SRBS2_MOUSE - dbPTM
SRBS2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SRBS2_MOUSE
UniProt AC Q3UTJ2
Protein Name Sorbin and SH3 domain-containing protein 2
Gene Name Sorbs2
Organism Mus musculus (Mouse).
Sequence Length 1180
Subcellular Localization Cytoplasm, perinuclear region. Cytoplasm, myofibril, sarcomere, Z line. Apical cell membrane . Cell junction, focal adhesion . Cell projection, lamellipodium . Cytoplasm, cytoskeleton. Found at the Z line sarcomeres, stress fibers, dense bodies and f
Protein Description Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity)..
Protein Sequence MNTDSGGCARKRAAMSVTLTSVKRVQSSPNLLAAGRESQSPDSAWRSYNDRNPETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITINGNSGGAVSPVSYYQRPFSPSAYSLPASLNSSIIMQHGRSLDSAETYSQHAQSLDGTMGSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNSPYSAQSHPAAKTQTYRPLSKSHSDNGTDAFKEVPSPVPPPHVPPRPRDQSSTLKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPVSIYQSSIDRSLERPSSSASMAGDFRKRRKSEPAVGPLRGLGDQSSSRTSPGRADLPGSSSTFTKSFISSSPSSPSRAQGGDDSKMCPPLCSYSGLNGTPSGELECCNAYRQHLDVPGDSQRAITFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKTKSESMGSLLCEEDSKESCPMTWASPYIQEVCGNSRSRLKHRSAHNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYEKEQQHRGLLHGWSQSSTEEVPRDVVPTRISEFEKLIQKSKSMPNLGDEMLSPITLEPPQNGLCPKRRFSIESLLEEETQVRHPSQGQRSCKSNTLVPIHIEVTSDEQPRTHMEFSDSDQDGVVSDHSDYVHVEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERAKHENMDRPRRQEMDPGLSKLAFLVSPVPFRRKKILTPQKQTEKAKCKASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPERNSSLHALKRSPMHQPFHPLPPDGASHCPLYQNDCGRMPHSASFPDVDTTSNYHAQDYGSALSLQDHESPRSYSSTLTDLGRSASRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPVQPGEIGEAIAKYNFNADTNVELSLRKGDRIILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKRNAKGAEDYPDPPLPHSYSSDRIYTLSSNKPQRPGFSHENIQGGGEPFQALYNYTPRNEDELELRESDVVDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3 (in isoform 3)Phosphorylation-43.3223984901
3 (in isoform 4)Phosphorylation-43.3223984901
7 (in isoform 3)Phosphorylation-13.0823984901
7 (in isoform 4)Phosphorylation-13.0823984901
9 (in isoform 3)Phosphorylation-24.2526824392
9 (in isoform 4)Phosphorylation-24.2526824392
12 (in isoform 3)Phosphorylation-23.2523984901
12 (in isoform 4)Phosphorylation-23.2523984901
16PhosphorylationARKRAAMSVTLTSVK
HHHHHCEEEEEEEEE		13.7629472430
18PhosphorylationKRAAMSVTLTSVKRV
HHHCEEEEEEEEEEC		19.6029472430
20PhosphorylationAAMSVTLTSVKRVQS
HCEEEEEEEEEECCC		23.3129472430
21O-linked_GlycosylationAMSVTLTSVKRVQSS
CEEEEEEEEEECCCC		28.8430059200
21PhosphorylationAMSVTLTSVKRVQSS
CEEEEEEEEEECCCC		28.8429472430
27PhosphorylationTSVKRVQSSPNLLAA
EEEEECCCCCCCHHC		44.9325521595
27 (in isoform 5)Phosphorylation-44.9324759943
27 (in isoform 6)Phosphorylation-44.9324759943
