IQEC3_MOUSE - dbPTM
IQEC3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IQEC3_MOUSE
UniProt AC Q3TES0
Protein Name IQ motif and SEC7 domain-containing protein 3
Gene Name Iqsec3
Organism Mus musculus (Mouse).
Sequence Length 1195
Subcellular Localization Cytoplasm.
Protein Description Acts as a guanine nucleotide exchange factor (GEF) for ARF1..
Protein Sequence MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLLQAQPPPGLVPPPPSAPLPAPAVTAPAAAAAQEPLQDHGQLIPASPEPPLQHHGQLLAQPQPAPSSRVQTPQSPHQHPVAPGAIADKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPENETVLHQFCCPAADTEQKPACSDLASQSDGSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGRQQPALATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRAPTAESLVAEKALLEGCGLLGLPLGRSPSLPPTFAGSLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAAAREPESGPGSGDEAGGLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTAQATAEPAAAQAEQEDTADQEVSEVPASEQMDPPSEDSEAAESRAQSAQEPAVAQAVVEEAVATEAEEEEEGAKQAGKGAEAEGGDNSEQLSSSSASTKSAKSSSEASAAASKEALQAVILSLPRYHCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSVRSAGAQGDPQSKQGSPTAKREAMAGEKAAESSGEVSIHNRLQTSQHSPKLGVERGAPAPSPPTSPPPLPPDPQPSPLREQPPPLPLPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYASSSSDSCGSTPLRGPGSPVKVIHQPPLPPPPPPYNHPHQFCPPGSMLLRRRYSSGSRSLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
129PhosphorylationAPSSRVQTPQSPHQH
CCCCCCCCCCCCCCC		22.0425521595
132PhosphorylationSRVQTPQSPHQHPVA
CCCCCCCCCCCCCCC		26.0822324799
166PhosphorylationGALLQHASPAALGKG
HHHHHHCCHHHCCCC		16.9729899451
176PhosphorylationALGKGVLSRRPENET
HCCCCHHCCCCCCCC		24.6824719451
256PhosphorylationERPGAVGSPRAGPLR
CCCCCCCCCCCCCCC		12.4725521595
266PhosphorylationAGPLRAASPGRQQPA
CCCCCCCCCCCCCCH		27.2329899451
306PhosphorylationIEMLEHKYGGHLVSR
HHHHHHHHCCCHHHH		30.19-
312PhosphorylationKYGGHLVSRRAACTI
HHCCCHHHHHHHHHH		23.55-
349PhosphorylationSRLPRRISLRKVRAP
CCCCCCCCCCCCCCC		21.9523140645
357PhosphorylationLRKVRAPTAESLVAE
CCCCCCCCHHHHHHH		41.9122817900
360PhosphorylationVRAPTAESLVAEKAL
CCCCCHHHHHHHHHH		26.1929899451
383PhosphorylationLPLGRSPSLPPTFAG
CCCCCCCCCCCCCCC		55.5529899451
409PhosphorylationQVQSLAKSIDDALST
HHHHHHHHHHHHHHH		26.1629899451
415PhosphorylationKSIDDALSTWSLKTM
HHHHHHHHHHHHHHH		29.56-
461PhosphorylationEPESGPGSGDEAGGL
CCCCCCCCCCCCCCC		46.3225521595
574PhosphorylationVVEEAVATEAEEEEE
HHHHHHHHHHHHHHH		29.18-
598PhosphorylationEAEGGDNSEQLSSSS
CCCCCCCHHHHCCCC		31.3129899451
605PhosphorylationSEQLSSSSASTKSAK
HHHHCCCCCCCCHHC		28.3429899451
607PhosphorylationQLSSSSASTKSAKSS
HHCCCCCCCCHHCCC		38.0129899451
613PhosphorylationASTKSAKSSSEASAA
CCCCHHCCCHHHHHH		38.5223737553
614PhosphorylationSTKSAKSSSEASAAA
CCCHHCCCHHHHHHH		31.3323737553
615PhosphorylationTKSAKSSSEASAAAS
CCHHCCCHHHHHHHC		44.2523737553
618PhosphorylationAKSSSEASAAASKEA
HCCCHHHHHHHCHHH		17.8723737553
622PhosphorylationSEASAAASKEALQAV
HHHHHHHCHHHHHHH		26.7123737553
632PhosphorylationALQAVILSLPRYHCE
HHHHHHHHCCCCCCC		25.7922817900
643PhosphorylationYHCENPASCRSPTLS
CCCCCCHHCCCCCCC		16.0129899451
646PhosphorylationENPASCRSPTLSTDT
CCCHHCCCCCCCHHH		26.9429899451
648PhosphorylationPASCRSPTLSTDTLR
CHHCCCCCCCHHHHH		34.2929899451
653PhosphorylationSPTLSTDTLRKRLYR
CCCCCHHHHHHHHHH		28.6622817900
917PhosphorylationKLCPKKKSSFTYTFC
HHCCCCCCCCHHHHH		39.2929899451
1003PhosphorylationELEKQQGTKTLSVRS
EHHHHCCCEEEEEEE		19.2724719451
1005PhosphorylationEKQQGTKTLSVRSAG
HHHCCCEEEEEEECC		24.8924719451
1007PhosphorylationQQGTKTLSVRSAGAQ
HCCCEEEEEEECCCC		22.2524719451
1010PhosphorylationTKTLSVRSAGAQGDP
CEEEEEEECCCCCCC		28.9724719451
1023PhosphorylationDPQSKQGSPTAKREA
CCCCCCCCHHHHHHH		19.3116452087
1052PhosphorylationIHNRLQTSQHSPKLG
CCCCCCCCCCCCCCC		16.9723335269
1055PhosphorylationRLQTSQHSPKLGVER
CCCCCCCCCCCCCCC		18.9822817900
1068PhosphorylationERGAPAPSPPTSPPP
CCCCCCCCCCCCCCC		45.6922817900
1071PhosphorylationAPAPSPPTSPPPLPP
CCCCCCCCCCCCCCC		58.1919060867
1072PhosphorylationPAPSPPTSPPPLPPD
CCCCCCCCCCCCCCC		40.9819060867
1083PhosphorylationLPPDPQPSPLREQPP
CCCCCCCCCCCCCCC		31.1723384938
1152PhosphorylationTPLRGPGSPVKVIHQ
CCCCCCCCCCEEEEC		29.6529899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IQEC3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IQEC3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IQEC3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DMD_MOUSEDmdphysical
21198641
MAGI2_MOUSEMagi2physical
21198641
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IQEC3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1023, AND MASSSPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-653, AND MASSSPECTROMETRY.

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