ARVC_MOUSE - dbPTM
ARVC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARVC_MOUSE
UniProt AC P98203
Protein Name Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog
Gene Name Arvcf
Organism Mus musculus (Mouse).
Sequence Length 962
Subcellular Localization
Protein Description Involved in protein-protein interactions at adherens junctions..
Protein Sequence MEDCNVHSAASILASVKEQEARFERLTRALEQERRHVALQLERAQQPGMSSGGMVGSGQPLPMAWQQLVLQEQSPGSQASLATMPEAPEVLEETVTVEEDPGTPTSHVSIVTSEDGTTRRTETKVTKTVKTVTTRTVRQVPLGPDGLPLLDGGPPLGSFADGPLDRHYLLRGGGGPAATLSRTYHSSGGGFPDGPESRDIPSYGSLSRGLGVRPPRTGLLGPGPGDGCFTLPGRREAFPMGSESGPPSGRSLPEHFQAEPYGLEDDTRSLAADDEGGPDLEPDYSTATRRRPEYGRGLRARAFEDTADDAGELIEERPPFPAATAPLAQPERGSLGSLDRVVRRSPSVDSTRKEPRWRDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGIKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADRYQEAEPGIPGSTTSQRRRKDDASCFGGKKAKEEWFHQGKKDAEMDRNFDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWTWATYIRATVRKERGLPVLVELLQSETDKVVRAVAIALRNLSLDQRNKDLIGSYAMTELVRNVRNAQAPAHPSAHLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGVPALVALVASSQSVREAKAASHVLQTVWSYKELRGALQRDGWTKSRFQSASTAKGPKGTPSSGGFDDSTLPLVDKSLDGEKSNTRDVIPMDTLGPDGYATVDRRERRTLGSDSTGDTSEKELLRPDPGRKAPPPGPSRPSVRLVDAVGDTKPQPVDSWV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
103PhosphorylationTVEEDPGTPTSHVSI
EEECCCCCCCCCEEE		28.87-
105PhosphorylationEEDPGTPTSHVSIVT
ECCCCCCCCCEEEEE		31.16-
126PhosphorylationRRTETKVTKTVKTVT
EEEEEEEEEEEEEEE		23.6622418434
168PhosphorylationDGPLDRHYLLRGGGG
CCCCCCCCHHCCCCC		14.34-
171MethylationLDRHYLLRGGGGPAA
CCCCCHHCCCCCCCH		38.8324129315
171DimethylationLDRHYLLRGGGGPAA
CCCCCHHCCCCCCCH		38.83-
179PhosphorylationGGGGPAATLSRTYHS
CCCCCCHHCCEEECC		27.6326824392
181PhosphorylationGGPAATLSRTYHSSG
CCCCHHCCEEECCCC		20.44-
183PhosphorylationPAATLSRTYHSSGGG
CCHHCCEEECCCCCC		23.3929472430
184PhosphorylationAATLSRTYHSSGGGF
CHHCCEEECCCCCCC		9.9029472430
186PhosphorylationTLSRTYHSSGGGFPD
HCCEEECCCCCCCCC		21.9226643407
187PhosphorylationLSRTYHSSGGGFPDG
CCEEECCCCCCCCCC		28.3026643407
197PhosphorylationGFPDGPESRDIPSYG
CCCCCCCCCCCCCCC		38.0829472430
202PhosphorylationPESRDIPSYGSLSRG
CCCCCCCCCCCCCCC		42.3225619855
203PhosphorylationESRDIPSYGSLSRGL
CCCCCCCCCCCCCCC		12.8425619855
205PhosphorylationRDIPSYGSLSRGLGV
CCCCCCCCCCCCCCC		18.2226824392
207PhosphorylationIPSYGSLSRGLGVRP
CCCCCCCCCCCCCCC		26.4627742792
242PhosphorylationREAFPMGSESGPPSG
CCCCCCCCCCCCCCC		23.4929472430
244PhosphorylationAFPMGSESGPPSGRS
CCCCCCCCCCCCCCC		59.2929472430
248PhosphorylationGSESGPPSGRSLPEH
CCCCCCCCCCCCCHH		50.3928285833
251PhosphorylationSGPPSGRSLPEHFQA
CCCCCCCCCCHHHCC		52.3725521595
261PhosphorylationEHFQAEPYGLEDDTR
HHHCCCCCCCCCCCC		26.3326239621
267PhosphorylationPYGLEDDTRSLAADD
