CAVN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAVN1_MOUSE
• UniProt AC: O54724
• Protein Name: Caveolae-associated protein 1
• Gene Name: Cavin1
• Organism: Mus musculus (Mouse).
• Sequence Length: 392
• Subcellular Localization: Membrane, caveola . Cell membrane . Microsome . Endoplasmic reticulum . Cytoplasm, cytosol . Mitochondrion . Nucleus . Translocates to the cytoplasm from caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipo
• Protein Description: Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. [PubMed: 18191225]
• Protein Sequence: MEDVTLHIVERPYSGFPDASSEGPEPTQGEARATEEPSGTGSDELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSVSKSLKESEALPEKEGDELGEGERPEDDTAAIELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPVERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGEVEVLKATEMVEVGPEDDEVGAERGEATDLLRGSSPDVHTLLEITEESDAVLVDKSDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDVTLHI -------CCCEEEEE		-
5	Phosphorylation	---MEDVTLHIVERP ---CCCEEEEEEECC		25619855
13	Phosphorylation	LHIVERPYSGFPDAS EEEEECCCCCCCCCC		25619855
14	Phosphorylation	HIVERPYSGFPDASS EEEECCCCCCCCCCC		25619855
20	Phosphorylation	YSGFPDASSEGPEPT CCCCCCCCCCCCCCC		26824392
21	Phosphorylation	SGFPDASSEGPEPTQ CCCCCCCCCCCCCCC		26824392
27	Phosphorylation	SSEGPEPTQGEARAT CCCCCCCCCCCCCCC		25619855
34	Phosphorylation	TQGEARATEEPSGTG CCCCCCCCCCCCCCC		25619855
38	Phosphorylation	ARATEEPSGTGSDEL CCCCCCCCCCCCCHH		25521595
40	Phosphorylation	ATEEPSGTGSDELIK CCCCCCCCCCCHHHC		24925903
42	Phosphorylation	EEPSGTGSDELIKSD CCCCCCCCCHHHCCC		24925903
47	Ubiquitination	TGSDELIKSDQVNGV CCCCHHHCCCCCCCE		22790023
48	Phosphorylation	GSDELIKSDQVNGVL CCCHHHCCCCCCCEE		27180971
58	Phosphorylation	VNGVLVLSLLDKIIG CCCEEHHHHHHHHHH		25338131
90	Phosphorylation	EMEGAVQSIQGELSK HHHHHHHHHHHHHHH		27180971
96	Phosphorylation	QSIQGELSKLGKAHA HHHHHHHHHHCCCCC		28464351
97	Ubiquitination	SIQGELSKLGKAHAT HHHHHHHHHCCCCCC		22790023
100	Ubiquitination	GELSKLGKAHATTSN HHHHHHCCCCCCCHH		22790023
104	Phosphorylation	KLGKAHATTSNTVSK HHCCCCCCCHHHHHH		23684622
105	Phosphorylation	LGKAHATTSNTVSKL HCCCCCCCHHHHHHH		23684622
106	Phosphorylation	GKAHATTSNTVSKLL CCCCCCCHHHHHHHH		23684622
110	Phosphorylation	ATTSNTVSKLLEKVR CCCHHHHHHHHHHHH		23684622
111	Acetylation	TTSNTVSKLLEKVRK CCHHHHHHHHHHHHC		22826441
111	Ubiquitination	TTSNTVSKLLEKVRK CCHHHHHHHHHHHHC		22790023
115	Ubiquitination	TVSKLLEKVRKVSVN HHHHHHHHHHCCCCC		22790023
118	Ubiquitination	KLLEKVRKVSVNVKT HHHHHHHCCCCCHHH		27667366
120	Phosphorylation	LEKVRKVSVNVKTVR HHHHHCCCCCHHHHH		24453211
124	Ubiquitination	RKVSVNVKTVRGSLE HCCCCCHHHHHHHHH		22790023
125	Phosphorylation	KVSVNVKTVRGSLER CCCCCHHHHHHHHHH		23737553
129	Phosphorylation	NVKTVRGSLERQAGQ CHHHHHHHHHHHCCC		24453211
139	Ubiquitination	RQAGQIKKLEVNEAE HHCCCEEEEECCHHH		22790023
