IQGA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IQGA2_MOUSE
• UniProt AC: Q3UQ44
• Protein Name: Ras GTPase-activating-like protein IQGAP2
• Gene Name: Iqgap2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1575
• Protein Description: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin..
• Protein Sequence: MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMEAIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIEKGVAKQTIITLRNPNAVLTCVDDSLSQEYQKELWEAKKKKEESAKLKNSCISEEERDAYEELLTQAEIQSNISTVNRMAAVDHINAVLQEGDPENTLLALKKPEAQLPAVYPFAAVMYQNELFNLQKQNTSNYLAHEELLIAVEMLSAVALLNQALESSDLVAVQNQLRSPTIGFNNLDEAHVDRYADALLSVKQEALSQGQDTLSWNEIQNCIDMINNQIQEENDRMVVLGYINEAIDAGNPLKTLDTLLLPTANIRDVDPDCAQHYQDVLFYTKSQKLGDPKNVSKVLWLDEIQQAINEANVDENRAKQWVTLVVDVNECLDRKQSDHILTALKSSPSNIHNILPECANKYYDTLVKAKESKTDNESSEGSWVTLNVQEKYNYYYNTDSKEGSWVPPELCLSKESWLTGEEIEDIVEEVTSDYIREKLWSASEDLLVRFEATTLGPALREEFEARKAFLYEQTESVVKIQAFWKGFKQRQEYLHRQQVFAGNVDSVVKIQSWFRMVTARKSYLSRLRYFEDHKNEIVKIQSLLRASKARDDYKALVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHRKKLNKKKGGEIEILNNTDNKGIKSLSKERRKTLETYQQLFYLLQTKPSYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIEDKALVINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRKVTDKVLGSIISSLDLLPYGLRYIAKVLKNSIREKFPDATEEELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSNQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFQEACDVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIINTHLLLLEHQDAIATEKSDLLNELLESLGEVPTVESFLGEGAVDPNDPNKENTLNQLSKTEISLSLTSKYDVKDGEAVDGRSLMIKTKKLIIDVTRNQPGSTLTEILETPATGQQELEHAKDMESRAVVDSRTPEEGKQSQAVIEDARLPLEQKKRKIQRNLRTLEQTGHVSSKNKYQDILNEIAKDIRNQRIHRKLRKAELSKLQQTLNALNKKAAFYEDQINYYDTYIKTCVDNLKRKNSRRSIKLDGKAEPKGTKRVKPVRYTAAKLHDKGVLLGIDDLQTNQFKNVMFDIIATEDMGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	PSLQRPRYGSIVDDE CCCCCCCCCCCCCHH	20.22	28833060
16	Phosphorylation	LQRPRYGSIVDDERL CCCCCCCCCCCHHHC	15.54	25521595
24	Phosphorylation	IVDDERLSAEEMDER CCCHHHCCHHHHHHH	39.60	23984901
42	S-palmitoylation	NIAYEYLCHLEEAKR HHHHHHHHCHHHHHH	3.18	28526873
72	Ubiquitination	LEEGLRNGVYLAKLA HHHHHHCCHHHHHHH	11.74	27667366
80	Ubiquitination	VYLAKLAKFFAPKMV HHHHHHHHHHCCCCC	51.99	22790023
85	Ubiquitination	LAKFFAPKMVSEKKI HHHHHCCCCCCCCCE	48.80	22790023
91	Malonylation	PKMVSEKKIYDVEQT CCCCCCCCEEEHHHH	42.31	26320211
93	Phosphorylation	MVSEKKIYDVEQTRY CCCCCCEEEHHHHCC	23.86	-
104	Ubiquitination	QTRYKKSGLHFRHTD HHCCCCCCCCCCCCC	31.86	27667366
127	Ubiquitination	MEAIGLPKIFYPETT HHHHCCCCCCCCCCC	50.95	22790023
145	Ubiquitination	DRKNIPRMIYCIHAL CCCCCCHHHHHHHHH	1.83	27667366
183	Dimethylation	EEEISNMRKELEKYG HHHHHHHHHHHHHHC	33.28	-
183	Methylation	EEEISNMRKELEKYG HHHHHHHHHHHHHHC	33.28	58856163
