dbPTM

RHG39_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHG39_MOUSE
UniProt AC	P59281
Protein Name	Rho GTPase-activating protein 39
Gene Name	Arhgap39
Organism	Mus musculus (Mouse).
Sequence Length	1107
Subcellular Localization	Nucleus .
Protein Description
Protein Sequence	MSQAQDYECRSHHVDEQEPRIPGSSTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVRIKRTSEDQWWELFDPNTSRFYYYSAASQRTVWHRPQNCDIIPLAKLQTLKQNTESPRASADNSPGRGSRDGSTGSSLEPELEERTQELPVRSGRATTLVTSKEDTSSCSPPGVLLEKDYEVYRDYSADGQLLHYRTSSLRWNSGNKERMLIKVADREPSFLTPQGNGYPADNQPGGHHRRPSGSQHSPNLQTFVPDTDGTVFFPERRPSPFLRRAELSGNCSPLLIQPRKPSSDSQPSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEANSPYQTGSPQRSPGRKPHPFLQTTKQTPTSPCQQLMRTKQKCPERFLSLEYSPVGKEYVRQLVYVEQAGSSPKLRAGPRHKYAPNPGGGTYSLQPSPCLLRDQRLGVRSGDYSTMEGPESRPSQPPTPLPQAQEDAMSWSSQQDTMSSTGYSPGTRKRKNRKPSLCQVPSTSSTDGAGGLLGEQPLTEERSPCRASLTPVKAEADLVRGTPEPFLAQARLAWEAQQAHFHMKQRGSWDSQQDGSGYESDGAVPLPMPGPVVRAFSEDEALAQQDSKHWKRSTFDKLGFPQILLEKSVSVQTNLASPEPHLHPSQSEDLGACAQFESSRQNRSAMPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANMLAWSSESIKKPMIVTSDRHVKKEACEIFKLIQMYMGDRRAKADPLHVALEIATKGWSAQGLRDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKVTQHIKELLERNSKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYESPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAITKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSQAQDYEC ------CCCHHCCHH	45.59	-
7	Phosphorylation	-MSQAQDYECRSHHV -CCCHHCCHHHHCCC	12.59	22668510
11	Phosphorylation	AQDYECRSHHVDEQE HHCCHHHHCCCCCCC	29.60	22668510
43	Phosphorylation	PRTRERMYANLVTGE CCCHHHHHHEEECCC	9.88	22817900
48	Phosphorylation	RMYANLVTGECVWDP HHHHEEECCCEEECC	30.35	22817900
113	Phosphorylation	LQTLKQNTESPRASA HHHHHHCCCCCCCCC	35.03	29899451
115	Phosphorylation	TLKQNTESPRASADN HHHHCCCCCCCCCCC	20.04	29899451
119	Phosphorylation	NTESPRASADNSPGR CCCCCCCCCCCCCCC	37.12	29899451
123	Phosphorylation	PRASADNSPGRGSRD CCCCCCCCCCCCCCC	29.31	22817900
128	Phosphorylation	DNSPGRGSRDGSTGS CCCCCCCCCCCCCCC	26.32	29899451
132	Phosphorylation	GRGSRDGSTGSSLEP CCCCCCCCCCCCCCH	33.61	25521595
133	Phosphorylation	RGSRDGSTGSSLEPE CCCCCCCCCCCCCHH	46.76	25293948
135	Phosphorylation	SRDGSTGSSLEPELE CCCCCCCCCCCHHHH	31.66	25293948
136	Phosphorylation	RDGSTGSSLEPELEE CCCCCCCCCCHHHHH	37.79	25293948
165	Phosphorylation	LVTSKEDTSSCSPPG EEECCCCCCCCCCCC	24.51	28066266
166	Phosphorylation	VTSKEDTSSCSPPGV EECCCCCCCCCCCCE	41.49	28066266
167	Phosphorylation	TSKEDTSSCSPPGVL ECCCCCCCCCCCCEE	22.25	28066266
169	Phosphorylation	KEDTSSCSPPGVLLE CCCCCCCCCCCEEEE	35.76	25521595
179	Phosphorylation	GVLLEKDYEVYRDYS CEEEECCEEEEEECC	20.54	29899451
