MINK1_MOUSE - dbPTM
MINK1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MINK1_MOUSE
UniProt AC Q9JM52
Protein Name Misshapen-like kinase 1
Gene Name Mink1 {ECO:0000250|UniProtKB:Q8N4C8}
Organism Mus musculus (Mouse).
Sequence Length 1308
Subcellular Localization Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, dendrite.
Protein Description Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1..
Protein Sequence MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERARMNKQQNSPLAKAKPSSAGPEPPISQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEGPGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPASYKRAIGEDFVLLKERTLDEAPKPPKKAMDYSSSSEEVESSEEEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEISGTQPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSKGQSPPTKDGGSDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationGDPAPARSLDDIDLS
CCCCCCCCCCCCCHH		37.9528066266
175PhosphorylationKLVDFGVSAQLDRTV
EEEEECCEEECCCCC		15.6323140645
181PhosphorylationVSAQLDRTVGRRNTF
CEEECCCCCCCCCCC		27.2922324799
187PhosphorylationRTVGRRNTFIGTPYW
CCCCCCCCCCCCCCC		18.1526643407
191PhosphorylationRRNTFIGTPYWMAPE
CCCCCCCCCCCCCCC		14.3723984901
193PhosphorylationNTFIGTPYWMAPEVI
CCCCCCCCCCCCCEE		13.9823984901
273PhosphorylationIDTCLIKTYLSRPPT
HHHHHHHHHHCCCCH		23.7729899451
319PhosphorylationKRGEKEETEYEYSGS
HHCCCCCCCCCCCCC		44.9820531401
321PhosphorylationGEKEETEYEYSGSEE
CCCCCCCCCCCCCCC		27.8219060867
323PhosphorylationKEETEYEYSGSEEED
CCCCCCCCCCCCCCC		19.8919060867
324PhosphorylationEETEYEYSGSEEEDD
CCCCCCCCCCCCCCC		24.7325521595
326PhosphorylationTEYEYSGSEEEDDSH
CCCCCCCCCCCCCCC		35.5725521595
332PhosphorylationGSEEEDDSHGEEGEP
CCCCCCCCCCCCCCC		45.7921183079
340PhosphorylationHGEEGEPSSIMNVPG
CCCCCCCHHHCCCCC		28.3520531401
341PhosphorylationGEEGEPSSIMNVPGE
CCCCCCHHHCCCCCC		36.2529899451
349PhosphorylationIMNVPGESTLRREFL
HCCCCCCHHHHHHHH		38.3620531401
350PhosphorylationMNVPGESTLRREFLR
CCCCCCHHHHHHHHH		21.7120531401
462PhosphorylationQLEEQRQSERLQRQL
HHHHHHHHHHHHHHH		27.2029899451
475PhosphorylationQLQQEHAYLKSLQQQ
HHHHHHHHHHHHHHH		19.3029514104
478PhosphorylationQEHAYLKSLQQQQQQ
HHHHHHHHHHHHHHH		28.9029899451
503MethylationQQILPGDRKPLYHYG
HCCCCCCCCCCCCCC		48.7024129315
507PhosphorylationPGDRKPLYHYGRGIN
CCCCCCCCCCCCCCC		11.0929514104
509PhosphorylationDRKPLYHYGRGINPA
CCCCCCCCCCCCCCC		8.5829514104
511MethylationKPLYHYGRGINPADK
CCCCCCCCCCCCCCC		35.3424129315
537PhosphorylationRMNKQQNSPLAKAKP
HHHHHCCCHHHHCCC		19.5625521595
545PhosphorylationPLAKAKPSSAGPEPP
HHHHCCCCCCCCCCC		31.9223140645
546PhosphorylationLAKAKPSSAGPEPPI
HHHCCCCCCCCCCCC		45.8523140645
