SPTA1_MOUSE - dbPTM
SPTA1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPTA1_MOUSE
UniProt AC P08032
Protein Name Spectrin alpha chain, erythrocytic 1
Gene Name Spta1
Organism Mus musculus (Mouse).
Sequence Length 2415
Subcellular Localization Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Protein Description Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane..
Protein Sequence METPKETAVESSGPKVLETAEEIQHRRAEVLNQYQRFKDRVAERGQKLEESYHYQVFRRDADDLEKWIMEKLEIAKDKTYEPTNIQGKYQKHESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATKTHLKQLRLLWDLLLELTQEKSDVLLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKKFEEFQEELTARKGKVDRVNQYANECAQEKHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSNAADLQRFKRDVNEAIQWMEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLAVMDDKVKELCAKADKLMISHSADAPQIQQMKLDLVSNWERIRALATNRYAKLKASYGYHRFLSDYDELSGWMKEKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQSADATGQELLDGNHEASEEIREKMTILANDWAALLELWDKCQHQYRQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSVGSVEALLQKHDDFEEAFTAQEEKIITLDETATKLIDNDHYDSENIAAIRDGLLARRDALRERAATRRKLLVDSQLLQQLYQDSDDLKTWINKKKKLADDDDYKDVQNLKSRVQKQQDFEEELAVNEIMLNNLEKTGQEMIEDGHYASEAVAARLSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEVEWQVTSEDYGKGLADVQNLLRKHGLLESDVTARQNQVDTLTDMAAHFEEIGHPDSGDIRARQESLLSRFEALKEPLAIRKKKLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILADIASHEPRIQVITERGNKMVEEGHFAAEDIASRVESLNKNMESLHARAIRRENDLKANVQLQQYLADLHEAEAWIKEKEPIVDNKNYGADEEAAGALLKKHEAFLVDLNAFENSIKALRDQAEVCQQQQAAPVDEAGREARVIALYDFEARSRREVSMKKNDVLTLLSSINKDWWKVEADDHQGFVPAVYVRKLAPDELPGFPQHRQEEPVNIPQLQQQVETLYHSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKTENTGVELDDVWELQKKFDEFQRDLKSNEPRLKDINKVADELLFEELLTPEGAHIRQELNTRWNSLKRLADEQYQLLSSAHAVEMFHREADDVKEQIDKKCRALNAADPGSDLLSVQALQRQHEVFERDIIPLGEKVTTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRKESLNEAHKFFLFLSKASDLENWIKTIGGVISSPELAEDLTGTEILLERHQEHHDDIKREDPTFQALEDFGTELIDSGHRNRREIDNTLQNINSKRDNLEKSWENRKKMLDQCLELQLFRGKCDQVESWMVARENSLRSDDRDHLNSLQALMKKRDDLDKAITAQEGKISDLENVATRLIDNDHYAKEEIAARLQRVLDRWKALKEQLLTELGKLGDYADLKQFYRDLEDLEEWINEMLPIACDESYKDPTNIQRKYLKHQAFENEVNGRAEQVDGVINLGNSLIERRVCDGDEENMQEQLDKLKENWDYLLERTTDKGQKLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLAREDPLKDLNDLAQELISSGTFNIDQIEEKMNGVNERFENVQSLAAAHHEKLKETYALFQFFQDLDDEEAWIEEKLLRVSSQDYGRDLQSVQNLLKKHKRLEGELVAHEPAVQNVLDTAESLRDKAAVGKEEIQERLAQFVQHWEKLKELAKTRGVNLEESLEYLQFMENAEEEEAWLGEKCALVSRGDSGDTLAATQSLLKKHEALENDFAVHKNRVQDVCAQGEDILNKEETQNKDKISTKIQVLNEKTASLAKALAAWKSQLDDVHAFQQFNWKADVVESWIGEKEASLKTKSNGADLTAFLTLLAKHDTLDASLQSFQQERLSEIAELKDQLVAGEHSQAKAIEEQHAALLRHWEQLLEASRVHRQKLLEKQLPLQKAEELFMEFAHKASAFNNWCENAEEDLSEPVHCVSLNEIRQLQKEHEAFLASLAGAQEDFNYLLELDKQIKALNVPSSPYTWLTVDVLGRIWNHLPDIIKEREQELQKEEARQIKNFEMCQEFEQNASAFLQWIQETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRHLTKIEDLGDSMEEALILDIKYSTIGLAQQWDQLHQLGMRMQHNLEQQIQAKDTIGVSEETLKEFSTTYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEGEPEPKFEKFLNAVDPGRKGYVSLEDYTSFLIDKESENIKTSDDIESAFQALAEGKAYITKEDMKQALTPEQVSFCTIHMQQYMDPRGRSQPAGYDYVGFTNSFFGN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----METPKETAVE
