FSTL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FSTL1_HUMAN
• UniProt AC: Q12841
• Protein Name: Follistatin-related protein 1
• Gene Name: FSTL1
• Organism: Homo sapiens (Human).
• Sequence Length: 308
• Subcellular Localization: Secreted .
• Protein Description: May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity)..
• Protein Sequence: MWKRWLALALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Phosphorylation	RDACLTGSKIQVDYD CCCCCCCCEEEECCC	22.73	30631047
103	Phosphorylation	GHCKEKKSVSPSASP CCCCCCCCCCCCCCC	38.61	25003641
105	Phosphorylation	CKEKKSVSPSASPVV CCCCCCCCCCCCCEE	21.89	24505115
107	O-linked_Glycosylation	EKKSVSPSASPVVCY CCCCCCCCCCCEEEE	33.59	OGP
107	Phosphorylation	EKKSVSPSASPVVCY CCCCCCCCCCCEEEE	33.59	27251275
109	Phosphorylation	KSVSPSASPVVCYQS CCCCCCCCCEEEECC	23.67	27251275
114	Phosphorylation	SASPVVCYQSNRDEL CCCCEEEECCCHHHH	11.90	27251275
116	Phosphorylation	SPVVCYQSNRDELRR CCEEEECCCHHHHHH	13.83	27251275
141	Ubiquitination	IPDGWFSKGSNYSEI CCCCCCCCCCCHHHH	57.81	-
144	N-linked_Glycosylation	GWFSKGSNYSEILDK CCCCCCCCHHHHHHH	53.68	UniProtKB CARBOHYD
161	Phosphorylation	KNFDNGDSRLDSSEF HCCCCCCCCCCHHHH	35.82	22617229
165	Phosphorylation	NGDSRLDSSEFLKFV CCCCCCCHHHHHHHH	36.04	19664994
166	Phosphorylation	GDSRLDSSEFLKFVE CCCCCCHHHHHHHHH	31.84	29255136
175	N-linked_Glycosylation	FLKFVEQNETAINIT HHHHHHCCCCCEECC	34.77	16335952
180	N-linked_Glycosylation	EQNETAINITTYPDQ HCCCCCEECCCCCCH	24.08	16335952
231	Ubiquitination	PSFNPPEKKCALEDE CCCCCCCCCCCCCCC	59.95	-
277	Phosphorylation	KNQKGAQTQTEEEMT CCCCCCCCCCHHHHH	36.60	21406692
279	Phosphorylation	QKGAQTQTEEEMTRY CCCCCCCCHHHHHHH	49.07	21406692
284	Phosphorylation	TQTEEEMTRYVQELQ CCCHHHHHHHHHHHH	23.33	21406692
286	Phosphorylation	TEEEMTRYVQELQKH CHHHHHHHHHHHHHH	9.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
165	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FSTL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FSTL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBP2_HUMAN	APPBP2	physical	19060904

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-175 AND ASN-180, AND MASSSPECTROMETRY.
PubMed: 16335952