dbPTM

LUZP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LUZP1_MOUSE
UniProt AC	Q8R4U7
Protein Name	Leucine zipper protein 1
Gene Name	Luzp1
Organism	Mus musculus (Mouse).
Sequence Length	1068
Subcellular Localization	Nucleus. Also detected in soma and dendrites of neurons..
Protein Description
Protein Sequence	MAELTNYKDAASNRHLRFKLQSLSRRLDELEEATKNLQRAEDELLDLQDKVIQAEGSDSSTLAEIEVLRQRVLKIEGKDEEIKRAEDLCHTMKEKLEEEENLTRELKSEIERLQKRMVDLEKLEEALSRSKNECSQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLVSELEKLKSLTLSFVNERKYLNEKEKENEKIIKELTQKLEQNKKMNRDHMRNASTFLERNDLRIEDGISSTLSSKESKRKGSLDYLKQVENETRDKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLTELNRNRSLASQLEEIKLQVRKQKELGNGDIEGEDAFLLGRGRHERTKLKGHGSEASVSKHTSRELSPQHKRERLRNREFALSNEHYSLSSKQASSPVFTNKRAAKASNMGMGTDSGTQETKRTEDRFAPGSSHSEGKRGREQPSVLSRYPPAAQEHTKVWKGAPKPGTESGLKGKVEKTTRTFSDSTHVSVPNDIVGKGDKTSDLSSEAHCGKRGQVPGHASQGTQAVESSCSKAIGALSSSQKASSEGLSKGKKTANGLAADANFSNSKAPILSKYPYSSRSQENILQGFSLPNKEGVDQPVAVVMEDSSQHEALRCRVIKSSGREKPDSDDDLDIESFVTAKLVNTTITPEPEPKPQPNSREKVKSRGGTRTALFENDKNAAIENDSVKPTRPSSNAIEFPDANCAGVKNQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEVVLEKQKSTSKSVTSKVTSSITIYPSDSSGPRAVPSEAPRERHTSTSNIQVGPPELTAISNHVSSPLELSIHKHDITLQLTEAERVGDGSPKNRAEMVVSRSSILIKPSESVEKNSHVPPAETIRWKSHSASSDSRHITVRNAWKSKRDLKCSEDPPTGIGRNMEATNAYTQRPCTDFLELEQPRSQPSEQGARRVGNSGDAPELSPRRTQSSLTASEVLTRRDRMGGAITAASCNHSSSMEEGEDSTFVTSRRIHNPLEHSELPGKQGLPEPEPVWTEERLHPAKPYAEED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAELTNYKD ------CCCCCCHHH	31.63	-
22	Phosphorylation	HLRFKLQSLSRRLDE HHHHHHHHHHHHHHH	38.45	29514104
57	Phosphorylation	KVIQAEGSDSSTLAE HHHHCCCCCCHHHHH	26.31	25338131
108	Phosphorylation	NLTRELKSEIERLQK HHHHHHHHHHHHHHH	57.33	24759943
122	Acetylation	KRMVDLEKLEEALSR HHHCCHHHHHHHHHC	69.37	7970469
233	Phosphorylation	RDHMRNASTFLERND HHHHHHHHHHHHHCC	24.20	22817900
234	Phosphorylation	DHMRNASTFLERNDL HHHHHHHHHHHHCCC	29.81	28066266
256	Phosphorylation	STLSSKESKRKGSLD HCCCCHHHHCCCCHH	41.31	-
261	Phosphorylation	KESKRKGSLDYLKQV HHHHCCCCHHHHHHH	22.54	26824392
264	Phosphorylation	KRKGSLDYLKQVENE HCCCCHHHHHHHHHH	22.54	24759943
272	Phosphorylation	LKQVENETRDKSENE HHHHHHHHCCCCHHH	56.61	30482847
276	Phosphorylation	ENETRDKSENEKNRN HHHHCCCCHHHHHHC	50.36	29514104
319	Ubiquitination	ELKKMRAKNNDLQDN HHHHHHHHCCCCCHH	46.01	-
345	Ubiquitination	ASQLEEIKLQVRKQK HHHHHHHHHHHHHHH	35.83	-
382	Phosphorylation	TKLKGHGSEASVSKH CCCCCCCCCCHHCHH	25.06	29899451
390	Phosphorylation	EASVSKHTSRELSPQ CCHHCHHCCCCCCHH	32.96	29899451
391	Phosphorylation	ASVSKHTSRELSPQH CHHCHHCCCCCCHHH	24.39	21454597
395	Phosphorylation	KHTSRELSPQHKRER HHCCCCCCHHHHHHH	20.12	25521595