CCCCCCCCCCCCCCC		34.1826239621
269PhosphorylationGLEDDTRSLAADDEG
CCCCCCCCCCCCCCC		25.1825521595
284PhosphorylationGPDLEPDYSTATRRR
CCCCCCCCCCCCCCC		20.7323984901
285PhosphorylationPDLEPDYSTATRRRP
CCCCCCCCCCCCCCC		20.9525619855
286PhosphorylationDLEPDYSTATRRRPE
CCCCCCCCCCCCCCC		26.3125521595
324PhosphorylationRPPFPAATAPLAQPE
CCCCCCCCCCCCCCC		30.8022324799
334PhosphorylationLAQPERGSLGSLDRV
CCCCCCCCCCCHHHH		35.4625521595
337PhosphorylationPERGSLGSLDRVVRR
CCCCCCCCHHHHHHC		32.1827087446
345PhosphorylationLDRVVRRSPSVDSTR
HHHHHHCCCCCCCCC		15.8029895711
347PhosphorylationRVVRRSPSVDSTRKE
HHHHCCCCCCCCCCC		39.5424899341
350PhosphorylationRRSPSVDSTRKEPRW
HCCCCCCCCCCCCCC		28.1424899341
351PhosphorylationRSPSVDSTRKEPRWR
CCCCCCCCCCCCCCC		41.1023737553
447UbiquitinationAIRDCGGVPALVRLL
HHHHCCHHHHHHHHH		1.2027667366
511UbiquitinationREPNEDSKPRDAEWT
CCCCCCCCCCCCCCE		57.2927667366
606PhosphorylationPGIPGSTTSQRRRKD
CCCCCCCCCHHHCCC		25.2629899451
607PhosphorylationGIPGSTTSQRRRKDD
CCCCCCCCHHHCCCC		23.06-
643PhosphorylationEMDRNFDTLDLPKRT
HHCCCCCCCCCCCHH		20.3125521595
862PhosphorylationTAKGPKGTPSSGGFD
CCCCCCCCCCCCCCC		26.5625521595
864PhosphorylationKGPKGTPSSGGFDDS
CCCCCCCCCCCCCCC		41.2626239621
865PhosphorylationGPKGTPSSGGFDDST
CCCCCCCCCCCCCCC		44.1126239621
871PhosphorylationSSGGFDDSTLPLVDK
CCCCCCCCCCCCCCC		33.4226239621
872PhosphorylationSGGFDDSTLPLVDKS
CCCCCCCCCCCCCCC		39.1127742792
879PhosphorylationTLPLVDKSLDGEKSN
CCCCCCCCCCCCCCC		27.5129899451
901PhosphorylationDTLGPDGYATVDRRE
HHCCCCCCEEECHHH		13.3823140645
903PhosphorylationLGPDGYATVDRRERR
CCCCCCEEECHHHHH		17.9219060867
911PhosphorylationVDRRERRTLGSDSTG
ECHHHHHCCCCCCCC		41.5129899451
914PhosphorylationRERRTLGSDSTGDTS
HHHHCCCCCCCCCCC		31.3420139300
916PhosphorylationRRTLGSDSTGDTSEK
HHCCCCCCCCCCCHH		35.6725521595
917PhosphorylationRTLGSDSTGDTSEKE
HCCCCCCCCCCCHHH		44.0327742792
920PhosphorylationGSDSTGDTSEKELLR
CCCCCCCCCHHHHCC		39.8827742792
921PhosphorylationSDSTGDTSEKELLRP
CCCCCCCCHHHHCCC		51.9527742792
923UbiquitinationSTGDTSEKELLRPDP
CCCCCCHHHHCCCCC		54.1222790023
940PhosphorylationKAPPPGPSRPSVRLV
CCCCCCCCCCCEEEE		63.8429899451
943PhosphorylationPPGPSRPSVRLVDAV
CCCCCCCCEEEEECC		20.8229899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARVC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARVC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARVC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ARVC_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARVC_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, AND MASSSPECTROMETRY.
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, AND MASSSPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-643, AND MASSSPECTROMETRY.

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