dbPTM

BORA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BORA_HUMAN
UniProt AC	Q6PGQ7
Protein Name	Protein aurora borealis
Gene Name	BORA
Organism	Homo sapiens (Human).
Sequence Length	559
Subcellular Localization
Protein Description	Required for the activation of AURKA at the onset of mitosis..
Protein Sequence	MGDVKESKMQITPETPGRIPVLNPFESPSDYSNLHEQTLASPSVFKSTKLPTPGKFRWSIDQLAVINPVEIDPEDIHRQALYLSHSRIDKDVEDKRQKAIEEFFTKDVIVPSPWTDHEGKQLSQCHSSKCTNINSDSPVGKKLTIHSEKSDAACQTLLSLPVDFNLENILGDYFRADEFADQSPGNLSSSSLRRKLFLDGNGSISDSLPSASPGSPHSGVQTSLEMFYSIDLSPVKCRSPLQTPSSGQFSSSPIQASAKKYSLGSITSPSPISSPTFSPIEFQIGETPLSEQRKFTVHSPDASSGTNSNGITNPCIRSPYIDGCSPIKNWSPMRLQMYSGGTQYRTSVIQIPFTLETQGEDEEDKENIPSTDVSSPAMDAAGIHLRQFSNEASTHGTHLVVTAMSVTQNQSSASEKELALLQDVEREKDNNTVDMVDPIEIADETTWIKEPVDNGSLPMTDFVSGIAFSIENSHMCMSPLAESSVIPCESSNIQMDSGYNTQNCGSNIMDTVGAESYCKESDAQTCEVESKSQAFNMKQDHTTQRCWMKTASPFQCSSP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	PVLNPFESPSDYSNL CCCCCCCCCCCCCCC	30.04	27732954
29	Phosphorylation	LNPFESPSDYSNLHE CCCCCCCCCCCCCCH	59.46	27732954
31	Phosphorylation	PFESPSDYSNLHEQT CCCCCCCCCCCCHHH	12.09	27732954
32	Phosphorylation	FESPSDYSNLHEQTL CCCCCCCCCCCHHHC	37.60	27732954
36	Ubiquitination	SDYSNLHEQTLASPS CCCCCCCHHHCCCCC	48.72	-
38	Phosphorylation	YSNLHEQTLASPSVF CCCCCHHHCCCCCHH	22.70	27732954
41	Phosphorylation	LHEQTLASPSVFKST CCHHHCCCCCHHCCC	22.33	17001009
43	Phosphorylation	EQTLASPSVFKSTKL HHHCCCCCHHCCCCC	37.38	27732954
52	Phosphorylation	FKSTKLPTPGKFRWS HCCCCCCCCCCCCCE	55.92	23898821
55	Acetylation	TKLPTPGKFRWSIDQ CCCCCCCCCCCEEEE	32.72	25953088
59	Phosphorylation	TPGKFRWSIDQLAVI CCCCCCCEEEEEEEE	16.42	22199227
82	Phosphorylation	DIHRQALYLSHSRID HHHHHHHHHHHHCCC	14.80	-
95	Acetylation	IDKDVEDKRQKAIEE CCCCHHHHHHHHHHH	43.13	18603065
98	Acetylation	DVEDKRQKAIEEFFT CHHHHHHHHHHHHHH	56.20	18603073
106	Acetylation	AIEEFFTKDVIVPSP HHHHHHHCCCCCCCC	44.86	18603081
106	Ubiquitination	AIEEFFTKDVIVPSP HHHHHHHCCCCCCCC	44.86	-
112	Phosphorylation	TKDVIVPSPWTDHEG HCCCCCCCCCCCCCC	23.36	22199227
115	Phosphorylation	VIVPSPWTDHEGKQL CCCCCCCCCCCCCCH	30.75	22199227
116	Phosphorylation	IVPSPWTDHEGKQLS CCCCCCCCCCCCCHH	33.69	-
121	Ubiquitination	WTDHEGKQLSQCHSS CCCCCCCCHHHHHHC	58.15	-
127	Phosphorylation	KQLSQCHSSKCTNIN CCHHHHHHCCCCCCC	38.84	-
131	Phosphorylation	QCHSSKCTNINSDSP HHHHCCCCCCCCCCC	42.76	26074081
135	Phosphorylation	SKCTNINSDSPVGKK CCCCCCCCCCCCCCE	35.35	29255136
137	Phosphorylation	CTNINSDSPVGKKLT CCCCCCCCCCCCEEE	22.70	29255136
