dbPTM

K1522_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K1522_HUMAN
UniProt AC	Q9P206
Protein Name	Uncharacterized protein KIAA1522
Gene Name	KIAA1522
Organism	Homo sapiens (Human).
Sequence Length	1035
Subcellular Localization
Protein Description
Protein Sequence	MVVFVGRRLPALLGLFKKKGSAKAENDKHLSVGPGQGPGSAVDEHQDNVFFPSGRPPHLEELHTQAQEGLRSLQHQEKQKLNKGGWDHGDTQSIQSSRTGPDEDNISFCSQTTSYVAESSTAEDALSIRSEMIQRKGSTFRPHDSFPKSGKSGRRRRERRSTVLGLPQHVQKELGLRNEREAPGTPRAPGARDAVRIPTVDGRPRGTSGMGARVSLQALEAEAEAGAETEAMLQRHIDRVYRDDTFVGRSTGTRAPPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGPEEKMGLPGSDSQKELA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 3)	Myristoylation	-	7.32	20213681
31	Phosphorylation	AENDKHLSVGPGQGP CCCCCCCCCCCCCCC	25.42	22468782
32 (in isoform 2)	Phosphorylation	-	15.70	20068231
39	Phosphorylation	VGPGQGPGSAVDEHQ CCCCCCCCCCCHHCC	34.75	24719451
39 (in isoform 2)	Phosphorylation	-	34.75	22617229
49	Ubiquitination	VDEHQDNVFFPSGRP CHHCCCCEECCCCCC	7.62	33845483
80	Phosphorylation	LQHQEKQKLNKGGWD HHHHHHHHHHCCCCC	66.16	-
80 (in isoform 2)	Phosphorylation	-	66.16	20068231
91	Phosphorylation	GGWDHGDTQSIQSSR CCCCCCCCHHHHCCC	28.89	30266825
93	Phosphorylation	WDHGDTQSIQSSRTG CCCCCCHHHHCCCCC	25.37	30266825
96	Phosphorylation	GDTQSIQSSRTGPDE CCCHHHHCCCCCCCC	21.81	30266825
97	Phosphorylation	DTQSIQSSRTGPDED CCHHHHCCCCCCCCC	19.93	23663014
127	Phosphorylation	STAEDALSIRSEMIQ CCHHHHHHHHHHHHH	20.06	22468782
130	Phosphorylation	EDALSIRSEMIQRKG HHHHHHHHHHHHHCC	29.82	22468782
136	Methylation	RSEMIQRKGSTFRPH HHHHHHHCCCCCCCC	40.62	115972031
138	Phosphorylation	EMIQRKGSTFRPHDS HHHHHCCCCCCCCCC	27.66	25159151
139	Phosphorylation	MIQRKGSTFRPHDSF HHHHCCCCCCCCCCC	32.12	25159151
145	Phosphorylation	STFRPHDSFPKSGKS CCCCCCCCCCCCCCC	40.18	25159151
150	Phosphorylation	HDSFPKSGKSGRRRR CCCCCCCCCCCCCHH	33.98	27251275
152	Phosphorylation	SFPKSGKSGRRRRER CCCCCCCCCCCHHHH	40.85	24719451
155	Phosphorylation	KSGKSGRRRRERRST CCCCCCCCHHHHHHH	45.60	24719451
161	Phosphorylation	RRRRERRSTVLGLPQ CCHHHHHHHHHCCCH	29.14	23401153
162	Phosphorylation	RRRERRSTVLGLPQH CHHHHHHHHHCCCHH	20.24	22167270
173	Phosphorylation	LPQHVQKELGLRNER CCHHHHHHHCCCCCC	30.86	32645325
185	Phosphorylation	NEREAPGTPRAPGAR CCCCCCCCCCCCCCC	14.45	30266825
197	Phosphorylation	GARDAVRIPTVDGRP CCCCCEECCCCCCCC	2.42	24719451
199	Phosphorylation	RDAVRIPTVDGRPRG CCCEECCCCCCCCCC	28.94	24719451
204	Phosphorylation	IPTVDGRPRGTSGMG CCCCCCCCCCCCCCC	44.58	24719451
207	Phosphorylation	VDGRPRGTSGMGARV CCCCCCCCCCCCCHH	24.32	22210691
208	Phosphorylation	DGRPRGTSGMGARVS CCCCCCCCCCCCHHH	29.61	22210691
