ZSC25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZSC25_HUMAN
• UniProt AC: Q6NSZ9
• Protein Name: Zinc finger and SCAN domain-containing protein 25
• Gene Name: ZSCAN25
• Organism: Homo sapiens (Human).
• Sequence Length: 544
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MLKEHPEMAEAPQQQLGIPVVKLEKELPWGRGREDPSPETFRLRFRQFRYQEAAGPQEALRELQELCRRWLRPELHTKEQILELLVLEQFLTILPREFYAWIREHGPESGKALAAMVEDLTERALEAKAVPCHRQGEQEETALCRGAWEPGIQLGPVEVKPEWGMPPGEGVQGPDPGTEEQLSQDPGDETRAFQEQALPVLQAGPGLPAVNPRDQEMAAGFFTAGSQGLGPFKDMALAFPEEEWRHVTPAQIDCFGEYVEPQDCRVSPGGGSKEKEAKPPQEDLKGALVALTSERFGEASLQGPGLGRVCEQEPGGPAGSAPGLPPPQHGAIPLPDEVKTHSSFWKPFQCPECGKGFSRSSNLVRHQRTHEEKSYGCVECGKGFTLREYLMKHQRTHLGKRPYVCSECWKTFSQRHHLEVHQRSHTGEKPYKCGDCWKSFSRRQHLQVHRRTHTGEKPYTCECGKSFSRNANLAVHRRAHTGEKPYGCQVCGKRFSKGERLVRHQRIHTGEKPYHCPACGRSFNQRSILNRHQKTQHRQEPLVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Sumoylation	-----MLKEHPEMAE -----CCCCCHHHHH		28112733
22	Sumoylation	QLGIPVVKLEKELPW HHCCCEEEEECCCCC		28112733
22	Sumoylation	QLGIPVVKLEKELPW HHCCCEEEEECCCCC		-
77	Phosphorylation	WLRPELHTKEQILEL HHCHHHCCHHHHHHH		-
111	Ubiquitination	EHGPESGKALAAMVE HHCCCCHHHHHHHHH		-
128	Ubiquitination	TERALEAKAVPCHRQ HHHHHHHHCCCCCCC		29967540
128	Sumoylation	TERALEAKAVPCHRQ HHHHHHHHCCCCCCC		28112733
248	Phosphorylation	EEEWRHVTPAQIDCF HHHHCCCCHHHCCCC		23312004
258	Phosphorylation	QIDCFGEYVEPQDCR HCCCCCCCCCCCCCE		28796482
267	Phosphorylation	EPQDCRVSPGGGSKE CCCCCEECCCCCCCC		23401153
272	Phosphorylation	RVSPGGGSKEKEAKP EECCCCCCCCCCCCC		28450419
278	Sumoylation	GSKEKEAKPPQEDLK CCCCCCCCCCHHHHH		28112733
285	Sumoylation	KPPQEDLKGALVALT CCCHHHHHHHHHHHH		28112733
285	Ubiquitination	KPPQEDLKGALVALT CCCHHHHHHHHHHHH		29967540
300	Phosphorylation	SERFGEASLQGPGLG CCCHHCHHHCCCCCC		23401153
361	Phosphorylation	GKGFSRSSNLVRHQR CCCCCCCCCCCCCCC		24719451
385	Phosphorylation	VECGKGFTLREYLMK EECCCCCCHHHHHHH		24719451
426	Phosphorylation	EVHQRSHTGEKPYKC CHHCCCCCCCCCEEC		24719451
441	Phosphorylation	GDCWKSFSRRQHLQV CHHHHHHCHHHCEEE		17081983
452	Phosphorylation	HLQVHRRTHTGEKPY CEEEECCCCCCCCCE		-
454	Phosphorylation	QVHRRTHTGEKPYTC EEECCCCCCCCCEEE		-
468	Phosphorylation	CECGKSFSRNANLAV ECCCCCCCCCCCEEE		17081983
481	Phosphorylation	AVHRRAHTGEKPYGC EEECCCCCCCCCCCC		-
509	Phosphorylation	VRHQRIHTGEKPYHC HEECEECCCCCCCCC		28111955
522	Phosphorylation	HCPACGRSFNQRSIL CCCCCCCCCCHHHHH		28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZSC25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZSC25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZSC25_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZSC25_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.