FZD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FZD1_HUMAN
• UniProt AC: Q9UP38
• Protein Name: Frizzled-1
• Gene Name: FZD1
• Organism: Homo sapiens (Human).
• Sequence Length: 647
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor for Wnt proteins. [PubMed: 10557084 Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B]
• Protein Sequence: MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EEEAPKKSRAAGGGA CCCCCCHHCCCCCCH	33.02	-
130	N-linked_Glycosylation	LCTDIAYNQTIMPNL EECCCCCCCCCCHHH	24.40	UniProtKB CARBOHYD
231	N-linked_Glycosylation	GELCVGQNTSDKGTP CCEECCCCCCCCCCC	35.30	UniProtKB CARBOHYD
239	O-linked_Glycosylation	TSDKGTPTPSLLPEF CCCCCCCCHHHCCCH	25.91	OGP
241	O-linked_Glycosylation	DKGTPTPSLLPEFWT CCCCCCHHHCCCHHC	45.04	OGP
269	Phosphorylation	FPGGAGASERGKFSC CCCCCCCCCCCCCCC	27.23	-
521	Ubiquitination	FRIRTIMKHDGTKTE HHHHHHHCCCCCCHH	34.39	33845483
607	Phosphorylation	FTVFMIKYLMTLIVG HHHHHHHHHHHHHHH	7.26	22817900
616	Phosphorylation	MTLIVGITSGFWIWS HHHHHHHHCCCEECC	19.50	-
623	Phosphorylation	TSGFWIWSGKTLNSW HCCCEECCCCCHHHH	22.68	-
640	Phosphorylation	FYTRLTNSKQGETTV HHHHHHCCCCCCCCC	22.56	24719451
641	Ubiquitination	YTRLTNSKQGETTV- HHHHHCCCCCCCCC-	65.48	21906983
646	Phosphorylation	NSKQGETTV------ CCCCCCCCC------	21.66	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FZD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FZD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FZD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSK3B_HUMAN	GSK3B	physical	22939629
ATPB_HUMAN	ATP5B	physical	26496610
GOGA2_HUMAN	GOLGA2	physical	26496610
DERL2_HUMAN	DERL2	physical	26496610
RBM26_HUMAN	RBM26	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.