dbPTM

AFTIN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AFTIN_HUMAN
UniProt AC	Q6ULP2
Protein Name	Aftiphilin
Gene Name	AFTPH
Organism	Homo sapiens (Human).
Sequence Length	936
Subcellular Localization	Cytoplasm . Colocalizes with AP1G1 and clathrin.
Protein Description	May play a role in membrane trafficking..
Protein Sequence	MEPDIIRMYSSSPPPLDNGAEDDDDDEFGEFGGFSEVSPSGVGFVDFDTPDYTRPKEEFVPSNHFMPIHEFSENVDSLTSFKSIKNGNDKDITAELSAPVKGQSDVLLSTTSKEIISSEMLATSIDGMERPGNLNKVVEQRQNVGTLESFSPGDFRTNMNVVHQNKQLESCNGEKPPCLEILTNGFAVLETVNPQGTDDLDNVADSKGRKPLSTHSTEYNLDSVPSPAEEFADFATFSKKERIQLEEIECAVLNDREALTIRENNKINRVNELNSVKEVALGRSLDNKGDTDGEDQVCVSEISIVTNRGFSVEKQGLPTLQQDEFLQSGVQSKAWSLVDSADNSEAIRREQCKTEEKLDLLTSKCAHLCMDSVKTSDDEVGSPKEESRKFTNFQSPNIDPTEENDLDDSLSVKNGDSSNDFVTCNDINEDDFGDFGDFGSASGSTPPFVTGTQDSMSDATFEESSEHFPHFSEPGDDFGEFGDINAVSCQEETILTKSDLKQTSDNLSEECQLARKSSGTGTEPVAKLKNGQEGEIGHFDSVPNIQDDCNGFQDSDDFADFSSAGPSQVVDWNAFEDEQKDSCSWAAFGDQQATESHHRKEAWQSHRTDENIDTPGTPKTHSVPSATSKGAVASGHLQESATSVQTALLNRLERIFEACFPSILVPDAEEEVTSLKHLLETSTLPIKTREALPESGELLDVWTELQDIHDAHGLRYQWGGSHSNKKLLSSLGIDTRNILFTGNKKQPVIVPMYAAGLGMLEPTKEPLKPLSAAEKIASIGQTATMSPDMNTCTSDQFQESLPPVQFDWSSSGLTNPLDASGGSTLLNLDFFGPVDDSSSSSSTTIPGVDPELYELTTSKLEISTSSLKVTDAFARLMSTVEKTSTSTRKPKREEHLSEEAIKVIAGLPDLTFMHAKVLMFPATLTPSTSSQEKADG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	DIIRMYSSSPPPLDN CCEEECCCCCCCCCC	29.40	28348404
12	Phosphorylation	IIRMYSSSPPPLDNG CEEECCCCCCCCCCC	35.17	26074081
38	Phosphorylation	FGGFSEVSPSGVGFV CCCCCCCCCCCCCEE	14.86	22468782
52	Phosphorylation	VDFDTPDYTRPKEEF EECCCCCCCCCHHHC	13.07	138789
77	Phosphorylation	EFSENVDSLTSFKSI HCCCCCCHHHHCCCC	29.30	113322191
82	Acetylation	VDSLTSFKSIKNGND CCHHHHCCCCCCCCC	51.55	25953088
93	Phosphorylation	NGNDKDITAELSAPV CCCCCCCEEEECCCC	24.98	28555341
109	Phosphorylation	GQSDVLLSTTSKEII CCCCEEEECCCHHHH	26.02	28348404
110	Phosphorylation	QSDVLLSTTSKEIIS CCCEEEECCCHHHHC	34.75	21586687
111	Phosphorylation	SDVLLSTTSKEIISS CCEEEECCCHHHHCH	34.13	21586697
112	Phosphorylation	DVLLSTTSKEIISSE CEEEECCCHHHHCHH	28.51	28348404
117	Phosphorylation	TTSKEIISSEMLATS CCCHHHHCHHHHHHH	26.38	29900121
118	Phosphorylation	TSKEIISSEMLATSI CCHHHHCHHHHHHHC	19.33	29900121
123	Phosphorylation	ISSEMLATSIDGMER HCHHHHHHHCCCCCC	23.43	24719451
124	Phosphorylation	SSEMLATSIDGMERP CHHHHHHHCCCCCCC	17.05	28348404
130	Methylation	TSIDGMERPGNLNKV HHCCCCCCCCCHHHH	35.22	-
146	Phosphorylation	EQRQNVGTLESFSPG HHHCCCCCCCCCCCC	24.06	25850435
149	Phosphorylation	QNVGTLESFSPGDFR CCCCCCCCCCCCCCH	33.85	25850435
151	Phosphorylation	VGTLESFSPGDFRTN CCCCCCCCCCCCHHC	36.93	25159151
213	Phosphorylation	SKGRKPLSTHSTEYN CCCCCCCCCCCCEEC	32.38	27080861
214	Phosphorylation	KGRKPLSTHSTEYNL CCCCCCCCCCCEECC	27.77	27080861
216	Phosphorylation	RKPLSTHSTEYNLDS CCCCCCCCCEECCCC	24.03	27080861
217	Phosphorylation	KPLSTHSTEYNLDSV CCCCCCCCEECCCCC	34.58	27080861
219	Phosphorylation	LSTHSTEYNLDSVPS CCCCCCEECCCCCCC	22.55	27080861
