C170B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C170B_MOUSE
• UniProt AC: Q80U49
• Protein Name: Centrosomal protein of 170 kDa protein B
• Gene Name: Cep170b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1574
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Plays a role in microtubule organization..
• Protein Sequence: MSVTSWFLVSSSGTRHRLPRELIFVGRDECELMLQSRSVDKQHAVINYDQDRDEHWVKDLGSLNGTFVNDVRIPDQKYITLKLNDVIRFGYDSNMYVLERVQHRVPEEALKHEKYTSQLQVSVKVSAPKRGDALPDHTPYCESSQPRPEKGDRRHGAEAVAYRTPLYGQPSWWGEDDSGAPSEDRHQEEPYSERPKDLAQQNGELDSCRAPAEPPDYSFRREPSYFEIPTKETPQPPRLPEVPTQEVPTKDQEAGVGGTAPVVQSHASFTIEFDDCSPGKVKIKDHITKFSLRQRRAPSKETTPVETVSAETKVADWLVQNDPSLLRRDGPGDDRHSTKSDLPVHTRTLKGHKHEDGTQSDSEDPLAKTASVSGASAEASGEQVRLQRQIKRDPQELLHNQQAFVIEFFDGDTPRKKRSQSFTHTPPADPKADKRRGPGTSDRDRPGVSVRATGSSSGPQRASSLKREKTEERLGNTSPVPRASTRSFGSVGRRSRLAQDFMAQCMRDSSPATRPAPEKTPPVLPAPLTPRGASPVTPSTTPPPPTDPQLTKARKQEEDDSLSDAGTYTIETEAQDQEVEEARRMIDQVFGVFESPELSRVSSATFRPVIRGDKDESSDGGMAQRMALLQEFASRAPGMAPQMEQQSLLVPGSPGGQKWVSRWASLADSYSDAGLPEDGPGRRTGEPEGPLPVRTRRLLPQLPSGRADSPAGLEAARRNGPGPPELGSEPANCLIGQEDLDPDSLSDASGSDGGRGPEPGTERQEDLAWVRGRRSPRAPGELVPTSFFIGDQNGEATFPKKSFVGPGEVDGPGRVVQTSPSARDGLYVSSNGRMVIQLRSGRSPEPDPAPPKETLTFARQESFTKEPTSGPPAPGKLPHISSHPLLQDLAAARASRLDFHAQDTHLILKETETALAALEARLRSKSADECDGGSTPRPPEDSLSGDSDVDTASTISLLSGKNGPSPTTPQTPGPQKESPLSPPTVPDPGGATPGSARERMSERQHRPTPADLGPGDTSRRAAMRRGHGSRGSLDWPEEERGSGLAHLPSSNHETPEATLAGRQGPRRKPAAPPPSPAAREEQSRSSATAQKVQQALTRSNSLSTPRPTRASRLRRARLGDASDTEAVDGERGTAANPEPANRAAPEQAKKLTRLDILAMPRKRAGSFTGPSDSETAPARTGFSGRSAELYSTSRKPTIAEARAAAKKAAATAANTGPRQPFSRARPGSARYSSNTRRRQQGSDYTSTSEEEYGSHHSSPKHTRSHASTATQTPRGSSSTRARSQGPRDTDDDEEEPDPYGFIVQTAEIAEIARLSQTLVKDVAILAREIHDVAGDGDSLGSPGPTRSPSLGNVPNTPASTISAREELVQRIPEASLNFQKVPPGSMNSHNLDQNMNDSRDDALTNKTRPRNREEVIFDNLMLNPVSQLSHAIRENTEHLAEKMKVLFQNTGRAWEDLEARINSENEVPILKTSNKEISSILKELRRVQKQLEVINAIVDPSLNLDLLMGNRAPSGSGQPGLGKARPAAQSSTSPASVDTLLPALPLRSFPQRANCGPPGLPEPAFLPDAERFLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	Phosphorylation	GDALPDHTPYCESSQ CCCCCCCCCCCCCCC		22817900
140	Phosphorylation	ALPDHTPYCESSQPR CCCCCCCCCCCCCCC		22817900
224	Phosphorylation	YSFRREPSYFEIPTK CCCCCCCCCCCCCCC		25521595
225	Phosphorylation	SFRREPSYFEIPTKE CCCCCCCCCCCCCCC		21183079
