| UniProt ID | TZAP_HUMAN | |
|---|---|---|
| UniProt AC | P10074 | |
| Protein Name | Telomere zinc finger-associated protein {ECO:0000303|PubMed:28082411} | |
| Gene Name | ZBTB48 {ECO:0000312|HGNC:HGNC:4930} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 688 | |
| Subcellular Localization | Nucleus . Chromosome, telomere . Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, co | |
| Protein Description | Telomere-binding protein that acts as a regulator of telomere length. [PubMed: 28500257] | |
| Protein Sequence | MDGSFVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQSFKPKTSVGQAAGGQSGLGPPASQNVNSHVKEPAGLEEEEVSRTLGLVPRDQEPRGSHSPQRPQLHSPAQSEGPSSLCGKLKQALKPCPLEDKKPEDCKVPPRPLEAEGAQLQGGSNEWEVVVQVEDDGDGDYMSEPEAVLTRRKSNVIRKPCAAEPALSAGSLAAEPAENRKGTAVPVECPTCHKKFLSKYYLKVHNRKHTGEKPFECPKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFRRRMELRVHMVSHTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGEKLFVCEECGHRASSRNGLQMHIKAKHRNERPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQASLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAHLRRHMEIHDRVENYNPRQRKLRNLIIEDEKMVVVALQPPAELEVGSAEVIVESLAQGGLASQLPGQRLCAEESFTGPGVLEPSLIITAAVPEDCDT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Ubiquitination | RVLQELNKQREKGQY HHHHHHHHHHHCCCC | - | ||
| 119 | Phosphorylation | QSFKPKTSVGQAAGG HHCCCCCCCCCCCCC | 28555341 | ||
| 143 | Sumoylation | QNVNSHVKEPAGLEE HCHHHHCCCCCCCCH | 28112733 | ||
| 169 | Phosphorylation | RDQEPRGSHSPQRPQ CCCCCCCCCCCCCCC | 23401153 | ||
| 171 | Phosphorylation | QEPRGSHSPQRPQLH CCCCCCCCCCCCCCC | 23401153 | ||
| 179 | Phosphorylation | PQRPQLHSPAQSEGP CCCCCCCCCCCCCCC | 30266825 | ||
| 183 | Phosphorylation | QLHSPAQSEGPSSLC CCCCCCCCCCCCHHH | 23927012 | ||
| 187 | Phosphorylation | PAQSEGPSSLCGKLK CCCCCCCCHHHHHHH | 23663014 | ||
| 188 | Phosphorylation | AQSEGPSSLCGKLKQ CCCCCCCHHHHHHHH | 23663014 | ||
| 192 | Acetylation | GPSSLCGKLKQALKP CCCHHHHHHHHHHCC | 25953088 | ||
| 258 | Phosphorylation | AVLTRRKSNVIRKPC HHEECCCCCCCCCCC | 25159151 | ||
| 263 | Sumoylation | RKSNVIRKPCAAEPA CCCCCCCCCCCCCCC | 28112733 | ||
| 295 | Phosphorylation | AVPVECPTCHKKFLS CCEEECCCCCHHHHH | 25159151 | ||
| 314 | Phosphorylation | KVHNRKHTGEKPFEC CCCCCCCCCCCCCCC | 23532336 | ||
| 371 | Phosphorylation | ELRVHMVSHTGEMPY HEEEEEEECCCCCCC | 24719451 | ||
| 373 | Phosphorylation | RVHMVSHTGEMPYKC EEEEEECCCCCCCCC | 23917254 | ||
| 486 | Phosphorylation | NLNMHLRTHTGEKPF CCEEEEEECCCCCCE | - | ||
| 488 | Phosphorylation | NMHLRTHTGEKPFQC EEEEEECCCCCCEEE | - | ||
| 514 | Phosphorylation | SLDKHNRTHTGERPF HHHCCCCCCCCCCCC | 21712546 | ||
| 516 | Phosphorylation | DKHNRTHTGERPFSC HCCCCCCCCCCCCCC | 30576142 | ||
| 560 | Ubiquitination | QICGKTFKAVEQLRV HHCCCHHHHHHHHHH | - | ||
| 577 | Sumoylation | RRHKGVRKFECTECG HHCCCCCEEEECCCC | - | ||
| 577 | Sumoylation | RRHKGVRKFECTECG HHCCCCCEEEECCCC | - | ||
| 585 | Phosphorylation | FECTECGYKFTRQAH EEECCCCCHHHHHHH | - | ||
| 602 | Methylation | RHMEIHDRVENYNPR HHHHHHHHHHHCCHH | 12018491 | ||
| 609 | Methylation | RVENYNPRQRKLRNL HHHHCCHHHHHHHHH | 12018499 | ||
| 611 | Methylation | ENYNPRQRKLRNLII HHCCHHHHHHHHHEE | 12018507 | ||
| 679 | Phosphorylation | LEPSLIITAAVPEDC CCCEEEEEEECCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TZAP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TZAP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TZAP_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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