DMD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DMD_MOUSE
• UniProt AC: P11531
• Protein Name: Dystrophin
• Gene Name: Dmd
• Organism: Mus musculus (Mouse).
• Sequence Length: 3678
• Subcellular Localization: Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell junction, synapse, postsynaptic cell membrane . In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to
• Protein Description: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission..
• Protein Sequence: MLWWEEVEDCYEREDVQKKTFTKWINAQFSKFGKQHIDNLFSDLQDGKRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQKNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKTIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTSSWSDGLALNALIHSHRPDLFDWNSVVSQHSATQRLEHAFNIAKCQLGIEKLLDPEDVATTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRTSSKVTREEHFQLHHQMHYSQQITVSLAQGYEQTSSSPKPRFKSYAFTQAAYVATSDSTQSPYPSQHLEAPRDKSLDSSLMETEVNLDSYQTALEEVLSWLLSAEDTLRAQGEISNDVEEVKEQFHAHEGFMMDLTSHQGLVGNVLQLGSQLVGKGKLSEDEEAEVQEQMNLLNSRWECLRVASMEKQSKLHKVLMDLQNQKLKELDDWLTKTEERTKKMEEEPFGPDLEDLKCQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWIVLQDILLKWQHFTEEQCLFSTWLSEKEDAMKNIQTSGFKDQNEMMSSLHKISTLKIDLEKKKPTMEKLSSLNQDLLSALKNKSVTQKMEIWMENFAQRWDNLTQKLEKSSAQISQAVTTTQPSLTQTTVMETVTMVTTREQIMVKHAQEELPPPPPQKKRQITVDSELRKRLDVDITELHSWITRSEAVLQSSEFAVYRKEGNISDLQEKVNAIAREKAEKFRKLQDASRSAQALVEQMANEGVNAESIRQASEQLNSRWTEFCQLLSERVNWLEYQTNIITFYNQLQQLEQMTTTAENLLKTQSTTLSEPTAIKSQLKICKDEVNRLSALQPQIEQLKIQSLQLKEKGQGPMFLDADFVAFTNHFNHIFDGVRAKEKELQTIFDTLPPMRYQETMSSIRTWIQQSESKLSVPYLSVTEYEIMEERLGKLQALQSSLKEQQNGFNYLSDTVKEMAKKAPSEICQKYLSEFEEIEGHWKKLSSQLVESCQKLEEHMNKLRKFQNHIKTLQKWMAEVDVFLKEEWPALGDAEILKKQLKQCRLLVGDIQTIQPSLNSVNEGGQKIKSEAELEFASRLETELRELNTQWDHICRQVYTRKEALKAGLDKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQTAVEEMKRAKEEALQKETKVKLLTETVNSVIAHAPPSAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVELKLKTMENVPAGPEEITEVLESLENLMHHSEENPNQIRLLAQTLTDGGVMDELINEELETFNSRWRELHEEAVRKQKLLEQSIQSAQEIEKSLHLIQESLEFIDKQLAAYITDKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKDANQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLEESKMILDEVKMHLPALETKSVEQEVIQSQLSHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDTELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKAHLKSVTELGESLKMVLGKKETLVEDKLSLLNSNWIAVTSRVEEWLNLLLEYQKHMETFDQNIEQITKWIIHADELLDESEKKKPQQKEDILKRLKAEMNDMRPKVDSTRDQAAKLMANRGDHCRKVVEPQISELNRRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMSEDNEGTVNELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDEIEKKLASLPEPRDERKLKEIDRELQKKKEELNAVRRQAEGLSENGAAMAVEPTQIQLSKRWRQIESNFAQFRRLNFAQIHTLHEETMVVTTEDMPLDVSYVPSTYLTEISHILQALSEVDHLLNTPELCAKDFEDLFKQEESLKNIKDNLQQISGRIDIIHKKKTAALQSATSMEKVKVQEAVAQMDFQGEKLHRMYKERQGRFDRSVEKWRHFHYDMKVFNQWLNEVEQFFKKTQNPENWEHAKYKWYLKELQDGIGQRQAVVRTLNATGEEIIQQSSKTDVNILQEKLGSLSLRWHDICKELAERRKRIEEQKNVLSEFQRDLNEFVLWLEEADNIAITPLGDEQQLKEQLEQVKLLAEELPLRQGILKQLNETGGAVLVSAPIRPEEQDKLEKKLKQTNLQWIKVSRALPEKQGELEVHLKDFRQLEEQLDHLLLWLSPIRNQLEIYNQPSQAGPFDIKEIEVTVHGKQADVERLLSKGQHLYKEKPSTQPVKRKLEDLRSEWEAVNHLLRELRTKQPDRAPGLSTTGASASQTVTLVTQSVVTKETVISKLEMPSSLLLEVPALADFNRAWTELTDWLSLLDRVIKSQRVMVGDLEDINEMIIKQKATLQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQIQWDEVQEQLQNRRQQLNEMLKDSTQWLEAKEEAEQVIGQVRGKLDSWKEGPHTVDAIQKKITETKQLAKDLRQRQISVDVANDLALKLLRDYSADDTRKVHMITENINTSWGNIHKRVSEQEAALEETHRLLQQFPLDLEKFLSWITEAETTANVLQDASRKEKLLEDSRGVRELMKPWQDLQGEIETHTDIYHNLDENGQKILRSLEGSDEAPLLQRRLDNMNFKWSELQKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDIHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNAEWDKLNLRSADWQRKIDEALERLQELQEAADELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVNRVNDLAHQLTTLGIQLSPYNLSTLEDLNTRWRLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSESMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNAPGKPMREDTM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	LDLLEGLTGQKLPKE HHHHHHHCCCCCCCC	48.72	25159016
225	Ubiquitination	VATTYPDKKSILMYI HHHHCCCHHHHHHHH	43.87	22790023
624	Phosphorylation	PTMEKLSSLNQDLLS CCHHHHHHCCHHHHH	41.60	-
717	Phosphorylation	PQKKRQITVDSELRK CCCCCCEECCHHHHH	15.21	28464351
731	Phosphorylation	KRLDVDITELHSWIT HHCCCCHHHHHHHHH	28.20	24759943
735	Phosphorylation	VDITELHSWITRSEA CCHHHHHHHHHHHHH	32.57	24759943
738	Phosphorylation	TELHSWITRSEAVLQ HHHHHHHHHHHHHHH	23.14	24759943
807	Phosphorylation	AESIRQASEQLNSRW HHHHHHHHHHHHHHH	19.96	23527152
812	Phosphorylation	QASEQLNSRWTEFCQ HHHHHHHHHHHHHHH	37.47	23527152
822	Phosphorylation	TEFCQLLSERVNWLE HHHHHHHHHHCCHHH	31.76	25338131
870	Phosphorylation	SEPTAIKSQLKICKD CCCHHHHHHHHHCHH	34.33	28464351
1127	Phosphorylation	EAELEFASRLETELR HHHHHHHHHHHHHHH	42.60	26239621
1275	Phosphorylation	ACWHELLSYLEKANK HHHHHHHHHHHHHCH	40.05	22942356
1276	Phosphorylation	CWHELLSYLEKANKW HHHHHHHHHHHHCHH	20.89	28833060
1430	Acetylation	EISLEEMKKHNQGKD CCCHHHHHHHCCCCC	54.91	30985857
1444	Phosphorylation	DANQRVLSQIDVAQK CHHHHHHHHHHHHHH	23.41	23737553
1565	Ubiquitination	GAKVTERKQQLEKCL CHHHHHHHHHHHHHH	35.84	22790023
1770	Phosphorylation	NRRFAAISHRIKTGK HHHHHHHHHHHHCCC	11.28	22817900
1841	Phosphorylation	DNLQQRITDERKREE CCHHHHHCCHHHHHH	33.71	-
1913	Acetylation	PEPRDERKLKEIDRE CCCCCHHHHHHHHHH	62.96	7630819
1923	Acetylation	EIDRELQKKKEELNA HHHHHHHHHHHHHHH	77.70	19860071
2062	Phosphorylation	DIIHKKKTAALQSAT HHHHHHHHHHHHHCC	26.49	23737553
