SRBS1_MOUSE - dbPTM
SRBS1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SRBS1_MOUSE
UniProt AC Q62417
Protein Name Sorbin and SH3 domain-containing protein 1
Gene Name Sorbs1 {ECO:0000312|MGI:MGI:700014}
Organism Mus musculus (Mouse).
Sequence Length 1290
Subcellular Localization Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Nucleus matrix. Colocalized with PXN at focal adhesions during myogenic differentiation (By similarity). Colocalizes with actin stress f
Protein Description Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions..
Protein Sequence MSSECDVGSSKAVVNGLASGNHGPDKDMDPTKICTGKGTVTLRASSSYRGTPSSSPVSPQESPKHESKSGLEPEDPSADEWKLSSSADTNGNAQPSPLAAKGYRSVHPSLSADKPQGSPLLNEVSSSHIETDSQDFPPTSRPSSAYPSTTIVNPTIVLLQHNRDPASERRAGEQDPVPTPAELTSPGRASERRAKDASRRVVRSAQDLSDVSTDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDVHSPRYSFSDDTKSPLSVPRSKSEMNYIEGEKVVKRSATLPLPARSSSLKSSPERNDWEPLDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGRPTNLEKDLSFCQAELEADLEKVETVNKSPSANSPQSSAVSPTPDITSEPPGYIYSSNFHAVKRESDGTPGGLASLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKVDRKGGNAHMISSSSVHSRTFHTSNALGPGCKHKKPLSAAKACISEILPSKFKPRLSAPSALLQEQKSVLLPSEKAQSCENLCVSLNDSKRGLPLRVGGSIENLLMRSRRDYDSKSSSTMSLQEYGTSSRRPCPLSRKAGLHFSMFYRDMHQINRAGLSLGSISSSSVRDLASHFERSSLTLARGELGASQEGSEHIPKHTVSSRITAFEQLIQRSRSMPSLDFSGRLSKSPTPVLSRSGLTSARSAESLLESTKLRPREMDGMDSGGVYASPTCSNMADHALSFRSLVPSEPLSICSDELDHCSNVSNDSREGSGGSVHGDFPKHRLNKCKGTCPASYTRFTTIRKHEQQSSRQSDWRSDSRGDKNSLLRNIHLMSPLPFRLKKPLQQHPRQPPPSDSSESPAGQKADLPCHDPQDQPHSAGKPQVPTRLSSRHTMARLSHNSEPPLDRPAGLEDCTRAINNGNPVPYSDHGLDRNNNPQSELAAAHGDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGLEMRPARAKFDFKAQTLKELPLQKGDVVYIYRQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPRKLAPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVLKRPLVKTPVDYIDLPYSSSPSRSATVSPQQPQAQQRRVTPDRSQPSLDLCSYQALYSYVPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36 (in isoform 4)Phosphorylation-23.2223737553
37MalonylationPTKICTGKGTVTLRA
CCCCCCCCCEEEEEE		33.0026320211
45PhosphorylationGTVTLRASSSYRGTP
CEEEEEECCCCCCCC		17.2426160508
46PhosphorylationTVTLRASSSYRGTPS
EEEEEECCCCCCCCC		30.3326160508
47PhosphorylationVTLRASSSYRGTPSS
EEEEECCCCCCCCCC		19.1625521595
48PhosphorylationTLRASSSYRGTPSSS
EEEECCCCCCCCCCC		18.2723737553
48 (in isoform 4)Phosphorylation-18.2723737553
50 (in isoform 4)Phosphorylation-33.4723737553
51PhosphorylationASSSYRGTPSSSPVS
ECCCCCCCCCCCCCC		15.8225521595
53PhosphorylationSSYRGTPSSSPVSPQ
CCCCCCCCCCCCCCC		43.2025521595
54PhosphorylationSYRGTPSSSPVSPQE
