ITIH6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITIH6_HUMAN
• UniProt AC: Q6UXX5
• Protein Name: Inter-alpha-trypsin inhibitor heavy chain H6
• Gene Name: ITIH6
• Organism: Homo sapiens (Human).
• Sequence Length: 1313
• Subcellular Localization: Secreted.
• Protein Sequence: MSGWRYLICVSFLLTILLELTYQGPPVPASSSTKLLMTSYSMRSTVVSRYAHTLVTSVLFNPHAEAHEAIFDLDLPHLAFISNFTMTINNKVYIAEVKEKHQAKKIYEEAHQQGKTAAHVGIRDRESEKFRISTSLAAGTEVTFSLAYEELLQRHQGQYQLVVSLRPGQLVKRLSIEVTVSERTGISYVHIPPLRTGRLRTNAHASEVDSPPSTRIERGETCVRITYCPTLQDQSSISGSGIMADFLVQYDVVMEDIIGDVQIYDDYFIHYFAPRGLPPMEKNVVFVIDVSSSMFGTKMEQTKTAMNVILSDLQANDYFNIISFSDTVNVWKAGGSIQATIQNVHSAKDYLHCMEADGWTDVNSALLAAASVLNHSNQEPGRGPSVGRIPLIIFLTDGEPTAGVTTPSVILSNVRQALGHRVSLFSLAFGDDADFTLLRRLSLENRGIARRIYEDTDAALQLKGLYEEISMPLLADVRLNYLGGLVGASPWAVFPNYFGGSELVVAGQVQPGKQELGIHLAARGPKDQLLVAHHSEGATNNSQKAFGCPGEPAPNVAHFIRRLWAYVTIGELLDAHFQARDTTTRHLLAAKVLNLSLEYNFVTPLTSLVMVQPKQASEETRRQTSTSAGPDTIMPSSSSRHGLGVSTAQPALVPKVISPKSRPVKPKFYLSSTTTASTKKMLSSKELEPLGESPHTLSMPTYPKAKIPAQQDSGTLAQPTLRTKPTILVPSNSGTLLPLKPGSLSHQNPDILPTNSRTQVPPVKPGIPASPKADTVKCVTPLHSKPGAPSHPQLGALTSQAPKGLPQSRPGVSTLQVPKYPLHTRPRVPAPKTRNNMPHLGPGILLSKTPKILLSLKPSAPPHQISTSISLSKPETPNPHMPQTPLPPRPDRPRPPLPESLSTFPNTISSSTGPSSTTTTSVLGEPLPMPFTPTLPPGRFWHQYDLLPGPQRTRQVLGPSRPGVPTMSLLNSSRPTPEGSPPNLPILLPSSILPEAISLLLLPEELELLSESMVESKFVESLNPPAFYTFLTPDEDGSPNWDGNSEEILGGAGGSMESQGSSVGLAKGTLPSIFTFSSSVDGDPHFVIQIPHSEEKICFTLNGHPGDLLQLIEDPKAGLHVSGKLLGAPPRPGHKDQTRTYFQIITVTTDKPRAYTITISRSSISLRGEGTLRLSWDQPALLKRPQLELYVAAAARLTLRLGPYLEFLVLRHRYRHPSTLQLPHLGFYVANGSGLSPSARGLIGQFQHADIRLVTGPMGPCLRRHHGPDVPVILGKRLLKDSPRLLPRWASCWLVKRSHVELLLGHPYLSYVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	MTSYSMRSTVVSRYA EEECCHHHHHHHHHH	19.53	-
45	Phosphorylation	TSYSMRSTVVSRYAH EECCHHHHHHHHHHH	17.98	-
48	Phosphorylation	SMRSTVVSRYAHTLV CHHHHHHHHHHHHHH	18.42	-
83	N-linked_Glycosylation	PHLAFISNFTMTINN CCEEEEEEEEEEECC	31.43	UniProtKB CARBOHYD
374	N-linked_Glycosylation	LAAASVLNHSNQEPG HHHHHHHHCCCCCCC	34.09	UniProtKB CARBOHYD
453	Phosphorylation	RGIARRIYEDTDAAL CCCHHHHHCCCHHHH	13.12	29978859
456	Phosphorylation	ARRIYEDTDAALQLK HHHHHCCCHHHHHHC	18.65	29978859
466	Phosphorylation	ALQLKGLYEEISMPL HHHHCCHHHHCCCHH	21.86	24719451