223	Phosphorylation	STEYNLDSVPSPAEE CCEECCCCCCCCHHH	38.81	29496963
226	Phosphorylation	YNLDSVPSPAEEFAD ECCCCCCCCHHHHHH	34.29	25159151
236	Phosphorylation	EEFADFATFSKKERI HHHHHHHCCCHHHCC	28.56	28270605
238	Phosphorylation	FADFATFSKKERIQL HHHHHCCCHHHCCCH	38.16	23312004
275	Phosphorylation	NRVNELNSVKEVALG CCHHHCCCCCHHHHC	47.38	113322199
284	Phosphorylation	KEVALGRSLDNKGDT CHHHHCCCCCCCCCC	37.97	46349001
291	Phosphorylation	SLDNKGDTDGEDQVC CCCCCCCCCCCCCEE	55.35	30266825
311	Phosphorylation	IVTNRGFSVEKQGLP EEECCCCCHHHCCCC	31.99	24719451
336	Phosphorylation	GVQSKAWSLVDSADN CCCHHHHHHHHCCCC	24.31	30624053
340	Phosphorylation	KAWSLVDSADNSEAI HHHHHHHCCCCHHHH	30.00	113322207
357	Acetylation	EQCKTEEKLDLLTSK HHCCCHHHHHHHHHH	40.86	20167786
362	Phosphorylation	EEKLDLLTSKCAHLC HHHHHHHHHHHHHHH	33.18	29396449
363	Phosphorylation	EKLDLLTSKCAHLCM HHHHHHHHHHHHHHH	26.21	29396449
372	Phosphorylation	CAHLCMDSVKTSDDE HHHHHHHHCCCCCCC	9.91	23663014
375	Phosphorylation	LCMDSVKTSDDEVGS HHHHHCCCCCCCCCC	34.92	23927012
376	Phosphorylation	CMDSVKTSDDEVGSP HHHHCCCCCCCCCCC	37.03	25159151
382	Phosphorylation	TSDDEVGSPKEESRK CCCCCCCCCHHHHHC	37.66	23401153
387	Phosphorylation	VGSPKEESRKFTNFQ CCCCHHHHHCCCCCC	41.69	23927012
391	Phosphorylation	KEESRKFTNFQSPNI HHHHHCCCCCCCCCC	37.85	21712546
395	Phosphorylation	RKFTNFQSPNIDPTE HCCCCCCCCCCCCCC	18.77	25159151
401	Phosphorylation	QSPNIDPTEENDLDD CCCCCCCCCCCCCCC	52.78	30266825
409	Phosphorylation	EENDLDDSLSVKNGD CCCCCCCCCEECCCC	23.39	30266825
411	Phosphorylation	NDLDDSLSVKNGDSS CCCCCCCEECCCCCC	34.69	30266825
450	O-linked_Glycosylation	GSTPPFVTGTQDSMS CCCCCCCCCCCCCCC	34.59	23301498
452	O-linked_Glycosylation	TPPFVTGTQDSMSDA CCCCCCCCCCCCCCC	21.60	23301498
503	Phosphorylation	TKSDLKQTSDNLSEE CHHHHHHHCCCHHHH	36.14	23882029
504	Phosphorylation	KSDLKQTSDNLSEEC HHHHHHHCCCHHHHH	23.23	23882029
508	Phosphorylation	KQTSDNLSEECQLAR HHHCCCHHHHHHHHH	37.29	21815630
517	Phosphorylation	ECQLARKSSGTGTEP HHHHHHHCCCCCCCC	28.57	11603737
518	Phosphorylation	CQLARKSSGTGTEPV HHHHHHCCCCCCCCC	43.33	27273156
520	Phosphorylation	LARKSSGTGTEPVAK HHHHCCCCCCCCCEE	42.76	23927012
522	Phosphorylation	RKSSGTGTEPVAKLK HHCCCCCCCCCEECC	36.63	23927012
584	Phosphorylation	DEQKDSCSWAAFGDQ CCCCCCCCCHHHCCH	24.57	27251275
605	Phosphorylation	HRKEAWQSHRTDENI HHHHHHHHHCCCCCC	12.30	28985074
608	Phosphorylation	EAWQSHRTDENIDTP HHHHHHCCCCCCCCC	42.09	23312004
614	Phosphorylation	RTDENIDTPGTPKTH CCCCCCCCCCCCCCC	21.59	30266825
617	Phosphorylation	ENIDTPGTPKTHSVP CCCCCCCCCCCCCCC	23.86	23401153
620	Phosphorylation	DTPGTPKTHSVPSAT CCCCCCCCCCCCCCC	22.16	23312004
622	Phosphorylation	PGTPKTHSVPSATSK CCCCCCCCCCCCCCC	40.74	23312004
625	Phosphorylation	PKTHSVPSATSKGAV CCCCCCCCCCCCCCH	41.86	23312004
627	Phosphorylation	THSVPSATSKGAVAS CCCCCCCCCCCCHHC	35.00	23312004
628	Phosphorylation	HSVPSATSKGAVASG CCCCCCCCCCCHHCC	28.89	23312004
640	Phosphorylation	ASGHLQESATSVQTA HCCCHHHHHHHHHHH	24.72	28122231