CCCCCCCCCCCCCCC		39.6025521595
55PhosphorylationYRGTPSSSPVSPQES
CCCCCCCCCCCCCCC		33.3925521595
55 (in isoform 2)Phosphorylation-33.3926824392
55 (in isoform 3)Phosphorylation-33.3926824392
55 (in isoform 5)Phosphorylation-33.3926824392
55 (in isoform 6)Phosphorylation-33.3926824392
55 (in isoform 7)Phosphorylation-33.3926824392
58PhosphorylationTPSSSPVSPQESPKH
CCCCCCCCCCCCCCC		25.0125521595
58 (in isoform 2)Phosphorylation-25.0126824392
58 (in isoform 3)Phosphorylation-25.0126824392
58 (in isoform 5)Phosphorylation-25.0126824392
58 (in isoform 6)Phosphorylation-25.0126824392
58 (in isoform 7)Phosphorylation-25.0126824392
62PhosphorylationSPVSPQESPKHESKS
CCCCCCCCCCCCCCC		33.7225521595
62 (in isoform 2)Phosphorylation-33.7226824392
62 (in isoform 3)Phosphorylation-33.7226824392
62 (in isoform 5)Phosphorylation-33.7226824392
62 (in isoform 6)Phosphorylation-33.7226824392
62 (in isoform 7)Phosphorylation-33.7226824392
67PhosphorylationQESPKHESKSGLEPE
CCCCCCCCCCCCCCC		31.6624925903
84PhosphorylationSADEWKLSSSADTNG
CCCCCEECCCCCCCC		20.6525777480
85PhosphorylationADEWKLSSSADTNGN
CCCCEECCCCCCCCC		39.7325777480
85 (in isoform 4)Phosphorylation-39.7326824392
86PhosphorylationDEWKLSSSADTNGNA
CCCEECCCCCCCCCC		27.1325777480
88 (in isoform 4)Phosphorylation-42.5326824392
89PhosphorylationKLSSSADTNGNAQPS
EECCCCCCCCCCCCC		44.7517203969
92 (in isoform 4)Phosphorylation-37.1626824392
96PhosphorylationTNGNAQPSPLAAKGY
CCCCCCCCCCHHCCC		22.0730352176
103PhosphorylationSPLAAKGYRSVHPSL
CCCHHCCCCCCCCCC		10.0617203969
105PhosphorylationLAAKGYRSVHPSLSA
CHHCCCCCCCCCCCC		19.12-
111PhosphorylationRSVHPSLSADKPQGS
CCCCCCCCCCCCCCC		38.4727841257
141 (in isoform 7)Phosphorylation-37.2826060331
144 (in isoform 7)Phosphorylation-34.2126060331
161 (in isoform 2)Phosphorylation-31.1225521595
161 (in isoform 5)Phosphorylation-31.1225521595
162 (in isoform 2)Phosphorylation-36.7727180971
162 (in isoform 5)Phosphorylation-36.7727180971
162 (in isoform 7)Phosphorylation-36.77-
164PhosphorylationVLLQHNRDPASERRA
EEEECCCCHHHHCCC		48.7324719451
164 (in isoform 2)Phosphorylation-48.7326824392
164 (in isoform 5)Phosphorylation-48.7326824392
168 (in isoform 2)Phosphorylation-48.5727742792
168 (in isoform 5)Phosphorylation-48.5727742792
172 (in isoform 6)Phosphorylation-31.1425521595
173 (in isoform 6)Phosphorylation-51.3227180971
175 (in isoform 6)Phosphorylation-41.6926824392
179PhosphorylationGEQDPVPTPAELTSP
CCCCCCCCCHHHCCC		35.0527742792
179 (in isoform 6)Phosphorylation-35.0527742792
184PhosphorylationVPTPAELTSPGRASE
CCCCHHHCCCCCHHH		25.1226824392