215	Phosphorylation	SGMGARVSLQALEAE CCCCCHHHHHHHHHH	14.82	30278072
220	Phosphorylation	RVSLQALEAEAEAGA HHHHHHHHHHHHCCC	47.69	24719451
221	Phosphorylation	VSLQALEAEAEAGAE HHHHHHHHHHHCCCC	23.34	32645325
229	Phosphorylation	EAEAGAETEAMLQRH HHHCCCCHHHHHHHH	28.63	22210691
241	Phosphorylation	QRHIDRVYRDDTFVG HHHHHHHHCCCCCCC	14.82	25394399
244	Phosphorylation	IDRVYRDDTFVGRST HHHHHCCCCCCCCCC	32.80	27251275
245	Phosphorylation	DRVYRDDTFVGRSTG HHHHCCCCCCCCCCC	25.22	-
258	Phosphorylation	TGTRAPPLTRPMSLA CCCCCCCCCCCCEEC	6.54	24719451
259	Phosphorylation	GTRAPPLTRPMSLAV CCCCCCCCCCCEECC	38.20	20068231
263	Phosphorylation	PPLTRPMSLAVPGLT CCCCCCCEECCCCCC	18.83	20068231
270	Phosphorylation	SLAVPGLTGGAGPAE EECCCCCCCCCCCCC	39.21	29523821
274	Phosphorylation	PGLTGGAGPAEPLSP CCCCCCCCCCCCCCC	25.81	24719451
280	Phosphorylation	AGPAEPLSPAMSISP CCCCCCCCCCCCCCC	22.71	25106551
284	Phosphorylation	EPLSPAMSISPQATY CCCCCCCCCCCCHHH	23.24	25106551
286	Phosphorylation	LSPAMSISPQATYLS CCCCCCCCCCHHHHH	12.03	25106551
290	Phosphorylation	MSISPQATYLSKLIP CCCCCCHHHHHHHCC	21.54	26434776
291	Phosphorylation	SISPQATYLSKLIPH CCCCCHHHHHHHCCC	16.40	20068231
293	Phosphorylation	SPQATYLSKLIPHAV CCCHHHHHHHCCCCC	18.27	20068231
294	Acetylation	PQATYLSKLIPHAVL CCHHHHHHHCCCCCC	48.09	7431947
300	Phosphorylation	SKLIPHAVLPPTVDV HHHCCCCCCCCCCCE	8.19	27642862
304	Phosphorylation	PHAVLPPTVDVVALG CCCCCCCCCCEEEEC	27.65	26434776
314	Phosphorylation	VVALGRCSLRTLSRC EEEECCCCHHHHCCC	21.37	27422710
317	Phosphorylation	LGRCSLRTLSRCSLH ECCCCHHHHCCCCCC	34.09	20873877
318	Phosphorylation	GRCSLRTLSRCSLHS CCCCHHHHCCCCCCC	2.16	27251275
319	Phosphorylation	RCSLRTLSRCSLHSA CCCHHHHCCCCCCCC	30.54	25849741
320	Asymmetric dimethylarginine	CSLRTLSRCSLHSAS CCHHHHCCCCCCCCC	19.70	-
320	Methylation	CSLRTLSRCSLHSAS CCHHHHCCCCCCCCC	19.70	-
322	Phosphorylation	LRTLSRCSLHSASPA HHHHCCCCCCCCCCH	28.18	30266825
325	Phosphorylation	LSRCSLHSASPASVR HCCCCCCCCCCHHHH	35.42	30266825
327	Phosphorylation	RCSLHSASPASVRSL CCCCCCCCCHHHHHH	24.82	30266825
330	Phosphorylation	LHSASPASVRSLGRF CCCCCCHHHHHHCCC	22.80	30266825
333	Phosphorylation	ASPASVRSLGRFSSV CCCHHHHHHCCCCCC	32.78	30266825
338	Phosphorylation	VRSLGRFSSVSSPQP HHHHCCCCCCCCCCC	28.59	30266825
339	Phosphorylation	RSLGRFSSVSSPQPR HHHCCCCCCCCCCCC	24.25	30266825
341	Phosphorylation	LGRFSSVSSPQPRSR HCCCCCCCCCCCCCC	37.94	30266825
342	Phosphorylation	GRFSSVSSPQPRSRH CCCCCCCCCCCCCCC	25.96	22167270
345	Phosphorylation	SSVSSPQPRSRHPSS CCCCCCCCCCCCCCC	39.33	-
347	Phosphorylation	VSSPQPRSRHPSSSS CCCCCCCCCCCCCCC	41.44	20873877
