SFRP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SFRP1_HUMAN
• UniProt AC: Q8N474
• Protein Name: Secreted frizzled-related protein 1
• Gene Name: SFRP1
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Subcellular Localization: Secreted. Cell membrane or extracellular matrix-associated. Released by heparin-binding.
• Protein Description: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription..
• Protein Sequence: MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	O-linked_Glycosylation	ASEYDYVSFQSDIGP CCCCCEEEECCCCCC	16.02	OGP
173	N-linked_Glycosylation	CIAMTPPNATEASKP EEEECCCCCCCCCCC	61.78	11741940
175	O-linked_Glycosylation	AMTPPNATEASKPQG EECCCCCCCCCCCCC	38.43	OGP
183	O-linked_Glycosylation	EASKPQGTTVCPPCD CCCCCCCCCCCCCCC	15.71	OGP
184	O-linked_Glycosylation	ASKPQGTTVCPPCDN CCCCCCCCCCCCCCC	27.25	OGP
223	Acetylation	VKKENGDKKIVPKKK HHHHHCCCCCCCCCC	45.88	88849
224	Acetylation	KKENGDKKIVPKKKK HHHHCCCCCCCCCCC	54.39	88845
231	Acetylation	KIVPKKKKPLKLGPI CCCCCCCCCCCCCCC	65.54	88853
239	Acetylation	PLKLGPIKKKDLKKL CCCCCCCCHHHHHHH	57.83	88857

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SFRP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SFRP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SFRP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FZD6_HUMAN	FZD6	physical	10347172
WNT4_HUMAN	WNT4	physical	11287180
PP1G_HUMAN	PPP1CC	physical	21382349

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Disulfide bond assignments of secreted Frizzled-related protein-1provide insights about Frizzled homology and netrin modules.";
Chong J.M., Ueren A., Rubin J.S., Speicher D.W.;
J. Biol. Chem. 277:5134-5144(2002).
Cited for: PROTEIN SEQUENCE OF 32-314, DISULFIDE BONDS, MASS SPECTROMETRY,GLYCOSYLATION AT ASN-173, AND MUTAGENESIS OF ASN-173 AND ASN-263.
PubMed: 11741940