642	Phosphorylation	GHLQESATSVQTALL CCHHHHHHHHHHHHH	38.42	28122231
643	Phosphorylation	HLQESATSVQTALLN CHHHHHHHHHHHHHH	16.37	28122231
646	Phosphorylation	ESATSVQTALLNRLE HHHHHHHHHHHHHHH	19.67	28122231
687	Ubiquitination	ETSTLPIKTREALPE HHCCCCCCCHHHCCC	39.32	-
729	Phosphorylation	HSNKKLLSSLGIDTR CCCHHHHHHCCCCCC	33.67	23403867
730	Phosphorylation	SNKKLLSSLGIDTRN CCHHHHHHCCCCCCC	30.50	23403867
735	Phosphorylation	LSSLGIDTRNILFTG HHHCCCCCCCEEECC	24.56	23403867
745	Acetylation	ILFTGNKKQPVIVPM EEECCCCCCCEEEEE	64.93	19413330
753	Phosphorylation	QPVIVPMYAAGLGML CCEEEEECCCCCCCC	6.29	21945579
763	Phosphorylation	GLGMLEPTKEPLKPL CCCCCCCCCCCCCCC	38.37	21945579
850 (in isoform 5)	Phosphorylation	-	30.96	118409
851 (in isoform 5)	Phosphorylation	-	60.56	29083192
855 (in isoform 5)	Phosphorylation	-	3.90	29083192
856 (in isoform 5)	Phosphorylation	-	19.65	29083192
857 (in isoform 5)	Phosphorylation	-	36.17	29083192
858 (in isoform 5)	Phosphorylation	-	29.97	29083192
859 (in isoform 5)	Phosphorylation	-	48.31	29083192
863	Phosphorylation	TTSKLEISTSSLKVT CCCEEEEECCHHHHH	16.92	26657352
864	Phosphorylation	TSKLEISTSSLKVTD CCEEEEECCHHHHHH	28.17	26437602
865	Phosphorylation	SKLEISTSSLKVTDA CEEEEECCHHHHHHH	27.21	25159151
866	Phosphorylation	KLEISTSSLKVTDAF EEEEECCHHHHHHHH	32.09	26437602
870	Phosphorylation	STSSLKVTDAFARLM ECCHHHHHHHHHHHH	21.74	30301811
878	Phosphorylation	DAFARLMSTVEKTST HHHHHHHHHHHHCCC	33.61	30576142
878 (in isoform 4)	Phosphorylation	-	33.61	118409
879	Phosphorylation	AFARLMSTVEKTSTS HHHHHHHHHHHCCCC	20.79	30301811
879 (in isoform 4)	Phosphorylation	-	20.79	29083192
883 (in isoform 4)	Phosphorylation	-	24.59	29083192
884 (in isoform 4)	Phosphorylation	-	31.28	29083192
885 (in isoform 4)	Phosphorylation	-	41.05	29083192
886	Phosphorylation	TVEKTSTSTRKPKRE HHHHCCCCCCCCCCH	24.93	30576142
886 (in isoform 4)	Phosphorylation	-	24.93	29083192
887 (in isoform 4)	Phosphorylation	-	32.41	29083192
924	Phosphorylation	VLMFPATLTPSTSSQ EEEEECCCCCCCCCC	31.25	28348404
925	Phosphorylation	LMFPATLTPSTSSQE EEEECCCCCCCCCCC	7.82	27251275
926	Phosphorylation	MFPATLTPSTSSQEK EEECCCCCCCCCCCC	15.73	27050516
928	Phosphorylation	PATLTPSTSSQEKAD ECCCCCCCCCCCCCC	35.37	28348404
929	Phosphorylation	ATLTPSTSSQEKADG CCCCCCCCCCCCCCC	33.33	25850435
930	Phosphorylation	TLTPSTSSQEKADG- CCCCCCCCCCCCCC-	34.07	25850435
931	Phosphorylation	LTPSTSSQEKADG-- CCCCCCCCCCCCC--	42.31	25850435

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AFTIN_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AFTIN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AFTIN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
STA5B_HUMAN	STAT5B	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AFTIN_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517 AND THR-522, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-617, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-617, AND MASSSPECTROMETRY.	16964243 [Abstract]