351	Phosphorylation	QPRSRHPSSSSDTWS CCCCCCCCCCCCCCC	36.41	27273156
352	Phosphorylation	PRSRHPSSSSDTWSH CCCCCCCCCCCCCCC	38.01	20873877
353	Phosphorylation	RSRHPSSSSDTWSHS CCCCCCCCCCCCCCC	36.25	20873877
354	Phosphorylation	SRHPSSSSDTWSHSQ CCCCCCCCCCCCCCC	40.79	20873877
356	Phosphorylation	HPSSSSDTWSHSQSS CCCCCCCCCCCCCCC	30.71	20873877
358	Phosphorylation	SSSSDTWSHSQSSDT CCCCCCCCCCCCCCE	18.49	20873877
360	Phosphorylation	SSDTWSHSQSSDTIV CCCCCCCCCCCCEEE	26.66	20873877
362	Phosphorylation	DTWSHSQSSDTIVSD CCCCCCCCCCEEEEC	32.94	23186163
363	Phosphorylation	TWSHSQSSDTIVSDG CCCCCCCCCEEEECC	31.01	23186163
365	Phosphorylation	SHSQSSDTIVSDGST CCCCCCCEEEECCCC	25.81	20873877
368	Phosphorylation	QSSDTIVSDGSTLSS CCCCEEEECCCCCCC	32.19	23186163
373	Phosphorylation	IVSDGSTLSSKGGSE EEECCCCCCCCCCCC	6.11	24719451
379	Phosphorylation	TLSSKGGSEGQPESS CCCCCCCCCCCCCCC	47.42	23663014
381	Phosphorylation	SSKGGSEGQPESSTA CCCCCCCCCCCCCCC	50.47	24719451
384	Phosphorylation	GGSEGQPESSTASNS CCCCCCCCCCCCCCC	49.81	24719451
385	Phosphorylation	GSEGQPESSTASNSV CCCCCCCCCCCCCCC	39.41	23663014
386	Phosphorylation	SEGQPESSTASNSVV CCCCCCCCCCCCCCC	26.74	23663014
387	Phosphorylation	EGQPESSTASNSVVP CCCCCCCCCCCCCCC	43.30	23663014
389	Phosphorylation	QPESSTASNSVVPPP CCCCCCCCCCCCCCC	29.71	23663014
391	Phosphorylation	ESSTASNSVVPPPQG CCCCCCCCCCCCCCC	23.23	23663014
397	Phosphorylation	NSVVPPPQGGSGRGS CCCCCCCCCCCCCCC	74.73	24719451
398	Phosphorylation	SVVPPPQGGSGRGSP CCCCCCCCCCCCCCC	37.70	-
400	Phosphorylation	VPPPQGGSGRGSPSG CCCCCCCCCCCCCCC	31.94	30624053
401	Phosphorylation	PPPQGGSGRGSPSGG CCCCCCCCCCCCCCC	41.04	24719451
404	Phosphorylation	QGGSGRGSPSGGSTA CCCCCCCCCCCCCCC	17.96	19664994
406	Phosphorylation	GSGRGSPSGGSTAEA CCCCCCCCCCCCCCC	58.44	30266825
409	Phosphorylation	RGSPSGGSTAEASDT CCCCCCCCCCCCCCC	28.15	30266825
410	Phosphorylation	GSPSGGSTAEASDTL CCCCCCCCCCCCCCE	31.62	30266825
411	Phosphorylation	SPSGGSTAEASDTLS CCCCCCCCCCCCCEE	16.44	-
412	Phosphorylation	PSGGSTAEASDTLSI CCCCCCCCCCCCEEE	49.12	-
413	Phosphorylation	SGGSTAEASDTLSIR CCCCCCCCCCCEEEC	15.39	-
414	Phosphorylation	GGSTAEASDTLSIRS CCCCCCCCCCEEECC	23.72	23663014
415	Phosphorylation	GSTAEASDTLSIRSS CCCCCCCCCEEECCC	59.73	32142685
416	Phosphorylation	STAEASDTLSIRSSG CCCCCCCCEEECCCC	21.65	23663014
418	Phosphorylation	AEASDTLSIRSSGQL CCCCCCEEECCCCCC	20.32	25849741
421	Phosphorylation	SDTLSIRSSGQLSGR CCCEEECCCCCCCCC	36.83	20363803
422	Phosphorylation	DTLSIRSSGQLSGRS CCEEECCCCCCCCCE	22.25	30266825
426	Phosphorylation	IRSSGQLSGRSVSLR ECCCCCCCCCEEEHH	25.03	28985074
429	Phosphorylation	SGQLSGRSVSLRKLK CCCCCCCEEEHHHCC	21.42	24719451
