKKEMLVD HHHHHHHHHHHEEEC | 21.70 | 28576409 | |
| 474 | Phosphorylation | DAVIFVFSLEDESSF CEEEEEEECCCHHHH | 26.08 | 21149613 | |
| 479 | Phosphorylation | VFSLEDESSFQAVSR EEECCCHHHHHHHHH | 49.10 | 21149613 | |
| 480 | Phosphorylation | FSLEDESSFQAVSRL EECCCHHHHHHHHHH | 21.23 | 21149613 | |
| 485 | Phosphorylation | ESSFQAVSRLHGQLS HHHHHHHHHHHHHHH | 31.94 | 21149613 | |
| 492 | Phosphorylation | SRLHGQLSSLRGEGR HHHHHHHHHHCCCCC | 21.31 | 25159016 | |
| 493 | Phosphorylation | RLHGQLSSLRGEGRG HHHHHHHHHCCCCCC | 30.58 | 25159016 | |
| 514 | Phosphorylation | VGTQDRISASSPRVV EECCCCCCCCCCCCC | 24.00 | 22817900 | |
| 516 | Phosphorylation | TQDRISASSPRVVGD CCCCCCCCCCCCCCH | 33.80 | 20469934 | |
| 517 | Phosphorylation | QDRISASSPRVVGDA CCCCCCCCCCCCCHH | 19.22 | 22817900 | |
| 537 | Phosphorylation | CTDMKRCSYYETCAT HCCCCCCCHHHHHHH | 34.48 | 29899451 | |
| 575 | Phosphorylation | QLLAACKSLPSSPSH HHHHHHHCCCCCCCC | 45.45 | - | |
| 578 | Phosphorylation | AACKSLPSSPSHSAA HHHHCCCCCCCCCCC | 61.24 | - | |
| 579 | Phosphorylation | ACKSLPSSPSHSAAS HHHCCCCCCCCCCCC | 28.60 | 30372032 | |
| 586 | Phosphorylation | SPSHSAASTPVAGQA CCCCCCCCCCCCCCC | 32.72 | - | |
| 602 | Phosphorylation | NGGHTSDYSSSLPSS CCCCCCCCCCCCCCC | 15.37 | 30482847 | |
| 603 | Phosphorylation | GGHTSDYSSSLPSSP CCCCCCCCCCCCCCC | 20.59 | 21082442 | |
| 605 | Phosphorylation | HTSDYSSSLPSSPNV CCCCCCCCCCCCCCC | 38.06 | 19060867 | |
| 608 | Phosphorylation | DYSSSLPSSPNVGHR CCCCCCCCCCCCCCH | 64.82 | 19060867 | |
| 609 | Phosphorylation | YSSSLPSSPNVGHRE CCCCCCCCCCCCCHH | 20.67 | - | |
| 628 | Phosphorylation | AAAVAGLSTPGSLHR HHHHHCCCCHHHHHH | 31.47 | 28833060 | |
| 629 | Phosphorylation | AAVAGLSTPGSLHRA HHHHCCCCHHHHHHH | 36.39 | 28833060 | |
| 632 | Phosphorylation | AGLSTPGSLHRAAKR HCCCCHHHHHHHHHH | 23.39 | 25177544 | |
| 641 | Phosphorylation | HRAAKRRTSLFANRR HHHHHHHHHHHCCCC | 33.54 | 22324799 | |
| 642 | Phosphorylation | RAAKRRTSLFANRRG HHHHHHHHHHCCCCC | 21.48 | 22942356 | |
| 650 | Phosphorylation | LFANRRGSDAEKRSL HHCCCCCCHHHHCCC | 31.66 | 25266776 | |
| 656 | Phosphorylation | GSDAEKRSLDSRGET CCHHHHCCCCCCCCC | 47.82 | 22817900 | |
| 659 | Phosphorylation | AEKRSLDSRGETTGS HHHCCCCCCCCCCCC | 47.69 | 29899451 | |
| 664 | Phosphorylation | LDSRGETTGSGRAIP CCCCCCCCCCCCEEE | 25.66 | 29899451 | |
| 675 | Phosphorylation | RAIPIKQSFLLKRSG CEEECCHHEEECCCC | 16.92 | 27600695 | |
| 681 | Phosphorylation | QSFLLKRSGNSLNKE HHEEECCCCCCCCHH | 40.51 | 22324799 | |
| 684 | Phosphorylation | LLKRSGNSLNKEWKK EECCCCCCCCHHHHH | 36.52 | 22324799 | |
| 693 | Phosphorylation | NKEWKKKYVTLSSNG CHHHHHHEEEECCCC | 13.93 | 28576409 | |
| 739 | Phosphorylation | KRPPRAISAFGPSAS CCCCCCHHHCCCCCH | 19.29 | 20495213 | |
| 744 | Phosphorylation | AISAFGPSASINGLV CHHHCCCCCHHCCEE | 34.72 | 22324799 | |