299	Phosphorylation	LRQRRAPSKETTPVE CHHCCCCCCCCCCCE		29899451
337	Phosphorylation	GPGDDRHSTKSDLPV CCCCCCCCCCCCCCC		22817900
338	Phosphorylation	PGDDRHSTKSDLPVH CCCCCCCCCCCCCCC		21183079
340	Phosphorylation	DDRHSTKSDLPVHTR CCCCCCCCCCCCCCC		22324799
346	Phosphorylation	KSDLPVHTRTLKGHK CCCCCCCCCCCCCCC		20415495
358	Phosphorylation	GHKHEDGTQSDSEDP CCCCCCCCCCCCCCC		25521595
360	Phosphorylation	KHEDGTQSDSEDPLA CCCCCCCCCCCCCHH		25521595
362	Phosphorylation	EDGTQSDSEDPLAKT CCCCCCCCCCCHHHH		22324799
369	Phosphorylation	SEDPLAKTASVSGAS CCCCHHHHCCCCCCC		23984901
371	Phosphorylation	DPLAKTASVSGASAE CCHHHHCCCCCCCHH		25521595
376	Phosphorylation	TASVSGASAEASGEQ HCCCCCCCHHHHHHH		29899451
419	Phosphorylation	DTPRKKRSQSFTHTP CCCCCCCCCCCCCCC		27087446
421	Phosphorylation	PRKKRSQSFTHTPPA CCCCCCCCCCCCCCC		25521595
423	Phosphorylation	KKRSQSFTHTPPADP CCCCCCCCCCCCCCC		26239621
425	Phosphorylation	RSQSFTHTPPADPKA CCCCCCCCCCCCCCC		26239621
470	Phosphorylation	SSLKREKTEERLGNT HHHCHHHHHHHHCCC		26060331
477	Phosphorylation	TEERLGNTSPVPRAS HHHHHCCCCCCCCHH		20469934
478	Phosphorylation	EERLGNTSPVPRAST HHHHCCCCCCCCHHC		26824392
485	Phosphorylation	SPVPRASTRSFGSVG CCCCCHHCCCCCCHH		29514104
487	Phosphorylation	VPRASTRSFGSVGRR CCCHHCCCCCCHHHH		23984901
490	Phosphorylation	ASTRSFGSVGRRSRL HHCCCCCCHHHHHHH		26824392
509	Phosphorylation	MAQCMRDSSPATRPA HHHHHHCCCCCCCCC		25521595
510	Phosphorylation	AQCMRDSSPATRPAP HHHHHCCCCCCCCCC		25263469
513	Phosphorylation	MRDSSPATRPAPEKT HHCCCCCCCCCCCCC		23984901
520	Phosphorylation	TRPAPEKTPPVLPAP CCCCCCCCCCCCCCC		26160508
529	Phosphorylation	PVLPAPLTPRGASPV CCCCCCCCCCCCCCC		26824392
534	Phosphorylation	PLTPRGASPVTPSTT CCCCCCCCCCCCCCC		25521595
537	Phosphorylation	PRGASPVTPSTTPPP CCCCCCCCCCCCCCC		22942356
539	Phosphorylation	GASPVTPSTTPPPPT CCCCCCCCCCCCCCC		21082442
540	Phosphorylation	ASPVTPSTTPPPPTD CCCCCCCCCCCCCCC		22942356
541	Phosphorylation	SPVTPSTTPPPPTDP CCCCCCCCCCCCCCH		25521595
546	Phosphorylation	STTPPPPTDPQLTKA CCCCCCCCCHHHHHH		25521595
551	Phosphorylation	PPTDPQLTKARKQEE CCCCHHHHHHHHHHC		26745281
561	Phosphorylation	RKQEEDDSLSDAGTY HHHHCCCCCCCCCEE		25293948
563	Phosphorylation	QEEDDSLSDAGTYTI HHCCCCCCCCCEEEE		27087446
567	Phosphorylation	DSLSDAGTYTIETEA CCCCCCCEEEEEEHH		25293948