28PhosphorylationSVKRVQSSPNLLAAG
EEEECCCCCCCHHCC		10.7527087446
28 (in isoform 5)Phosphorylation-10.7524759943
28 (in isoform 6)Phosphorylation-10.7524759943
38PhosphorylationLLAAGRESQSPDSAW
CHHCCCCCCCCCCHH		34.3027180971
38 (in isoform 5)Phosphorylation-34.3026160508
38 (in isoform 6)Phosphorylation-34.3026160508
40PhosphorylationAAGRESQSPDSAWRS
HCCCCCCCCCCHHHH		39.7027087446
40 (in isoform 5)Phosphorylation-39.7026824392
40 (in isoform 6)Phosphorylation-39.7026824392
43PhosphorylationRESQSPDSAWRSYND
CCCCCCCCHHHHCCC		32.8726160508
43 (in isoform 5)Phosphorylation-32.8722324799
43 (in isoform 6)Phosphorylation-32.8722324799
61PhosphorylationETLNGDATYSSLAAK
CCCCCCCCHHHHHHC		28.77-
82PhosphorylationPNLQDKRSPTQSQIT
CCCCCCCCCCCCEEE		37.7321743459
84PhosphorylationLQDKRSPTQSQITIN
CCCCCCCCCCEEEEE		41.9425293948
86PhosphorylationDKRSPTQSQITINGN
CCCCCCCCEEEEECC		26.4825293948
89PhosphorylationSPTQSQITINGNSGG
CCCCCEEEEECCCCC		10.7625293948
94PhosphorylationQITINGNSGGAVSPV
EEEEECCCCCCCCCC		39.7526160508
99PhosphorylationGNSGGAVSPVSYYQR
CCCCCCCCCCEECCC		21.0326160508
102PhosphorylationGGAVSPVSYYQRPFS
CCCCCCCEECCCCCC		22.8526160508
103PhosphorylationGAVSPVSYYQRPFSP
CCCCCCEECCCCCCC		12.1226160508
104PhosphorylationAVSPVSYYQRPFSPS
CCCCCEECCCCCCCC		7.1926160508
109PhosphorylationSYYQRPFSPSAYSLP
EECCCCCCCCHHCCC		22.1926824392
111PhosphorylationYQRPFSPSAYSLPAS
CCCCCCCCHHCCCCH		38.3426160508
114PhosphorylationPFSPSAYSLPASLNS
CCCCCHHCCCCHHCC		27.8221082442
118PhosphorylationSAYSLPASLNSSIIM
CHHCCCCHHCCHHHH		26.5827742792
121PhosphorylationSLPASLNSSIIMQHG
CCCCHHCCHHHHHCC		28.3621082442
130PhosphorylationIIMQHGRSLDSAETY
HHHHCCCCCCCHHHH		40.9127087446
133PhosphorylationQHGRSLDSAETYSQH
HCCCCCCCHHHHHHH		33.0430352176
136PhosphorylationRSLDSAETYSQHAQS
CCCCCHHHHHHHHHH		28.3423737553
137PhosphorylationSLDSAETYSQHAQSL
CCCCHHHHHHHHHHH		9.6123737553
138PhosphorylationLDSAETYSQHAQSLD
CCCHHHHHHHHHHHC		23.9426239621
143PhosphorylationTYSQHAQSLDGTMGS
HHHHHHHHHCCCCCC		29.2527087446
147PhosphorylationHAQSLDGTMGSSIPL
HHHHHCCCCCCCCCC		20.3026160508
150PhosphorylationSLDGTMGSSIPLYRS
HHCCCCCCCCCCCCC		17.8026160508
151PhosphorylationLDGTMGSSIPLYRSS
HCCCCCCCCCCCCCC		23.6126160508
155PhosphorylationMGSSIPLYRSSEEEK
CCCCCCCCCCCHHHH		11.7726160508
165PhosphorylationSEEEKRVTVIKAPHY
CHHHHCEEEEECCCC		22.1325777480
172PhosphorylationTVIKAPHYPGIGPVD
EEEECCCCCCCCCCC		11.3325777480
181PhosphorylationGIGPVDESGIPTAIR
CCCCCCCCCCCCEEE		37.2425777480
185PhosphorylationVDESGIPTAIRTTVD
CCCCCCCCEEEECCC		32.5625777480
189PhosphorylationGIPTAIRTTVDRPKD
CCCCEEEECCCCCHH		25.6725777480
190PhosphorylationIPTAIRTTVDRPKDW
CCCEEEECCCCCHHH		15.5725777480
200PhosphorylationRPKDWYKTMFKQIHM
CCHHHHHHHHHHHHC		16.4921183079
230PhosphorylationHPAAKTQTYRPLSKS
