dbPTM

CADH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CADH1_MOUSE
UniProt AC	P09803
Protein Name	Cadherin-1
Gene Name	Cdh1
Organism	Mus musculus (Mouse).
Sequence Length	884
Subcellular Localization	Cell junction . Cell membrane Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through associa
Protein Description	Cadherins are calcium-dependent cell adhesion proteins. [PubMed: 11976333 They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells]
Protein Sequence	MGARCRSFSALLLLLQVSSWLCQELEPESCSPGFSSEVYTFPVPERHLERGHVLGRVRFEGCTGRPRTAFFSEDSRFKVATDGTITVKRHLKLHKLETSFLVRARDSSHRELSTKVTLKSMGHHHHRHHHRDPASESNPELLMFPSVYPGLRRQKRDWVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVNARIATLKVTDDDAPNTPAWKAVYTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQYILHVRVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQEITSYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAEHVKNSTYVALIIATDDGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQRNPQPHIITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAAQESLILQPRKDLEIGEYKIHLKLADNQNKDQVTTLDVHVCDCEGTVNNCMKAGIVAAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEDD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
135	Phosphorylation	HHHRDPASESNPELL CCCCCCCCCCCCHHH	47.12	28973931
282	O-linked_Glycosylation	EGAVPGTSVMKVSAT CCCCCCCEEEEEEEC	26.57	28973932
287	O-linked_Glycosylation	GTSVMKVSATDADDD CCEEEEEEECCCCCC	21.67	28973932
360	O-linked_Glycosylation	QGEGLSTTAKAVITV CCCCCCCCEEEEEEE	23.84	28973932
415	Phosphorylation	TPAWKAVYTVVNDPD CCCEEEEEEEECCCC	9.93	25777480
416	Phosphorylation	PAWKAVYTVVNDPDQ CCEEEEEEEECCCCC	16.04	25777480
429	Phosphorylation	DQQFVVVTDPTTNDG CCCEEEEECCCCCCC	25.34	25777480
432	Phosphorylation	FVVVTDPTTNDGILK EEEEECCCCCCCHHH	40.83	25777480
433	Phosphorylation	VVVTDPTTNDGILKT EEEECCCCCCCHHHC	36.38	25777480
472	O-linked_Glycosylation	EGSLVPSTATVTVDV CCCCCCCCCEEEEEE	21.93	28973932
474	O-linked_Glycosylation	SLVPSTATVTVDVVD CCCCCCCEEEEEEEE	19.46	28973932
511	O-linked_Glycosylation	GQEITSYTAREPDTF CCEEEEEECCCCCCC	21.00	28973932
560	N-linked_Glycosylation	EDAEHVKNSTYVALI HHHHHHCCCCEEEEE	38.20	-
578	O-linked_Glycosylation	DDGSPIATGTGTLLL CCCCCCCCCCCEEEE	35.68	28973932
580	O-linked_Glycosylation	GSPIATGTGTLLLVL CCCCCCCCCEEEEEE	23.73	28973932
582	O-linked_Glycosylation	PIATGTGTLLLVLLD CCCCCCCEEEEEEEE	17.67	28973932
639	N-linked_Glycosylation	LTHGASVNWTIEYND ECCCCCEEEEEEECC	27.90	-
740	Ubiquitination	LRRRTVVKEPLLPPD HHHCCCCCCCCCCCC	49.64	-
750	Phosphorylation	LLPPDDDTRDNVYYY CCCCCCCCCCCEEEE	47.09	28507225
755	Phosphorylation	DDTRDNVYYYDEEGG CCCCCCEEEECCCCC	11.54	22817900
756	Phosphorylation	DTRDNVYYYDEEGGG CCCCCEEEECCCCCC	10.52	22817900
757	Phosphorylation	TRDNVYYYDEEGGGE CCCCEEEECCCCCCC	10.13	-
772	Phosphorylation	EDQDFDLSQLHRGLD CCCCCCHHHHHCCCC	32.32	-
795	Phosphorylation	DVAPTLMSVPQYRPR CCCCCCCCCCCCCCC	33.48	-
