PRLR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRLR_MOUSE
• UniProt AC: Q08501
• Protein Name: Prolactin receptor
• Gene Name: Prlr
• Organism: Mus musculus (Mouse).
• Sequence Length: 608
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: This is a receptor for the anterior pituitary hormone prolactin..
• Protein Sequence: MSSALAYMLLVLSISLLNGQSPPGKPEIHKCRSPDKETFTCWWNPGSDGGLPTNYSLTYSKEGEKNTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATNEMGSSTSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWLPPTITDVKTGWFTMEYEIRLKSEEADEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWGQEKSIEIPNDFTLKDTTVWIIVAVLSAVICLIMVWAVALKGYSMMTCIFPPVPGPKIKGFDTHLLEKGKSEELLSALGCQDFPPTSDCEDLLVEFLEVDDNEDERLMPSHSKEYPGQGVKPTHLDPDSDSGHGSYDSHSLLSEKCEEPQAYPPAFHIPEITEKPENPEANIPPTPNPQNNTPNCHTDTSKSTTWPLPPGQHTRRSPYHSIADVCKLAGSPGDTLDSFLDKAEENVLKLSEDAGEEEVAVQEGAKSFPSDKQNTSWPPLQEKGPIVYAKPPDYVEIHKVNKDGVLSLLPKQRENHQTENPGVPETSKEYAKVSGVTDNNILVLVPDSRAQNTALLEESAKKVPPSLEQNQSEKDLASFTATSSNCRLQLGRLDYLDPTCFMHSFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSALAYML ------CCHHHHHHH	25.07	25293948
3	Phosphorylation	-----MSSALAYMLL -----CCHHHHHHHH	26.46	25293948
7	Phosphorylation	-MSSALAYMLLVLSI -CCHHHHHHHHHHHH	6.80	25293948
13	Phosphorylation	AYMLLVLSISLLNGQ HHHHHHHHHHHHCCC	11.58	25293948
15	Phosphorylation	MLLVLSISLLNGQSP HHHHHHHHHHCCCCC	24.35	25293948
21	Phosphorylation	ISLLNGQSPPGKPEI HHHHCCCCCCCCCCC	34.17	25293948
54	N-linked_Glycosylation	SDGGLPTNYSLTYSK CCCCCCCEEEEEEEC	23.58	-
99	N-linked_Glycosylation	KIYIITVNATNEMGS EEEEEEEECCCCCCC	32.19	-
127	N-linked_Glycosylation	VEPEPPRNLTLEVKQ CCCCCCCCEEEEEEE	43.05	-
356	Phosphorylation	YDSHSLLSEKCEEPQ CCHHHHHHHCCCCCC	40.06	-
419	Phosphorylation	PGQHTRRSPYHSIAD CCCCCCCCCCCCHHH	26.90	23684622
421	Phosphorylation	QHTRRSPYHSIADVC CCCCCCCCCCHHHHH	14.94	26643407
423	Phosphorylation	TRRSPYHSIADVCKL CCCCCCCCHHHHHHH	17.39	26643407
433	Phosphorylation	DVCKLAGSPGDTLDS HHHHHCCCCCCCHHH	21.80	26643407
532	Phosphorylation	VPETSKEYAKVSGVT CCCCHHHHHCCCCCC	18.56	12761205
585	Phosphorylation	LASFTATSSNCRLQL HHHHEECCCCCEEEE	19.65	24719451
597	Phosphorylation	LQLGRLDYLDPTCFM EEECCCCCCCCCCCC	20.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
532	Y	Phosphorylation	Kinase	JAK2	O60674	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRLR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRLR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STA5A_MOUSE	Stat5a	physical	12388746
AGAP2_MOUSE	Agap2	physical	20075866
NECT4_MOUSE	Pvrl4	physical	28258213

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.