141	Acetylation	NSDSPVGKKLTIHSE CCCCCCCCEEEECCC	44.86	25953088
144	Phosphorylation	SPVGKKLTIHSEKSD CCCCCEEEECCCCCH	26.06	26074081
181	Ubiquitination	FRADEFADQSPGNLS HCHHHHCCCCCCCCC	55.61	-
183	Phosphorylation	ADEFADQSPGNLSSS HHHHCCCCCCCCCCH	35.01	26055452
187	Phosphorylation	ADQSPGNLSSSSLRR CCCCCCCCCCHHHCC	6.96	-
188	Phosphorylation	DQSPGNLSSSSLRRK CCCCCCCCCHHHCCC	31.97	26055452
189	Phosphorylation	QSPGNLSSSSLRRKL CCCCCCCCHHHCCCE	27.41	23401153
190	Ubiquitination	SPGNLSSSSLRRKLF CCCCCCCHHHCCCEE	29.98	-
190	Phosphorylation	SPGNLSSSSLRRKLF CCCCCCCHHHCCCEE	29.98	18669648
191	Phosphorylation	PGNLSSSSLRRKLFL CCCCCCHHHCCCEEE	28.04	21712546
195	Ubiquitination	SSSSLRRKLFLDGNG CCHHHCCCEEECCCC	36.84	-
197	Phosphorylation	SSLRRKLFLDGNGSI HHHCCCEEECCCCCC	7.01	27251275
210	Phosphorylation	SISDSLPSASPGSPH CCCCCCCCCCCCCCC	46.82	-
212	Phosphorylation	SDSLPSASPGSPHSG CCCCCCCCCCCCCCC	33.85	19413330
217	Ubiquitination	SASPGSPHSGVQTSL CCCCCCCCCCCCCCH	38.59	-
229	Phosphorylation	TSLEMFYSIDLSPVK CCHHEEEEECCCCCC	9.81	26074081
233	Phosphorylation	MFYSIDLSPVKCRSP EEEEECCCCCCCCCC	24.73	26074081
239	Phosphorylation	LSPVKCRSPLQTPSS CCCCCCCCCCCCCCC	39.16	25159151
243	Phosphorylation	KCRSPLQTPSSGQFS CCCCCCCCCCCCCCC	32.59	23663014
245	Phosphorylation	RSPLQTPSSGQFSSS CCCCCCCCCCCCCCC	50.95	23663014
246	Phosphorylation	SPLQTPSSGQFSSSP CCCCCCCCCCCCCCC	37.51	23663014
250	Phosphorylation	TPSSGQFSSSPIQAS CCCCCCCCCCCCCCC	23.24	23663014
251	Phosphorylation	PSSGQFSSSPIQASA CCCCCCCCCCCCCCC	41.23	23663014
252	Phosphorylation	SSGQFSSSPIQASAK CCCCCCCCCCCCCCC	25.48	25159151
257	Phosphorylation	SSSPIQASAKKYSLG CCCCCCCCCCEECCC	25.01	23663014
258	Phosphorylation	SSPIQASAKKYSLGS CCCCCCCCCEECCCC	18.51	18669648
260	Ubiquitination	PIQASAKKYSLGSIT CCCCCCCEECCCCCC	39.53	-
261	Phosphorylation	IQASAKKYSLGSITS CCCCCCEECCCCCCC	14.39	23090842
262	Phosphorylation	QASAKKYSLGSITSP CCCCCEECCCCCCCC	34.82	28634298
263	Phosphorylation	ASAKKYSLGSITSPS CCCCEECCCCCCCCC	5.91	-
264	Phosphorylation	SAKKYSLGSITSPSP CCCEECCCCCCCCCC	15.86	18669648
265	Phosphorylation	AKKYSLGSITSPSPI CCEECCCCCCCCCCC	28.17	28634298
266	Phosphorylation	KKYSLGSITSPSPIS CEECCCCCCCCCCCC	4.14	18669648
267	Phosphorylation	KYSLGSITSPSPISS EECCCCCCCCCCCCC	35.96	28634298
268	Phosphorylation	YSLGSITSPSPISSP ECCCCCCCCCCCCCC	23.01	28450419
270	Phosphorylation	LGSITSPSPISSPTF CCCCCCCCCCCCCCC	34.33	28450419
273	Phosphorylation	ITSPSPISSPTFSPI CCCCCCCCCCCCCCE	33.38	28450419
