STA5A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STA5A_MOUSE
• UniProt AC: P42230
• Protein Name: Signal transducer and activator of transcription 5A
• Gene Name: Stat5a
• Organism: Mus musculus (Mouse).
• Sequence Length: 793
• Subcellular Localization: Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation.
• Protein Description: Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation..
• Protein Sequence: MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQRFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASTDAGASATYMDQAPSPVVCPQPHYNMYPPNPDPVLDQDGEFDLDESMDVARHVEELLRRPMDSLDARLSPPAGLFTSARSSLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	LKIKLGHYATQLQNT EEEHHHHHHHHHHHH	15.00	22817900
114	Phosphorylation	RCIRHILYNEQRLVR HHHHHHHHCHHHHHH	18.95	22817900
127	Phosphorylation	VREANNCSSPAGVLV HHHHHCCCCCCCHHH	41.29	25266776
128	Phosphorylation	REANNCSSPAGVLVD HHHHCCCCCCCHHHH	22.44	15863494
171	Phosphorylation	KLQQTQEYFIIQYQE HHHHHHHEEHEEHHH	7.11	-
279	S-palmitoylation	LDVLQSWCEKLAEII HHHHHHHHHHHHHHH	3.91	28680068
420	Phosphorylation	SAHFRNMSLKRIKRA HHHHHHCCHHHHHHH	34.00	22942356
682	Phosphorylation	KDEVFAKYYTPVLAK CCHHHHHHHHHHHHH	14.78	-
683	Phosphorylation	DEVFAKYYTPVLAKA CHHHHHHHHHHHHHH	12.12	-
694	Phosphorylation	LAKAVDGYVKPQIKQ HHHHHCCCCCHHHHH	10.80	26824392
725	Phosphorylation	TYMDQAPSPVVCPQP EECCCCCCCEECCCC	33.08	10744710
756	Phosphorylation	GEFDLDESMDVARHV CCCCCCHHHHHHHHH	21.68	12529425
773	Phosphorylation	LLRRPMDSLDARLSP HHHCCHHHCCCCCCC	23.15	28833060
779	Phosphorylation	DSLDARLSPPAGLFT HHCCCCCCCCCCHHH	24.23	12732616
786	Phosphorylation	SPPAGLFTSARSSLS CCCCCHHHCCHHCCC	26.90	28833060
787	Phosphorylation	PPAGLFTSARSSLS- CCCCHHHCCHHCCC-	17.85	28833060
790	Phosphorylation	GLFTSARSSLS---- CHHHCCHHCCC----	35.03	26643407
791	Phosphorylation	LFTSARSSLS----- HHHCCHHCCC-----	27.38	25266776
793	Phosphorylation	TSARSSLS------- HCCHHCCC-------	39.87	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
694	Y	Phosphorylation	Kinase	BTK	Q06187	PSP
694	Y	Phosphorylation	Kinase	BTK	P35991	PSP
694	Y	Phosphorylation	Kinase	JAK2	Q62120	PSP
725	S	Phosphorylation	Kinase	CDK8	Q8R3L8	PSP
779	S	Phosphorylation	Kinase	CDK8	P49336	GPS
779	S	Phosphorylation	Kinase	PAK1	Q13153	PSP
779	S	Phosphorylation	Kinase	PAK1	O88643	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Cbl	P22682	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STA5A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STA5A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CENPJ_HUMAN	CENPJ	physical	12198240
CENPJ_MOUSE	Cenpj	physical	12198240
HDAC1_MOUSE	Hdac1	physical	12574125
ESR1_MOUSE	Esr1	physical	15304355
AGAP2_MOUSE	Agap2	physical	20075866

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.