CCCCCCCCCCCCCCC		27.0823984901
231PhosphorylationPAAKTQTYRPLSKSH
CCCCCCCCCCCCCCC		10.6223984901
235PhosphorylationTQTYRPLSKSHSDNG
CCCCCCCCCCCCCCC		34.4927180971
237PhosphorylationTYRPLSKSHSDNGTD
CCCCCCCCCCCCCCC		25.5025521595
239PhosphorylationRPLSKSHSDNGTDAF
CCCCCCCCCCCCCCH		39.6025521595
243PhosphorylationKSHSDNGTDAFKEVP
CCCCCCCCCCHHCCC		30.3427742792
251PhosphorylationDAFKEVPSPVPPPHV
CCHHCCCCCCCCCCC		43.6425521595
267PhosphorylationPRPRDQSSTLKHDWD
CCCCCCCCCCCCCCC		31.9321183079
268PhosphorylationRPRDQSSTLKHDWDP
CCCCCCCCCCCCCCC		45.1021183079
291PhosphorylationKFRSEPRSIFEYEPG
HCCCCCCCCEECCCC		42.2021183079
292 (in isoform 5)Phosphorylation-3.0018846507
293 (in isoform 5)Phosphorylation-9.6118846507
306 (in isoform 5)Phosphorylation-45.8026824392
308 (in isoform 5)Phosphorylation-22.6326824392
310PhosphorylationLQHERPVSIYQSSID
CCCCCCCEEEHHCHH		20.4726824392
310 (in isoform 7)Phosphorylation-20.4726824392
312PhosphorylationHERPVSIYQSSIDRS
CCCCCEEEHHCHHHH		8.5426160508
314PhosphorylationRPVSIYQSSIDRSLE
CCCEEEHHCHHHHCC		16.5826160508
315PhosphorylationPVSIYQSSIDRSLER
CCEEEHHCHHHHCCC		17.0026160508
315 (in isoform 2)Phosphorylation-17.0018846507
316 (in isoform 2)Phosphorylation-6.5418846507
319PhosphorylationYQSSIDRSLERPSSS
EHHCHHHHCCCCCCC		30.7327742792
320 (in isoform 5)Phosphorylation-7.2424899341
322 (in isoform 5)Phosphorylation-41.5125521595
324PhosphorylationDRSLERPSSSASMAG
HHHCCCCCCCCHHHH		43.0525521595
324 (in isoform 5)Phosphorylation-43.0525521595
325PhosphorylationRSLERPSSSASMAGD
HHCCCCCCCCHHHHH		32.3827742792
325 (in isoform 5)Phosphorylation-32.3825521595
326PhosphorylationSLERPSSSASMAGDF
HCCCCCCCCHHHHHH		28.8027742792
328PhosphorylationERPSSSASMAGDFRK
CCCCCCCHHHHHHHH		15.8926824392
329 (in isoform 2)Phosphorylation-4.9026824392
330 (in isoform 5)Phosphorylation-16.3525521595
331 (in isoform 2)Phosphorylation-26.4226824392
332 (in isoform 5)Phosphorylation-30.5525521595
339PhosphorylationDFRKRRKSEPAVGPL
HHHHHCCCCCCCCCC		47.1825521595
343 (in isoform 2)Phosphorylation-13.6924899341
343 (in isoform 4)Phosphorylation-13.6926160508
345 (in isoform 2)Phosphorylation-16.5825521595
346 (in isoform 4)Phosphorylation-5.8122324799
347 (in isoform 2)Phosphorylation-41.2325521595
347 (in isoform 4)Phosphorylation-41.2326824392
348 (in isoform 2)Phosphorylation-41.5125521595
348 (in isoform 4)Phosphorylation-41.5126239621
350 (in isoform 4)Phosphorylation-33.4622324799
350 (in isoform 5)Phosphorylation-33.4620139300
351 (in isoform 4)Phosphorylation-50.6726824392
352 (in isoform 5)Phosphorylation-43.3327742792
353PhosphorylationLRGLGDQSSSRTSPG
CCCCCCCCCCCCCCC		34.7126160508
353 (in isoform 2)Phosphorylation-34.7125521595
353 (in isoform 4)Phosphorylation-34.7126239621