274	Phosphorylation	TSPSPISSPTFSPIE CCCCCCCCCCCCCEE	28.78	28450419
276	Phosphorylation	PSPISSPTFSPIEFQ CCCCCCCCCCCEEEE	38.40	28464451
278	Phosphorylation	PISSPTFSPIEFQIG CCCCCCCCCEEEEEC	27.69	28464451
296	Phosphorylation	LSEQRKFTVHSPDAS CCCCCCEEEECCCCC	21.97	28450419
299	Phosphorylation	QRKFTVHSPDASSGT CCCEEEECCCCCCCC	21.82	25159151
303	Phosphorylation	TVHSPDASSGTNSNG EEECCCCCCCCCCCC	36.36	28450419
304	Phosphorylation	VHSPDASSGTNSNGI EECCCCCCCCCCCCC	51.89	28450419
306	Phosphorylation	SPDASSGTNSNGITN CCCCCCCCCCCCCCC	37.10	28450419
308	Phosphorylation	DASSGTNSNGITNPC CCCCCCCCCCCCCCC	35.95	28464451
314	Phosphorylation	NSNGITNPCIRSPYI CCCCCCCCCCCCCCC	13.28	-
318	Phosphorylation	ITNPCIRSPYIDGCS CCCCCCCCCCCCCCC	11.35	26552605
320	Phosphorylation	NPCIRSPYIDGCSPI CCCCCCCCCCCCCCC	16.94	28464451
325	Phosphorylation	SPYIDGCSPIKNWSP CCCCCCCCCCCCCCC	34.88	19664994
327	Phosphorylation	YIDGCSPIKNWSPMR CCCCCCCCCCCCCCE	2.87	-
331	Phosphorylation	CSPIKNWSPMRLQMY CCCCCCCCCCEEEEE	20.43	22617229
339	Phosphorylation	PMRLQMYSGGTQYRT CCEEEEECCCCEEEE	25.96	22199227
342	Phosphorylation	LQMYSGGTQYRTSVI EEEECCCCEEEEEEE	26.42	22199227
345	Phosphorylation	YSGGTQYRTSVIQIP ECCCCEEEEEEEEEE	15.65	-
349	Phosphorylation	TQYRTSVIQIPFTLE CEEEEEEEEEEEEEE	2.85	-
353	Phosphorylation	TSVIQIPFTLETQGE EEEEEEEEEEEECCC	15.09	-
354	Phosphorylation	SVIQIPFTLETQGED EEEEEEEEEEECCCC	20.52	-
359	Phosphorylation	PFTLETQGEDEEDKE EEEEEECCCCHHHHC	52.31	27251275
374	Phosphorylation	NIPSTDVSSPAMDAA CCCCCCCCCHHHHHH	33.15	25627689
375	Phosphorylation	IPSTDVSSPAMDAAG CCCCCCCCHHHHHHC	19.27	22199227
385	Phosphorylation	MDAAGIHLRQFSNEA HHHHCCEEEEECCCC	4.32	27251275
400	Phosphorylation	STHGTHLVVTAMSVT CCCCCEEEEEEEEEC	2.53	19664994
406	Phosphorylation	LVVTAMSVTQNQSSA EEEEEEEECCCCCCC	4.02	-
414	Phosphorylation	TQNQSSASEKELALL CCCCCCCCHHHHHHH	51.66	-
432	Phosphorylation	EREKDNNTVDMVDPI HHHCCCCCCCCCCCE	24.92	22199227
445	Phosphorylation	PIEIADETTWIKEPV CEEECCCCCEEECCC	28.16	28102081
446	Phosphorylation	IEIADETTWIKEPVD EEECCCCCEEECCCC	24.12	28102081
468	Ubiquitination	DFVSGIAFSIENSHM HCCCCEEEEEECCCC	7.75	-
497	Phosphorylation	SSNIQMDSGYNTQNC CCCCEECCCCCCCCC	37.52	18521620
501	Phosphorylation	QMDSGYNTQNCGSNI EECCCCCCCCCCCCC	16.81	18521620
538	Ubiquitination	KSQAFNMKQDHTTQR HHHHHCCCCCCCCCC	54.39	-
550	Phosphorylation	TQRCWMKTASPFQCS CCCCCCCCCCCCCCC	19.09	23403867
552	Phosphorylation	RCWMKTASPFQCSSP CCCCCCCCCCCCCCC	31.32	26552605
557	Phosphorylation	TASPFQCSSP----- CCCCCCCCCC-----	34.56	30108239
