MROH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MROH1_HUMAN
• UniProt AC: Q8NDA8
• Protein Name: Maestro heat-like repeat-containing protein family member 1
• Gene Name: MROH1
• Organism: Homo sapiens (Human).
• Sequence Length: 1641
• Protein Sequence: MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIILLASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDTVRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGILALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDTSNERTRVGTLQVVRHVINSAAAQMEDKKPFILSSMRLPLLDTNSKVKRAVVQVISAMAHHGYLEQPGGEAMIEYIVQQCALPPEQEPEKPGPGSKDPKADSVRAISVRTLYLVSTTVDRMSHVLWPYLLQFLTPVRFTGALTPLCRSLVHLAQKRQEAGADAFLIQYDAHASLPSPYAVTGRLLVVSSSPYLGDGRGAAALRLLSVLHPNIHPLLGQHWETTVPLLLGYLDEHTEETLPQEEWEEKLLMFLRDTLAIISDNAWICQLSLELCRQLPCYDEAPQEKNFLYKCIGTTLGAASSKEVVRKHLQELLETARYQEEAEREGLACCFGICAISHLEDTLAQLEDFVRSEVFRKSIGILNIFKDRSENEVEKVKSALILCYGHVAARAPRELVLAKVESDILRNICQHFSTKVLGIKVETKDPALKLCLVQSVCMVSRAICSSTQAGSFHFTRKAELVAQMMEFIRAEPPDSLRTPIRKKAMLTCTYLVSVEPALDEQARADVIHGCLHSIMALLPEPKEEDGGCQKSLYLETLHALEDLLTSLLQRNMTPQGLQIMIEHLSPWIKSPRGHERARALGLSALLLRYFLEHLRVSALVPFHNLGLLIGLFSPRCADLWPATRQEAVDCVYSLLYLQLGYEGFSRDYRDDVAERLLSLKDGLVHPDPAILFHTCHSVGQIIAKRLPPDQLISLLLTMFEALGDPEKNCSRAATVMINCLLQERGGVLQEKVPEIVSVLRSKLQEAQGEHVLPAAQHSVYLLATQHCAAVVSSLLGSPLPLDSHTCMLWRALAVEPRLAAQVLGLLLEKMSRDVPFKESRAFLLGRTPDRVATLLPLSATCALFEVMSTPAAGPAVLELYPQLFVVLLLRVSCTVGVQLPRNLQAQERRGASPALATRNLEPCSSAVDTLRSMLLRSGSEDVVQRMDLEGGWELLRTSAGHEEGATRLARAMAEHAGPRLPLVLKTLACTHSSAYENQRVTTTAFLAELLNSNVANDLMLLDSLLESLAARQKDTCASVRRLVLRGLANLASGCPDKVRTHGPQLLTAMIGGLDDGDNPHSPVALEAMLGLARLVHLVESWDLRSGLLHVAIRIRPFFDSEKMEFRTASIRLFGHLNKVCHGDCEDVFLDQVVGGLAPLLLHLQDPQATVASACRFALRMCGPNLACEELSAAFQKHLQEGRALHFGEFLNTTCKHLMHHFPDLLGRLLTTCLFYFKSSWENVRAAAPLFTGFLVLHSEPRQQPQVDLDQLIAALQILLKDPAPEVRTRAAEALGRLVKLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTESSMKKL ------CCHHHHHHH		-
4	Phosphorylation	----MTESSMKKLAS ----CCHHHHHHHHH		30387612
11	Phosphorylation	SSMKKLASTLLDAIT HHHHHHHHHHHHHHH		30108239
12	Phosphorylation	SMKKLASTLLDAITD HHHHHHHHHHHHHHC		30108239
18	Phosphorylation	STLLDAITDKDPLVQ HHHHHHHHCCCHHHH		30387612
30 (in isoform 6)	Ubiquitination	-		21906983
53 (in isoform 3)	Ubiquitination	-		21906983
56	Ubiquitination	EYLRQHDKLAHPYRA HHHHHHCCCCCHHHH		-
75	Phosphorylation	AMERVLSSRASELDK HHHHHHHHCCHHCCC		24719451
78	Phosphorylation	RVLSSRASELDKDTA HHHHHCCHHCCCCHH		24719451
86	Phosphorylation	ELDKDTASTIILLAS HCCCCHHHHHHHHHC		22210691
87	Phosphorylation	LDKDTASTIILLASS CCCCHHHHHHHHHCC		22210691
93	Phosphorylation	STIILLASSEMTKTK HHHHHHHCCCCCCCC		24719451
94	Phosphorylation	TIILLASSEMTKTKD HHHHHHCCCCCCCCC		19845377
98 (in isoform 1)	Ubiquitination	-		21890473
98 (in isoform 2)	Ubiquitination	-		21890473
98 (in isoform 4)	Ubiquitination	-		21906983
98 (in isoform 5)	Ubiquitination	-		21906983
98 (in isoform 7)	Ubiquitination	-		21906983
98	Ubiquitination	LASSEMTKTKDLVWD HHCCCCCCCCCCCCC		21906983
99	Phosphorylation	ASSEMTKTKDLVWDW HCCCCCCCCCCCCCH		24719451
131	Methylation	KVMEELLRRLHPGTL HHHHHHHHHHCCCCC		-
139 (in isoform 3)	Ubiquitination	-		21906983