185PhosphorylationPTPAELTSPGRASER
CCCHHHCCCCCHHHH		37.6725521595
186PhosphorylationTPAELTSPGRASERR
CCHHHCCCCCHHHHH		30.9324719451
190PhosphorylationLTSPGRASERRAKDA
HCCCCCHHHHHHHHH		30.2129899451
191 (in isoform 4)Phosphorylation-45.2425521595
192 (in isoform 4)Phosphorylation-41.1627180971
194 (in isoform 4)Phosphorylation-21.9426824392
198 (in isoform 4)Phosphorylation-30.6527742792
203 (in isoform 7)Phosphorylation-24.3426824392
204PhosphorylationASRRVVRSAQDLSDV
HHHHHHHHHHHHHCC		20.7627742792
209PhosphorylationVRSAQDLSDVSTDEV
HHHHHHHHCCCCCCC		44.2325619855
212PhosphorylationAQDLSDVSTDEVGIP
HHHHHCCCCCCCCCC		34.8225619855
213PhosphorylationQDLSDVSTDEVGIPL
HHHHCCCCCCCCCCC		35.7125619855
232PhosphorylationRSKDWYKTMFKQIHK
CCHHHHHHHHHHHHH		16.4921183079
246PhosphorylationKLNRDDDSDVHSPRY
HCCCCCCCCCCCCCC		48.8326824392
250PhosphorylationDDDSDVHSPRYSFSD
CCCCCCCCCCCCCCC		15.7726824392
253PhosphorylationSDVHSPRYSFSDDTK
CCCCCCCCCCCCCCC		19.9027742792
254PhosphorylationDVHSPRYSFSDDTKS
CCCCCCCCCCCCCCC		21.3925521595
255PhosphorylationVHSPRYSFSDDTKSP
CCCCCCCCCCCCCCC		7.4224719451
256PhosphorylationHSPRYSFSDDTKSPL
CCCCCCCCCCCCCCC		28.7425521595
259PhosphorylationRYSFSDDTKSPLSVP
CCCCCCCCCCCCCCC		38.1127742792
260UbiquitinationYSFSDDTKSPLSVPR
CCCCCCCCCCCCCCC		58.01-
261PhosphorylationSFSDDTKSPLSVPRS
CCCCCCCCCCCCCCC		32.9226824392
264PhosphorylationDDTKSPLSVPRSKSE
CCCCCCCCCCCCHHH		33.2027742792
268PhosphorylationSPLSVPRSKSEMNYI
CCCCCCCCHHHHCCC		34.1725521595
269UbiquitinationPLSVPRSKSEMNYIE
CCCCCCCHHHHCCCC		52.28-
270PhosphorylationLSVPRSKSEMNYIEG
CCCCCCHHHHCCCCC		43.2425521595
274PhosphorylationRSKSEMNYIEGEKVV
CCHHHHCCCCCCEEE		10.0723737553
284PhosphorylationGEKVVKRSATLPLPA
CCEEEEEEECCCCCC		21.6422324799
285 (in isoform 7)Phosphorylation-19.7225521595
286PhosphorylationKVVKRSATLPLPARS
EEEEEEECCCCCCCC		30.1025521595
286 (in isoform 7)Phosphorylation-30.1027180971
288 (in isoform 7)Phosphorylation-31.7626824392
292 (in isoform 7)Phosphorylation-34.8227742792
293PhosphorylationTLPLPARSSSLKSSP
CCCCCCCCCCCCCCC		26.7827681418
294PhosphorylationLPLPARSSSLKSSPE
CCCCCCCCCCCCCCC		33.8523140645
295PhosphorylationPLPARSSSLKSSPER
CCCCCCCCCCCCCCC		40.8523140645
298PhosphorylationARSSSLKSSPERNDW
CCCCCCCCCCCCCCC		57.3226745281
299PhosphorylationRSSSLKSSPERNDWE
CCCCCCCCCCCCCCC		29.2324899341
325PhosphorylationRAEPKSIYEYQPGKS
CCCCCCEEECCCCCC		18.7020116462
327PhosphorylationEPKSIYEYQPGKSSV
CCCCEEECCCCCCCC		11.75-
341PhosphorylationVLTNEKMSRDISPEE
CCCCCCCCCCCCHHH		37.5627180971
