CSK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSK_MOUSE
• UniProt AC: P41241
• Protein Name: Tyrosine-protein kinase CSK
• Gene Name: Csk
• Organism: Mus musculus (Mouse).
• Sequence Length: 450
• Subcellular Localization: Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts.
• Protein Description: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity)..
• Protein Sequence: MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQLEHIKTHELHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAIQAAWP ------CCCCCCCCC	33.79	-
18	Phosphorylation	GTECIAKYNFHGTAE CCEEEEEECCCCCCC	17.65	25195567
64	Phosphorylation	EGIIPANYVQKREGV CCCCCHHHCCHHHCC	13.33	29514104
97	Phosphorylation	EQAERLLYPPETGLF HHHHHHCCCCCCEEE	22.72	-
184	Phosphorylation	VAAQDEFYRSGWALN EECCHHHHHHCCCCC	11.21	22817900
193	Acetylation	SGWALNMKELKLLQT HCCCCCHHHHHHHHH	59.84	23864654
196	Acetylation	ALNMKELKLLQTIGK CCCHHHHHHHHHHCC	48.52	23864654
203	Acetylation	KLLQTIGKGEFGDVM HHHHHHCCCCCCCEE	51.95	23864654
290	Glutathionylation	RSVLGGDCLLKFSLD CCCCCCCCEEEEEHH	5.61	24333276
304	Phosphorylation	DVCEAMEYLEGNNFV HHHHHHHHHCCCCCC	9.29	-
364	Phosphorylation	ALREKKFSTKSDVWS HHHHCCCCCHHHHHH	43.75	-
416	Phosphorylation	DGCPPAVYEVMKNCW CCCCHHHHHHHHHCC	12.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
364	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
364	S	Phosphorylation	Phosphorylated at Ser-364 by PKA, leading to increased activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSK_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSK_HUMAN	CSK	physical	20360068
CADH5_MOUSE	Cdh5	physical	15861137
CSK_MOUSE	Csk	physical	15861137
ITB3_MOUSE	Itgb3	physical	24558484
DOK1_MOUSE	Dok1	physical	9221755
KCC2G_HUMAN	CAMK2G	physical	26496610
COX11_HUMAN	COX11	physical	26496610
T22D3_HUMAN	TSC22D3	physical	26496610
HMGA1_HUMAN	HMGA1	physical	26496610
PLCG2_HUMAN	PLCG2	physical	26496610
RAD52_HUMAN	RAD52	physical	26496610
RO52_HUMAN	TRIM21	physical	26496610
QCR2_HUMAN	UQCRC2	physical	26496610
ZO2_HUMAN	TJP2	physical	26496610
HOME3_HUMAN	HOMER3	physical	26496610
RBG10_HUMAN	RABGAP1L	physical	26496610
RBG1L_HUMAN	RABGAP1L	physical	26496610
CELF2_HUMAN	CELF2	physical	26496610
EBP2_HUMAN	EBNA1BP2	physical	26496610
ZFY26_HUMAN	ZFYVE26	physical	26496610
SHLB1_HUMAN	SH3GLB1	physical	26496610
AFTIN_HUMAN	AFTPH	physical	26496610
K1522_HUMAN	KIAA1522	physical	26496610
ZN668_HUMAN	ZNF668	physical	26496610
QSER1_HUMAN	QSER1	physical	26496610
LMA2L_HUMAN	LMAN2L	physical	26496610
PYM1_HUMAN	WIBG	physical	26496610
PCGF5_HUMAN	PCGF5	physical	26496610
FRYL_HUMAN	FRYL	physical	26496610
ITIH6_HUMAN	ITIH6	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.