256	Phosphorylation	PMSHLLPSERLEEQL CHHHHCCHHHHHHHH		24719451
276	Ubiquitination	GILALYKKHAETFYL HHHHHHHHHHHHHHH		-
396 (in isoform 4)	Phosphorylation	-		24719451
493	Phosphorylation	PYLLQFLTPVRFTGA HHHHHHHCCCCCCCC		21130716
498	Phosphorylation	FLTPVRFTGALTPLC HHCCCCCCCCHHHHH		17924679
502	Phosphorylation	VRFTGALTPLCRSLV CCCCCCHHHHHHHHH		17924679
514	Ubiquitination	SLVHLAQKRQEAGAD HHHHHHHHHHHCCCC		-
551	Phosphorylation	LVVSSSPYLGDGRGA EEEECCCCCCCCHHH		-
645	Ubiquitination	YDEAPQEKNFLYKCI CCCCCCCCCCHHHHH		-
650	Ubiquitination	QEKNFLYKCIGTTLG CCCCCHHHHHHHHHC		-
662	Ubiquitination	TLGAASSKEVVRKHL HHCCCCCHHHHHHHH		-
667	Ubiquitination	SSKEVVRKHLQELLE CCHHHHHHHHHHHHH		-
717	Ubiquitination	VRSEVFRKSIGILNI HHHHHHHHHHHHHHH		21890473
717 (in isoform 1)	Ubiquitination	-		21890473
717 (in isoform 2)	Ubiquitination	-		21890473
718	Phosphorylation	RSEVFRKSIGILNIF HHHHHHHHHHHHHHH		28348404
726 (in isoform 1)	Ubiquitination	-		21890473
726 (in isoform 2)	Ubiquitination	-		21890473
726	Ubiquitination	IGILNIFKDRSENEV HHHHHHHCCCCCCHH		21906983
759 (in isoform 1)	Ubiquitination	-		21890473
759 (in isoform 2)	Ubiquitination	-		21890473
759	Ubiquitination	PRELVLAKVESDILR CHHHHHHHHHHHHHH		21906983
773 (in isoform 2)	Phosphorylation	-		30266825
774 (in isoform 2)	Phosphorylation	-		30266825
817	Ubiquitination	GSFHFTRKAELVAQM CCCCHHHHHHHHHHH		-
929	Ubiquitination	EHLSPWIKSPRGHER HHHHHHCCCCCHHHH		-
930	Phosphorylation	HLSPWIKSPRGHERA HHHHHCCCCCHHHHH		24719451
949	Phosphorylation	LSALLLRYFLEHLRV HHHHHHHHHHHHHCH		26552605
1018	Phosphorylation	DVAERLLSLKDGLVH HHHHHHHCCCCCCCC		24719451
1020	Ubiquitination	AERLLSLKDGLVHPD HHHHHCCCCCCCCCC		-
1082 (in isoform 2)	Ubiquitination	-		21890473
1091	Ubiquitination	RGGVLQEKVPEIVSV CCCCHHHHHHHHHHH		21906983
1091 (in isoform 1)	Ubiquitination	-		21890473
1097	Phosphorylation	EKVPEIVSVLRSKLQ HHHHHHHHHHHHHHH		-
1169	Ubiquitination	VLGLLLEKMSRDVPF HHHHHHHHHCCCCCH		-
1177 (in isoform 1)	Ubiquitination	-		21890473
1177	Ubiquitination	MSRDVPFKESRAFLL HCCCCCHHHHHHHHC		2190698
1187	Phosphorylation	RAFLLGRTPDRVATL HHHHCCCCHHHHHHH		28555341
1252	Phosphorylation	AQERRGASPALATRN HHHHCCCCCCHHHCC		23312004
1264	Phosphorylation	TRNLEPCSSAVDTLR HCCCCCCCHHHHHHH		25693802
1265	Phosphorylation	RNLEPCSSAVDTLRS CCCCCCCHHHHHHHH		25693802
1269	Phosphorylation	PCSSAVDTLRSMLLR CCCHHHHHHHHHHHH		25693802
1341	Phosphorylation	AYENQRVTTTAFLAE HHCCCCHHHHHHHHH		24043423
1342	Phosphorylation	YENQRVTTTAFLAEL HCCCCHHHHHHHHHH		24043423
1343	Phosphorylation	ENQRVTTTAFLAELL CCCCHHHHHHHHHHH		24043423
1352	Phosphorylation	FLAELLNSNVANDLM HHHHHHCCCCHHHHH		24043423
1363	Phosphorylation	NDLMLLDSLLESLAA HHHHHHHHHHHHHHH		24043423
1367	Phosphorylation	LLDSLLESLAARQKD HHHHHHHHHHHHCCC		24043423
1397	Ubiquitination	LASGCPDKVRTHGPQ HHCCCCHHHHHCCHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MROH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MROH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MROH1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MROH1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.