SACS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SACS_MOUSE
• UniProt AC: Q9JLC8
• Protein Name: Sacsin
• Gene Name: Sacs
• Organism: Mus musculus (Mouse).
• Sequence Length: 4582
• Subcellular Localization: Cytoplasm. Predominantly cytoplasmic, a small portion is present in the nucleus and also shows a partial mitochondrial overlap with the mitochondrial marker Hsp60..
• Protein Description: Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins..
• Protein Sequence: METKFQRWVRVTVLRGCVGCRTVAVPATATGRDLKERIFAETSFPVAEQRLWRGDREVPDWIKIGDLTSKTCHLFVNLQSKGLKGGGRFGQTTPPLVDFLKDILRRYPEGGQILKELIQNAEDAGATEVKFLYDETQYGTETLWSKDMAQYQGSALYVYNNAVFTPEDWHGIQEIARSRKKDDPLKVGRFGIGFNSVYHITDVPCIFSGDQIGMLDPHQTLFGPHESGQCWNLKDDIKEINELPDQFAPFIGVFGSTKETFTNGSFPGTFFRFPLRLQPSQLSSNLYTKQKVLELFDSFRADADTVLLFLKSVQAVSLHVREADGTEKLVFRVTASENKALKHERPNSIKILGTAISNYCKKIPSNSVTCVTYHINIVLEDESTKDAQKTSWLVCNSVGGRGISSKLDSLADELKFVPIIGLAMPLSGKDEENGAISDFSGKAFCFLPLPPGEESRTGLPVHISGFFGLTDNRRSIKWRELDQWRDPAALWNEYLIVNVVPKTYATLILDSIKRLETEKSSDFPLSVDTIYKLWPEASKVKAHWHPVLGPLFSELFQHAVIYSIGGEWVKLEQVHFSELDGSLESTRSVLNYLQSSGKQIAKVPGNLAAAVQLSAASATSSASPVRKVTPAWVRQVLRKCAHLGSAEEKLHLLEFVLSDQAYSELLGLELLPLQSGAFVPFSSSVSDQDVVYITSEEFPRSLFPGLEARLILENLKPHLLAALKEAAQTRGRPCTQLQLLNPERFARLIKEVMNTFWPGRELVVQWYPFSEDKRHPSLSWLKMVWKNLYIHFSEDLTLFDEMPLIPRTLLNEDQTCVELIRLRIPSVVILDDETEAQLPEFLADIVQKLGGIVLKRLDTSIQHPLVKKYIHSPLPSAILQIMEKIPLQKLCNQIASLLPTHKDALRKFLASLTDTSEKEKRIIQELTIFKRINHSSDQGISSYTKLKGCKVLDHTAKLPTDLRLSVSVIDSSDEATIRLANMLKIEKLKTTSCLKFVLKDIGNAFYTQEEVTQLMLWILENLSSLKNENSNVLDWLMPLKFIHMSQGHVVAAGDLFDPDIEVLRDLFYNEEEACFPPTIFTSPDILHSLRQIGLKNESSLKEKDVVQVARKIEALQVSSCQNQDVLMKKAKTLLLVLNKNQTLLQSSEGKMALKKIKWVPACKERPPNYPGSLVWKGDLCNLCAPPDMCDAAHAVLVGSSLPLVESVHVNLEQALSIFTKPTINAVLKHFKTVVDWYTSKTFSDEDYYQFQHILLEIYGFMHDHLSEGKDSFKALKFPWVWTGKNFCPLAQAVIKPTHDLDLQPYLYNVPKTMAKFHQLFKACGSIEELTSDHISMVIQKVYLKSDQELSEEESKQNLHLMLNIMRWLYSNQIPASPNTPVPIYHSRNPSKLVMKPIHECCYCDIKVDDLNDLLEDSVEPIILVHEDIPMKTAEWLKVPCLSTRLINPENMGFEQSGQREPLTVRIKNILEEYPSVSDIFKELLQNADDANATECSFMIDMRRNMDIRENLLDPGMAACHGPALWSFNNSEFSDSDFLNITRLGESLKRGEVDKVGKFGLGFNSVYHITDIPIIMSREFMIMFDPNINHISKHIKDRSNPGIKINWSKQQKRLRKFPNQFKPFIDVFGCQLPLAVEAPYSYNGTLFRLSFRTQQEAKVSEVSSTCYNTADIYSLVDEFSLCGHRLIIFTQSVNSMYLKYLKIEETNPSLAQDTIIIKKKVCPSKALNAPVLSVLKEAAKLMKTCSSSNKKLPTDVPKSSCILQITVEEFHHVFRRIADLQSPLFRGPDDDPATLFEMAKSGQSKKPSDELPQKTVDCTTWLICTCMDTGEALKFSLNESGRRLGLVPCGAVGVLLHETQEQKWTVKPHIGEVFCYLPLRIKTGLPIHINGCFAVTSNRKEIWKTDTKGRWNTTFMRHVIVKAYLQALSVLRDLAIGGELTDYTYYAVWPDPDLVHDDFSVICKGFYEDIAHGKGKELTRVFSDGSMWVSMKNVRFLDDSILQRKDVGSAAFKIFLKYLKKTGSKNLCAVELPSSVKAGFEEAGCKQILLENTFSEKQFFSEVFFPNIQEIEAELRDPLMNFVLNEKLDEFSGILRVTPCVPCSLEGHPLVLPSRLIHPEGRVAKLFDTKDGRFPYGSTQDYLNPIILIKLVQLGMAKDDILWDDMLERAESVAEINKSDHAAACLRSSILLSLIDEKLKIKDPRAKDFAAKYQTIPFLPFLTKPAGFSLEWKGNSFKPETMFAATDIYTAEYQDIVCLLQPILNENSHSFRGCGSVSLAVKEFLGLLKKPTVDLVINQLKQVAKSVDDGITLYQENITNACYKYLHEAVLQNEMAKATIIEKLKPFCFILVENVYVESEKVSFHLNFEAAPYLYQLPNKYKNNFRELFESVGVRQSFTVEDFALVLESIDQERGKKQITEENFQLCRRIISEGIWSLIREKRQEFCEKNYGKILLPDTNLLLLPAKSLCYNDCPWIKVKDSTVKYCHADIPREVAVKLGAIPKRHKALERYASNICFTALGTEFGQKEKLTSRIKSILNAYPSEKEMLKELLQNADDAKATEICFVFDPRQHPVDRIFDDKWAPLQGPALCVYNNQPFTEDDVRGIQNLGKGTKEGNPCKTGHYGIGFNSVYHITDCPSFISGNDILGIFDPHARYAPGATSVSPGRMFRDLDADFRTQFSDVLDLYLGNHFKLDNCTMFRFPLRNAEMAQVSEISSVPSSDRMVQNLLDKLRSDGAELLMFLNHMEKISICEIDKATGGLNVLYSVKGKITDGDRLKRKQFHASVIDSVTKKRQLKDIPVQQITYTMDTEDSEGNLTTWLICNRSGFSSMEKVSKSVISAHKNQDITLFPRGGVAACITHNYKKPHRAFCFLPLSLETGLPFHVNGHFALDSARRNLWRDDNGVGVRSDWNNSLMTALIAPAYVELLIQLKKRYFPGSDPTLSVLQNTPIHVVKDTLKKFLSFFPVNRLDLQPDLYCLVKALYSCIHEDMKRLLPVVRAPNIDGSDLHSAVIITWINMSTSNKTRPFFDNLLQDELQHLKNADYNITTRKTVAENVYRLKHLLLEIGFNLVYNCDETANLYHCLVDADIPVSYVTPADVRSFLMTFSSPDTNCHIGKLPCRLQQTNLKLFHSLKLLVDYCFKDAEESEFEVEGLPLLITLDSVLQIFDGKRPKFLTTYHELIPSRKDLFMNTLYLKYSSVLLNCKVAKVFDISSFADLLSSVLPREYKTKNCAKWKDNFASESWLKNAWHFISESVSVTDDQEEPKPAFDVIVDILKDWALLPGTKFTVSTSQLVVPEGDVLIPLSLMHIAVFPNAQSDKVFHALMKAGCIQLALNKICSKDSALVPLLSCHTANIDSPASILKAVHYMVQTSTFRTEKLMENDFEALLMYFNCNLSHLMSQDDIKILKSLPCYKSISGRYMSIAKFGTCYVLTKSIPSAEVEKWTQSSSSAFLEEKVHLKELYEVLGCVPVDDLEVYLKHLLPKIENLSYDAKLEHLIYLKNRLASIEEPSEIKEQLFEKLESLLIIHDANNRLKQAKHFYDRTVRVFEVMLPEKLFIPKEFFKKLEQVIKPKNQAAFMTSWVEFLRNIGLKYALSQQQLLQFAKEISVRANTENWSKETLQSTVDILLHHIFQERMDLLSGNFLKELSLIPFLCPERAPAEYIRFHPQYQEVNGTLPLIKFNGAQVNPKFKQCDVLQLLWTSCPILPEKATPLSIKEQEGSDLAPQEQLEQVLNMLNVNLDPPLDKVINNCRNICNITTLDEEMVKTRAKVLRSIYEFLSAEKREFRFQLRGVAFVMVEDGWKLLKPEEVVINLEYEADFKPYLYKLPLELGTFHQLFKHLGTEDIISTKQYVEVLSRIFKSSEGKQLDPNEMRTVKRVVSGLFKSLQNDSVKVRSDLENARDLALYLPSQDGKLVKSSILVFDDAPHYKSRIQGNIGVQMLVDLSQCYLGKDHGFHTKLIMLFPQKLRPRLLSSILEEQLDEETPKVCQFGALCSLQGRLQLLLSSEQFITGLIRIMKHENDNAFLANEEKAIRLCKALREGLKVSCFEKLQTTLRVKGFNPIPHSRSETFAFLKRFGNAVILLYIQHSDSKDINFLLALAMTLKSATDNLISDTSYLIAMLGCNDIYRISEKLDSLGVKYDSSEPSKLELPMPGTPIPAEIHYTLLMDPMNVFYPGEYVGYLVDAEGGDIYGSYQPTYTYAIIVQEVEREDADNTSFLGKIYQIDIGYSEYKIVSSLDLYKFSRPDESSQNRDSAPTTPTSPTEFLTPGLRSIPPLFSGKESHKSPSTKHHSPRKLKVNALPEILKEVTSVVEQAWKLPESERKKIIRRLYLKWHPDKNPENHDIANEVFKHLQNEINRLEKQAFLDQNADRASRRTFSTSASRFQSDKYSFQRFYTSWNQEATSHKSERQQQSKEKCPPSAGQTYSQRFFVPPTFKSVGNPVEARRWLRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAADYAVRGKSDKDVKPTALAQKIEEYSQQLEGLTNDVHTLEAYGVDSLKTRYPDLLPFPQIPNDRFTSEVAMRVMECTACIIIKLENFIQQKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
621	Phosphorylation	SAASATSSASPVRKV HHHHCCCCCCCCCCC	28.54	23737553
623	Phosphorylation	ASATSSASPVRKVTP HHCCCCCCCCCCCCH	26.35	23737553
872	Phosphorylation	LVKKYIHSPLPSAIL HHHHHCCCCCCHHHH	20.69	28059163
911	Phosphorylation	ALRKFLASLTDTSEK HHHHHHHHCCCCCHH	33.67	21149613
913	Phosphorylation	RKFLASLTDTSEKEK HHHHHHCCCCCHHHH	34.43	21149613
915	Phosphorylation	FLASLTDTSEKEKRI HHHHCCCCCHHHHHH	33.28	21149613
916	Phosphorylation	LASLTDTSEKEKRII HHHCCCCCHHHHHHH	49.86	21149613
945	Acetylation	QGISSYTKLKGCKVL CCCCCCHHCCCCEEC	39.71	-
1376	Phosphorylation	YSNQIPASPNTPVPI HHCCCCCCCCCCCCE	17.21	21183079
1379	Phosphorylation	QIPASPNTPVPIYHS CCCCCCCCCCCEECC	29.10	21183079
1657	Acetylation	FRTQQEAKVSEVSST EECCCCHHHHHCCHH	45.61	7712087
1749	Acetylation	KTCSSSNKKLPTDVP HHHCCCCCCCCCCCC	58.60	19852231
1781	Phosphorylation	RRIADLQSPLFRGPD HHHHCCCCCCCCCCC	30.76	25521595
1800	Phosphorylation	TLFEMAKSGQSKKPS HHHHHHHHCCCCCCC	32.31	28285833
1803	Phosphorylation	EMAKSGQSKKPSDEL HHHHHCCCCCCCCCC	46.29	28285833
2052	Phosphorylation	KQILLENTFSEKQFF CEEEEECCCCHHHHH	21.11	25777480
2054	Phosphorylation	ILLENTFSEKQFFSE EEEECCCCHHHHHHH	41.67	25777480
2511	Phosphorylation	RHKALERYASNICFT HHHHHHHHHHHHHHH	12.66	21659605
2513	Phosphorylation	KALERYASNICFTAL HHHHHHHHHHHHHHH	20.14	25521595