2067	Phosphorylation	KKTAALQSATSMEKV HHHHHHHHCCCHHHH	34.07	23737553
2069	Phosphorylation	TAALQSATSMEKVKV HHHHHHCCCHHHHHH	33.58	27742792
2070	Phosphorylation	AALQSATSMEKVKVQ HHHHHCCCHHHHHHH	25.35	27742792
2377	Phosphorylation	ADVERLLSKGQHLYK HHHHHHHHCCCHHHC	39.05	25619855
2488	Phosphorylation	LLDRVIKSQRVMVGD HHHHHHHCCCEEECC	16.46	25777480
2598	Phosphorylation	QVRGKLDSWKEGPHT HHHCCHHHCCCCCCH	50.95	21454597
2661	Phosphorylation	MITENINTSWGNIHK EEECCCCCCCCHHHH	23.27	23737553
2662	Phosphorylation	ITENINTSWGNIHKR EECCCCCCCCHHHHH	28.62	23737553
2721	Phosphorylation	KEKLLEDSRGVRELM HHHHHHCCHHHHHHH	22.89	29514104
2836	Ubiquitination	GDFPAVQKQNDIHRA CCCHHHHCHHHHHHH	44.46	22790023
2921	Ubiquitination	RSADWQRKIDEALER CCHHHHHHHHHHHHH	39.13	22790023
2982	Ubiquitination	RGEIAPLKENVNRVN CCCCHHHHHHHHHHH	46.30	22790023
3042	Phosphorylation	HRDFGPASQHFLSTS HHHHCCHHHHHHHCC	27.59	23737553
3047	Phosphorylation	PASQHFLSTSVQGPW CHHHHHHHCCCCCCH	20.07	23737553
3048	Phosphorylation	ASQHFLSTSVQGPWE HHHHHHHCCCCCCHH	34.76	23737553
3049	Phosphorylation	SQHFLSTSVQGPWER HHHHHHCCCCCCHHH	14.74	23737553
3059	Phosphorylation	GPWERAISPNKVPYY CCHHHCCCCCCCCEE	22.80	23737553
3062	Ubiquitination	ERAISPNKVPYYINH HHCCCCCCCCEEEEC	48.23	22790023
3213	Ubiquitination	DKYRYLFKQVASSTG HHHHHHHHHHHHCCC	41.07	22790023
3301	Ubiquitination	VAAAETAKHQAKCNI HHHHHHHHHHHHCCC	43.60	22790023
3381	Ubiquitination	RTKRYFAKHPRMGYL HCCCHHCCCCCCCCC	44.22	-
3387	Phosphorylation	AKHPRMGYLPVQTVL CCCCCCCCCCCEECE	9.86	23737553
3392	Phosphorylation	MGYLPVQTVLEGDNM CCCCCCEECEECCCC	27.56	23737553
3401	Phosphorylation	LEGDNMETPVTLINF EECCCCCCCEEEEEE	16.58	23737553
3404	Phosphorylation	DNMETPVTLINFWPV CCCCCCEEEEEEEEC	24.11	23737553
3413	Phosphorylation	INFWPVDSAPASSPQ EEEEECCCCCCCCCC	36.06	23737553
3417	Phosphorylation	PVDSAPASSPQLSHD ECCCCCCCCCCCCCC	41.30	23737553
3418	Phosphorylation	VDSAPASSPQLSHDD CCCCCCCCCCCCCCC	20.83	23737553
3422	Phosphorylation	PASSPQLSHDDTHSR CCCCCCCCCCCHHHH	21.44	23737553
3426	Phosphorylation	PQLSHDDTHSRIEHY CCCCCCCHHHHHHHH	28.01	23737553
3428	Phosphorylation	LSHDDTHSRIEHYAS CCCCCHHHHHHHHHH	36.73	23737553
3433	Phosphorylation	THSRIEHYASRLAEM HHHHHHHHHHHHHHH	8.09	25195567
3435	Phosphorylation	SRIEHYASRLAEMEN HHHHHHHHHHHHHHC	22.21	23737553
3476	Phosphorylation	CQSLNQDSPLSQPRS HHHCCCCCCCCCCCC	20.27	-
3483	Phosphorylation	SPLSQPRSPAQILIS CCCCCCCCHHHEEEE	31.13	28973931
3490	Phosphorylation	SPAQILISLESEERG CHHHEEEEECHHHCC	23.73	26643407
3493	Phosphorylation	QILISLESEERGELE HEEEEECHHHCCHHH	50.48	26643407
3530	Phosphorylation	QHEHKGLSPLPSPPE HHHCCCCCCCCCCCC	32.81	26643407