-----CCCCHHHHCC		52.0726643407
7Phosphorylation-METPKETAVESSGP
-CCCCHHHHCCCCCC		41.9726643407
249PhosphorylationAAWDRLWSLALKRRE
HHHHHHHHHHHHHHH		14.3522817900
257PhosphorylationLALKRRESLSNAADL
HHHHHHHHHCCHHHH		34.9727742792
259PhosphorylationLKRRESLSNAADLQR
HHHHHHHCCHHHHHH		33.4322817900
387AcetylationLSGWMKEKTALINAD
HCHHHHHHHCCCCHH		33.3119848119
473S-palmitoylationCQHQYRQCLDFHLFY
HHHHHHHHHHEEEEE		2.6626165157
505PhosphorylationENEDLGNSVGSVEAL
CCCCCCCCCHHHHHH		26.5123737553
508PhosphorylationDLGNSVGSVEALLQK
CCCCCCHHHHHHHHH		18.0327180971
615UbiquitinationYKDVQNLKSRVQKQQ
HHHHHHHHHHHHHHH		43.7122790023
661PhosphorylationEAVAARLSEVANLWK
HHHHHHHHHHHHHHH		25.1922817900
698UbiquitinationENNAEDLKRWLEEVE
CCCHHHHHHHHHHCC		54.5822790023
800PhosphorylationLQQICRDSEDEEAWI
HHHHHCCCCCHHHHH		27.8221183079
990PhosphorylationLYDFEARSRREVSMK
EEEHHCCCCCCCCCC		42.61-
1165PhosphorylationELNTRWNSLKRLADE
HHHHHHHHHHHHHHH		28.4526487105
1280AcetylationQGLTSDRKESLNEAH
HHHCCCCHHHHHHHH		57.5619860969
1367PhosphorylationNRREIDNTLQNINSK
CHHHHHHHHHHHHHH		26.4428609623
1373PhosphorylationNTLQNINSKRDNLEK
HHHHHHHHHHHHHHH		25.8528609623
1415PhosphorylationWMVARENSLRSDDRD
HHHHHHCCCCCCCHH		22.0223140645
1426PhosphorylationDDRDHLNSLQALMKK
CCHHHHHHHHHHHHC		28.3722817900
1525PhosphorylationLPIACDESYKDPTNI
HCCCCCCCCCCCCHH		25.0025777480
1526PhosphorylationPIACDESYKDPTNIQ
CCCCCCCCCCCCHHH		19.8425777480
1638PhosphorylationKDQARDLTSAGNLLK
HHHHHHCHHHHHHHH		22.3318779572
1645UbiquitinationTSAGNLLKKHQLLEA
HHHHHHHHHHHHHHH		51.9122790023
1905AcetylationKIQVLNEKTASLAKA
HHHHHCHHHHHHHHH		48.6023201123
1938PhosphorylationWKADVVESWIGEKEA
CCHHHHHHHHCCCCH		16.6327180971
1972PhosphorylationKHDTLDASLQSFQQE
HCCCCCHHHHHHHHH		26.97-
2163PhosphorylationQEFEQNASAFLQWIQ
HHHHHHHHHHHHHHH		27.4023737553
2172PhosphorylationFLQWIQETRAYFLDG
HHHHHHHHHHHHCCC		12.2923737553
2198MethylationQLEANKRKQKEIQAM
HHHHHHHHHHHHHHH		68.29-
2206MethylationQKEIQAMKRHLTKIE
HHHHHHHHHHHHHHH		39.42-
2270UbiquitinationGVSEETLKEFSTTYK
CCCHHHHHHHHHHHH		65.2222790023
2277UbiquitinationKEFSTTYKHFDENLT
HHHHHHHHHCCCCCC		35.3922790023
2317UbiquitinationEPEPKFEKFLNAVDP
CCCCHHHHHHHHCCC		59.2822790023
2331PhosphorylationPGRKGYVSLEDYTSF
CCCCCEECHHHHHHH		19.9819060867
2337PhosphorylationVSLEDYTSFLIDKES
ECHHHHHHHEECCCC		16.3021183079
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPTA1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPTA1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPTA1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CBL_MOUSECblphysical
7517397
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPTA1_MOUSE

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Related Literatures of Post-Translational Modification

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