554PhosphorylationAGPEPPISQASPSPP
CCCCCCCCCCCCCCC		26.0123140645
557PhosphorylationEPPISQASPSPPGPL
CCCCCCCCCCCCCCC		20.4823140645
559PhosphorylationPISQASPSPPGPLSQ
CCCCCCCCCCCCCCC		41.0323140645
565PhosphorylationPSPPGPLSQTPPMQR
CCCCCCCCCCCCCCC		34.8323140645
567PhosphorylationPPGPLSQTPPMQRPV
CCCCCCCCCCCCCCC		26.4523140645
583PhosphorylationPQEGPHKSLVAHRVP
CCCCCCCCCEEECCC		25.6629899451
594PhosphorylationHRVPLKPYAAPVPRS
ECCCCCCCCCCCCCC		17.5129514104
601PhosphorylationYAAPVPRSQSLQDQP
CCCCCCCCCCCCCCC		20.3227087446
603PhosphorylationAPVPRSQSLQDQPTR
CCCCCCCCCCCCCCC		29.2825521595
644PhosphorylationGAVIRQNSDPTSEGP
CCEEECCCCCCCCCC		36.3125521595
644 (in isoform 3)Phosphorylation-36.3119144319
647PhosphorylationIRQNSDPTSEGPGPS
EECCCCCCCCCCCCC		44.3824925903
648PhosphorylationRQNSDPTSEGPGPSP
ECCCCCCCCCCCCCC		46.0424925903
654PhosphorylationTSEGPGPSPNPPSWV
CCCCCCCCCCCCCCC		43.1323984901
675PhosphorylationPPKVPQRTSSIATAL
CCCCCCCHHHHHHHH		22.9029472430
676PhosphorylationPKVPQRTSSIATALN
CCCCCCHHHHHHHHC		23.1829472430
677PhosphorylationKVPQRTSSIATALNT
CCCCCHHHHHHHHCC		18.6822942356
680PhosphorylationQRTSSIATALNTSGA
CCHHHHHHHHCCCCC		29.9723984901
684PhosphorylationSIATALNTSGAGGSR
HHHHHHCCCCCCCCC		29.4123984901
685O-linked_GlycosylationIATALNTSGAGGSRP
HHHHHCCCCCCCCCH		26.1055412699
685PhosphorylationIATALNTSGAGGSRP
HHHHHCCCCCCCCCH		26.1023984901
690PhosphorylationNTSGAGGSRPAQAVR
CCCCCCCCCHHHHHH		33.8923984901
699PhosphorylationPAQAVRASNPDLRRS
HHHHHHHCCCCHHCC		38.0322324799
702 (in isoform 3)Phosphorylation-57.9927566939
704 (in isoform 3)Phosphorylation-43.3625521595
706PhosphorylationSNPDLRRSDPGWERS
CCCCHHCCCCCCCCC		41.54-
709 (in isoform 3)Phosphorylation-43.8223984901
713PhosphorylationSDPGWERSDSVLPAS
CCCCCCCCCCCCCCC		23.7925619855
715PhosphorylationPGWERSDSVLPASHG
CCCCCCCCCCCCCCC		27.1424925903
718 (in isoform 3)Phosphorylation-29.5725367039
720PhosphorylationSDSVLPASHGHLPQA
CCCCCCCCCCCCCCC		28.2325619855
729PhosphorylationGHLPQAGSLERNRNR
CCCCCCCCCCCCCCC		30.0318388127
735 (in isoform 3)Phosphorylation-46.6820469934
736 (in isoform 3)Phosphorylation-25.6325521595
740PhosphorylationNRNRVGASTKLDSSP
CCCCCCCCCCCCCCC		21.8323984901
741PhosphorylationRNRVGASTKLDSSPV
CCCCCCCCCCCCCCC		34.7823984901
745PhosphorylationGASTKLDSSPVLSPG
CCCCCCCCCCCCCCC		47.1525521595
746PhosphorylationASTKLDSSPVLSPGN
CCCCCCCCCCCCCCC		20.7724925903
750PhosphorylationLDSSPVLSPGNKAKP
CCCCCCCCCCCCCCC		30.8725521595
769PhosphorylationSRPGRPASYKRAIGE
CCCCCCHHHHHHHCC		33.59-
785PhosphorylationFVLLKERTLDEAPKP
EEEEEECCCCCCCCC		39.3929899451
827PhosphorylationPSEGSRDTPGGRSDG
