NMRL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMRL1_MOUSE
• UniProt AC: Q8K2T1
• Protein Name: NmrA-like family domain-containing protein 1
• Gene Name: Nmral1
• Organism: Mus musculus (Mouse).
• Sequence Length: 309
• Subcellular Localization: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios (By s
• Protein Description: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity)..
• Protein Sequence: MADRKLVVVFGATGAQGGSVARALLEDGTFRIRVVTRNPEQRAAKELKQQGAEVVRGDQDDAASMELALAGAHATFIVTNYWETCSQDREVQQPHQWDQVFKQGKLLADLAKRLGLHYVVYSGLENIRKLTAGKLAAGHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSYFLPQKAADGKSFLLDLPMGDVPMDGMSVSDLGPVVLSLLKKPEEYVGQNIGLSTCRHTAEEYAALLSKHTGKAVHHAKTTPEDYEKLGFQGAQDLANMFRFYTLKPDRNIHLTLRLNPKAQTLDQWLEQHKGDFAQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Malonylation	QRAAKELKQQGAEVV HHHHHHHHHCCCEEE	41.49	26320211
112	Acetylation	KLLADLAKRLGLHYV HHHHHHHHHHCCCEE	56.29	22826441
213	Ubiquitination	VVLSLLKKPEEYVGQ HHHHHHCCHHHHCCC	58.60	-
277	Ubiquitination	MFRFYTLKPDRNIHL HHHHEEECCCCCEEE	36.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMRL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMRL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMRL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NMRL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.