189	Phosphorylation	MRKELEKYGIQMPAF HHHHHHHHCCCCCHH	15.30	29514104
208	Phosphorylation	GILANELSVDEAALH CHHHHCCCCCHHHHH	22.73	26824392
231	Malonylation	AIEKGVAKQTIITLR HHHHCCCCEEEEECC	45.64	26320211
231	Ubiquitination	AIEKGVAKQTIITLR HHHHCCCCEEEEECC	45.64	-
245	Phosphorylation	RNPNAVLTCVDDSLS CCCCCEEEEECHHHC	12.13	28576409
246	S-palmitoylation	NPNAVLTCVDDSLSQ CCCCEEEEECHHHCH	2.49	28526873
255	Phosphorylation	DDSLSQEYQKELWEA CHHHCHHHHHHHHHH	19.76	28576409
257	Ubiquitination	SLSQEYQKELWEAKK HHCHHHHHHHHHHHH	54.60	22790023
276	Ubiquitination	SAKLKNSCISEEERD HHHHHHHCCCHHHHH	5.77	27667366
278	Ubiquitination	KLKNSCISEEERDAY HHHHHCCCHHHHHHH	43.19	27667366
356	Phosphorylation	FNLQKQNTSNYLAHE HHHHCCCCCCCCCHH	18.82	-
396	Phosphorylation	AVQNQLRSPTIGFNN HHHCCCCCCCCCCCC	34.68	21743459
398	Phosphorylation	QNQLRSPTIGFNNLD HCCCCCCCCCCCCCC	34.67	28066266
510	Malonylation	SQKLGDPKNVSKVLW CCCCCCCCCHHHHHH	74.79	26320211
524	Ubiquitination	WLDEIQQAINEANVD HHHHHHHHHHHCCCC	7.09	27667366
552	Ubiquitination	VNECLDRKQSDHILT HHHHHCHHCCHHHHH	54.54	22790023
554	Phosphorylation	ECLDRKQSDHILTAL HHHCHHCCHHHHHHH	33.90	21743459
563	Phosphorylation	HILTALKSSPSNIHN HHHHHHHCCHHHHHH	48.62	26643407
564	Phosphorylation	ILTALKSSPSNIHNI HHHHHHCCHHHHHHH	30.66	26643407
566	Phosphorylation	TALKSSPSNIHNILP HHHHCCHHHHHHHCH	50.82	26643407
578	Ubiquitination	ILPECANKYYDTLVK HCHHHHHHHHHHHHH	27.02	22790023
585	Ubiquitination	KYYDTLVKAKESKTD HHHHHHHHHHHCCCC	57.78	22790023
589	Ubiquitination	TLVKAKESKTDNESS HHHHHHHCCCCCCCC	39.90	27667366
595	Phosphorylation	ESKTDNESSEGSWVT HCCCCCCCCCCCEEE	39.69	-
599	Phosphorylation	DNESSEGSWVTLNVQ CCCCCCCCEEEEEEE	17.83	-
605	Ubiquitination	GSWVTLNVQEKYNYY CCEEEEEEEECCEEE	9.76	27667366
625	Ubiquitination	KEGSWVPPELCLSKE CCCCCCCHHHCCCCC	37.26	27667366
627	Ubiquitination	GSWVPPELCLSKESW CCCCCHHHCCCCCCC	4.37	27667366
658	Phosphorylation	YIREKLWSASEDLLV HHHHHHHCCCCCHHH	32.14	27180971
660	Phosphorylation	REKLWSASEDLLVRF HHHHHCCCCCHHHHH	26.57	28066266
739	Phosphorylation	RMVTARKSYLSRLRY HHHHHCHHHHHHHHH	26.25	20469934
751	Ubiquitination	LRYFEDHKNEIVKIQ HHHHHHHHCHHHHHH	69.47	27667366
756	Ubiquitination	DHKNEIVKIQSLLRA HHHCHHHHHHHHHHH	40.46	22790023
759	Phosphorylation	NEIVKIQSLLRASKA CHHHHHHHHHHHHHC	32.61	22324799
764	Phosphorylation	IQSLLRASKARDDYK HHHHHHHHHCCHHHH	22.03	22324799
771	Ubiquitination	SKARDDYKALVGSEN HHCCHHHHHHHCCCC	42.09	22790023
776	Phosphorylation	DYKALVGSENPPLTV HHHHHHCCCCCCHHH	27.07	20469934
782	Phosphorylation	GSENPPLTVIRKFVY CCCCCCHHHHHHHHH	21.47	28978645
814	Ubiquitination	LREEVVTKIRANQQL HHHHHHHHHHHHHHH	20.70	22790023
823	Acetylation	RANQQLEKDLNLMDI HHHHHHHHHCCHHHH	75.90	23954790
