dbPTM

SH2B2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SH2B2_MOUSE
UniProt AC	Q9JID9
Protein Name	SH2B adapter protein 2
Gene Name	Sh2b2
Organism	Mus musculus (Mouse).
Sequence Length	621
Subcellular Localization	Cytoplasm. Cell membrane. Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region (By similarity)..
Protein Description	Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity)..
Protein Sequence	MNGATPSSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGSAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHAATKARVRKGFSLRNMSLCVVDGVRDLWHRRSSPEPDGGATPKAAEPASEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVASCSCELLTDADMPRPPETTTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSENNNPGDEGAELDTDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPASPSNGAGASSSSGSSSSATSLPPRPAEGPLSAHSRSNSTEHLLDAASGATEEPTEATLGRARAVENQYSFY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	FLRDNPTYDTPDAGT HHCCCCCCCCCCCCC	21.05	10872802
98	Phosphorylation	SVTSALKTATYGHSR HHHHHHHHHHCCCCC	25.69	26643407
100	Phosphorylation	TSALKTATYGHSRSS HHHHHHHHCCCCCCH	34.96	26643407
101	Phosphorylation	SALKTATYGHSRSSE HHHHHHHCCCCCCHH	15.46	26643407
104	Phosphorylation	KTATYGHSRSSEDVS HHHHCCCCCCHHHHH	29.51	21454597
106	Phosphorylation	ATYGHSRSSEDVSAH HHCCCCCCHHHHHHH	40.88	26824392
107	Phosphorylation	TYGHSRSSEDVSAHA HCCCCCCHHHHHHHH	36.38	23684622
111	Phosphorylation	SRSSEDVSAHAATKA CCCHHHHHHHHHHHH	27.02	20415495
130	Phosphorylation	GFSLRNMSLCVVDGV CCCCCCEEEEEEECH	23.36	19060867
145	Phosphorylation	RDLWHRRSSPEPDGG HHHHHCCCCCCCCCC	50.64	25521595
146	Phosphorylation	DLWHRRSSPEPDGGA HHHHCCCCCCCCCCC	31.32	26824392
303	Phosphorylation	GCVDPGDSEEDTGLS CCCCCCCCHHHHCCC	49.12	25159016
307	Phosphorylation	PGDSEEDTGLSCARG CCCCHHHHCCCCCCC	43.21	25159016
323	Phosphorylation	CLASRVASCSCELLT HHHHHHHHCCEEECC	12.05	25367039
325	Phosphorylation	ASRVASCSCELLTDA HHHHHHCCEEECCCC	14.23	19060867
342	Phosphorylation	PRPPETTTAVGAVVT CCCCCCCCEEEEEEE	27.11	22942356
581	Phosphorylation	RPAEGPLSAHSRSNS CCCCCCCCCCCCCCC	27.37	28066266
584	Phosphorylation	EGPLSAHSRSNSTEH CCCCCCCCCCCCHHH	36.80	28066266
586	Phosphorylation	PLSAHSRSNSTEHLL CCCCCCCCCCHHHHH	37.84	23984901
588	Phosphorylation	SAHSRSNSTEHLLDA CCCCCCCCHHHHHHH	36.10	25177544
589	Phosphorylation	AHSRSNSTEHLLDAA CCCCCCCHHHHHHHH	31.51	22942356
597	Phosphorylation	EHLLDAASGATEEPT HHHHHHHCCCCCCCC	30.59	19144319
600	Phosphorylation	LDAASGATEEPTEAT HHHHCCCCCCCCHHH	44.39	23984901
618	Phosphorylation	ARAVENQYSFY---- HHHHHHCCCCC----	16.60	25619855
619	Phosphorylation	RAVENQYSFY----- HHHHHCCCCC-----	14.33	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
618	Y	Phosphorylation	Kinase	INSR	P15208	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SH2B2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SH2B2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHIP2_MOUSE	Inppl1	physical	17620296
CBL_MOUSE	Cbl	physical	9989826
GRB2_MOUSE	Grb2	physical	9989826
INSR_MOUSE	Insr	physical	11997497
CBL_MOUSE	Cbl	physical	11997497
ASB6_MOUSE	Asb6	physical	15231829

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SH2B2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-589, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Molecular cloning of the mouse APS as a member of the Lnk familyadaptor proteins."; Iseki M., Takaki S., Takatsu K.; Biochem. Biophys. Res. Commun. 272:45-54(2000). Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND PHOSPHORYLATION.	10872802 [Abstract]