342 (in isoform 2)Phosphorylation-41.6126745281
342 (in isoform 5)Phosphorylation-41.6126745281
343 (in isoform 2)Phosphorylation-38.1127180971
343 (in isoform 5)Phosphorylation-38.1127180971
345PhosphorylationEKMSRDISPEEIDLK
CCCCCCCCHHHHCCC		30.4625521595
346 (in isoform 2)Phosphorylation-43.5026824392
346 (in isoform 5)Phosphorylation-43.5026824392
348PhosphorylationSRDISPEEIDLKNEP
CCCCCHHHHCCCCCC		45.2324719451
348 (in isoform 2)Phosphorylation-45.2326745281
348 (in isoform 5)Phosphorylation-45.2326745281
352UbiquitinationSPEEIDLKNEPWYKF
CHHHHCCCCCCHHHH		56.36-
352 (in isoform 2)Phosphorylation-56.3625777480
352 (in isoform 5)Phosphorylation-56.3625777480
353 (in isoform 2)Phosphorylation-68.7925777480
353 (in isoform 5)Phosphorylation-68.7925777480
353 (in isoform 6)Phosphorylation-68.7926745281
354 (in isoform 6)Phosphorylation-35.3127180971
357PhosphorylationDLKNEPWYKFFSELE
CCCCCCHHHHHHHHH		14.50-
357 (in isoform 6)Phosphorylation-14.5026824392
358 (in isoform 2)Phosphorylation-35.7425777480
358 (in isoform 5)Phosphorylation-35.7425777480
359 (in isoform 6)Phosphorylation-4.8326745281
360 (in isoform 2)Phosphorylation-4.9225777480
360 (in isoform 5)Phosphorylation-4.9225777480
361 (in isoform 2)Phosphorylation-44.3925777480
361 (in isoform 5)Phosphorylation-44.3925777480
362 (in isoform 2)Phosphorylation-47.3525777480
362 (in isoform 5)Phosphorylation-47.3525777480
363 (in isoform 6)Phosphorylation-6.8225777480
364 (in isoform 6)Phosphorylation-41.8425777480
367 (in isoform 3)Phosphorylation-39.94-
369 (in isoform 6)Phosphorylation-51.5825777480
371PhosphorylationEFGRPTNLEKDLSFC
HCCCCCCHHHHHHHH		10.7424719451
371 (in isoform 6)Phosphorylation-10.7425777480
372 (in isoform 4)Phosphorylation-46.7426745281
372 (in isoform 6)Phosphorylation-46.7425777480
373 (in isoform 3)Phosphorylation-68.11-
373 (in isoform 4)Phosphorylation-68.1127180971
373 (in isoform 6)Phosphorylation-68.1125777480
376PhosphorylationTNLEKDLSFCQAELE
CCHHHHHHHHHHHHH		33.8225521595
376 (in isoform 4)Phosphorylation-33.8226824392
378 (in isoform 4)Phosphorylation-3.1726745281
382 (in isoform 3)Phosphorylation-8.0325367039
382 (in isoform 4)Phosphorylation-8.0325777480
383 (in isoform 3)Phosphorylation-31.4825367039
383 (in isoform 4)Phosphorylation-31.4825777480
386 (in isoform 3)Phosphorylation-9.8925367039
388 (in isoform 3)Phosphorylation-53.3125367039
388 (in isoform 4)Phosphorylation-53.3125777480
390 (in isoform 4)Phosphorylation-59.0925777480
391PhosphorylationADLEKVETVNKSPSA
HHHHHHHHCCCCCCC		32.1623737553