154	Ubiquitination	LLRRRNFKVMIYQDE HHHHCCCEEEEEECC		22790023
154	Acetylation	LLRRRNFKVMIYQDE HHHHCCCEEEEEECC		23806337
158	Phosphorylation	RNFKVMIYQDEVKLP CCCEEEEEECCCCCC		16873679
163	Ubiquitination	MIYQDEVKLPAKLSV EEEECCCCCCCEEEE		22790023
167	Ubiquitination	DEVKLPAKLSVSKSL CCCCCCCEEEECCCH		22790023
169	Phosphorylation	VKLPAKLSVSKSLKE CCCCCEEEECCCHHH		26824392
171	Phosphorylation	LPAKLSVSKSLKESE CCCEEEECCCHHHHH		26824392
172	Ubiquitination	PAKLSVSKSLKESEA CCEEEECCCHHHHHC		22790023
173	Phosphorylation	AKLSVSKSLKESEAL CEEEECCCHHHHHCC		26824392
175	Ubiquitination	LSVSKSLKESEALPE EEECCCHHHHHCCCC		22790023
177	Phosphorylation	VSKSLKESEALPEKE ECCCHHHHHCCCCCC		26824392
198	Phosphorylation	GERPEDDTAAIELSS CCCCCCCCEEEECCC		26160508
204	Phosphorylation	DTAAIELSSDEAVEV CCEEEECCCCCCEEH		27087446
205	Phosphorylation	TAAIELSSDEAVEVE CEEEECCCCCCEEHH		27087446
218	Phosphorylation	VEEVIEESRAERIKR HHHHHHHHHHHHHHH		26160508
239	Phosphorylation	DDFKKAFSKEKMEKT HHHHHHHCHHHHHHH		27681418
256	Ubiquitination	RTRENLEKTRLKTKE CCHHHHHHHCCHHHH		-
260	Ubiquitination	NLEKTRLKTKENLEK HHHHHCCHHHHHHHH		-
261	Phosphorylation	LEKTRLKTKENLEKT HHHHCCHHHHHHHHH		-
271	Phosphorylation	NLEKTRHTLEKRMNK HHHHHHHHHHHHHHH		27149854
281	Phosphorylation	KRMNKLGTRLVPVER HHHHHHCCCCCCHHH		27149854
301	Ubiquitination	TSRDKLRKSFTPDHV CCHHHHHHHCCCCCE		22790023
302	Phosphorylation	SRDKLRKSFTPDHVV CHHHHHHHCCCCCEE		25521595
304	Phosphorylation	DKLRKSFTPDHVVYA HHHHHHCCCCCEEEE		26824392
310	Phosphorylation	FTPDHVVYARSKTAV CCCCCEEEEECCCEE		26824392
313	Phosphorylation	DHVVYARSKTAVYKV CCEEEEECCCEEEEC		29514104
315	Phosphorylation	VVYARSKTAVYKVPP EEEEECCCEEEECCC		-
318	Phosphorylation	ARSKTAVYKVPPFTF EECCCEEEECCCCEE		29514104
319	Ubiquitination	RSKTAVYKVPPFTFH ECCCEEEECCCCEEE		22790023
361	Phosphorylation	GAERGEATDLLRGSS CCCCCCHHHHHCCCC		27180971
367	Phosphorylation	ATDLLRGSSPDVHTL HHHHHCCCCCCHHHH		23649490
368	Phosphorylation	TDLLRGSSPDVHTLL HHHHCCCCCCHHHHH		21082442
373	Phosphorylation	GSSPDVHTLLEITEE CCCCCHHHHHHCCCC		27180971
378	Phosphorylation	VHTLLEITEESDAVL HHHHHHCCCCCCCEE		23737553
381	Phosphorylation	LLEITEESDAVLVDK HHHCCCCCCCEEEEC		27180971
389	Phosphorylation	DAVLVDKSDSD---- CCEEEECCCCC----		25514038
391	Phosphorylation	VLVDKSDSD------ EEEECCCCC------		25514038

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
169	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
171	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
304	T	Phosphorylation	Kinase	PRKACA	P05132	GPS
368	S	Phosphorylation	Kinase	PRKACA	P05132	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAVN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAVN1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CAVN1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.