WLS_HUMAN - dbPTM
WLS_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WLS_HUMAN
UniProt AC Q5T9L3
Protein Name Protein wntless homolog
Gene Name WLS
Organism Homo sapiens (Human).
Sequence Length 541
Subcellular Localization Golgi apparatus membrane
Multi-pass membrane protein . Cytoplasmic vesicle membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein . Endoplasmic reticulum membrane
Multi-pass membrane protein . Golgi apparatus membrane
M
Protein Description Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity)..
Protein Sequence MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationGAIIENMSTKKLCIV
CCHHCCCCCCCHHHH		48.9720068231
11PhosphorylationAIIENMSTKKLCIVG
CHHCCCCCCCHHHHH		22.7920068231
16UbiquitinationMSTKKLCIVGGILLV
CCCCCHHHHHHHHHH		4.7121890473
28UbiquitinationLLVFQIIAFLVGGLI
HHHHHHHHHHHCCCC		8.0521890473
47PhosphorylationTTAVSYMSVKCVDAR
CCCCEEEEEEEECCC		15.3624719451
59UbiquitinationDARKNHHKTKWFVPW
CCCCCCCCCCEECCC		44.2221890473
59 (in isoform 2)Ubiquitination-44.2221890473
61UbiquitinationRKNHHKTKWFVPWGP
CCCCCCCCEECCCCC		43.3621890473
61UbiquitinationRKNHHKTKWFVPWGP
CCCCCCCCEECCCCC		43.3621890473
61 (in isoform 1)Ubiquitination-43.3621890473
70UbiquitinationFVPWGPNHCDKIRDI
ECCCCCCCHHHHHCH		25.0427667366
71 (in isoform 2)Ubiquitination-7.8721890473
71UbiquitinationVPWGPNHCDKIRDIE
CCCCCCCHHHHHCHH		7.8721890473
73UbiquitinationWGPNHCDKIRDIEEA
CCCCCHHHHHCHHHH		45.0621890473
73 (in isoform 1)Ubiquitination-45.0621890473
73UbiquitinationWGPNHCDKIRDIEEA
CCCCCHHHHHCHHHH		45.0673
77UbiquitinationHCDKIRDIEEAIPRE
CHHHHHCHHHHCCCH		3.5629967540
115UbiquitinationQFMLFILQLDIAFKL
HHHHHHHHHHHHHHH		32.0727667366
116UbiquitinationFMLFILQLDIAFKLN
HHHHHHHHHHHHHHC		4.6327667366
117UbiquitinationMLFILQLDIAFKLNN
HHHHHHHHHHHHHCH		19.7423503661
126UbiquitinationAFKLNNQIRENAEVS
HHHHCHHHHHCCEEC		6.9221890473
126UbiquitinationAFKLNNQIRENAEVS
HHHHCHHHHHCCEEC		6.9223000965
159UbiquitinationAHERVPRKLKCTFTS
HHHHCCCCEECEECC		46.3527667366
161UbiquitinationERVPRKLKCTFTSPK
HHCCCCEECEECCCC		33.9727667366
162UbiquitinationRVPRKLKCTFTSPKT
HCCCCEECEECCCCC		5.6923503661
163UbiquitinationVPRKLKCTFTSPKTP
CCCCEECEECCCCCC		28.4923503661
166UbiquitinationKLKCTFTSPKTPEHE
CEECEECCCCCCCCC		21.8729967540
168UbiquitinationKCTFTSPKTPEHEGR
ECEECCCCCCCCCCC		76.1929967540
172UbiquitinationTSPKTPEHEGRYYEC
CCCCCCCCCCCEEEE		43.9723000965
204 (in isoform 2)Ubiquitination-54.1321890473
204UbiquitinationLNIRLPVNEKKKINV
EEEECCCCCCCCCCE		54.1327667366
205UbiquitinationNIRLPVNEKKKINVG
EEECCCCCCCCCCEE		67.5023503661
206UbiquitinationIRLPVNEKKKINVGI
EECCCCCCCCCCEEC		54.9127667366
206 (in isoform 1)Ubiquitination-54.9121890473
2062-HydroxyisobutyrylationIRLPVNEKKKINVGI
EECCCCCCCCCCEEC		54.91-
206 (in isoform 2)Ubiquitination-54.9121890473
207UbiquitinationRLPVNEKKKINVGIG
ECCCCCCCCCCEECC		53.3523503661
208UbiquitinationLPVNEKKKINVGIGE
CCCCCCCCCCEECCC		51.0521906983
208 (in isoform 1)Ubiquitination-51.0521890473