2518	Phosphorylation	YASNICFTALGTEFG HHHHHHHHHHCCCCC	19.30	21183079
2541	Phosphorylation	IKSILNAYPSEKEML HHHHHHHCCCHHHHH	13.25	21183079
2543	Phosphorylation	SILNAYPSEKEMLKE HHHHHCCCHHHHHHH	48.93	21183079
2716	Phosphorylation	MAQVSEISSVPSSDR HHCHHHHCCCCCHHH	22.64	25338131
2720	Phosphorylation	SEISSVPSSDRMVQN HHHCCCCCHHHHHHH	42.59	25338131
2721	Phosphorylation	EISSVPSSDRMVQNL HHCCCCCHHHHHHHH	24.14	25338131
3437	Phosphorylation	TCYVLTKSIPSAEVE EEEEEECCCCHHHHH	34.20	-
3615	Phosphorylation	EISVRANTENWSKET HHHHHCCCCCCCHHH	29.70	22802335
3619	Phosphorylation	RANTENWSKETLQST HCCCCCCCHHHHHHH	32.00	22802335
3622	Phosphorylation	TENWSKETLQSTVDI CCCCCHHHHHHHHHH	33.56	22802335
3626	Phosphorylation	SKETLQSTVDILLHH CHHHHHHHHHHHHHH	14.83	22802335
3665	Phosphorylation	PERAPAEYIRFHPQY CCCCCHHHHCCCCCH	10.25	22982522
3978	Phosphorylation	LRPRLLSSILEEQLD HHHHHHHHHHHHHCC	31.03	24453211
4248	Phosphorylation	SLDLYKFSRPDESSQ EEEEEECCCCCCCCC	38.46	29899451
4253	Phosphorylation	KFSRPDESSQNRDSA ECCCCCCCCCCCCCC	44.60	29899451
4254	Phosphorylation	FSRPDESSQNRDSAP CCCCCCCCCCCCCCC	29.44	29899451
4259	Phosphorylation	ESSQNRDSAPTTPTS CCCCCCCCCCCCCCC	32.67	25619855
4262	Phosphorylation	QNRDSAPTTPTSPTE CCCCCCCCCCCCCHH	45.16	25619855
4263	Phosphorylation	NRDSAPTTPTSPTEF CCCCCCCCCCCCHHH	24.42	26824392
4265	Phosphorylation	DSAPTTPTSPTEFLT CCCCCCCCCCHHHCC	45.29	21082442
4266	Phosphorylation	SAPTTPTSPTEFLTP CCCCCCCCCHHHCCC	30.91	25521595
4268	Phosphorylation	PTTPTSPTEFLTPGL CCCCCCCHHHCCCCC	38.85	22942356
4272	Phosphorylation	TSPTEFLTPGLRSIP CCCHHHCCCCCCCCC	22.19	25619855
4277	Phosphorylation	FLTPGLRSIPPLFSG HCCCCCCCCCCCCCC	44.48	28576409
4384	Phosphorylation	RASRRTFSTSASRFQ HHHHHHCCCCHHHHH	22.34	29514104
4409	Phosphorylation	TSWNQEATSHKSERQ HHCCHHHHCCHHHHH	30.52	21183079
4410	Phosphorylation	SWNQEATSHKSERQQ HCCHHHHCCHHHHHH	35.65	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SACS_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SACS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SACS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SACS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-4265, AND MASSSPECTROMETRY.
PubMed: 17114649