391 (in isoform 4)Phosphorylation-32.1625777480
392 (in isoform 3)Phosphorylation-5.5625367039
392 (in isoform 4)Phosphorylation-5.5625777480
393 (in isoform 3)Phosphorylation-46.6525367039
395PhosphorylationKVETVNKSPSANSPQ
HHHHCCCCCCCCCCC		20.9123737553
397PhosphorylationETVNKSPSANSPQSS
HHCCCCCCCCCCCCC		47.3623737553
398 (in isoform 3)Phosphorylation-24.7325367039
400PhosphorylationNKSPSANSPQSSAVS
CCCCCCCCCCCCCCC		24.8423737553
400 (in isoform 3)Phosphorylation-24.8425367039
401 (in isoform 3)Phosphorylation-37.5725367039
402 (in isoform 3)Phosphorylation-50.2525367039
403PhosphorylationPSANSPQSSAVSPTP
CCCCCCCCCCCCCCC		24.5323737553
404PhosphorylationSANSPQSSAVSPTPD
CCCCCCCCCCCCCCC		27.6923737553
407PhosphorylationSPQSSAVSPTPDITS
CCCCCCCCCCCCCCC		23.8323737553
409PhosphorylationQSSAVSPTPDITSEP
CCCCCCCCCCCCCCC		26.5323737553
409 (in isoform 2)Phosphorylation-26.5326824392
409 (in isoform 5)Phosphorylation-26.5326824392
410 (in isoform 2)Phosphorylation-34.1026824392
410 (in isoform 5)Phosphorylation-34.1026824392
411 (in isoform 2)Phosphorylation-60.3123737553
411 (in isoform 5)Phosphorylation-60.3123737553
413PhosphorylationVSPTPDITSEPPGYI
CCCCCCCCCCCCCEE		34.1223737553
413 (in isoform 2)Phosphorylation-34.1226824392
413 (in isoform 5)Phosphorylation-34.1226824392
414PhosphorylationSPTPDITSEPPGYIY
CCCCCCCCCCCCEEE		48.7327742792
414 (in isoform 2)Phosphorylation-48.7323737553
414 (in isoform 5)Phosphorylation-48.7323737553
417 (in isoform 2)Phosphorylation-44.1426824392
417 (in isoform 5)Phosphorylation-44.1426824392
419PhosphorylationITSEPPGYIYSSNFH
CCCCCCCEEEECCEE		11.4923737553
419 (in isoform 2)Phosphorylation-11.4923737553
419 (in isoform 5)Phosphorylation-11.4923737553
420 (in isoform 6)Phosphorylation-3.1326824392
421PhosphorylationSEPPGYIYSSNFHAV
CCCCCEEEECCEEEE		9.5019891780
421 (in isoform 6)Phosphorylation-9.5026824392
422 (in isoform 6)Phosphorylation-14.8323737553
424 (in isoform 6)Phosphorylation-27.1226824392
425 (in isoform 6)Phosphorylation-4.1723737553
428 (in isoform 6)Phosphorylation-4.5126824392
430 (in isoform 6)Phosphorylation-41.8923737553
432PhosphorylationFHAVKRESDGTPGGL
EEEEEECCCCCCCCH		45.4325521595
435PhosphorylationVKRESDGTPGGLASL
EEECCCCCCCCHHHH		24.6126824392
439 (in isoform 4)Phosphorylation-3.4726824392
440 (in isoform 4)Phosphorylation-18.4926824392
441PhosphorylationGTPGGLASLENERQI
CCCCCHHHHHHHHHH		41.0626824392
441 (in isoform 4)Phosphorylation-41.0623737553
443 (in isoform 4)Phosphorylation-55.3326824392
444 (in isoform 4)Phosphorylation-55.8523737553