568	Phosphorylation	SLSDAGTYTIETEAQ CCCCCCEEEEEEHHC		25293948
569	Phosphorylation	LSDAGTYTIETEAQD CCCCCEEEEEEHHCH		25293948
572	Phosphorylation	AGTYTIETEAQDQEV CCEEEEEEHHCHHHH		29899451
595	Phosphorylation	QVFGVFESPELSRVS HHHCHHCCHHHHHCC		26239621
599	Phosphorylation	VFESPELSRVSSATF HHCCHHHHHCCCCEE		23984901
602	Phosphorylation	SPELSRVSSATFRPV CHHHHHCCCCEEECC		24719451
603	Phosphorylation	PELSRVSSATFRPVI HHHHHCCCCEEECCC		26824392
605	Phosphorylation	LSRVSSATFRPVIRG HHHCCCCEEECCCCC		23984901
617	Phosphorylation	IRGDKDESSDGGMAQ CCCCCCCCCCCHHHH		-
647	Phosphorylation	APQMEQQSLLVPGSP CCCCCCCCEECCCCC		28066266
653	Phosphorylation	QSLLVPGSPGGQKWV CCEECCCCCCHHHHH		25521595
665	Phosphorylation	KWVSRWASLADSYSD HHHHHHHHHHHHHHC		29899451
671	Phosphorylation	ASLADSYSDAGLPED HHHHHHHHCCCCCCC		29514104
709	Phosphorylation	LPSGRADSPAGLEAA CCCCCCCCHHHHHHH		23527152
728	Phosphorylation	PGPPELGSEPANCLI CCCCCCCCCCCCCCC		25293948
744	Phosphorylation	QEDLDPDSLSDASGS CCCCCCCHHHCCCCC		25293948
746	Phosphorylation	DLDPDSLSDASGSDG CCCCCHHHCCCCCCC		25293948
749	Phosphorylation	PDSLSDASGSDGGRG CCHHHCCCCCCCCCC		25293948
751	Phosphorylation	SLSDASGSDGGRGPE HHHCCCCCCCCCCCC		25293948
761	Phosphorylation	GRGPEPGTERQEDLA CCCCCCCCCCHHHCH		25293948
775	Phosphorylation	AWVRGRRSPRAPGEL HHHCCCCCCCCCCCC		29899451
818	Phosphorylation	GPGRVVQTSPSARDG CCCCEEECCCCCCCC		29472430
819	Phosphorylation	PGRVVQTSPSARDGL CCCEEECCCCCCCCE		25521595
821	Phosphorylation	RVVQTSPSARDGLYV CEEECCCCCCCCEEE		29472430
840	Phosphorylation	RMVIQLRSGRSPEPD EEEEEECCCCCCCCC		25521595
843	Phosphorylation	IQLRSGRSPEPDPAP EEECCCCCCCCCCCC		27087446
854	Phosphorylation	DPAPPKETLTFARQE CCCCCHHHHEEEEHH		22324799
856	Phosphorylation	APPKETLTFARQESF CCCHHHHEEEEHHHC		26160508
862	Phosphorylation	LTFARQESFTKEPTS HEEEEHHHCCCCCCC		26824392
864	Phosphorylation	FARQESFTKEPTSGP EEEHHHCCCCCCCCC		29899451
868	Phosphorylation	ESFTKEPTSGPPAPG HHCCCCCCCCCCCCC		26643407
869	Phosphorylation	SFTKEPTSGPPAPGK HCCCCCCCCCCCCCC		28066266
881	Phosphorylation	PGKLPHISSHPLLQD CCCCCCCCCCHHHHH		25177544
882	Phosphorylation	GKLPHISSHPLLQDL CCCCCCCCCHHHHHH		26824392
926	Phosphorylation	EARLRSKSADECDGG HHHHHCCCCCCCCCC		25293948
934	Phosphorylation	ADECDGGSTPRPPED CCCCCCCCCCCCCHH		25293948