CCCCCCCCCCCCCCC		23.7922807455
832PhosphorylationRDTPGGRSDGDTDSV
CCCCCCCCCCCCCCE		49.5819060867
836PhosphorylationGGRSDGDTDSVSTMV
CCCCCCCCCCEEEEE		35.3925777480
838PhosphorylationRSDGDTDSVSTMVVH
CCCCCCCCEEEEEEE		21.7619060867
840PhosphorylationDGDTDSVSTMVVHDV
CCCCCCEEEEEEEEH		18.1025777480
841PhosphorylationGDTDSVSTMVVHDVE
CCCCCEEEEEEEEHH		16.3025777480
851PhosphorylationVHDVEEISGTQPSYG
EEEHHHCCCCCCCCC		38.7825777480
853PhosphorylationDVEEISGTQPSYGGG
EHHHCCCCCCCCCCC		30.4325777480
856PhosphorylationEISGTQPSYGGGTMV
HCCCCCCCCCCCEEE		26.9625777480
857PhosphorylationISGTQPSYGGGTMVV
CCCCCCCCCCCEEEE		26.8625777480
861PhosphorylationQPSYGGGTMVVQRTP
CCCCCCCEEEEECCC		15.2925777480
867PhosphorylationGTMVVQRTPEEERSL
CEEEEECCCHHHHCE		20.2610708748
873PhosphorylationRTPEEERSLLLADSN
CCCHHHHCEEEECCC		27.0125619855
879PhosphorylationRSLLLADSNGYTNLP
HCEEEECCCCCCCCC		26.9225619855
882PhosphorylationLLADSNGYTNLPDVV
EEECCCCCCCCCCCC		9.1925619855
883PhosphorylationLADSNGYTNLPDVVQ
EECCCCCCCCCCCCC		31.5125619855
892PhosphorylationLPDVVQPSHSPTENS
CCCCCCCCCCCCCCC		21.3625521595
894PhosphorylationDVVQPSHSPTENSKG
CCCCCCCCCCCCCCC		37.5425521595
896PhosphorylationVQPSHSPTENSKGQS
CCCCCCCCCCCCCCC		51.3025619855
899PhosphorylationSHSPTENSKGQSPPT
CCCCCCCCCCCCCCC		31.7525619855
903PhosphorylationTENSKGQSPPTKDGG
CCCCCCCCCCCCCCC		41.3325521595
906PhosphorylationSKGQSPPTKDGGSDY
CCCCCCCCCCCCCCC		45.1922324799
907UbiquitinationKGQSPPTKDGGSDYQ
CCCCCCCCCCCCCCH		61.2122790023
907 (in isoform 3)Ubiquitination-61.2122790023
911PhosphorylationPPTKDGGSDYQSRGL
CCCCCCCCCCHHCCC		38.3829899451
913PhosphorylationTKDGGSDYQSRGLVK
CCCCCCCCHHCCCEE		15.3029514104
944 (in isoform 3)Ubiquitination-31.98-
969PhosphorylationQFDVRKGSVVNVNPT
EEEECCCCEEECCCC		26.4025521595
984PhosphorylationNTRAHSETPEIRKYK
CCCCCCCCHHHHHHH		29.2729899451
1050PhosphorylationEGLNLLITISGKRNK
HHCCEEEEEECCCCE		14.7321454597
1052PhosphorylationLNLLITISGKRNKLR
CCEEEEEECCCCEEH		29.6121454597
1064PhosphorylationKLRVYYLSWLRNKIL
EEHHHHHHHHHHHHH		14.1421183079
1299PhosphorylationSSQVYFMTLNRNCIM
CCEEEEEEECCCCCC		15.81-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MINK1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MINK1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MINK1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MINK1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MINK1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-729 AND SER-969, ANDMASS SPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-746; SER-750 ANDSER-892, AND MASS SPECTROMETRY.

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