| 746 | Phosphorylation | SAFGPSASINGLVKD HHCCCCCHHCCEECC | 22.41 | 20495213 | |
| 802 | Phosphorylation | RNLARALSTDCTPSG HHHHHHHCCCCCCCC | 22.63 | 25521595 | |
| 803 | Phosphorylation | NLARALSTDCTPSGD HHHHHHCCCCCCCCC | 35.62 | 25521595 | |
| 806 | Phosphorylation | RALSTDCTPSGDLSP HHHCCCCCCCCCCCC | 24.25 | 22324799 | |
| 808 | Phosphorylation | LSTDCTPSGDLSPLS HCCCCCCCCCCCCCC | 27.13 | 28833060 | |
| 812 | Phosphorylation | CTPSGDLSPLSREPP CCCCCCCCCCCCCCC | 28.65 | 28833060 | |
| 821 | Phosphorylation | LSREPPPSPMVKKQR CCCCCCCCCCHHHHH | 31.25 | 28833060 | |
| 826 | Acetylation | PPSPMVKKQRRKKLS CCCCCHHHHHHHCCC | 37.31 | 6568285 | |
| 830 | Acetylation | MVKKQRRKKLSTPSK CHHHHHHHCCCCCCC | 61.32 | 6568243 | |
| 833 | Phosphorylation | KQRRKKLSTPSKTEG HHHHHCCCCCCCCCC | 47.34 | 29899451 | |
| 834 | Phosphorylation | QRRKKLSTPSKTEGS HHHHCCCCCCCCCCH | 41.85 | 29472430 | |
| 836 | Phosphorylation | RKKLSTPSKTEGSAV HHCCCCCCCCCCHHH | 52.91 | 29899451 | |
| 838 | Phosphorylation | KLSTPSKTEGSAVQA CCCCCCCCCCHHHHH | 50.33 | 25521595 | |
| 841 | Phosphorylation | TPSKTEGSAVQAEAK CCCCCCCHHHHHHHH | 21.02 | 29899451 | |
| 856 | Phosphorylation | RKMWKLKSFGSLRNI HHHHHCCCHHHHHCE | 45.32 | 22324799 | |
| 859 | Phosphorylation | WKLKSFGSLRNIYKA HHCCCHHHHHCEEEE | 23.34 | 22324799 | |
| 919 | Phosphorylation | SSKVKLRTDSQSEAV HCCEEEECCCHHHHH | 50.90 | 28833060 | |
| 921 | Phosphorylation | KVKLRTDSQSEAVAI CEEEECCCHHHHHHH | 34.69 | 25521595 | |
| 923 | Phosphorylation | KLRTDSQSEAVAIQA EEECCCHHHHHHHHH | 31.32 | 28833060 | |
| 972 | Phosphorylation | GIHRNLGTHLSRVRS HHHHHHCHHHHHCCC | 23.86 | - | |
| 979 | Phosphorylation | THLSRVRSLDLDDWP HHHHHCCCCCCCCCC | 24.31 | 22817900 | |
| 1148 | Phosphorylation | GCPGEGGSTATTPSA CCCCCCCCCCCCCCC | 26.23 | 29899451 | |
| 1149 | Phosphorylation | CPGEGGSTATTPSAA CCCCCCCCCCCCCCC | 31.16 | 29899451 | |
| 1151 | Phosphorylation | GEGGSTATTPSAATT CCCCCCCCCCCCCCC | 39.05 | 29899451 | |
| 1152 | Phosphorylation | EGGSTATTPSAATTP CCCCCCCCCCCCCCC | 16.87 | 29899451 | |
| 1166 | Phosphorylation | PSITATPSPRRRSSA CCCCCCCCCCCCCCC | 27.04 | 23384938 | |
| 1171 | Phosphorylation | TPSPRRRSSAASLGR CCCCCCCCCCHHHCC | 23.63 | 25521595 | |
| 1172 | Phosphorylation | PSPRRRSSAASLGRV CCCCCCCCCHHHCCC | 26.49 | 25521595 | |
| 1175 | Phosphorylation | RRRSSAASLGRVDTT CCCCCCHHHCCCCCE | 30.95 | 28833060 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AGAP2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AGAP2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AGAP2_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-802; SER-859AND SER-921, AND MASS SPECTROMETRY. | |
| "Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149 AND SER-262, ANDMASS SPECTROMETRY. | |
