CADH5_MOUSE - dbPTM
CADH5_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CADH5_MOUSE
UniProt AC P55284
Protein Name Cadherin-5
Gene Name Cdh5
Organism Mus musculus (Mouse).
Sequence Length 784
Subcellular Localization Cell junction . Cell membrane
Single-pass type I membrane protein . Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions (By similarity).
Protein Description Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction..
Protein Sequence MQRLTELATALGAFLGLLAVAAMAGPNFPQIDTPNMLPAHHRQKRDWIWNQMHIDEEKNESLPHYVGKIKSNVNRQNAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTNKNLEQPSSFTVKVHDINDNWPVFSHQVFNASVPEMSAIGTSVIRVTAVDADDPTVAGHATVLYQIVKGNEYFSIDNSGLIFTKIKNLDREKQAEYKIVVETQDALGLRGESGTATVMIRLEDINDNFPVFTQSTYTFSVPEDIRVGKPLGFLTVVDPDEPQNRMTKYSIMQGEYRDTFTIETDPKRNEGIIKPTKSLDYEVIQQYTFYIEATDPTIRYEYLSSTSGKNKAMVTINVLDVDEPPVFQRHFYHFKLPENQKKPLIGTVVAKDPDKAQRSIGYSIRKTSDRGQFFRITKQGNIYNEKELDRETYAWYNLTVEANELDSRGNPVGKESIVQVYIEVLDENDNPPEFAQPYEPKVCENAAQGKLVVQISATDKDVVPVNPKFKFALKNEDSNFTLINNHDNTANITVKYGQFNREHAKFHYLPVLISDNGVPSLTGTSTLTVGVCKCNEQGEFTFCEEMAAQAGVSIQALVAIFLCILTITVITLLIILRRRIRKQAHAHSKSALEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRGGSTKPLRSTMDARPAVYTQVQKPPRLAPGLHGGPREMATMIDVKKEEADNDGGGPPYDTLHIYGYEGAESIAESLSSLSTNSSDSDIDYDFLNDWGPRFKMLAELYGSDPQEELII
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
59N-linked_GlycosylationMHIDEEKNESLPHYV
CCCCHHHCCCCCHHH
47.58-
114PhosphorylationDREKVSEYFLTALIV
CHHHHHHHHHHEEEE
9.0726239621
117PhosphorylationKVSEYFLTALIVDKN
HHHHHHHHEEEEECC
14.9826239621
155N-linked_GlycosylationVFSHQVFNASVPEMS
EEEEEEEECCCCCHH
32.23-
293PhosphorylationPQNRMTKYSIMQGEY
CCCCCCEEEEECCCC
8.35-
294PhosphorylationQNRMTKYSIMQGEYR
CCCCCEEEEECCCCC
17.09-
300PhosphorylationYSIMQGEYRDTFTIE
EEEECCCCCCCEEEE
22.1829895711
308PhosphorylationRDTFTIETDPKRNEG
CCCEEEECCCCCCCC
54.4729895711
320PhosphorylationNEGIIKPTKSLDYEV
CCCCCCCCCCCCHHH
28.4121454597
407PhosphorylationAQRSIGYSIRKTSDR
HHHHHCEEEEECCCC
15.6529514104
441N-linked_GlycosylationRETYAWYNLTVEANE
CCEEEEEEEEEEHHH
20.66-
523N-linked_GlycosylationALKNEDSNFTLINNH
EEECCCCCEEEEECC
46.36-
535N-linked_GlycosylationNNHDNTANITVKYGQ
ECCCCCCEEEEEECC
28.55-
645PhosphorylationIHEQLVTYDEEGGGE
HHHHHEEECCCCCCE
17.5522817900
658PhosphorylationGEMDTTSYDVSVLNS
CEEECCEEEEEHHCC
20.4820530207
665PhosphorylationYDVSVLNSVRGGSTK
EEEEHHCCCCCCCCC
14.72-
685PhosphorylationMDARPAVYTQVQKPP
CCCCCCCEECCCCCC
8.1222817900
686PhosphorylationDARPAVYTQVQKPPR
CCCCCCEECCCCCCC
18.7029472430
690UbiquitinationAVYTQVQKPPRLAPG
CCEECCCCCCCCCCC
59.1222790023
731PhosphorylationPYDTLHIYGYEGAES
CCCCEEEECCCHHHH
11.6922817900
733PhosphorylationDTLHIYGYEGAESIA
CCEEEECCCHHHHHH
8.3322817900
776PhosphorylationMLAELYGSDPQEELI
HHHHHHCCCCCHHCC
32.3420047332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
685YPhosphorylationKinaseSRCP12931
PSP

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CADH5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CADH5_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSK_MOUSECskphysical
15861137

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CADH5_MOUSE

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Related Literatures of Post-Translational Modification

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