935	Phosphorylation	DECDGGSTPRPPEDS CCCCCCCCCCCCHHC		25293948
942	Phosphorylation	TPRPPEDSLSGDSDV CCCCCHHCCCCCCCC		22817900
944	Phosphorylation	RPPEDSLSGDSDVDT CCCHHCCCCCCCCCC		22817900
947	Phosphorylation	EDSLSGDSDVDTAST HHCCCCCCCCCCHHH		22817900
951	Phosphorylation	SGDSDVDTASTISLL CCCCCCCCHHHHHHH		25293948
953	Phosphorylation	DSDVDTASTISLLSG CCCCCCHHHHHHHCC		25293948
954	Phosphorylation	SDVDTASTISLLSGK CCCCCHHHHHHHCCC		25293948
956	Phosphorylation	VDTASTISLLSGKNG CCCHHHHHHHCCCCC		25293948
959	Phosphorylation	ASTISLLSGKNGPSP HHHHHHHCCCCCCCC		25293948
965	Phosphorylation	LSGKNGPSPTTPQTP HCCCCCCCCCCCCCC		25521595
967	Phosphorylation	GKNGPSPTTPQTPGP CCCCCCCCCCCCCCC		25521595
968	Phosphorylation	KNGPSPTTPQTPGPQ CCCCCCCCCCCCCCC		25521595
971	Phosphorylation	PSPTTPQTPGPQKES CCCCCCCCCCCCCCC		29899451
978	Phosphorylation	TPGPQKESPLSPPTV CCCCCCCCCCCCCCC		21082442
981	Phosphorylation	PQKESPLSPPTVPDP CCCCCCCCCCCCCCC		25521595
984	Phosphorylation	ESPLSPPTVPDPGGA CCCCCCCCCCCCCCC		29899451
1029	Phosphorylation	AMRRGHGSRGSLDWP HHHCCCCCCCCCCCC		21743459
1032	Phosphorylation	RGHGSRGSLDWPEEE CCCCCCCCCCCCHHH		25521595
1075	Phosphorylation	KPAAPPPSPAAREEQ CCCCCCCCHHHHHHH		26824392
1099	Phosphorylation	VQQALTRSNSLSTPR HHHHHHHCCCCCCCC		25266776
1101	Phosphorylation	QALTRSNSLSTPRPT HHHHHCCCCCCCCCC		27149854
1103	Phosphorylation	LTRSNSLSTPRPTRA HHHCCCCCCCCCCHH		28066266
1104	Phosphorylation	TRSNSLSTPRPTRAS HHCCCCCCCCCCHHH		28066266
1122	Phosphorylation	RARLGDASDTEAVDG HHHCCCCCCCCCCCC		25521595
1124	Phosphorylation	RLGDASDTEAVDGER HCCCCCCCCCCCCCC		25521595
1166	Phosphorylation	MPRKRAGSFTGPSDS CCCCCCCCCCCCCCC		27087446
1168	Phosphorylation	RKRAGSFTGPSDSET CCCCCCCCCCCCCCC		26239621
1171	Phosphorylation	AGSFTGPSDSETAPA CCCCCCCCCCCCCCC		26824392
1173	Phosphorylation	SFTGPSDSETAPART CCCCCCCCCCCCCCC		23984901
1175	Phosphorylation	TGPSDSETAPARTGF CCCCCCCCCCCCCCC		23984901
1180	Phosphorylation	SETAPARTGFSGRSA CCCCCCCCCCCCCCC		26643407
1183	Phosphorylation	APARTGFSGRSAELY CCCCCCCCCCCCCCE		26643407
1186	Phosphorylation	RTGFSGRSAELYSTS CCCCCCCCCCCEECC		28973931
1191	Phosphorylation	GRSAELYSTSRKPTI CCCCCCEECCCCCCH		26643407
1211	Phosphorylation	AAKKAAATAANTGPR HHHHHHHHHHHCCCC		27149854
1215	Phosphorylation	AAATAANTGPRQPFS HHHHHHHCCCCCCCC		24719451