558	Phosphorylation	ASPFQCSSP------ CCCCCCCCC------	42.11	25159151
572	Phosphorylation	-------------------- --------------------		-
576	Phosphorylation	------------------------ ------------------------		-
606	Ubiquitination	------------------------------------------------------ ------------------------------------------------------		-
613	Ubiquitination	------------------------------------------------------------- -------------------------------------------------------------		-
618	Phosphorylation	------------------------------------------------------------------ ------------------------------------------------------------------		27251275
627	Phosphorylation	--------------------------------------------------------------------------- ---------------------------------------------------------------------------		19413330
633	Phosphorylation	--------------------------------------------------------------------------------- ---------------------------------------------------------------------------------		19413330

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
41	S	Phosphorylation	Kinase	CDK1	P06493	PSP
112	S	Phosphorylation	Kinase	CDK1	P06493	PSP
137	S	Phosphorylation	Kinase	CDK1	P06493	PSP
252	S	Phosphorylation	Kinase	CDK1	P06493	PSP
274	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
278	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
325	S	Phosphorylation	Kinase	CDK9	P50750	PSP
497	S	Phosphorylation	Kinase	PLK1	P53350	PSP
501	T	Phosphorylation	Kinase	ATR	Q13535	PSP
501	T	Phosphorylation	Kinase	PLK1	P53350	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:26697838
-	K	Ubiquitination	E3 ubiquitin ligase	KLHL13	Q9P2N7	PMID:17543862
-	K	Ubiquitination	E3 ubiquitin ligase	KLHL9	Q9P2J3	PMID:17543862

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BORA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BORA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FEZ1_HUMAN	FEZ1	physical	16169070
PLK1_HUMAN	PLK1	physical	18378770
FBW1A_HUMAN	BTRC	physical	18378770
CUL1_HUMAN	CUL1	physical	18378770
SKP1_HUMAN	SKP1	physical	18378770
BRCA1_HUMAN	BRCA1	physical	24067368
PIBF1_HUMAN	PIBF1	physical	26496610
NGDN_HUMAN	NGDN	physical	26496610
RN219_HUMAN	RNF219	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BORA_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-552 ANDSER-558, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183; SER-189 ANDSER-191, AND MASS SPECTROMETRY.	18669648 [Abstract]