PRAG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRAG1_MOUSE
• UniProt AC: Q571I4
• Protein Name: Tyrosine-protein kinase PRAG1 {ECO:0000312|MGI:MGI:1196223}
• Gene Name: PRAG1 {ECO:0000312|MGI:MGI:1196223}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1179
• Protein Sequence: MTSSCPKGPRPCTSPQPLRESLPSEDDSDQRCSPSGDSEGGEYCSILDCCPESKDAVHSTEGSGRRGGDCSPTCREQGPRTRPTEEEKQGLSFPRECCGQGSTANPPRLGPKKPSLNSEAASSSDGLSCGSSRSGASSPFAPHLENDYCSLVKEPASGKQQDLSGHFLTSGKCVGQAAELQPASLLRDPVQPEPIYAESAKRKKAAPGPPRPEPKKEQVPAGHSQGQVWTGDTWIQKTPPSWSQDREGANPAPQVATTITVIAAHPEEDHRTIYLSSPDSAVGVQWPRGPSNQDLQAGEEEPLVAQGLTSRESHPHNVTENTAKEKPAIPPKLSKSSPGGSPVSPAAPPLTDHSDGNTGGSSVGPQLLSRVPANLTSSCHTNGVATAGDSAKCPPPATSSSVLDQRRPRYQTGAWSRQCRIEEEEEVGQELSQSWGRELENGTADHSNSSTWHRLHPIDGTSGQNSKTNSGMSKSASFAFEFPKDRGRLEAFSPPPPPPKSRHLLKMNKSSSDLEKVSQSSAESLSPSFRGAHVSFTTGSTDSLASDSRPCSDGGPSYEPTHSPTISGKKLFAPVPFPSGSTEDVSPGGGPAQPPPLPQKKIVSRAASSPDGFFWTQGSPKPRTASPKLNLSHSETNVCAHDEPPFNCSLNSGNRSHHVFSSSEPLGKAFKGNAPWAPALGLANSKGGCGSPSLQCRAATSTSSSQLSVSSQASSSSTQLQLHSLLSSISSKEGTYAKLGGLYTQSLARLVTKCEDLFMGGQKKELRFNENYWSLFKLTCNKPCCDSGDAIYYCATCSEDPGSIYAVKICKTPEPKSASYCSPSVPVHFNIQQDCGHFVASVPSSMLASPDTSSKDTAPAVSPQPPAQEQDCVVVITREVPHQTASDFVRDSMASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLAHCNPQSSPGPSATPTVPTTTSRCPSAAPAATTACQGGPGEKQLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLLWGPRRELVEQPCTSEEVLCNTLHNWIDMKRALMMMKFAEKAVDRRRGVELEDWLCCQYLASAEPGALLQSLKLLQLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	PKGPRPCTSPQPLRE CCCCCCCCCCCCHHH		28066266
14	Phosphorylation	KGPRPCTSPQPLRES CCCCCCCCCCCHHHC		25521595
21	Phosphorylation	SPQPLRESLPSEDDS CCCCHHHCCCCCCCC		30635358
24	Phosphorylation	PLRESLPSEDDSDQR CHHHCCCCCCCCCCC		29899451
40	Phosphorylation	SPSGDSEGGEYCSIL CCCCCCCCCCEEEEE		26824392
40	Phosphorylation	SPSGDSEGGEYCSIL CCCCCCCCCCEEEEE		24719451
43	Phosphorylation	GDSEGGEYCSILDCC CCCCCCCEEEEEECC		25521595
71	Phosphorylation	GRRGGDCSPTCREQG CCCCCCCCCCHHHCC		29550500
73	Phosphorylation	RGGDCSPTCREQGPR CCCCCCCCHHHCCCC		29550500
115	Phosphorylation	RLGPKKPSLNSEAAS CCCCCCCCCCCHHCC		25521595
119	Phosphorylation	KKPSLNSEAASSSDG CCCCCCCHHCCCCCC		-
119	Phosphorylation	KKPSLNSEAASSSDG CCCCCCCHHCCCCCC		-
131	Phosphorylation	SDGLSCGSSRSGASS CCCCCCCCCCCCCCC		24719451
131	Phosphorylation	SDGLSCGSSRSGASS CCCCCCCCCCCCCCC		24453211
134	Phosphorylation	LSCGSSRSGASSPFA CCCCCCCCCCCCCCC		26643407
137	Phosphorylation	GSSRSGASSPFAPHL CCCCCCCCCCCCCCC		26643407
138	Phosphorylation	SSRSGASSPFAPHLE CCCCCCCCCCCCCCC		26745281
148	Phosphorylation	APHLENDYCSLVKEP CCCCCCCCEEEEECC		26032504