431	Phosphorylation	QLSGRSVSLRKLKRP CCCCCEEEHHHCCCC	24.57	29496963
438	Phosphorylation	SLRKLKRPPPPPRRT EHHHCCCCCCCCCCC	44.13	27251275
445	Phosphorylation	PPPPPRRTHSLHQRG CCCCCCCCCCHHHCC	19.66	26657352
447	Phosphorylation	PPPRRTHSLHQRGLA CCCCCCCCHHHCCCC	27.25	26657352
463	Phosphorylation	PDGPLGLPPKPERKQ CCCCCCCCCCCCCCC	32.82	24719451
465	Phosphorylation	GPLGLPPKPERKQQP CCCCCCCCCCCCCCC	58.53	27251275
468	Phosphorylation	GLPPKPERKQQPQLP CCCCCCCCCCCCCCC	51.08	27251275
480	Phosphorylation	QLPRPPTTGGSEGAG CCCCCCCCCCCCCCC	45.37	24719451
488	Phosphorylation	GGSEGAGAAPCPPNP CCCCCCCCCCCCCCC	14.01	24719451
490	Phosphorylation	SEGAGAAPCPPNPAN CCCCCCCCCCCCCCC	30.52	24719451
498	Phosphorylation	CPPNPANSWVPGLSP CCCCCCCCCCCCCCC	31.40	29083192
504	Phosphorylation	NSWVPGLSPGGSRRP CCCCCCCCCCCCCCC	27.67	25159151
506	Phosphorylation	WVPGLSPGGSRRPPR CCCCCCCCCCCCCCC	43.25	-
508	Phosphorylation	PGLSPGGSRRPPRSP CCCCCCCCCCCCCCC	30.91	23663014
514	Phosphorylation	GSRRPPRSPERTLSP CCCCCCCCCCCCCCC	36.57	30266825
518	Phosphorylation	PPRSPERTLSPSSGY CCCCCCCCCCCCCCC	29.90	21945579
520	Phosphorylation	RSPERTLSPSSGYSS CCCCCCCCCCCCCCC	23.32	21945579
522	Phosphorylation	PERTLSPSSGYSSQS CCCCCCCCCCCCCCC	32.78	21945579
523	Phosphorylation	ERTLSPSSGYSSQSG CCCCCCCCCCCCCCC	45.17	21945579
525	Phosphorylation	TLSPSSGYSSQSGTP CCCCCCCCCCCCCCC	13.70	21945579
526	Phosphorylation	LSPSSGYSSQSGTPT CCCCCCCCCCCCCCC	25.98	21945579
527	Phosphorylation	SPSSGYSSQSGTPTL CCCCCCCCCCCCCCC	21.63	21945579
529	Phosphorylation	SSGYSSQSGTPTLPP CCCCCCCCCCCCCCC	46.73	21945579
531	Phosphorylation	GYSSQSGTPTLPPKG CCCCCCCCCCCCCCC	20.53	21945579
533	Phosphorylation	SSQSGTPTLPPKGLA CCCCCCCCCCCCCCC	52.30	21945579
545	Phosphorylation	GLAGPPASPGKAQPP CCCCCCCCCCCCCCC	39.70	19664994
556	Phosphorylation	AQPPKPERVTSLRSP CCCCCCCCCCCCCCC	45.61	32142685
558	Phosphorylation	PPKPERVTSLRSPGA CCCCCCCCCCCCCCC	28.41	30278072
559	Phosphorylation	PKPERVTSLRSPGAS CCCCCCCCCCCCCCC	20.94	23927012
562	Phosphorylation	ERVTSLRSPGASVSS CCCCCCCCCCCCHHH	32.74	30266825
563	Phosphorylation	RVTSLRSPGASVSSS CCCCCCCCCCCHHHH	35.62	27251275
566	Phosphorylation	SLRSPGASVSSSLTS CCCCCCCCHHHHHHH	28.57	30266825
568	Phosphorylation	RSPGASVSSSLTSLC CCCCCCHHHHHHHHH	16.24	30266825
569	Phosphorylation	SPGASVSSSLTSLCS CCCCCHHHHHHHHHC	27.49	30266825
570	Phosphorylation	PGASVSSSLTSLCSS CCCCHHHHHHHHHCC	28.32	30266825
572	Phosphorylation	ASVSSSLTSLCSSSS CCHHHHHHHHHCCCC	22.92	30266825
573	Phosphorylation	SVSSSLTSLCSSSSD CHHHHHHHHHCCCCC	32.44	30266825
576	Phosphorylation	SSLTSLCSSSSDPAP HHHHHHHCCCCCCCC	38.25	30266825