447 (in isoform 4)Phosphorylation-36.8726824392
449 (in isoform 3)Phosphorylation-6.7226824392
449 (in isoform 4)Phosphorylation-6.7223737553
450 (in isoform 3)Phosphorylation-35.4026824392
451PhosphorylationNERQIYKSVLEGGDI
HHHHHHHHHHCCCCC		18.2427180971
451 (in isoform 3)Phosphorylation-18.2423737553
453 (in isoform 3)Phosphorylation-6.9926824392
454 (in isoform 3)Phosphorylation-60.0023737553
457 (in isoform 3)Phosphorylation-50.6326824392
459 (in isoform 3)Phosphorylation-24.3023737553
466 (in isoform 7)Phosphorylation-3.7026745281
467UbiquitinationLQGLSGLKRPSSSAS
CCCCCCCCCCCCCCC		66.83-
467 (in isoform 7)Phosphorylation-66.8327180971
470PhosphorylationLSGLKRPSSSASTKV
CCCCCCCCCCCCCCC		40.7423737553
470 (in isoform 7)Phosphorylation-40.7426824392
471PhosphorylationSGLKRPSSSASTKVD
CCCCCCCCCCCCCCC		32.3823737553
472PhosphorylationGLKRPSSSASTKVDR
CCCCCCCCCCCCCCC		30.4923737553
472 (in isoform 7)Phosphorylation-30.4926745281
474PhosphorylationKRPSSSASTKVDRKG
CCCCCCCCCCCCCCC		30.6123737553
475PhosphorylationRPSSSASTKVDRKGG
CCCCCCCCCCCCCCC		34.5023737553
476 (in isoform 7)Phosphorylation-39.3825777480
477 (in isoform 7)Phosphorylation-9.7325777480
482 (in isoform 7)Phosphorylation-31.0525777480
484 (in isoform 7)Phosphorylation-9.2625777480
485 (in isoform 7)Phosphorylation-20.3625777480
486 (in isoform 7)Phosphorylation-2.7125777480
489PhosphorylationGNAHMISSSSVHSRT
CCEEEEECCCCCCCC		18.7328285833
494PhosphorylationISSSSVHSRTFHTSN
EECCCCCCCCCCCCC		30.7528285833
497PhosphorylationSSVHSRTFHTSNALG
CCCCCCCCCCCCCCC		6.0224719451
533PhosphorylationSKFKPRLSAPSALLQ
CCCCCCCCCCHHHHH		39.1422324799
533 (in isoform 7)Phosphorylation-39.1426824392
534 (in isoform 7)Phosphorylation-13.4726824392
535 (in isoform 7)Phosphorylation-19.4323737553
536PhosphorylationKPRLSAPSALLQEQK
CCCCCCCHHHHHHHH		31.1229899451
537 (in isoform 7)Phosphorylation-15.9526824392
538 (in isoform 7)Phosphorylation-6.2723737553
541 (in isoform 7)Phosphorylation-61.0026824392
543 (in isoform 7)Phosphorylation-41.6023737553
554PhosphorylationLPSEKAQSCENLCVS
CCHHHHHHCCCEEEE		28.4025521595
576PhosphorylationLPLRVGGSIENLLMR
CCEECCCHHHHHHHH		22.3222324799
592PhosphorylationRRDYDSKSSSTMSLQ
CCCCCCCCCCCCCHH		33.2123527152
593O-linked_GlycosylationRDYDSKSSSTMSLQE
CCCCCCCCCCCCHHH		33.3022517741
594PhosphorylationDYDSKSSSTMSLQEY
CCCCCCCCCCCHHHH		34.9123527152
597O-linked_GlycosylationSKSSSTMSLQEYGTS
CCCCCCCCHHHHCCC		27.3022517741
597PhosphorylationSKSSSTMSLQEYGTS
CCCCCCCCHHHHCCC		27.3029899451
635PhosphorylationQINRAGLSLGSISSS