354PhosphorylationRGLGDQSSSRTSPGR
CCCCCCCCCCCCCCC		20.4326239621
355PhosphorylationGLGDQSSSRTSPGRA
CCCCCCCCCCCCCCC		44.8426239621
355 (in isoform 2)Phosphorylation-44.8425521595
357PhosphorylationGDQSSSRTSPGRADL
CCCCCCCCCCCCCCC		41.0225521595
358PhosphorylationDQSSSRTSPGRADLP
CCCCCCCCCCCCCCC		25.0125521595
358 (in isoform 3)Phosphorylation-25.0126160508
360 (in isoform 2)Phosphorylation-36.8627742792
360 (in isoform 4)Phosphorylation-36.8626824392
361 (in isoform 3)Phosphorylation-28.4522324799
361 (in isoform 5)Phosphorylation-28.4521183079
362 (in isoform 3)Phosphorylation-28.7126824392
363 (in isoform 3)Phosphorylation-52.6226239621
365 (in isoform 3)Phosphorylation-40.9622324799
365 (in isoform 4)Phosphorylation-40.9626824392
366 (in isoform 3)Phosphorylation-47.6726824392
367PhosphorylationGRADLPGSSSTFTKS
CCCCCCCCCCCCCHH		21.1226160508
368PhosphorylationRADLPGSSSTFTKSF
CCCCCCCCCCCCHHH		39.0326160508
368 (in isoform 2)Phosphorylation-39.0326824392
368 (in isoform 3)Phosphorylation-39.0326239621
369PhosphorylationADLPGSSSTFTKSFI
CCCCCCCCCCCHHHH		29.2726160508
370PhosphorylationDLPGSSSTFTKSFIS
CCCCCCCCCCHHHHC		36.9526160508
370 (in isoform 5)Phosphorylation-36.9521183079
372PhosphorylationPGSSSTFTKSFISSS
CCCCCCCCHHHHCCC		26.3526160508
373UbiquitinationGSSSTFTKSFISSSP
CCCCCCCHHHHCCCC		38.9022790023
373 (in isoform 2)Phosphorylation-38.9026824392
373 (in isoform 2)Ubiquitination-38.9022790023
374PhosphorylationSSSTFTKSFISSSPS
CCCCCCHHHHCCCCC		25.4224925903
375 (in isoform 2)Phosphorylation-7.1826824392
375 (in isoform 3)Phosphorylation-7.1826824392
377PhosphorylationTFTKSFISSSPSSPS
CCCHHHHCCCCCCCC		23.8224925903
377 (in isoform 2)Phosphorylation-23.8223984901
378PhosphorylationFTKSFISSSPSSPSR
CCHHHHCCCCCCCCC		41.2624925903
379PhosphorylationTKSFISSSPSSPSRA
CHHHHCCCCCCCCCC		23.2425521595
379 (in isoform 5)Phosphorylation-23.2429899451
380 (in isoform 3)Phosphorylation-40.5526824392
381PhosphorylationSFISSSPSSPSRAQG
HHHCCCCCCCCCCCC		57.7525521595
382PhosphorylationFISSSPSSPSRAQGG
HHCCCCCCCCCCCCC		30.2225521595
384PhosphorylationSSSPSSPSRAQGGDD
CCCCCCCCCCCCCCC		42.0425521595
412 (in isoform 2)Phosphorylation-7.5221183079
421 (in isoform 2)Phosphorylation-18.2621183079
430 (in isoform 2)Phosphorylation-31.7329899451
438 (in isoform 5)Phosphorylation-8.3126160508
441 (in isoform 5)Phosphorylation-8.5322324799
442 (in isoform 5)Phosphorylation-25.5826824392
443 (in isoform 5)Phosphorylation-43.9026239621
445 (in isoform 5)Phosphorylation-11.0022324799
446 (in isoform 5)Phosphorylation-53.1726824392
448 (in isoform 5)Phosphorylation-4.2626239621
449PhosphorylationRQNAEIWSSTEETVS
HHCCCHHCCCCCCCC		32.8029899451
450PhosphorylationQNAEIWSSTEETVSP
HCCCHHCCCCCCCCC		25.4927841257