470	Phosphorylation	KGLYEEISMPLLADV CCHHHHCCCHHHHHH	20.02	24719451
540	N-linked_Glycosylation	HHSEGATNNSQKAFG ECCCCCCCCCCHHCC	45.69	UniProtKB CARBOHYD
594	N-linked_Glycosylation	LLAAKVLNLSLEYNF HHHHHHHCCCCEECC	30.48	UniProtKB CARBOHYD
669	Phosphorylation	RPVKPKFYLSSTTTA CCCCCCEEEECCCCH	16.29	28270605
671	Phosphorylation	VKPKFYLSSTTTAST CCCCEEEECCCCHHH	17.79	28270605
672	Phosphorylation	KPKFYLSSTTTASTK CCCEEEECCCCHHHH	27.46	28270605
673	Phosphorylation	PKFYLSSTTTASTKK CCEEEECCCCHHHHH	25.45	28270605
674	Phosphorylation	KFYLSSTTTASTKKM CEEEECCCCHHHHHH	23.47	28270605
675	Phosphorylation	FYLSSTTTASTKKML EEEECCCCHHHHHHC	20.78	28270605
677	Phosphorylation	LSSTTTASTKKMLSS EECCCCHHHHHHCCC	38.37	28270605
678	Phosphorylation	SSTTTASTKKMLSSK ECCCCHHHHHHCCCC	32.02	28270605
679	Acetylation	STTTASTKKMLSSKE CCCCHHHHHHCCCCC	33.42	7675381
731	Phosphorylation	KPTILVPSNSGTLLP CCEEEECCCCCCEEE	35.83	22210691
770	Phosphorylation	VKPGIPASPKADTVK CCCCCCCCCCCCCEE	22.91	24719451
808	Phosphorylation	APKGLPQSRPGVSTL CCCCCCCCCCCCCEE	38.20	20860994
855	Phosphorylation	KTPKILLSLKPSAPP CCCCEEEECCCCCCC	30.79	24719451
870	Phosphorylation	HQISTSISLSKPETP CEEEEEEECCCCCCC	26.76	24719451
971	N-linked_Glycosylation	VPTMSLLNSSRPTPE CCCHHHHCCCCCCCC	43.14	UniProtKB CARBOHYD
1055	Phosphorylation	ILGGAGGSMESQGSS CCCCCCCCCCCCCCC	20.61	25332170
1062	Phosphorylation	SMESQGSSVGLAKGT CCCCCCCCHHCCCCC	27.33	25332170
1160	Phosphorylation	RAYTITISRSSISLR EEEEEEEECCCEECC	19.91	24719451
1162	Phosphorylation	YTITISRSSISLRGE EEEEEECCCEECCCC	25.82	24732914
1163	Phosphorylation	TITISRSSISLRGEG EEEEECCCEECCCCE	18.32	24732914
1165	Phosphorylation	TISRSSISLRGEGTL EEECCCEECCCCEEE	17.60	29496963
1171	Phosphorylation	ISLRGEGTLRLSWDQ EECCCCEEEEEECCC	12.38	-
1211	Methylation	YLEFLVLRHRYRHPS HHHHHHHHCCCCCCC	12.54	18583715
1215	Methylation	LVLRHRYRHPSTLQL HHHHCCCCCCCCCCC	34.89	18583721
1231	N-linked_Glycosylation	HLGFYVANGSGLSPS CEEEEEECCCCCCHH	34.81	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITIH6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITIH6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITIH6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ITIH6_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.