HHHHCCCCCCCCCHH		29.7529899451
638PhosphorylationRAGLSLGSISSSSVR
HCCCCCCCCCHHHHH		25.2929899451
641PhosphorylationLSLGSISSSSVRDLA
CCCCCCCHHHHHHHH		25.5929899451
643PhosphorylationLGSISSSSVRDLASH
CCCCCHHHHHHHHHH		24.1029899451
649PhosphorylationSSVRDLASHFERSSL
HHHHHHHHHHHHHHH		35.6929899451
650PhosphorylationSVRDLASHFERSSLT
HHHHHHHHHHHHHHH		23.9924719451
659PhosphorylationERSSLTLARGELGAS
HHHHHHHHCCCCCCC		16.5224719451
666PhosphorylationARGELGASQEGSEHI
HCCCCCCCCCCCCCC		27.2827841257
670PhosphorylationLGASQEGSEHIPKHT
CCCCCCCCCCCCCCC		25.8329899451
692PhosphorylationFEQLIQRSRSMPSLD
HHHHHHHHHCCCCCC		16.6019060867
694PhosphorylationQLIQRSRSMPSLDFS
HHHHHHHCCCCCCCC		35.9725521595
697PhosphorylationQRSRSMPSLDFSGRL
HHHHCCCCCCCCCCC		31.7422324799
707PhosphorylationFSGRLSKSPTPVLSR
CCCCCCCCCCCCCCC		30.5422324799
709PhosphorylationGRLSKSPTPVLSRSG
CCCCCCCCCCCCCCC		32.8722324799
713PhosphorylationKSPTPVLSRSGLTSA
CCCCCCCCCCCCCCH		25.3229899451
715PhosphorylationPTPVLSRSGLTSARS
CCCCCCCCCCCCHHH		34.4829899451
719PhosphorylationLSRSGLTSARSAESL
CCCCCCCCHHHHHHH		27.08-
722PhosphorylationSGLTSARSAESLLES
CCCCCHHHHHHHHHH		35.7825521595
725PhosphorylationTSARSAESLLESTKL
CCHHHHHHHHHHCCC		37.6625521595
729PhosphorylationSAESLLESTKLRPRE
HHHHHHHHCCCCCCC		30.7129899451
730PhosphorylationAESLLESTKLRPREM
HHHHHHHCCCCCCCC		25.4029899451
742PhosphorylationREMDGMDSGGVYASP
CCCCCCCCCCCCCCC		28.6729895711
746PhosphorylationGMDSGGVYASPTCSN
CCCCCCCCCCCCCCH		12.4929895711
748PhosphorylationDSGGVYASPTCSNMA
CCCCCCCCCCCCHHC		11.7629895711
752PhosphorylationVYASPTCSNMADHAL
CCCCCCCCHHCCCCC		31.9229895711
775 (in isoform 7)Phosphorylation-56.9429514104
781PhosphorylationSDELDHCSNVSNDSR
CCCCCCCCCCCCCCC		36.53-
784PhosphorylationLDHCSNVSNDSREGS
CCCCCCCCCCCCCCC		38.89-
787PhosphorylationCSNVSNDSREGSGGS
CCCCCCCCCCCCCCC		36.16-
908PhosphorylationPQVPTRLSSRHTMAR
CCCCCCCCCHHHHHH		23.2623140645
909PhosphorylationQVPTRLSSRHTMARL
CCCCCCCCHHHHHHC		32.4523140645
967PhosphorylationLAAAHGDSESPRHFI
HHHHHCCCCCCCCCC		44.5629899451
969PhosphorylationAAHGDSESPRHFIPA
HHHCCCCCCCCCCCH		31.0530372032
978PhosphorylationRHFIPADYLESTEEF
CCCCCHHHHHCHHHH		17.9329899451
1018PhosphorylationDIAARRHTGVIPTHH
HHHHHHCCCCCCCCC		31.1926824392
1042PhosphorylationDLLNIDDTAKRKSGL
HHCCCCCHHHHHCCC		30.2627180971
1047PhosphorylationDDTAKRKSGLEMRPA
CCHHHHHCCCCCCCC		53.2827180971
1077PhosphorylationLQKGDVVYIYRQIDQ
CCCCCEEEEEEECCC		7.65-
1111UbiquitinationELLPPAEKAQPRKLA
HHCCHHHHCCCCCCC		55.20-
1116UbiquitinationAEKAQPRKLAPVQVL
HHHCCCCCCCCEEEE		56.54-
1125PhosphorylationAPVQVLEYGEAIAKF