1246	Phosphorylation	QQGSDYTSTSEEEYG CCCCCCCCCCHHHHC		26643407
1247	Phosphorylation	QGSDYTSTSEEEYGS CCCCCCCCCHHHHCC		26643407
1248	Phosphorylation	GSDYTSTSEEEYGSH CCCCCCCCHHHHCCC		26643407
1252	Phosphorylation	TSTSEEEYGSHHSSP CCCCHHHHCCCCCCC		26643407
1254	Phosphorylation	TSEEEYGSHHSSPKH CCHHHHCCCCCCCCC		21082442
1257	Phosphorylation	EEYGSHHSSPKHTRS HHHCCCCCCCCCCCC		26643407
1258	Phosphorylation	EYGSHHSSPKHTRSH HHCCCCCCCCCCCCC		26643407
1267	Phosphorylation	KHTRSHASTATQTPR CCCCCCCCCCCCCCC		29899451
1283	Phosphorylation	SSSTRARSQGPRDTD CCCCCHHHCCCCCCC		26239621
1289	Phosphorylation	RSQGPRDTDDDEEEP HHCCCCCCCCCCCCC		27087446
1299	Phosphorylation	DEEEPDPYGFIVQTA CCCCCCCCCEEEEHH		23984901
1320	Ubiquitination	RLSQTLVKDVAILAR HHHHHHHHHHHHHHH		22790023
1338	Phosphorylation	DVAGDGDSLGSPGPT HHCCCCCCCCCCCCC		25521595
1341	Phosphorylation	GDGDSLGSPGPTRSP CCCCCCCCCCCCCCC		25521595
1345	Phosphorylation	SLGSPGPTRSPSLGN CCCCCCCCCCCCCCC		24925903
1347	Phosphorylation	GSPGPTRSPSLGNVP CCCCCCCCCCCCCCC		21082442
1349	Phosphorylation	PGPTRSPSLGNVPNT CCCCCCCCCCCCCCC		25521595
1356	Phosphorylation	SLGNVPNTPASTISA CCCCCCCCCHHHHHH		23984901
1359	Phosphorylation	NVPNTPASTISAREE CCCCCCHHHHHHHHH		23984901
1360	Phosphorylation	VPNTPASTISAREEL CCCCCHHHHHHHHHH		23984901
1362	Phosphorylation	NTPASTISAREELVQ CCCHHHHHHHHHHHH		23984901
1472	Phosphorylation	NEVPILKTSNKEISS CCCCEEECCHHHHHH		22871156
1478	Phosphorylation	KTSNKEISSILKELR ECCHHHHHHHHHHHH		22871156
1514	Phosphorylation	LMGNRAPSGSGQPGL HCCCCCCCCCCCCCC		27149854
1530	Phosphorylation	KARPAAQSSTSPASV CCCCCCCCCCCCCCH		26643407
1531	Phosphorylation	ARPAAQSSTSPASVD CCCCCCCCCCCCCHH		23984901
1532	Phosphorylation	RPAAQSSTSPASVDT CCCCCCCCCCCCHHH		23984901
1533	Phosphorylation	PAAQSSTSPASVDTL CCCCCCCCCCCHHHH		26824392
1536	Phosphorylation	QSSTSPASVDTLLPA CCCCCCCCHHHHHCC		26643407
1539	Phosphorylation	TSPASVDTLLPALPL CCCCCHHHHHCCCCC		26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
529	T	Phosphorylation	Kinase	MAPK1	P63085	GPS
968	T	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C170B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C170B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of C170B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.