451PhosphorylationNAEIWSSTEETVSPK
CCCHHCCCCCCCCCC		32.1229899451
455 (in isoform 5)Phosphorylation-11.8826824392
456PhosphorylationSSTEETVSPKIKSRS
CCCCCCCCCCCCCCC		28.0929899451
460 (in isoform 5)Phosphorylation-46.0426824392
461PhosphorylationTVSPKIKSRSCDDLL
CCCCCCCCCCHHHHC		32.6624759943
463PhosphorylationSPKIKSRSCDDLLND
CCCCCCCCHHHHCCC		29.0522324799
474PhosphorylationLLNDDCDSFPDPKTK
HCCCCCCCCCCCCCC		45.0422324799
480PhosphorylationDSFPDPKTKSESMGS
CCCCCCCCCCHHHHH		45.2329899451
482PhosphorylationFPDPKTKSESMGSLL
CCCCCCCCHHHHHHC		39.8922324799
484PhosphorylationDPKTKSESMGSLLCE
CCCCCCHHHHHHCCC		35.2222324799
487PhosphorylationTKSESMGSLLCEEDS
CCCHHHHHHCCCCCC		14.9925521595
488 (in isoform 2)Ubiquitination-5.41-
574PhosphorylationRGLLHGWSQSSTEEV
CCCCCCCCCCCCCCC		25.4429899451
576PhosphorylationLLHGWSQSSTEEVPR
CCCCCCCCCCCCCCC		33.4425521595
577PhosphorylationLHGWSQSSTEEVPRD
CCCCCCCCCCCCCCC		32.0025521595
578PhosphorylationHGWSQSSTEEVPRDV
CCCCCCCCCCCCCCC		41.2229899451
588PhosphorylationVPRDVVPTRISEFEK
CCCCCCCCCHHHHHH		29.0822324799
591PhosphorylationDVVPTRISEFEKLIQ
CCCCCCHHHHHHHHH		32.7022324799
600PhosphorylationFEKLIQKSKSMPNLG
HHHHHHHCCCCCCCC		17.3721082442
602PhosphorylationKLIQKSKSMPNLGDE
HHHHHCCCCCCCCCC		46.7123527152
612PhosphorylationNLGDEMLSPITLEPP
CCCCCCCCCCCCCCC		16.9723527152
630PhosphorylationLCPKRRFSIESLLEE
CCCCCCCCHHHHHCH		24.5122324799
633PhosphorylationKRRFSIESLLEEETQ
CCCCCHHHHHCHHHH		36.2622324799
655PhosphorylationQRSCKSNTLVPIHIE
CCCCCCCCEEEEEEE		35.9027841257
665PhosphorylationPIHIEVTSDEQPRTH
EEEEEECCCCCCCCE		44.3019060867
745PhosphorylationGRCPASYTRFTTMLK
CCCCCCHHHHHHHHH		19.4622807455
748PhosphorylationPASYTRFTTMLKHER
CCCHHHHHHHHHHHH		14.1722807455
781PhosphorylationSKLAFLVSPVPFRRK
HHHHHHHCCCCCCCC		23.4820415495
792PhosphorylationFRRKKILTPQKQTEK
CCCCCCCCCHHHHHH		27.44-
797PhosphorylationILTPQKQTEKAKCKA
CCCCHHHHHHHHHHH		46.63-
803AcetylationQTEKAKCKASVVEAL
HHHHHHHHHHHHHHH		42.887719901
803UbiquitinationQTEKAKCKASVVEAL
HHHHHHHHHHHHHHH		42.8822790023
803 (in isoform 2)Ubiquitination-42.8822790023
805PhosphorylationEKAKCKASVVEALDS
HHHHHHHHHHHHHHH		16.5225521595
827DimethylationQIKAEKRRGSLPDNS
HHHHHHHHCCCCCCH		50.55-
829PhosphorylationKAEKRRGSLPDNSIL
HHHHHHCCCCCCHHH		34.6125521595
834PhosphorylationRGSLPDNSILHRLIS
HCCCCCCHHHHHHHH		33.6320415495
892PhosphorylationGRMPHSASFPDVDTT
CCCCCCCCCCCCCCC		40.0827841257
900PhosphorylationFPDVDTTSNYHAQDY
CCCCCCCCCCCCCCC		37.17-
918 (in isoform 2)Ubiquitination-23.38-
921O-linked_GlycosylationQDHESPRSYSSTLTD
CCCCCCCCCCHHHHH		32.5219528053
921PhosphorylationQDHESPRSYSSTLTD
CCCCCCCCCCHHHHH		32.5227742792
922PhosphorylationDHESPRSYSSTLTDL
CCCCCCCCCHHHHHH		14.1227742792
923PhosphorylationHESPRSYSSTLTDLG
CCCCCCCCHHHHHHH		20.3526824392
