WNT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WNT4_HUMAN
• UniProt AC: P56705
• Protein Name: Protein Wnt-4
• Gene Name: WNT4
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue..
• Protein Sequence: MSPRSCLRSLRLLVFAVFSAAASNWLYLAKLSSVGSISEEETCEKLKGLIQRQVQMCKRNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAQVELAERCSCKFHWCCFVKCRQCQRLVELHTCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	RNLEVMDSVRRGAQL HCHHHHHHHHHHHHH	10.22	-
88	N-linked_Glycosylation	QFRNRRWNCSTLDSL HHHCCCCCCCCCCCC	14.19	UniProtKB CARBOHYD
106	Phosphorylation	GKVVTQGTREAAFVY EEEECCCCHHHHHHH	18.60	-
113	Phosphorylation	TREAAFVYAISSAGV CHHHHHHHHHHHHCH	7.55	19835603
116	Phosphorylation	AAFVYAISSAGVAFA HHHHHHHHHHCHHHH	13.13	17929957
117	Phosphorylation	AFVYAISSAGVAFAV HHHHHHHHHCHHHHH	23.95	17929957
130	Phosphorylation	AVTRACSSGELEKCG HHHHHCCCCCHHHCC	35.85	-
196	Acetylation	HNNEAGRKAILTHMR CCCHHHHHHHHHEEE	38.57	19828913
212	O-palmitoleoylation	ECKCHGVSGSCEVKT EEEECCCCCCCEEEE	29.58	-
295	Phosphorylation	VLGTRGRTCNKTSKA CCCCCCCCCCCCCCC	24.21	-
297	N-linked_Glycosylation	GTRGRTCNKTSKAID CCCCCCCCCCCCCCC	50.45	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WNT4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WNT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WNT4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
WLS_HUMAN	WLS	physical	26186194
GRP78_HUMAN	HSPA5	physical	26186194
KCC2D_HUMAN	CAMK2D	physical	26186194
WNT7B_HUMAN	WNT7B	physical	26186194
BORA_HUMAN	BORA	physical	26186194
PASK_HUMAN	PASK	physical	26186194
INT14_HUMAN	VWA9	physical	26186194
TOM40_HUMAN	TOMM40	physical	26186194
BRE1B_HUMAN	RNF40	physical	26186194
MTCH2_HUMAN	MTCH2	physical	26186194
WNT5A_HUMAN	WNT5A	physical	26186194
CREL2_HUMAN	CRELD2	physical	26186194
ITPA_HUMAN	ITPA	physical	26186194
FBLN1_HUMAN	FBLN1	physical	26186194
TFCP2_HUMAN	TFCP2	physical	26186194
LMF1_HUMAN	LMF1	physical	26186194
FRAS1_HUMAN	FRAS1	physical	26186194
RA51C_HUMAN	RAD51C	physical	26186194
N42L2_HUMAN	N4BP2L2	physical	26186194
WNT7B_HUMAN	WNT7B	physical	28514442
WNT5A_HUMAN	WNT5A	physical	28514442
WLS_HUMAN	WLS	physical	28514442
N42L2_HUMAN	N4BP2L2	physical	28514442
PASK_HUMAN	PASK	physical	28514442
ITPA_HUMAN	ITPA	physical	28514442
MTCH2_HUMAN	MTCH2	physical	28514442
TOM40_HUMAN	TOMM40	physical	28514442
FSTL1_HUMAN	FSTL1	physical	28514442
BORA_HUMAN	BORA	physical	28514442
CO6A1_HUMAN	COL6A1	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 611812: 46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL)
• 158330: Mullerian aplasia and hyperandrogenism (MULLAPL)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.