184	Phosphorylation	AAELQPASLLRDPVQ CHHCCCHHHCCCCCC		22499769
196	Phosphorylation	PVQPEPIYAESAKRK CCCCCCCCHHHHCHH		18515860
199	Phosphorylation	PEPIYAESAKRKKAA CCCCCHHHHCHHCCC		22499769
208	Phosphorylation	KRKKAAPGPPRPEPK CHHCCCCCCCCCCCC		-
209	Phosphorylation	RKKAAPGPPRPEPKK HHCCCCCCCCCCCCC		-
224	Phosphorylation	EQVPAGHSQGQVWTG CCCCCCCCCCCEEEC		28285833
238	Phosphorylation	GDTWIQKTPPSWSQD CCCCCCCCCCCCCCC		-
272	Phosphorylation	HPEEDHRTIYLSSPD CCCCCCCEEEECCCC		23970565
274	Phosphorylation	EEDHRTIYLSSPDSA CCCCCEEEECCCCCC		23984901
276	Phosphorylation	DHRTIYLSSPDSAVG CCCEEEECCCCCCCC		26745281
277	Phosphorylation	HRTIYLSSPDSAVGV CCEEEECCCCCCCCC		26745281
280	Phosphorylation	IYLSSPDSAVGVQWP EEECCCCCCCCCCCC		26643407
333	Phosphorylation	KPAIPPKLSKSSPGG CCCCCCCCCCCCCCC		-
336	Phosphorylation	IPPKLSKSSPGGSPV CCCCCCCCCCCCCCC		21082442
337	Phosphorylation	PPKLSKSSPGGSPVS CCCCCCCCCCCCCCC		21082442
341	Phosphorylation	SKSSPGGSPVSPAAP CCCCCCCCCCCCCCC		21082442
343	Phosphorylation	SSPGGSPVSPAAPPL CCCCCCCCCCCCCCC		-
391	Phosphorylation	VATAGDSAKCPPPAT CCCCCCCCCCCCCCC		15592455
394	Phosphorylation	AGDSAKCPPPATSSS CCCCCCCCCCCCCCH		-
471	Phosphorylation	QNSKTNSGMSKSASF CCCCCCCCCCCCCEE		-
472	Phosphorylation	NSKTNSGMSKSASFA CCCCCCCCCCCCEEE		-
475	Phosphorylation	TNSGMSKSASFAFEF CCCCCCCCCEEEEEC		28833060
477	Phosphorylation	SGMSKSASFAFEFPK CCCCCCCEEEEECCC		25521595
493	Phosphorylation	RGRLEAFSPPPPPPK CCCCCCCCCCCCCCC		27180971
510	Phosphorylation	HLLKMNKSSSDLEKV HHHHCCCCHHHHHHH		30635358
511	Phosphorylation	LLKMNKSSSDLEKVS HHHCCCCHHHHHHHH		30635358
512	Phosphorylation	LKMNKSSSDLEKVSQ HHCCCCHHHHHHHHH		30635358
518	Phosphorylation	SSDLEKVSQSSAESL HHHHHHHHHHHHHHC		25619855
520	Phosphorylation	DLEKVSQSSAESLSP HHHHHHHHHHHHCCC		25619855
521	Phosphorylation	LEKVSQSSAESLSPS HHHHHHHHHHHCCCC		25619855
524	Phosphorylation	VSQSSAESLSPSFRG HHHHHHHHCCCCCCC		25619855
526	Phosphorylation	QSSAESLSPSFRGAH HHHHHHCCCCCCCCE		26824392
528	Phosphorylation	SAESLSPSFRGAHVS HHHHCCCCCCCCEEE		25619855
531	Phosphorylation	SLSPSFRGAHVSFTT HCCCCCCCCEEEEEC		26643407
532	Phosphorylation	LSPSFRGAHVSFTTG CCCCCCCCEEEEECC		26643407
536	Phosphorylation	FRGAHVSFTTGSTDS CCCCEEEEECCCCCC		26643407
539	Phosphorylation	AHVSFTTGSTDSLAS CEEEEECCCCCCCCC		26643407
545	Phosphorylation	TGSTDSLASDSRPCS CCCCCCCCCCCCCCC		26643407
548	Phosphorylation	TDSLASDSRPCSDGG CCCCCCCCCCCCCCC		26643407
552	Phosphorylation	ASDSRPCSDGGPSYE CCCCCCCCCCCCCCC		26643407
555	Phosphorylation	SRPCSDGGPSYEPTH CCCCCCCCCCCCCCC		26643407
563	Phosphorylation	PSYEPTHSPTISGKK CCCCCCCCCCCCCCE		30482847