411	Phosphorylation	RNREFALSNEHYSLS HHHHHHHCCCCCCCC	36.42	27180971
415	Phosphorylation	FALSNEHYSLSSKQA HHHCCCCCCCCCCCC	12.72	29514104
423	Phosphorylation	SLSSKQASSPVFTNK CCCCCCCCCCCCCCH	32.45	28066266
424	Phosphorylation	LSSKQASSPVFTNKR CCCCCCCCCCCCCHH	28.26	26824392
428	Phosphorylation	QASSPVFTNKRAAKA CCCCCCCCCHHHHHH	39.81	28066266
511	Phosphorylation	KVEKTTRTFSDSTHV EEEEEEECCCCCCCE	25.96	23984901
513	Phosphorylation	EKTTRTFSDSTHVSV EEEEECCCCCCCEEC	30.00	25266776
515	Phosphorylation	TTRTFSDSTHVSVPN EEECCCCCCCEECCC	21.15	23984901
516	Phosphorylation	TRTFSDSTHVSVPND EECCCCCCCEECCCC	31.15	25266776
519	Phosphorylation	FSDSTHVSVPNDIVG CCCCCCEECCCCCCC	25.01	23984901
569	Phosphorylation	SKAIGALSSSQKASS HHHHHHHCCCCCHHH	27.66	29176673
570	Phosphorylation	KAIGALSSSQKASSE HHHHHHCCCCCHHHC	37.32	29176673
571	Phosphorylation	AIGALSSSQKASSEG HHHHHCCCCCHHHCC	32.12	29176673
575	Phosphorylation	LSSSQKASSEGLSKG HCCCCCHHHCCCCCC	35.64	29899451
576	Phosphorylation	SSSQKASSEGLSKGK CCCCCHHHCCCCCCC	40.31	29899451
580	Phosphorylation	KASSEGLSKGKKTAN CHHHCCCCCCCCCCC	50.66	29899451
606	Phosphorylation	KAPILSKYPYSSRSQ CCCHHHCCCCCCCCC	12.20	23984901
608	Phosphorylation	PILSKYPYSSRSQEN CHHHCCCCCCCCCCC	19.05	23984901
609	Phosphorylation	ILSKYPYSSRSQENI HHHCCCCCCCCCCCH	18.12	23984901
610	Phosphorylation	LSKYPYSSRSQENIL HHCCCCCCCCCCCHH	30.06	23984901
612	Phosphorylation	KYPYSSRSQENILQG CCCCCCCCCCCHHCC	43.74	25521595
652	Phosphorylation	LRCRVIKSSGREKPD HHCEEEECCCCCCCC	27.22	23984901
653	Phosphorylation	RCRVIKSSGREKPDS HCEEEECCCCCCCCC	36.55	23984901
660	Phosphorylation	SGREKPDSDDDLDIE CCCCCCCCCCCCCHH	52.01	24925903
668	Phosphorylation	DDDLDIESFVTAKLV CCCCCHHHHHEEEEE	25.92	25619855
671	Phosphorylation	LDIESFVTAKLVNTT CCHHHHHEEEEECCC	18.96	25619855
677	Phosphorylation	VTAKLVNTTITPEPE HEEEEECCCCCCCCC	16.46	28066266
678	Phosphorylation	TAKLVNTTITPEPEP EEEEECCCCCCCCCC	20.04	28066266
680	Phosphorylation	KLVNTTITPEPEPKP EEECCCCCCCCCCCC	21.36	21659605
691	Phosphorylation	EPKPQPNSREKVKSR CCCCCCCCHHHHHHC	48.80	21659605
746	Phosphorylation	VKNQRPFSPREALRS CCCCCCCCHHHHHHC	26.23	26824392
773	Phosphorylation	VKKIMGGSGTEVVLE HHHHHCCCCCCEEEE	36.49	29899451
781	Acetylation	GTEVVLEKQKSTSKS CCCEEEEECCCCCCC	59.89	6566103
787	Acetylation	EKQKSTSKSVTSKVT EECCCCCCCCCCEEE	49.38	23576753
792	Acetylation	TSKSVTSKVTSSITI CCCCCCCEEECEEEE	39.92	23576753
820	Phosphorylation	EAPRERHTSTSNIQV CCCCCCCCCCCCEEC	39.66	25266776
821	Phosphorylation	APRERHTSTSNIQVG CCCCCCCCCCCEECC	24.58	27717184
822	Phosphorylation	PRERHTSTSNIQVGP CCCCCCCCCCEECCC	27.27	23984901
823	Phosphorylation	RERHTSTSNIQVGPP CCCCCCCCCEECCCH	31.53	23649490