577	Phosphorylation	SLTSLCSSSSDPAPS HHHHHHCCCCCCCCC	32.63	30266825
578	Phosphorylation	LTSLCSSSSDPAPSD HHHHHCCCCCCCCCC	23.59	30278072
579	Phosphorylation	TSLCSSSSDPAPSDR HHHHCCCCCCCCCCC	49.95	30278072
584	Phosphorylation	SSSDPAPSDRSGPQI CCCCCCCCCCCCCCC	48.00	33259812
586	Phosphorylation	SDPAPSDRSGPQILT CCCCCCCCCCCCCCC	48.10	24719451
587	Phosphorylation	DPAPSDRSGPQILTP CCCCCCCCCCCCCCC	60.87	27251275
588	Phosphorylation	PAPSDRSGPQILTPL CCCCCCCCCCCCCCC	21.01	24719451
590	Phosphorylation	PSDRSGPQILTPLGD CCCCCCCCCCCCCCC	47.01	24719451
593	Phosphorylation	RSGPQILTPLGDRFV CCCCCCCCCCCCCEE	20.35	30266825
598	Methylation	ILTPLGDRFVIPPHP CCCCCCCCEECCCCC	26.40	81450635
604	Phosphorylation	DRFVIPPHPKVPAPF CCEECCCCCCCCCCC	29.47	24719451
612	Phosphorylation	PKVPAPFSPPPSKPR CCCCCCCCCCCCCCC	35.12	30266825
616	Phosphorylation	APFSPPPSKPRSPNP CCCCCCCCCCCCCCC	62.15	22199227
617	Phosphorylation	PFSPPPSKPRSPNPA CCCCCCCCCCCCCCC	50.66	27251275
618	Phosphorylation	FSPPPSKPRSPNPAA CCCCCCCCCCCCCCC	46.44	-
620	Phosphorylation	PPPSKPRSPNPAAPA CCCCCCCCCCCCCHH	37.24	28188228
621	Phosphorylation	PPSKPRSPNPAAPAL CCCCCCCCCCCCHHH	52.70	24719451
623	Phosphorylation	SKPRSPNPAAPALAA CCCCCCCCCCHHHCC	32.93	32142685
628	Phosphorylation	PNPAAPALAAPAVVP CCCCCHHHCCCEEEC	3.98	24719451
632	Phosphorylation	APALAAPAVVPGPVS CHHHCCCEEECCCCC	15.37	33259812
635	Phosphorylation	LAAPAVVPGPVSTTD HCCCEEECCCCCCCC	34.47	24719451
639	Phosphorylation	AVVPGPVSTTDASPQ EEECCCCCCCCCCCC	28.82	29802988
640	Phosphorylation	VVPGPVSTTDASPQS EECCCCCCCCCCCCC	29.00	27251275
641	Phosphorylation	VPGPVSTTDASPQSP ECCCCCCCCCCCCCC	23.28	27251275
644	Phosphorylation	PVSTTDASPQSPPTP CCCCCCCCCCCCCCC	26.70	28348404
647	Phosphorylation	TTDASPQSPPTPQTT CCCCCCCCCCCCCCC	35.91	28348404
650	Phosphorylation	ASPQSPPTPQTTLTP CCCCCCCCCCCCCCC	31.26	28348404
652	Phosphorylation	PQSPPTPQTTLTPLQ CCCCCCCCCCCCCCC	49.98	24719451
653	Phosphorylation	QSPPTPQTTLTPLQE CCCCCCCCCCCCCCC	25.61	28348404
654	Phosphorylation	SPPTPQTTLTPLQES CCCCCCCCCCCCCCC	24.32	28348404
656	Phosphorylation	PTPQTTLTPLQESPV CCCCCCCCCCCCCCC	21.62	28348404
661	Phosphorylation	TLTPLQESPVISKDQ CCCCCCCCCCCCCCC	16.11	29802988
665	Phosphorylation	LQESPVISKDQSPPP CCCCCCCCCCCCCCC	30.34	22468782
669	Phosphorylation	PVISKDQSPPPSPPP CCCCCCCCCCCCCCC	49.89	19664994
671	Phosphorylation	ISKDQSPPPSPPPSY CCCCCCCCCCCCCCC	47.44	24719451
673	Phosphorylation	KDQSPPPSPPPSYHP CCCCCCCCCCCCCCC	56.67	19664994
677	Phosphorylation	PPPSPPPSYHPPPPP CCCCCCCCCCCCCCC	41.68	21945579
678	Phosphorylation	PPSPPPSYHPPPPPT CCCCCCCCCCCCCCC	24.91	21945579
