CAD10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAD10_HUMAN
• UniProt AC: Q9Y6N8
• Protein Name: Cadherin-10
• Gene Name: CDH10
• Organism: Homo sapiens (Human).
• Sequence Length: 788
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types..
• Protein Sequence: MTIHQFLLLFLFWVCLPHFCSPEIMFRRTPVPQQRILSSRVPRSDGKILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKEHDLDPTAPPYDSLATYAYEGNDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	PEIMFRRTPVPQQRI HHHHHCCCCCCHHHH	25.12	-
38	Phosphorylation	VPQQRILSSRVPRSD CCHHHHHHCCCCCCC	17.46	24719451
39	Phosphorylation	PQQRILSSRVPRSDG CHHHHHHCCCCCCCC	33.57	24719451
44	Phosphorylation	LSSRVPRSDGKILHR HHCCCCCCCCCCCCH	44.65	-
91	Phosphorylation	KGDGSLKYILSGDGA CCCCCEEEEEECCCC	16.64	25278378
94	Phosphorylation	GSLKYILSGDGAGTL CCEEEEEECCCCCEE	25.86	25278378
100	Phosphorylation	LSGDGAGTLFIIDEK EECCCCCEEEEEECC	20.26	25278378
126	Phosphorylation	REEKAFYTLRAQAIN HHHHHHHHHHHHHHH	11.87	24719451
256	N-linked_Glycosylation	LSGTTTVNITLTDVN CCCCEEEEEEEEECC	21.31	UniProtKB CARBOHYD
344	Phosphorylation	DYESRRLYTLKVEAE CCCCCCEEEEEEEEE	14.28	22817900
360	Phosphorylation	THVDPRFYYLGPFKD CCCCCCEEEECCCCC	10.08	22817900
361	Phosphorylation	HVDPRFYYLGPFKDT CCCCCEEEECCCCCC	11.50	22817900
421	Phosphorylation	ISSPIRFSLDRHTDL CCCCEEEEECCCCCH	21.36	24719451
438	N-linked_Glycosylation	IFNIHSGNGSLYTSK HEEEECCCCCEEECC	39.64	UniProtKB CARBOHYD
444	Phosphorylation	GNGSLYTSKPLDREL CCCCEEECCCCCHHH	20.79	24719451
456	N-linked_Glycosylation	RELSQWHNLTVIAAE HHHHHHCCEEEEEEE	34.15	UniProtKB CARBOHYD
534	N-linked_Glycosylation	SLAAVNPNFTVQDNE EEEEECCCCEEECCC	39.76	UniProtKB CARBOHYD
646	Phosphorylation	KKEPLILSKEDIRDN CCCCCEECHHHHHHC	27.31	26657352
667	Phosphorylation	EGGGEEDTQAFDIGT CCCCCCCCCCEECCC	25.69	28857561
674	Phosphorylation	TQAFDIGTLRNPAAI CCCEECCCCCCHHHH	23.91	30576142
694	Phosphorylation	RRDIIPETLFIPRRT CCCCCCCCCCCCCCC	22.93	20068231
701	Phosphorylation	TLFIPRRTPTAPDNT CCCCCCCCCCCCCCC	26.69	25307156
726	Phosphorylation	KEHDLDPTAPPYDSL HHCCCCCCCCCCCHH	52.00	30576142
747	Phosphorylation	GNDSIAESLSSLESG CCCHHHHHHHHCCCC	25.24	30576142
753	Phosphorylation	ESLSSLESGTTEGDQ HHHHHCCCCCCCCCC	46.89	30576142
779	Phosphorylation	FNKLAEMYGGGESDK HHHHHHHHCCCCCCC	12.25	29691806
784	Phosphorylation	EMYGGGESDKDS--- HHHCCCCCCCCC---	53.92	23927012
788	Phosphorylation	GGESDKDS------- CCCCCCCC-------	48.11	29691806

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAD10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAD10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAD10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN6_HUMAN	COPS6	physical	16169070
PTN_HUMAN	PTN	physical	16169070
PLAK_HUMAN	JUP	physical	24722188

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-784, AND MASSSPECTROMETRY.
PubMed: 18669648