840	Phosphorylation	LVFDYEGSGSEAASL EEEECCCCCCCCCCH	27.49	11348595
842	Phosphorylation	FDYEGSGSEAASLSS EECCCCCCCCCCHHH	26.26	11348595
846	Phosphorylation	GSGSEAASLSSLNSS CCCCCCCCHHHCCCC	35.51	-
848	Phosphorylation	GSEAASLSSLNSSES CCCCCCHHHCCCCCC	30.22	11348595
849	Phosphorylation	SEAASLSSLNSSESD CCCCCHHHCCCCCCC	36.54	22817900
853	Phosphorylation	SLSSLNSSESDQDQD CHHHCCCCCCCCCCC	39.79	22817900
855	Phosphorylation	SSLNSSESDQDQDYD HHCCCCCCCCCCCHH	42.38	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
755	Y	Phosphorylation	Kinase	SRC	P05480	Uniprot
756	Y	Phosphorylation	Kinase	SRC	P05480	Uniprot
757	Y	Phosphorylation	Kinase	SRC	P05480	Uniprot
840	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
840	S	Phosphorylation	Kinase	CSK21	Q60737	PhosphoELM
842	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
848	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
849	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
849	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
849	S	Phosphorylation	Kinase	GSK-3_GROUP	-	PhosphoELM
853	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
853	S	Phosphorylation	Kinase	CSK21	Q60737	PhosphoELM
855	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
855	S	Phosphorylation	Kinase	CSK21	Q60737	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	Cbll1	Q9JIY2	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
639	N	Glycosylation		-
N-glycosylation at Asn-639 is essential for expression, folding and trafficking.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CADH1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_MOUSE	Ctnnb1	physical	12695331
DNMT1_MOUSE	Dnmt1	physical	15899874
P85A_MOUSE	Pik3r1	physical	15192701
ARVC_MOUSE	Arvcf	physical	11719554
CTND1_MOUSE	Ctnnd1	physical	22693575
NUMB_MOUSE	Numb	physical	17589506
SKP2_MOUSE	Skp2	physical	24115035
CTND1_MOUSE	Ctnnd1	physical	19726720
CTNA1_MOUSE	Ctnna1	physical	19726720
CTNB1_MOUSE	Ctnnb1	physical	19726720
ARVC_HUMAN	ARVCF	physical	26496610
CAD10_HUMAN	CDH10	physical	26496610
CTNA1_HUMAN	CTNNA1	physical	26496610
CTNB1_HUMAN	CTNNB1	physical	26496610
CTND1_HUMAN	CTNND1	physical	26496610
ECHB_HUMAN	HADHB	physical	26496610
TZAP_HUMAN	ZBTB48	physical	26496610
HMGB2_HUMAN	HMGB2	physical	26496610
PLAK_HUMAN	JUP	physical	26496610
AAAT_HUMAN	SLC1A5	physical	26496610
TBP_HUMAN	TBP	physical	26496610
PKP4_HUMAN	PKP4	physical	26496610
LPPRC_HUMAN	LRPPRC	physical	26496610
MACF1_HUMAN	MACF1	physical	26496610
ERBIN_HUMAN	ERBB2IP	physical	26496610
KLHL7_HUMAN	KLHL7	physical	26496610
RHG21_HUMAN	ARHGAP21	physical	26496610
SLIRP_HUMAN	SLIRP	physical	26496610
LZTS2_HUMAN	LZTS2	physical	26496610
PRC2B_HUMAN	PRRC2B	physical	26496610
PCX3_HUMAN	PCNXL3	physical	26496610
MROH1_HUMAN	MROH1	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CADH1_MOUSE

Related Literatures of Post-Translational Modification

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