840	Phosphorylation	TAISNHVSSPLELSI HHEECCCCCCCEEEE	20.77	26824392
878	Phosphorylation	AEMVVSRSSILIKPS HHHEEECCCEEECCC	17.77	22817900
879	Phosphorylation	EMVVSRSSILIKPSE HHEEECCCEEECCCH	21.94	18846507
885	Phosphorylation	SSILIKPSESVEKNS CCEEECCCHHCCCCC	37.19	26239621
887	Phosphorylation	ILIKPSESVEKNSHV EEECCCHHCCCCCCC	39.66	27180971
904	Phosphorylation	AETIRWKSHSASSDS HHHEEEECCCCCCCC	18.73	30635358
906	Phosphorylation	TIRWKSHSASSDSRH HEEEECCCCCCCCCC	36.62	30635358
908	Phosphorylation	RWKSHSASSDSRHIT EEECCCCCCCCCCEE	37.38	30635358
909	Phosphorylation	WKSHSASSDSRHITV EECCCCCCCCCCEEE	39.04	30635358
929	Phosphorylation	SKRDLKCSEDPPTGI CCCCCCCCCCCCCCC	43.37	24759943
946	Phosphorylation	NMEATNAYTQRPCTD CHHHCCCCCCCCCCC	12.89	29514104
947	Phosphorylation	MEATNAYTQRPCTDF HHHCCCCCCCCCCCC	18.72	21454597
952	Phosphorylation	AYTQRPCTDFLELEQ CCCCCCCCCCCCCCC	32.25	-
952	O-linked_Glycosylation	AYTQRPCTDFLELEQ CCCCCCCCCCCCCCC	32.25	118943
975	Phosphorylation	GARRVGNSGDAPELS HHHCCCCCCCCCCCC	31.92	27149854
982	Phosphorylation	SGDAPELSPRRTQSS CCCCCCCCCCCCHHC	18.07	27087446
986	Phosphorylation	PELSPRRTQSSLTAS CCCCCCCCHHCCCHH	33.80	25619855
988	Phosphorylation	LSPRRTQSSLTASEV CCCCCCHHCCCHHHH	27.05	26824392
989	Phosphorylation	SPRRTQSSLTASEVL CCCCCHHCCCHHHHC	21.66	25619855
991	Phosphorylation	RRTQSSLTASEVLTR CCCHHCCCHHHHCCC	30.04	25619855
993	Phosphorylation	TQSSLTASEVLTRRD CHHCCCHHHHCCCHH	24.01	25619855
997	Phosphorylation	LTASEVLTRRDRMGG CCHHHHCCCHHCCCC	28.91	25619855
1007	Phosphorylation	DRMGGAITAASCNHS HCCCCCEEEEECCCC	18.68	23984901
1010	Phosphorylation	GGAITAASCNHSSSM CCCEEEEECCCCCCC	17.00	23984901
1014	Phosphorylation	TAASCNHSSSMEEGE EEEECCCCCCCCCCC	15.32	23984901
1015	Phosphorylation	AASCNHSSSMEEGED EEECCCCCCCCCCCC	26.59	23984901
1016	Phosphorylation	ASCNHSSSMEEGEDS EECCCCCCCCCCCCC	32.98	23984901
1023	Phosphorylation	SMEEGEDSTFVTSRR CCCCCCCCCCCEECC	21.31	23984901
1024	Phosphorylation	MEEGEDSTFVTSRRI CCCCCCCCCCEECCC	34.15	23984901
1064	Phosphorylation	RLHPAKPYAEED--- CCCCCCCCCCCC---	26.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LUZP1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LUZP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LUZP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LUZP1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LUZP1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-660, AND MASSSPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-660, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261 AND SER-660, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261 AND SER-660, ANDMASS SPECTROMETRY.	16452087 [Abstract]