679	Phosphorylation	PSPPPSYHPPPPPTK CCCCCCCCCCCCCCC	32.50	27251275
680	Phosphorylation	SPPPSYHPPPPPTKK CCCCCCCCCCCCCCC	34.56	32142685
684	Phosphorylation	SYHPPPPPTKKPEVV CCCCCCCCCCCCCEE	63.72	32142685
685	Phosphorylation	YHPPPPPTKKPEVVV CCCCCCCCCCCCEEE	58.43	21945579
699	Phosphorylation	VEAPSASETAEEPLQ EECCCCCCCCCCCCC	52.32	27251275
709	Phosphorylation	EEPLQDPNWPPPPPP CCCCCCCCCCCCCCC	72.65	27251275
728	Phosphorylation	QDLSMADFPPPEEAF CCCCCCCCCCCHHHC	7.70	27251275
732	Phosphorylation	MADFPPPEEAFFSVA CCCCCCCHHHCCCCC	68.67	27251275
736	Phosphorylation	PPPEEAFFSVASPEP CCCHHHCCCCCCCCC	8.07	-
737	Phosphorylation	PPEEAFFSVASPEPA CCHHHCCCCCCCCCC	15.43	27642862
744	Phosphorylation	SVASPEPAGPSGSPE CCCCCCCCCCCCCCH	40.65	-
821	Phosphorylation	DVGAPLVTPSLLQMV HCCCCCCCHHHHHHH	18.16	-
832	Phosphorylation	LQMVRLRSVGAPGGA HHHHHHHHCCCCCCC	29.51	26657352
841	Phosphorylation	GAPGGAPTPALGPSA CCCCCCCCCCCCCCC	22.21	24850871
847	Phosphorylation	PTPALGPSAPQKPLR CCCCCCCCCCCHHHH	51.27	24850871
858	Phosphorylation	KPLRRALSGRASPVP HHHHHHHCCCCCCCC	25.83	22167270
862	Phosphorylation	RALSGRASPVPAPSS HHHCCCCCCCCCCCC	25.68	29255136
868	Phosphorylation	ASPVPAPSSGLHAAV CCCCCCCCCCHHHHH	38.86	22167270
869	Phosphorylation	SPVPAPSSGLHAAVR CCCCCCCCCHHHHHH	44.29	23927012
873	Phosphorylation	APSSGLHAAVRLKAC CCCCCHHHHHHHHHH	16.82	32142685
876	Methylation	SGLHAAVRLKACSLA CCHHHHHHHHHHHHH	26.24	81450623
881	Phosphorylation	AVRLKACSLAASEGL HHHHHHHHHHHHCCC	26.38	28348404
889	Phosphorylation	LAASEGLSSAQPNGP HHHHCCCCCCCCCCC	34.19	30183078
890	Phosphorylation	AASEGLSSAQPNGPP HHHCCCCCCCCCCCC	35.65	28102081
891	Phosphorylation	ASEGLSSAQPNGPPE HHCCCCCCCCCCCCC	26.02	24719451
906	Phosphorylation	AEPRPPQSPASTASF CCCCCCCCCCCCCEE	28.36	26657352
909	Phosphorylation	RPPQSPASTASFIFS CCCCCCCCCCEEEEE	28.08	25850435
910	Phosphorylation	PPQSPASTASFIFSK CCCCCCCCCEEEEEC	28.55	25850435
912	Phosphorylation	QSPASTASFIFSKGS CCCCCCCEEEEECCC	20.97	25850435
916	Phosphorylation	STASFIFSKGSRKLQ CCCEEEEECCCCEEE	31.15	30576142
917	Phosphorylation	TASFIFSKGSRKLQL CCEEEEECCCCEEEE	50.59	24719451
921	Phosphorylation	IFSKGSRKLQLERPV EEECCCCEEEEECCC	42.13	24719451
927	Phosphorylation	RKLQLERPVSPETQA CEEEEECCCCHHHHH	22.89	-
928	Phosphorylation	KLQLERPVSPETQAD EEEEECCCCHHHHHH	21.84	-
929	Phosphorylation	LQLERPVSPETQADL EEEECCCCHHHHHHH	21.50	19664994
932	Phosphorylation	ERPVSPETQADLQRN ECCCCHHHHHHHHHH	32.23	30266825
940	Phosphorylation	QADLQRNLVAELRSI HHHHHHHHHHHHHHH	4.15	32142685
948	Phosphorylation	VAELRSISEQRPPQA HHHHHHHHHCCCCCC	28.99	25159151
959	Phosphorylation	PPQAPKKSPKAPPPV CCCCCCCCCCCCCCC	37.45	23403867
