SGCA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGCA_MOUSE
• UniProt AC: P82350
• Protein Name: Alpha-sarcoglycan
• Gene Name: Sgca
• Organism: Mus musculus (Mouse).
• Sequence Length: 387
• Subcellular Localization: Cell membrane, sarcolemma ; Single-pass type I membrane protein . Cytoplasm, cytoskeleton .
• Protein Description: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix..
• Protein Sequence: MAAAVTWIPLLAGLLAGLRDTKAQQTTLHLLVGRVFVHPLEHATFLRLPEHVAVPPTVRLTYHAHLQGHPDLPRWLHYTQRSPYNPGFLYGSPTPEDRGYQVIEVTAYNRDSFDTTRQRLLLLIGDPEGPRLPYQAEFLVRSHDVEEVLPTTPANRFLTALGGLWEPGELQLLNITSALDRGGRVPLPIEGRKEGVYIKVGSATPFSTCLKMVASPDSYARCAQGQPPLLSCYDTLAPHFRVDWCNVSLVDKSVPEPLDEVPTPGDGILEHDPFFCPPTEATDRDFLTDALVTLLVPLLVALLLTLLLAYIMCFRREGRLKRDMATSDIQMFHHCSIHGNTEELRQMAASREVPRPLSTLPMFNVRTGERLPPRVDSAQMPLILDQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
151	Phosphorylation	DVEEVLPTTPANRFL CHHHHCCCCCHHHHH	41.05	27742792
152	Phosphorylation	VEEVLPTTPANRFLT HHHHCCCCCHHHHHH	20.61	27742792
174	N-linked_Glycosylation	PGELQLLNITSALDR CCCEEEEEHHHCCCC	44.05	-
202	Phosphorylation	GVYIKVGSATPFSTC CEEEEECCCCCHHHH	31.77	25266776
204	Phosphorylation	YIKVGSATPFSTCLK EEEECCCCCHHHHHH	26.94	25266776
246	N-linked_Glycosylation	HFRVDWCNVSLVDKS CCEEEEECEEEECCC	23.35	-
326	Phosphorylation	RLKRDMATSDIQMFH CCCCCCCCCCCHHHH	21.94	27742792
327	Phosphorylation	LKRDMATSDIQMFHH CCCCCCCCCCHHHHH	24.15	27742792
336	Phosphorylation	IQMFHHCSIHGNTEE CHHHHHHHCCCCHHH	17.17	27742792
341	Phosphorylation	HCSIHGNTEELRQMA HHHCCCCHHHHHHHH	35.11	27742792
377	Phosphorylation	RLPPRVDSAQMPLIL CCCCCCCCCCCCEEC	19.97	23737553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SGCA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGCA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGCA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAG1_MOUSE	Dag1	physical	1461282
SGCB_MOUSE	Sgcb	physical	1461282
SGCD_MOUSE	Sgcd	physical	1461282

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.