823	Ubiquitination	RANQQLEKDLNLMDI HHHHHHHHHCCHHHH	75.90	22790023
837	Ubiquitination	IKIGLLVKNRITLED HHHHHHHCCCCCHHH	40.24	22790023
855	Ubiquitination	HRKKLNKKKGGEIEI HHHHHCCCCCCCEEE	56.42	-
856	Ubiquitination	RKKLNKKKGGEIEIL HHHHCCCCCCCEEEC	73.99	22790023
869	Ubiquitination	ILNNTDNKGIKSLSK ECCCCCCCCHHHCCH	65.90	22790023
880	Ubiquitination	SLSKERRKTLETYQQ HCCHHHHHHHHHHHH	64.78	22790023
881	Phosphorylation	LSKERRKTLETYQQL CCHHHHHHHHHHHHH	28.19	26643407
884	Phosphorylation	ERRKTLETYQQLFYL HHHHHHHHHHHHHHH	29.73	23984901
885	Phosphorylation	RRKTLETYQQLFYLL HHHHHHHHHHHHHHH	5.72	26643407
910	Acetylation	IFQMPQNKSTKFMDT HHCCCCCCCCCCHHH	55.01	23806337
910	Malonylation	IFQMPQNKSTKFMDT HHCCCCCCCCCCHHH	55.01	26320211
910	Succinylation	IFQMPQNKSTKFMDT HHCCCCCCCCCCHHH	55.01	-
910	Ubiquitination	IFQMPQNKSTKFMDT HHCCCCCCCCCCHHH	55.01	27667366
940	Acetylation	YLLLKLFKTALEEEI HHHHHHHHHHHHHHH	43.24	23954790
940	Ubiquitination	YLLLKLFKTALEEEI HHHHHHHHHHHHHHH	43.24	22790023
950	Ubiquitination	LEEEIKSKVDQVQDI HHHHHHHHCHHHHHH	44.84	22790023
970	Phosphorylation	TVIKMVVSFNRGARG CEEEEEEECCCCCCC	12.85	22817900
990	Ubiquitination	QLLAPVVKEIIEDKA HHHHHHHHHHHCCCC	43.35	22790023
996	Acetylation	VKEIIEDKALVINTN HHHHHCCCCEEECCC	30.72	23954790
996	Ubiquitination	VKEIIEDKALVINTN HHHHHCCCCEEECCC	30.72	22790023
1002	Phosphorylation	DKALVINTNPVEVYK CCCEEECCCHHHHHH	29.76	-
1024	Ubiquitination	TQTGEASKLPYDVTT HCCCCCCCCCCCCCH	61.60	22790023
1041	Ubiquitination	ALTYPEVKNKLEASI CCCCHHHHHHHHHHH	46.86	22790023
1043	Malonylation	TYPEVKNKLEASIEN CCHHHHHHHHHHHHH	41.82	26320211
1043	Ubiquitination	TYPEVKNKLEASIEN CCHHHHHHHHHHHHH	41.82	27667366
1055	Phosphorylation	IENLRKVTDKVLGSI HHHHHHHHHHHHHHH	32.89	26643407
1061	Phosphorylation	VTDKVLGSIISSLDL HHHHHHHHHHHHHHC	16.76	26643407
1064	Phosphorylation	KVLGSIISSLDLLPY HHHHHHHHHHHCHHH	24.15	26643407
1065	Phosphorylation	VLGSIISSLDLLPYG HHHHHHHHHHCHHHH	18.59	26643407
1071	Phosphorylation	SSLDLLPYGLRYIAK HHHHCHHHHHHHHHH	28.85	26643407
1106	Phosphorylation	IVGNLLYYRYMNPAI HHHHHHHHHHCCCCE	8.67	26032504
1177	Ubiquitination	ETYQEFRKYFQEACD HHHHHHHHHHHHHCC	56.59	22790023
1196	Acetylation	EEKFNMDKYTDLVTV HHHCCCCCCCCCEEC	39.00	23954790
1197	Phosphorylation	EKFNMDKYTDLVTVS HHCCCCCCCCCEECC	10.96	25195567
1269	Phosphorylation	NDPNKENTLNQLSKT CCCCCCCHHHHHCCC	28.33	-
1279	Phosphorylation	QLSKTEISLSLTSKY HHCCCEEEEEECCCC	12.98	-
1281	Phosphorylation	SKTEISLSLTSKYDV CCCEEEEEECCCCCC	23.86	22871156
1289	Ubiquitination	LTSKYDVKDGEAVDG ECCCCCCCCCCEECC	58.06	22790023
1298	Phosphorylation	GEAVDGRSLMIKTKK CCEECCCEEEEEECE	28.02	22324799
1305	Malonylation	SLMIKTKKLIIDVTR EEEEEECEEEEECCC	50.58	26320211