965	Phosphorylation	KSPKAPPPVARKPSV CCCCCCCCCCCCCCC	31.20	27251275
971	Phosphorylation	PPVARKPSVGVPPPA CCCCCCCCCCCCCCC	34.24	23927012
979	Phosphorylation	VGVPPPASPSYPRAE CCCCCCCCCCCCCCC	21.83	25159151
981	Phosphorylation	VPPPASPSYPRAEPL CCCCCCCCCCCCCCC	45.32	30266825
982	Phosphorylation	PPPASPSYPRAEPLT CCCCCCCCCCCCCCC	10.50	30278072
988	Phosphorylation	SYPRAEPLTAPPTNG CCCCCCCCCCCCCCC	4.86	27251275
989	Phosphorylation	YPRAEPLTAPPTNGL CCCCCCCCCCCCCCC	48.08	23312004
990	Phosphorylation	PRAEPLTAPPTNGLP CCCCCCCCCCCCCCC	18.76	32142685
993	Phosphorylation	EPLTAPPTNGLPHTQ CCCCCCCCCCCCCCC	40.64	23312004
999	Phosphorylation	PTNGLPHTQDRTKRE CCCCCCCCCCCHHHH	30.17	23312004
1018	Phosphorylation	GGVLQLVGPEEKMGL CCEEEEECCHHHCCC	32.28	24719451
1028	Phosphorylation	EKMGLPGSDSQKELA HHCCCCCCHHHHHHC	31.95	23663014
1030	Phosphorylation	MGLPGSDSQKELA-- CCCCCCHHHHHHC--	44.86	25159151
1038	Phosphorylation	QKELA---------- HHHHC----------		24719451
1040	Phosphorylation	ELA------------ HHC------------		-
1041	Phosphorylation	LA------------- HC-------------		-
1089	Phosphorylation	------------------------------------------------------------- -------------------------------------------------------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of K1522_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of K1522_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K1522_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NCK1_HUMAN	NCK1	physical	21988832
SFRP1_HUMAN	SFRP1	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K1522_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-545, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215; SER-545; THR-593;SER-669; SER-673; SER-858; SER-862; SER-929; SER-971 AND SER-979, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-929, AND MASSSPECTROMETRY.	18220336 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-339; SER-342 ANDSER-545, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-858; SER-862; SER-929AND SER-979, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Phosphoproteomic analysis of synaptosomes from human cerebralcortex."; DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P.,Pant H.C., Dosemeci A.; J. Proteome Res. 4:306-315(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-185 AND SER-573, ANDMASS SPECTROMETRY.	15822905 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-404; SER-520; SER-545;SER-669 AND SER-673, AND MASS SPECTROMETRY.	15302935 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-241, AND MASSSPECTROMETRY.	17389395 [Abstract]