CCEEEEECCEEEEEE		18.9925195567
1189PhosphorylationLKRPLVKTPVDYIDL
HCCCCCCCCCCEECC		22.5124925903
1193PhosphorylationLVKTPVDYIDLPYSS
CCCCCCCEECCCCCC		9.1424925903
1198PhosphorylationVDYIDLPYSSSPSRS
CCEECCCCCCCCCCC		28.6025521595
1199O-linked_GlycosylationDYIDLPYSSSPSRSA
CEECCCCCCCCCCCC		23.5422517741
1199PhosphorylationDYIDLPYSSSPSRSA
CEECCCCCCCCCCCC		23.5424925903
1200O-linked_GlycosylationYIDLPYSSSPSRSAT
EECCCCCCCCCCCCC		40.19-
1200PhosphorylationYIDLPYSSSPSRSAT
EECCCCCCCCCCCCC		40.1925521595
1201O-linked_GlycosylationIDLPYSSSPSRSATV
ECCCCCCCCCCCCCC		22.43-
1201PhosphorylationIDLPYSSSPSRSATV
ECCCCCCCCCCCCCC		22.4325521595
1203PhosphorylationLPYSSSPSRSATVSP
CCCCCCCCCCCCCCC		40.5924925903
1205PhosphorylationYSSSPSRSATVSPQQ
CCCCCCCCCCCCCCC		32.4027087446
1207PhosphorylationSSPSRSATVSPQQPQ
CCCCCCCCCCCCCCH		23.8223527152
1209PhosphorylationPSRSATVSPQQPQAQ
CCCCCCCCCCCCHHH		16.7925521595
1221PhosphorylationQAQQRRVTPDRSQPS
HHHHCCCCCCCCCCC		20.0523140645
1238PhosphorylationLCSYQALYSYVPQND
HCCHHHHHHCCCCCC		10.8516141072
1270PhosphorylationDDGWFVGTSRRTRQF
CCCEEECCCCCEEEC		17.48-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
325YPhosphorylationKinaseABL1P00520
Uniprot
326YPhosphorylationKinaseABL1P00519
GPS
326YPhosphorylationKinaseSRCP12931
PSP
360YPhosphorylationKinaseABL1P00519
GPS
360YPhosphorylationKinaseSRCP12931
PSP
421YPhosphorylationKinaseABL1P00520
Uniprot
632YPhosphorylationKinaseABL1P00519
GPS
1238YPhosphorylationKinaseABL1P00520
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SRBS1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SRBS1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CBL_MOUSECblphysical
12765336
SH2B2_MOUSESh2b2physical
11997497
CBL_MOUSECblphysical
11997497
CBL_MOUSECblphysical
9447983
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SRBS1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-286 AND SER-432, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND SER-407, AND MASSSPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-184 AND SER-533, ANDMASS SPECTROMETRY.
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270; THR-286 ANDSER-345, AND MASS SPECTROMETRY.
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-89 AND TYR-103, AND MASSSPECTROMETRY.
"Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Srckinases.";
Fernow I., Tomasovic A., Siehoff-Icking A., Tikkanen R.;
BMC Cell Biol. 10:80-80(2009).
Cited for: PHOSPHORYLATION AT TYR-325; TYR-421 AND TYR-1238.

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