215UbiquitinationKINVGIGEIKDIRLV
CCCEECCCEEEEEEE		44.9723000965
215 (in isoform 2)Ubiquitination-44.9721890473
217UbiquitinationNVGIGEIKDIRLVGI
CEECCCEEEEEEEEE		42.6823000965
217 (in isoform 1)Ubiquitination-42.6821890473
217UbiquitinationNVGIGEIKDIRLVGI
CEECCCEEEEEEEEE		42.6821890473
2172-HydroxyisobutyrylationNVGIGEIKDIRLVGI
CEECCCEEEEEEEEE		42.68-
232UbiquitinationHQNGGFTKVWFAMKT
EECCCHHHHHHHHHH		34.90-
244PhosphorylationMKTFLTPSIFIIMVW
HHHHCCHHHHHHHHH		25.5426503514
252PhosphorylationIFIIMVWYWRRITMM
HHHHHHHHHHHHHHH		4.2426503514
257PhosphorylationVWYWRRITMMSRPPV
HHHHHHHHHHCCCHH		12.6624719451
319UbiquitinationLSFWIIFCGEHMMDQ
HHHHHHHHCHHHHHH		4.3821963094
328UbiquitinationEHMMDQHERNHIAGY
HHHHHHHHHHHHHHH		49.9327667366
365UbiquitinationGVQLTNPFYSIWTTD
CCCCCCCCCCEEECC		8.9621963094
374UbiquitinationSIWTTDIGTELAMAF
CEEECCHHHHHHHHH		18.8827667366
408UbiquitinationFQVFRNISGKQSSLP
HHHHHHCCCCCCCCH		43.4121963094
408 (in isoform 2)Ubiquitination-43.4121890473
410 (in isoform 1)Ubiquitination-39.9721890473
410UbiquitinationVFRNISGKQSSLPAM
HHHHCCCCCCCCHHH		39.9721906983
412PhosphorylationRNISGKQSSLPAMSK
HHCCCCCCCCHHHHH		37.0123186163
413PhosphorylationNISGKQSSLPAMSKV
HCCCCCCCCHHHHHH		35.5623186163
417UbiquitinationKQSSLPAMSKVRRLH
CCCCCHHHHHHHHHH		3.6327667366
417 (in isoform 2)Ubiquitination-3.6321890473
418PhosphorylationQSSLPAMSKVRRLHY
CCCCHHHHHHHHHHH		30.06-
4192-HydroxyisobutyrylationSSLPAMSKVRRLHYE
CCCHHHHHHHHHHHC		27.03-
419 (in isoform 1)Ubiquitination-27.0321890473
419UbiquitinationSSLPAMSKVRRLHYE
CCCHHHHHHHHHHHC		27.0327667366
467UbiquitinationWKWGGVTVQVNSAFF
CCCCCEEEEECHHHH		5.7821963094
488UbiquitinationWNLYVFALMFLYAPS
HHHHHHHHHHHHCCH		1.3723503661
499PhosphorylationYAPSHKNYGEDQSNG
HCCHHCCCCCCCCCC		27.0529449344
504PhosphorylationKNYGEDQSNGDLGVH
CCCCCCCCCCCCCCC		55.9229449344
510UbiquitinationQSNGDLGVHSGEELQ
CCCCCCCCCCCCEEE		4.1721963094
512PhosphorylationNGDLGVHSGEELQLT
CCCCCCCCCCEEEEE		45.5629449344
512UbiquitinationNGDLGVHSGEELQLT
CCCCCCCCCCEEEEE		45.5621963094
519PhosphorylationSGEELQLTTTITHVD
CCCEEEEEEEEEECC		14.6629449344
520PhosphorylationGEELQLTTTITHVDG
CCEEEEEEEEEECCC		25.4529449344
521PhosphorylationEELQLTTTITHVDGP
CEEEEEEEEEECCCC		20.7429449344
523 (in isoform 2)Phosphorylation-17.4726356563
523PhosphorylationLQLTTTITHVDGPTE
EEEEEEEEECCCCHH		17.4729449344
528 (in isoform 2)Phosphorylation-23.53-
530 (in isoform 2)Phosphorylation-47.67-
531UbiquitinationHVDGPTEIYKLTRKE
ECCCCHHHHHHHHHH		3.9623503661
531 (in isoform 2)Ubiquitination-3.96-
533 (in isoform 2)Phosphorylation-49.3926471730
533UbiquitinationDGPTEIYKLTRKEAQ
CCCHHHHHHHHHHHH		49.3923503661
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WLS_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WLS_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WLS_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of WLS_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WLS_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory