| UniProt ID | WNT7B_HUMAN | |
|---|---|---|
| UniProt AC | P56706 | |
| Protein Name | Protein Wnt-7b | |
| Gene Name | WNT7B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 349 | |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix . Secreted . | |
| Protein Description | Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. Required for normal fusion of the chorion and the allantois during placenta development.. | |
| Protein Sequence | MHRNFRKWIFYVFLCFGVLYVKLGALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 83 | N-linked_Glycosylation | QFRFGRWNCSALGEK EEECCCCCCHHCCCC | 14.43 | UniProtKB CARBOHYD | |
| 91 | Phosphorylation | CSALGEKTVFGQELR CHHCCCCEEECEEEE | 19.43 | 24719451 | |
| 101 | Phosphorylation | GQELRVGSREAAFTY CEEEEECCHHHHHHH | 24.88 | - | |
| 127 | N-linked_Glycosylation | TAACSQGNLSNCGCD HHHHHCCCHHHCCCC | 32.43 | UniProtKB CARBOHYD | |
| 140 | Phosphorylation | CDREKQGYYNQAEGW CCHHHCCCCCCCCCC | 9.21 | - | |
| 141 | Phosphorylation | DREKQGYYNQAEGWK CHHHCCCCCCCCCCC | 13.97 | - | |
| 158 | Phosphorylation | GCSADVRYGIDFSRR CCCCCCCCCCCCCCC | 20.48 | - | |
| 206 | O-palmitoleoylation | ECKCHGVSGSCTTKT EEEECCCCCCCCCCC | 29.58 | - | |
| 213 | Phosphorylation | SGSCTTKTCWTTLPK CCCCCCCCCCCCCHH | 15.93 | - | |
| 216 | Phosphorylation | CTTKTCWTTLPKFRE CCCCCCCCCCHHHHH | 22.17 | - | |
| 217 | Phosphorylation | TTKTCWTTLPKFREV CCCCCCCCCHHHHHH | 19.30 | - | |
| 232 | Phosphorylation | GHLLKEKYNAAVQVE HHHHHHHHCCCEEEE | 15.89 | 21214269 | |
| 244 | Phosphorylation | QVEVVRASRLRQPTF EEEEHHHHCCCCCEE | 22.68 | 21214269 | |
| 289 | Phosphorylation | AATGSVGTQGRLCNR HCCCCCCCCCCCCCC | 26.20 | 23879269 | |
| 295 | N-linked_Glycosylation | GTQGRLCNRTSPGAD CCCCCCCCCCCCCCC | 55.65 | UniProtKB CARBOHYD | |
| 297 | Phosphorylation | QGRLCNRTSPGADGC CCCCCCCCCCCCCCC | 25.86 | 22210691 | |
| 298 | Phosphorylation | GRLCNRTSPGADGCD CCCCCCCCCCCCCCC | 20.35 | 22210691 | |
| 306 | Phosphorylation | PGADGCDTMCCGRGY CCCCCCCEECCCCCC | 19.04 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WNT7B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WNT7B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WNT7B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of WNT7B_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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