1305	Ubiquitination	SLMIKTKKLIIDVTR EEEEEECEEEEECCC	50.58	-
1317	Phosphorylation	VTRNQPGSTLTEILE CCCCCCCCCHHHHHH	27.25	29472430
1318	Phosphorylation	TRNQPGSTLTEILET CCCCCCCCHHHHHHC	43.55	30352176
1320	Phosphorylation	NQPGSTLTEILETPA CCCCCCHHHHHHCCC	22.52	29472430
1325	Phosphorylation	TLTEILETPATGQQE CHHHHHHCCCCCHHH	18.12	29472430
1328	Phosphorylation	EILETPATGQQELEH HHHHCCCCCHHHHHH	36.41	22871156
1337	Ubiquitination	QQELEHAKDMESRAV HHHHHHHHHHHHCCE	60.56	22790023
1347	Phosphorylation	ESRAVVDSRTPEEGK HHCCEECCCCCCCCC	26.83	29472430
1349	Phosphorylation	RAVVDSRTPEEGKQS CCEECCCCCCCCCCH	38.72	29472430
1354	Malonylation	SRTPEEGKQSQAVIE CCCCCCCCCHHHHHH	50.48	26320211
1354	Ubiquitination	SRTPEEGKQSQAVIE CCCCCCCCCHHHHHH	50.48	27667366
1356	Phosphorylation	TPEEGKQSQAVIEDA CCCCCCCHHHHHHHC	24.48	22871156
1370	Ubiquitination	ARLPLEQKKRKIQRN CCCCHHHHHHHHHHH	45.21	27667366
1380	Phosphorylation	KIQRNLRTLEQTGHV HHHHHHHHHHHHCCC	37.50	28978645
1384	Phosphorylation	NLRTLEQTGHVSSKN HHHHHHHHCCCCCCH	21.63	29472430
1388	Phosphorylation	LEQTGHVSSKNKYQD HHHHCCCCCCHHHHH	29.89	23984901
1389	Phosphorylation	EQTGHVSSKNKYQDI HHHCCCCCCHHHHHH	38.88	29472430
1390	Ubiquitination	QTGHVSSKNKYQDIL HHCCCCCCHHHHHHH	50.37	22790023
1392	Ubiquitination	GHVSSKNKYQDILNE CCCCCCHHHHHHHHH	48.28	22790023
1402	Acetylation	DILNEIAKDIRNQRI HHHHHHHHHHHHHHH	60.39	23954790
1402	Ubiquitination	DILNEIAKDIRNQRI HHHHHHHHHHHHHHH	60.39	22790023
1420	Acetylation	LRKAELSKLQQTLNA HHHHHHHHHHHHHHH	64.04	23954790
1420	Ubiquitination	LRKAELSKLQQTLNA HHHHHHHHHHHHHHH	64.04	22790023
1430	Malonylation	QTLNALNKKAAFYED HHHHHHHHHHHHHHH	44.64	26320211
1430	Ubiquitination	QTLNALNKKAAFYED HHHHHHHHHHHHHHH	44.64	-
1431	Ubiquitination	TLNALNKKAAFYEDQ HHHHHHHHHHHHHHH	43.82	22790023
1454	Ubiquitination	KTCVDNLKRKNSRRS HHHHHHHHHHCCCCC	68.53	22790023
1458	Phosphorylation	DNLKRKNSRRSIKLD HHHHHHCCCCCEECC	31.91	-
1461	Phosphorylation	KRKNSRRSIKLDGKA HHHCCCCCEECCCCC	23.98	30387612
1489	Ubiquitination	TAAKLHDKGVLLGID EEEHHHHCCEEEECC	39.92	22790023
1500	Phosphorylation	LGIDDLQTNQFKNVM EECCCCCCCCCCCCC	37.98	28059163
1513	Phosphorylation	VMFDIIATEDMGIFD CCEEEEECCCCCCCH	23.31	22802335
1524	Ubiquitination	GIFDVRSKFLGVEME CCCHHHHHCCCCCEE	33.76	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IQGA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IQGA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IQGA2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IQGA2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1389, AND MASSSPECTROMETRY.
PubMed: 19367708

"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.
PubMed: 18630941

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.
PubMed: 17242355