579	Phosphorylation	FAPVPFPSGSTEDVS EECCCCCCCCCCCCC		25266776
581	Phosphorylation	PVPFPSGSTEDVSPG CCCCCCCCCCCCCCC		23737553
582	Phosphorylation	VPFPSGSTEDVSPGG CCCCCCCCCCCCCCC		25266776
586	Phosphorylation	SGSTEDVSPGGGPAQ CCCCCCCCCCCCCCC		23984901
604	Phosphorylation	LPQKKIVSRAASSPD CCCHHHHCCCCCCCC		23375375
608	Phosphorylation	KIVSRAASSPDGFFW HHHCCCCCCCCCCCC		23684622
609	Phosphorylation	IVSRAASSPDGFFWT HHCCCCCCCCCCCCC		25266776
616	Phosphorylation	SPDGFFWTQGSPKPR CCCCCCCCCCCCCCC		26745281
619	Phosphorylation	GFFWTQGSPKPRTAS CCCCCCCCCCCCCCC		26745281
624	Phosphorylation	QGSPKPRTASPKLNL CCCCCCCCCCCCCCC		26160508
626	Phosphorylation	SPKPRTASPKLNLSH CCCCCCCCCCCCCCC		26160508
632	Phosphorylation	ASPKLNLSHSETNVC CCCCCCCCCCCCCCC		25266776
634	Phosphorylation	PKLNLSHSETNVCAH CCCCCCCCCCCCCCC		25266776
636	Phosphorylation	LNLSHSETNVCAHDE CCCCCCCCCCCCCCC		26160508
656	Phosphorylation	SLNSGNRSHHVFSSS CCCCCCCCEEEECCC		23737553
661	Phosphorylation	NRSHHVFSSSEPLGK CCCEEEECCCCCCHH		23737553
662	Phosphorylation	RSHHVFSSSEPLGKA CCEEEECCCCCCHHH		23737553
663	Phosphorylation	SHHVFSSSEPLGKAF CEEEECCCCCCHHHH		23737553
671	Phosphorylation	EPLGKAFKGNAPWAP CCCHHHHCCCCCCHH		-
687	Phosphorylation	LGLANSKGGCGSPSL HCCCCCCCCCCCCCC		-
691	Phosphorylation	NSKGGCGSPSLQCRA CCCCCCCCCCCEEEC		22006019
693	Phosphorylation	KGGCGSPSLQCRAAT CCCCCCCCCEEECCC		28066266
706	Phosphorylation	ATSTSSSQLSVSSQA CCCCCCCCEEECCCC		24719451
715	Phosphorylation	SVSSQASSSSTQLQL EECCCCCCCCHHHHH		-
720	Phosphorylation	ASSSSTQLQLHSLLS CCCCCHHHHHHHHHH		24719451
722	Phosphorylation	SSSTQLQLHSLLSSI CCCHHHHHHHHHHHH		-
724	Phosphorylation	STQLQLHSLLSSISS CHHHHHHHHHHHHHC		26239621
727	Phosphorylation	LQLHSLLSSISSKEG HHHHHHHHHHHCCCC		26239621
728	Phosphorylation	QLHSLLSSISSKEGT HHHHHHHHHHCCCCC		26239621
757	Phosphorylation	LVTKCEDLFMGGQKK HHHHHHHHHCCCCCC		-
774	Phosphorylation	RFNENYWSLFKLTCN CCCCCHHHHEEEECC		25338131
779	Phosphorylation	YWSLFKLTCNKPCCD HHHHEEEECCCCCCC		25338131
802	Phosphorylation	ATCSEDPGSIYAVKI EECCCCCCCEEEEEE		24719451
826	Phosphorylation	SYCSPSVPVHFNIQQ CCCCCCCCEEEEEEC		24719451
828	Phosphorylation	CSPSVPVHFNIQQDC CCCCCCEEEEEECCC		-
885	Phosphorylation	REVPHQTASDFVRDS ECCCCCCHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRAG1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRAG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRAG1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTN1_MOUSE	Actn1	physical	20697350
CSK_MOUSE	Csk	physical	20697350

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.