WNT5A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WNT5A_HUMAN
• UniProt AC: P41221
• Protein Name: Protein Wnt-5a
• Gene Name: WNT5A
• Organism: Homo sapiens (Human).
• Sequence Length: 380
• Subcellular Localization: Secreted, extracellular space, extracellular matrix . Secreted .
• Protein Description: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. [PubMed: 15735754 Mediates motility of melanoma cells]
• Protein Sequence: MKKSIGILSPGVALGMAGSAMSSKFFLVALAIFFSFAQVVIEANSWWSLGMNNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGKLVQVNSRFNSPTTQDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MKKSIGILSPG ----CCCCEEECCCC	22.11	22210691
19	Phosphorylation	VALGMAGSAMSSKFF HHHHCCHHHHHHHHH	15.97	22210691
22	Phosphorylation	GMAGSAMSSKFFLVA HCCHHHHHHHHHHHH	30.05	22210691
23	Phosphorylation	MAGSAMSSKFFLVAL CCHHHHHHHHHHHHH	22.01	22210691
86	Phosphorylation	QKKLCHLYQDHMQYI HHHHHHHHHHHHHHH	6.55	-
92	Phosphorylation	LYQDHMQYIGEGAKT HHHHHHHHHCCHHHH	11.88	-
99	Phosphorylation	YIGEGAKTGIKECQY HHCCHHHHCHHHHHH	43.54	-
114	N-linked_Glycosylation	QFRHRRWNCSTVDNT HHHCCCCCCCCCCCC	14.19	UniProtKB CARBOHYD
116	Phosphorylation	RHRRWNCSTVDNTSV HCCCCCCCCCCCCCH	28.40	-
117	Phosphorylation	HRRWNCSTVDNTSVF CCCCCCCCCCCCCHH	33.79	-
120	N-linked_Glycosylation	WNCSTVDNTSVFGRV CCCCCCCCCCHHCEE	29.89	UniProtKB CARBOHYD
121	Phosphorylation	NCSTVDNTSVFGRVM CCCCCCCCCHHCEEE	23.08	-
122	Phosphorylation	CSTVDNTSVFGRVMQ CCCCCCCCHHCEEEE	23.00	-
132	Phosphorylation	GRVMQIGSRETAFTY CEEEEECCCHHHHHH	28.68	23532336
160	Phosphorylation	ACREGELSTCGCSRA HHHCCCCCCCCCCCC	19.83	29262532
161	Phosphorylation	CREGELSTCGCSRAA HHCCCCCCCCCCCCC	26.07	29262532
165	Phosphorylation	ELSTCGCSRAARPKD CCCCCCCCCCCCCCC	15.39	29262532
194	Ubiquitination	DYGYRFAKEFVDARE CHHHHHHHHHCCHHH	49.31	-
208	Ubiquitination	ERERIHAKGSYESAR HHHHHCCCCCHHHHH	33.94	-
244	O-palmitoleoylation	ACKCHGVSGSCSLKT HHHCCCCCCCCCCCC	29.58	-
261	Ubiquitination	LQLADFRKVGDALKE EHHHHHHHHHHHHHH	51.03	-
270	Phosphorylation	GDALKEKYDSAAAMR HHHHHHHHHHHHHHH	19.07	24719451
272	Phosphorylation	ALKEKYDSAAAMRLN HHHHHHHHHHHHHHH	19.40	24719451
280	Phosphorylation	AAAMRLNSRGKLVQV HHHHHHHCCCCEEEE	47.18	24719451
283	Ubiquitination	MRLNSRGKLVQVNSR HHHHCCCCEEEEECC	44.36	-
312	N-linked_Glycosylation	SPDYCVRNESTGSLG CCCCEEECCCCCCCC	27.46	UniProtKB CARBOHYD
326	N-linked_Glycosylation	GTQGRLCNKTSEGMD CCCCCCCCCCCCCCC	56.05	UniProtKB CARBOHYD
348	Ubiquitination	GRGYDQFKTVQTERC CCCCCHHCCCCCCCC	42.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WNT5A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WNT5A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WNT5A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FZD1_HUMAN	FZD1	physical	10557084
FZD5_HUMAN	FZD5	physical	25241761
WNT5B_HUMAN	WNT5B	physical	28514442
WLS_HUMAN	WLS	physical	28514442
SDF2L_HUMAN	SDF2L1	physical	28514442
FSTL1_HUMAN	FSTL1	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442
POTEF_HUMAN	POTEF	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.