924PhosphorylationESPRSYSSTLTDLGR
CCCCCCCHHHHHHHH		21.1426239621
925PhosphorylationSPRSYSSTLTDLGRS
CCCCCCHHHHHHHHH		27.9526239621
927PhosphorylationRSYSSTLTDLGRSAS
CCCCHHHHHHHHHHH		29.3027742792
932O-linked_GlycosylationTLTDLGRSASRERRG
HHHHHHHHHHHHCCC		28.8855410921
932PhosphorylationTLTDLGRSASRERRG
HHHHHHHHHHHHCCC		28.88-
940PhosphorylationASRERRGTPEKEKLP
HHHHCCCCCCHHCCC		26.85-
955AcetylationAKAVYDFKAQTSKEL
CCEEEEECCCCCCEE		36.3723954790
955MalonylationAKAVYDFKAQTSKEL
CCEEEEECCCCCCEE		36.3726320211
958PhosphorylationVYDFKAQTSKELSFK
EEEECCCCCCEECCC		46.7727742792
959PhosphorylationYDFKAQTSKELSFKK
EEECCCCCCEECCCC		16.4427742792
1001PhosphorylationISYVEKLTPPEKAQP
HHHHHHCCCCHHCCC		48.1126824392
1038PhosphorylationADTNVELSLRKGDRI
CCCCEEEEEECCCEE		16.7825159016
1070 (in isoform 2)Malonylation-16.5426320211
1087PhosphorylationNAKGAEDYPDPPLPH
CCCCCCCCCCCCCCC		10.8827742792
1095PhosphorylationPDPPLPHSYSSDRIY
CCCCCCCCCCCCCEE		25.4426160508
1096PhosphorylationDPPLPHSYSSDRIYT
CCCCCCCCCCCCEEE		14.7926160508
1097PhosphorylationPPLPHSYSSDRIYTL
CCCCCCCCCCCEEEC		28.8625521595
1098PhosphorylationPLPHSYSSDRIYTLS
CCCCCCCCCCEEECC		23.7525521595
1102PhosphorylationSYSSDRIYTLSSNKP
CCCCCCEEECCCCCC		11.5226160508
1103PhosphorylationYSSDRIYTLSSNKPQ
CCCCCEEECCCCCCC		20.1426160508
1105PhosphorylationSDRIYTLSSNKPQRP
CCCEEECCCCCCCCC		24.8626160508
1106PhosphorylationDRIYTLSSNKPQRPG
CCEEECCCCCCCCCC		52.5726160508
1115PhosphorylationKPQRPGFSHENIQGG
CCCCCCCCCCCCCCC		35.4926160508
1171PhosphorylationRRTKFFGTFPGNYVK
CCCEEECCCCCCCCC		22.8426239621
1176PhosphorylationFGTFPGNYVKRL---
ECCCCCCCCCCC---		17.1723984901
1178UbiquitinationTFPGNYVKRL-----
CCCCCCCCCC-----		37.3122790023
1178 (in isoform 2)Ubiquitination-37.3122790023
1293 (in isoform 2)Ubiquitination--
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseCblP22682
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SRBS2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SRBS2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACTN1_MOUSEActn1physical
20886612
VINC_MOUSEVclphysical
20886612
PAXI_MOUSEPxnphysical
20886612
FLOT1_MOUSEFlot1physical
20886612
CBL_MOUSECblphysical
20886612
FAK2_MOUSEPtk2bphysical
20886612
SPTA1_MOUSESpta1physical
20886612
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SRBS2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239 AND SER-339, ANDMASS SPECTROMETRY.
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; SER-130; SER-358;SER-378; SER-379; SER-382; SER-1097 AND SER-1098, AND MASSSPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27; THR-451 AND SER-456.
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-829, AND MASSSPECTROMETRY.

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