185	Phosphorylation	DYEVYRDYSADGQLL CEEEEEECCCCCCEE	9.21	29899451
194	Phosphorylation	ADGQLLHYRTSSLRW CCCCEEEEEECCCEE	18.63	-
196	Phosphorylation	GQLLHYRTSSLRWNS CCEEEEEECCCEECC	18.59	25338131
197	Phosphorylation	QLLHYRTSSLRWNSG CEEEEEECCCEECCC	20.55	25338131
198	Phosphorylation	LLHYRTSSLRWNSGN EEEEEECCCEECCCC	22.72	29514104
242	Phosphorylation	GGHHRRPSGSQHSPN CCCCCCCCCCCCCCC	49.63	26160508
244	Phosphorylation	HHRRPSGSQHSPNLQ CCCCCCCCCCCCCCC	29.11	26160508
247	Phosphorylation	RPSGSQHSPNLQTFV CCCCCCCCCCCCCCC	14.09	26824392
252	Phosphorylation	QHSPNLQTFVPDTDG CCCCCCCCCCCCCCC	29.75	25293948
269	Phosphorylation	FFPERRPSPFLRRAE ECCCCCCCCCHHHHH	26.86	28066266
278	Phosphorylation	FLRRAELSGNCSPLL CHHHHHHCCCCCCCE	21.33	28066266
282	Phosphorylation	AELSGNCSPLLIQPR HHHCCCCCCCEECCC	23.68	26824392
292	Phosphorylation	LIQPRKPSSDSQPSS EECCCCCCCCCCCCC	50.22	29899451
293	Phosphorylation	IQPRKPSSDSQPSSP ECCCCCCCCCCCCCC	50.21	29899451
295	Phosphorylation	PRKPSSDSQPSSPRY CCCCCCCCCCCCCCC	46.03	29899451
298	Phosphorylation	PSSDSQPSSPRYGYE CCCCCCCCCCCCCCC	45.39	25263469
299	Phosphorylation	SSDSQPSSPRYGYEP CCCCCCCCCCCCCCC	21.78	29899451
340	Phosphorylation	NSPYQTGSPQRSPGR CCCCCCCCCCCCCCC	22.65	29899451
344	Phosphorylation	QTGSPQRSPGRKPHP CCCCCCCCCCCCCCC	26.85	26824392
356	O-linked_Glycosylation	PHPFLQTTKQTPTSP CCCCCCCCCCCCCCH	14.27	55410937
356	Phosphorylation	PHPFLQTTKQTPTSP CCCCCCCCCCCCCCH	14.27	-
359	Phosphorylation	FLQTTKQTPTSPCQQ CCCCCCCCCCCHHHH	30.04	26745281
361	Phosphorylation	QTTKQTPTSPCQQLM CCCCCCCCCHHHHHH	49.00	26745281
362	Phosphorylation	TTKQTPTSPCQQLMR CCCCCCCCHHHHHHH	25.53	26745281
380	Phosphorylation	KCPERFLSLEYSPVG CCCHHHHCCCCCCCC	19.22	26824392
383	Phosphorylation	ERFLSLEYSPVGKEY HHHHCCCCCCCCHHH	24.46	25521595
384	Phosphorylation	RFLSLEYSPVGKEYV HHHCCCCCCCCHHHH	12.06	26824392
390	Phosphorylation	YSPVGKEYVRQLVYV CCCCCHHHHHHHHHH	12.38	29514104
402	Phosphorylation	VYVEQAGSSPKLRAG HHHEECCCCCCCCCC	46.62	30352176
403	Phosphorylation	YVEQAGSSPKLRAGP HHEECCCCCCCCCCC	25.74	22942356
423	Phosphorylation	PNPGGGTYSLQPSPC CCCCCCCCCCCCCCC	15.62	-
441	Phosphorylation	DQRLGVRSGDYSTME CCCCCCCCCCCCCCC	33.34	28066266
444	Phosphorylation	LGVRSGDYSTMEGPE CCCCCCCCCCCCCCC	15.01	22817900
491	Acetylation	SPGTRKRKNRKPSLC CCCCCCCCCCCCCCC	65.23	7923523
496	Phosphorylation	KRKNRKPSLCQVPST CCCCCCCCCCCCCCC	44.83	29899451
502	Phosphorylation	PSLCQVPSTSSTDGA CCCCCCCCCCCCCCC	41.90	29899451
503	Phosphorylation	SLCQVPSTSSTDGAG CCCCCCCCCCCCCCC	22.19	29899451
504	Phosphorylation	LCQVPSTSSTDGAGG CCCCCCCCCCCCCCC	35.26	29899451
505	Phosphorylation	CQVPSTSSTDGAGGL CCCCCCCCCCCCCCC	30.52	29899451
506	Phosphorylation	QVPSTSSTDGAGGLL CCCCCCCCCCCCCCC	37.91	29899451
523	Phosphorylation	QPLTEERSPCRASLT CCCCCCCCCCCCCCC	31.47	-
530	Phosphorylation	SPCRASLTPVKAEAD CCCCCCCCCCCCCHH	24.44	27149854
532	Phosphorylation	CRASLTPVKAEADLV CCCCCCCCCCCHHHC	8.48	24719451
542	Phosphorylation	EADLVRGTPEPFLAQ CHHHCCCCCCCHHHH	17.57	29514104
568	Phosphorylation	FHMKQRGSWDSQQDG CHHHHCCCCCCCCCC	29.87	29899451
571	Phosphorylation	KQRGSWDSQQDGSGY HHCCCCCCCCCCCCC	24.39	29899451
576	Phosphorylation	WDSQQDGSGYESDGA CCCCCCCCCCCCCCC	46.63	29899451
580	Phosphorylation	QDGSGYESDGAVPLP CCCCCCCCCCCEECC	32.62	-
597 (in isoform 2)	Phosphorylation	-	43.06	19144319
597	Phosphorylation	GPVVRAFSEDEALAQ CCEEEEECHHHHHHH	43.06	25521595
607	Phosphorylation	EALAQQDSKHWKRST HHHHHCCCHHHHHHH	23.29	25619855
613	Phosphorylation	DSKHWKRSTFDKLGF CCHHHHHHHHHHCCC	29.69	29899451
637	Phosphorylation	SVQTNLASPEPHLHP CCCCCCCCCCCCCCC	32.72	29899451
645	Phosphorylation	PEPHLHPSQSEDLGA CCCCCCCCCCCCHHH	35.27	29899451
682	Phosphorylation	TFTLRKPSSETDIEN EEEECCCCCCCHHHH	43.79	25521595
683	Phosphorylation	FTLRKPSSETDIENW EEECCCCCCCHHHHH	53.71	25521595
685	Phosphorylation	LRKPSSETDIENWAS ECCCCCCCHHHHHHH	44.20	22817900
708	Phosphorylation	GLFRRKVSIANMLAW HHHHHHHHHHHHHHH	21.01	22817900
716	Phosphorylation	IANMLAWSSESIKKP HHHHHHHCCCCCCCC	20.72	29899451
719	Phosphorylation	MLAWSSESIKKPMIV HHHHCCCCCCCCEEE	41.47	22817900
727	Phosphorylation	IKKPMIVTSDRHVKK CCCCEEECCCHHHHH	17.62	29899451
746	Phosphorylation	IFKLIQMYMGDRRAK HHHHHHHHHCCCCCC	4.99	22817900
835	Phosphorylation	PVNDTKVTQHIKELL CCCCHHHHHHHHHHH	18.91	21454597
846	Phosphorylation	KELLERNSKKKSKLR HHHHHHHHHHHHHHC	52.66	21454597
937	Phosphorylation	RQLPWVQTRLSEEVL CCCCHHHHHCCHHHH	24.77	-
951	Phosphorylation	LALNGDQTEGIFRVP HHHCCCCCCCCEECC	40.70	-
991	Ubiquitination	HVPASLLKLWYRELE CCCHHHHHHHHHHCC	42.12	-
1037	Phosphorylation	INRMVLCYLIRFLQV CHHHHHHHHHHHHHH	10.87	25263469
1074	Phosphorylation	PNCLRCQSDDPRVIF CCCCCCCCCCCCEEE	47.83	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RHG39_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RHG39_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHG39_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RHG39_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHG39_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-597, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169 AND SER-597, ANDMASS SPECTROMETRY.	17114649 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-597, AND MASSSPECTROMETRY.	15345747 [Abstract]