GNA13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNA13_MOUSE
• UniProt AC: P27601
• Protein Name: Guanine nucleotide-binding protein subunit alpha-13
• Gene Name: Gna13
• Organism: Mus musculus (Mouse).
• Sequence Length: 377
• Subcellular Localization: Membrane ; Lipid-anchor . Melanosome. Cytoplasm . Nucleus . Cytoplasmic in adult somatic cells, but mainly nuclear in spermatids in the testes. Translocates from the cytoplasm to the nucleus during spermatogenesis, hence predominantly observed in the
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. [PubMed: 21212405]
• Protein Sequence: MADFLPSRSVLSVCFPGCVLTNGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNKNQLHGDKLMAFDTRAPMAAQGMVETRVFLQYLPAIRALWEDSGIQNAYDRRREFQLGESVKYFLDNLDKLGVPDYIPSQQDILLARRPTKGIHEYDFEIKNVPFKMVDVGGQRSERKRWFECFDSVTSILFLVSSSEFDQVLMEDRQTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQVVSIKDYFLEFEGDPHCLRDVQKFLVECFRGKRRDQQQRPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLMLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	S-palmitoylation	SRSVLSVCFPGCVLT CCCHHEEEECCCEEC	2.83	10922491
18	S-palmitoylation	LSVCFPGCVLTNGEA HEEEECCCEECCCHH	2.00	10922491
37	S-palmitoylation	KSKEIDKCLSREKTY HHHHHHHHHHCCHHH	3.56	10922491
43	Phosphorylation	KCLSREKTYVKRLVK HHHHCCHHHHHHHHH	28.88	-
59	Phosphorylation	LLLGAGESGKSTFLK HHHCCCCCCHHHHHH	51.07	22817900
175	Ubiquitination	FQLGESVKYFLDNLD HHCHHHHHHHHHCHH	39.29	-
203	Phosphorylation	ILLARRPTKGIHEYD EEECCCCCCCCEECC	39.84	-
214	Ubiquitination	HEYDFEIKNVPFKMV EECCEEEECCCCEEE	44.70	-
219	Ubiquitination	EIKNVPFKMVDVGGQ EEECCCCEEEECCCC	31.76	-
318	S-palmitoylation	EFEGDPHCLRDVQKF EECCCHHHHHHHHHH	3.97	28526873
329	S-palmitoylation	VQKFLVECFRGKRRD HHHHHHHHHCCCCCC	1.88	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNA13_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
203	T	Phosphorylation	Phosphorylation on Thr-203 destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNA13_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CADH1_MOUSE	Cdh1	physical	16368433

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.