dbPTM

NECT4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NECT4_MOUSE
UniProt AC	Q8R007
Protein Name	Nectin-4
Gene Name	Nectin4 {ECO:0000250\|UniProtKB:Q96NY8}
Organism	Mus musculus (Mouse).
Sequence Length	508
Subcellular Localization	Cell membrane Single-pass type I membrane protein . Cell junction, adherens junction .
Protein Description	Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1..
Protein Sequence	MPLSLGAEMWGPEAWLRLLFLASFTGQYSAGELETSDVVTVVLGQDAKLPCFYRGDPDEQVGQVAWARVDPNEGIRELALLHSKYGLHVNPAYEDRVEQPPPPRDPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARMRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTQSSRSFTHPRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDRRITHTLQVAFLAEASVRGLEDQNLWQVGREGATLKCLSEGQPPPKYNWTRLDGPLPSGVRVKGDTLGFPPLTTEHSGVYVCHVSNELSSRDSQVTVEVLDPEDPGKQVDLVSASVIIVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHSDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRTEEDDDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
280	N-linked_Glycosylation	GQPPPKYNWTRLDGP CCCCCCCCCEECCCC	-
395	Phosphorylation	LTLTRENSIRRLHSH HHCCCHHHHHHHHHC	23140645
417	Phosphorylation	PEESVGLRAEGHPDS CHHHHCCCCCCCCCC	24719451
424	Phosphorylation	RAEGHPDSLKDNSSC CCCCCCCCCCCCCCC	19367708
432	Phosphorylation	LKDNSSCSVMSEEPE CCCCCCCCCEECCCC	24719451
442	Phosphorylation	SEEPEGRSYSTLTTV ECCCCCCCCCCEEEE	24719451
444	Phosphorylation	EPEGRSYSTLTTVRE CCCCCCCCCEEEEEE	24719451
456	Phosphorylation	VREIETQTELLSPGS EEEEECCCCCCCCCC	30635358
460	Phosphorylation	ETQTELLSPGSGRTE ECCCCCCCCCCCCCC	24719451
463	Phosphorylation	TELLSPGSGRTEEDD CCCCCCCCCCCCCCC	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NECT4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NECT4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NECT4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PRLR_MOUSE	Prlr	physical	28258213

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NECT4_MOUSE

Related Literatures of Post-Translational Modification