3534	Phosphorylation	KGLSPLPSPPEMMPT CCCCCCCCCCCCCCC	61.85	26643407
3541	Phosphorylation	SPPEMMPTSPQSPRD CCCCCCCCCCCCHHH	34.83	26643407
3542	Phosphorylation	PPEMMPTSPQSPRDA CCCCCCCCCCCHHHH	18.31	26643407
3545	Phosphorylation	MMPTSPQSPRDAELI CCCCCCCCHHHHHHH	25.86	26643407
3556	Ubiquitination	AELIAEAKLLRQHKG HHHHHHHHHHHHCCC	39.29	22790023
3577	Ubiquitination	QILEDHNKQLESQLH HHHHHHHHHHHHHHH	53.49	22790023
3602	Phosphorylation	AEAKVNGTTVSSPST CHHHCCCEECCCCCC	20.86	23984901
3603	Phosphorylation	EAKVNGTTVSSPSTS HHHCCCEECCCCCCC	21.57	23984901
3605	Phosphorylation	KVNGTTVSSPSTSLQ HCCCEECCCCCCCCC	34.14	23527152
3606	Phosphorylation	VNGTTVSSPSTSLQR CCCEECCCCCCCCCC	20.66	25521595
3608	Phosphorylation	GTTVSSPSTSLQRSD CEECCCCCCCCCCCC	32.35	26643407
3609	Phosphorylation	TTVSSPSTSLQRSDS EECCCCCCCCCCCCC	36.52	26643407
3610	Phosphorylation	TVSSPSTSLQRSDSS ECCCCCCCCCCCCCC	27.17	26643407
3614	Phosphorylation	PSTSLQRSDSSQPML CCCCCCCCCCCCCEE	28.96	23737553
3616	Phosphorylation	TSLQRSDSSQPMLLR CCCCCCCCCCCEEEE	31.92	25521595
3617	Phosphorylation	SLQRSDSSQPMLLRV CCCCCCCCCCEEEEH	43.20	25521595
3620	Oxidation	RSDSSQPMLLRVVGS CCCCCCCEEEEHHCC	4.22	17242355
3627	Phosphorylation	MLLRVVGSQTSESMG EEEEHHCCCCCCCCC	20.76	23737553
3629	Phosphorylation	LRVVGSQTSESMGEE EEHHCCCCCCCCCCC	35.84	23737553
3630	Phosphorylation	RVVGSQTSESMGEED EHHCCCCCCCCCCCC	21.75	23737553
3632	Phosphorylation	VGSQTSESMGEEDLL HCCCCCCCCCCCCCC	31.67	23737553
3640	Phosphorylation	MGEEDLLSPPQDTST CCCCCCCCCCCCCCC	41.66	26643407
3659	Phosphorylation	VMEQLNNSFPSSRGR HHHHHHHCCCCCCCC	37.14	30352176
3677	Phosphorylation	GKPMREDTM------ CCCCCCCCC------	21.74	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
3321	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
3530	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
3616	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
3677	T	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DMD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DMD_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DGKZ_HUMAN	DGKZ	physical	11352924
DAG1_MOUSE	Dag1	physical	22937058
NOS1_MOUSE	Nos1	physical	22937058
SNTB1_MOUSE	Sntb1	physical	22937058
SNTB2_MOUSE	Sntb2	physical	22937058
SGCD_MOUSE	Sgcd	physical	22937058
SGCA_MOUSE	Sgca	physical	22937058
CAVN1_MOUSE	Ptrf	physical	22937058
SGCB_MOUSE	Sgcb	physical	22937058
SGCG_MOUSE	Sgcg	physical	22937058
CRYAB_MOUSE	Cryab	physical	22937058
LDB3_MOUSE	Ldb3	physical	22937058
DAG1_MOUSE	Dag1	physical	10355629
CAV3_MOUSE	Cav3	physical	8663016
NOS1_MOUSE	Nos1	physical	7545544

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3617, AND MASSSPECTROMETRY.
PubMed: 17242355